Search
About us
Research Centers
Key Laboratories
Research
Faculty
CAS Members
Center for Genome Biology
Molecular Agrobiology
Developmental Biology
Molecular Systems Biology
Agro-Resources Research
International Cooperation
News
Resources
Education & Training
Join Us
Societies & Publications
Papers
Links
  Location: Home >> Faculty >> Center for Genome Biology
  Center for Genome Biology


Guodong Wang


Education and Professional Training
Dec, 2006-May, 2009, postdoctoral research fellow, The Samuel Roberts Noble Foundation
Nov, 2003-Dec, 2006, postdoctoral research fellow, MCDB, University of Michigan (Ann Arbor)
Aug, 1999-Oct, 2003, Ph. D. (majored in molecular genetics), Shanghai Insititute of Plant
Physiology and Ecology, Chinese Academy of Sciences.
Aug, 1996-Jun, 1999, M.Sc (majored in organic chemistry), Shanghai Institute of Materia Medica,
 Chinese Academy of Sciences, China.
Aug, 1992-Jun, 1996, B.Sc (majored in chemistry), Nankai University,


Research Interest/Areas
The overall interest within my laboratory is to study how plant synthesizes the useful specialized metabolites in planta, the key enzymes potentially involved in these biosynthesis pathways and the mechanism of the enzymatic reactions. Meanwhile, we also apply the coupled chromatography-mass spectrometry techniques to profile the metabolomics of crop populations, combined with genomics, transcriptomic data, to explore the previously undescribed metabolic traits for crops. As a long-term goal, we will translate the knowledge into new crop cultivars with beneficial traits for human health.
 

Publications (* Corresponding author)  
PDF files are available at: www.researchgate.net/profile/Guodong_Wang9
 
1.   Lin, T., Xu, X., Du, H., Fan, X., …Wang, G., Liang, C*., Zhang, G*., Yu, H*., and Li, J*. (2022) Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum. Sci China Life Sci DOI: 10.1007/s11427-021-2033-2
 
2.   Chen, J., Liu, L., Wang, Y., Li, Z., Wang, G., Kraus, GA., Pichersky, E., and Xu, H*. (2021) Characterization of a cytosolic acyl-activating enzyme catalyzing the formation of 4-methylvaleryl-CoA for pogostone biosynthesis in Pogostemon cablin. Plant Cell Physiol 62, 1556-1571.
 
3.   Chen, Q., Li, J., Ma, Y., Yuan W., Zhang, P., and Wang, G*. (2021) Occurrence and biosynthesis of plant sesterterpenes (C25), a new addition to terpene diversity. Plant Commun 1, 100184.
 
4.   Chen, Q., Li, J., Liu, Z., Mitsuhashi T., Zhang, Y., Liu, H., Ma, Y., He J., Shinada, T., Sato T., h, Wang, Y., Liu H., Abe, I., Zhang, P*., and Wang, G*. (2020) Molecular basis for sesterterpene (C25) diversity produced by plant terpene synthases. Plant Commun 1, 100051. (Cover Story)
 
5.   He, J., Xin, P., Ma, X., Chu, J., and Wang, G*. (2020) Gibberellin metabolism in flowering plants: an update and perspectives. Front Plant Sci 11, 532.
 
6.   Tang, R., Wang, X., Zhou, J., Zhang, F., Zhao, S., Gan, Q., Zhao, L., Wang, F., Zhang, Q., Zhang, J., Wang, G., and Yang C*. (2020) Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans. J Genet Genomics 47, 145-156.
 
7.   Bian, X., Li, W., Niu, C., Wei, W., Hu, Y., Han, J., Lu, X., Tao, J., Jin, M., Qin, H., Zhou, B., Zhang, W., Ma, B., Wang, G., Lai, Y., Chen, S., and Zhang, J*. (2020) A class B heat shock factor selected for during soybean domestication contributes to salt tolerance by promoting flavonoid biosynthesis. New Phytol 225, 268-283.
 
8.   He, J., Chen, Q., Xin, P., Yuan, J., Ma, Y., Wang, X. Xu, M., Chu, J., Peters R., and Wang, G*. (2019) CYP72A enzymes catalyse 13-hydrolyzation of gibberellins. Nat Plants 5, 1057-1065. (Cover Story)
 
9.   Liu, L., Zhang, F., Li, G., and Wang, G*. (2019) Qualitative and quantitative NAD+ metabolomics leads to discovery of multiple functional nicotinate N-glycosyltransferase in Arabidopsis. Front Plant Sci 10, 1164.
 
10.   Xie, P., Shi, J., Tang, S., Chen, C., Khan, A., Zhang, F., Xiong, Y., Li, C., He, W., Wang, G., Lei, F., Wu, Y., and Xie, Q*. (2019) Control of bird feeding behavior by tannin1 through modulating the biosynthesis of polyphenols and fatty acid-derived volatiles in Sorghum. Mol Plant 12, 1315-1324.
 
11.   Gao, S., Xiao, Y., Xu, F., Gao, X., Cao, S., Zhang, F., Wang, G., Sanders, D., and Chu, C*. (2019) Cytokinin-dependent regulatory module underlies the maintenance of zinc nutrition in rice. New Phytol 224, 202-215.
 
12.   Chen, Q., Jiang, T., Liu, YX., Liu, H., Zhao, T., Liu, Z., Gan, X., Hallab, A., Wang, X., He, J., Ma, Y., Zhang, F., Jin, T., Schranz, ME., Wang, Y., Bai, Y.*, and Wang, G*. (2019) Recently duplicated sesterterpene (C25) gene clusters in Arabidopsis thaliana modulate root microbiota. Sci China Life Sci 62, 947-958.
 
