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  Location: Home >> Faculty >> Developmental Biology
  Developmental Biology


Mei Ding


Ding, Mei
PhD
Principal investigator
 
Education and Research experience
1995 B.S., Xiamen University
2004 Ph.D., University of California, Santa Cruz
2004-2008 Post Doctoral training, Stanford University
2008- Principal Investigator, Institute of Genetics and Developmental Biology (Chinese Academy of Sciences) 
 


Research interests
The simple nervous system of the nematode C. elegans is well suited for studying neural development. The complete synaptic connectivity of the nervous system is known from reconstructions of serial sections of electron micrographs, allowing the analysis to be carried out at the level of a single cell and single synapse. Furthermore, the use of fluorescent protein facilitates the visualization of neuronal processes and synapses in vivo and in living animals. We are studying the development of neural circuits by characterizing pathways for axon outgrowth, synapse specificity, and synaptogenesis
KEY PUBLICATIONS (# Corresponding Author) 
1. Guan L#, Zhan Z#, Yang Y, Miao Y, Huang X, and Ding M*. (2020) Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons. PLoS Genetics 16(9):e1008704.
 
2. Ji J, Yuan J, Guo X, Ji R, Quan Q, Ding M*, Li X*, and Liu Y*. (2019) Harmine suppresses hyper-activated Ras-MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans. Cancer Cell Int doi: 10.1186/s12935-019-0880-4.
 
3. Guo X, Yuan J, Song X, Wang X, Sun Q, Tian J, Li X*, Ding M*, and Liu Y*. (2019) Bacteria metabolites from Peganum harmala L. polysaccharides inhibits polyQ aggregation through proteasome-mediated protein degradation in C. elegans. Int J Biol Macromol doi: 10.1016/j.ijbiomac.2020.06.091.
 
4. Wang J# and Ding M*. (2018) Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in C. elegansPNAS doi:10.1073/pnas.1717468115.
 
5. Guan L#, Ma X#, Zhang J, Liu J, Wang Y, and Ding M*. (2016) The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions. PLoS Genetics Jul 14;12(7):e1006163.
 
6. Cheng Y#, Wang J#, Wang Y, and Ding M*. (2015) Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. eLife 4:e05118.
 
7. Wu J#, Cheng Y, Wang J, Chen L, Ding M, and Wu J*.(2015) Structural insight into the mechanism of synergic autoinhibition of SAD kinases. Nature Communications (DOI:10.1038/ncomms9953).
 
8. Wang J#, Chitturi J, Ge Q, Laskova V, Wang W, Li X, Ding M, Zhen M* and Huang X*. (2015) The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development 142:1447-1457
 
9. Qin J#, Liang J, and Ding M*. (2014) Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons. Journal of Neuroscience 34(31):10311-10324.
  
10. Zhang J#, Li X, Jevince AR, Guan L, Wang J, Hall DH, Huang X*, and Ding M*. (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegansPLoS Genetics 9(6): e1001056.
 
11. Song S#, Zhang B#, Sun H, Li X, Xiang Y, Liu Z, Huang X*, and Ding M*. (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegansPLoS Genetics 6(8): e1003618.
 
12. Ding M* and Shen K. (2008) The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessay 30: 1075-1083.
 
13. Ding M#, King RS, Berry EC, Wang Y, Hardin J, and Chisholm AD. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PloS One 3: e3346.
 
14. Ding M#, Chao D, Wang G, Shen K. (2007) Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science 317, 947-951.
 
15. Ding M#, Woo WM, Chisholm AD. (2004) The cytoskeleton and epidermal morphogenesis in C. elegansExp Cell Res 301:84-90.
 
16. Ding M#, Goncharov A, Jin Y, Chisholm AD. (2003) C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development 130:5791-5801.