13.   Zhou, J., Wang, X., Wang, M., Chang, Y., Zhang, F., Ban, Z., Tang, R., Gan, Q., Wu, S., Zhang, Q., Wang, F., Zhao, L., Jing, Y., Qian, W., Wang, G., Guo, W.*, and Yang, C*. (2019) Aberrant lysine catabolism disrupts mitochondrial homeostasis essential for animal development. J Cell Biol 218, 580-597.
 
14.   Wu, R., Zhang, F., Liu, L., Li, W., Pichersky, E., and Wang, G*. (2018) MeNA, controlled by reversible methylation of nicotinate, is a NAD precursor that undergoes long-distance transport in Arabidopsis. Mol Plant 10, 1264-1277.
 
15.   Ding, L., Yang, X., Tian, H., Liang, J., Zhang, F., Wang, G., Wang, Y., Ding, M., Shui, G., and Huang, X.* (2018) Mitochondrial calcium-dependent metabolism supports Seipin-mediated lipid homeostasis. EMBO J 37, e97572.
 
16.   Ban, Z., Qin, H., Mitchell, A.J., Liu, B., Zhang, F., Weng, J.K., Dixon, R.A.*, and Wang, G*. (2018) Non-catalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis. Proc Natl Acad Sci USA 115, E5223-E5232. (Cover Story)
 
17.   Du, L., Xu, F., Fang, J., Gao, S., Tang, J., Fang, S., Wang, H., Tong, H., Zhang, F., Chu, J., Wang, G., and Chu, C*. (2018) Endosperm sugar accumulation caused by mutation of PHS8/ISA1 leads to pre-harvest sprouting in rice. Plant J 95, 545-556.
 
18.   Yang, Y., Zhang, Y., Zhang, S., Chen, Q., Ma, K., Bao, L., Tao, Y., Yin, W., Wang, G., and Liu, H*. (2018). Identification and characterization of a membrane-bound sesterterpene cyclase from Streptomyces somaliensisJ Nat Prod 81, 1089-1092.
 
19.   Zhao, Y., Luo, L., Xu, J., Xin, P., Guo, H., Wu, J., Bai, L., Wang, G., Chu, J., Zuo, J., Yu, H*., Huang, X*., and Li, J*. (2018). Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thalianaCell Res 28, 448-461.
 
20.   Li, W., Zhang, H., Li, X., Zhang, F., Liu, C., Du, Y., Gao, X., Zhang, Z., Zhang, X., Hou, Z., Zhou, H., Sheng, X., Wang, G., and Guo, Y*. (2017). Integrative metabolomic and transcriptomic analyses unveil nutrient remobilization events in leaf senescence of tobacco. Sci Rep 7, 12126.
 
21.   Fang, C.#, Ma, Y.#, Wu, S.#, Liu Z., Wang, Z., Yang, R., Hu, G., Zhou, Z., Yu, H., Zhang, M., Pan, Y., Zhou, G., Ren, H., Du, W., Yan, H., Wang, Y., Han, D., Shen, Y., Liu, S., Liu, T., Zhang, J., Qin, H., Yuan, J., Yuan, X., Kong, F., Liu, B., Li, J., Zhang, Z.*, Wang, G*., Zhu, B*., and Tian, Z*. (2017). Genome-wide association studies dissect the genetic networks underlying agronomical traits in soybean. Genome Biol 18, 161.
 
22.   Li, W.#, Zhang, F.#, Wu, R.#, Jia, L., Li, G., Guo, Y., Liu, C., and Wang, G*. (2017) A novel N-methyltransferase in Arabidopsis appears to feed a conserved pathway for nicotinate detoxification among land plants and is associated with lignin biosynthesis. Plant Physiol 174, 1492-1504.
 
23.   Shao, J., Chen, Q., Lv, H., He, J., Liu, Z., Lu, Y.N., Liu, H*., Wang, G*., and Wang, Y*. (2017). (+)-Thalianatriene and (-)-Retigeranin B catalyzed by sesterterpene synthases from Arabidopsis thaliana. Org Lett 19, 1816-1819.
 
24.   Yang, X., Nian, J., Xie, Q., Feng, J., Zhang, F., Jing, H., Zhang, J., Dong, G., Liang, Y., Peng, J., Wang, G., Qian, Q., and Zuo, J*. (2016). Rice ferredoxin-dependent glutamate synthase regulates nitrogen-carbon metabolomes and is genetically differentiated between japonica and indica subspecies. Mol Plant 9, 1520-1534.
 
25.   Li, Q., Fang, C., Duan, Z., Liu, Y., Qin, H., Zhang, J., Sun, P., Li, W., Wang, G., and Tian, Z*. (2016). Functional conservation and divergence of GmCHLI genes in polyploid soybean. Plant J 88, 584-596.
 
26.   Wei, G., Tian, P., Zhang, F., Qin, H., Miao, H., Chen, Q., Hu, Z., Cao, L., Wang, M., Gu, X., Huang, S., Chen, M., and Wang, G*. (2016). Integrative analyses of non-targeted volatile profiling and transcriptome data provide molecular insight into VOC diversity in cucumber plants (Cucumis sativus L.). Plant Physiol 172, 603-618.
 
27.   Wang, C., Chen, Q., Fan, D., Li, J., Wang, G*., and Zhang, P*. (2016). Structural analyses of short-chain prenyltransferases identify an evolutionarily conserved GFPPS clade in Brassicaceae plants. Mol Plant 9, 195-204. (Cover Story)
 
28.   Li, W., Zhang, F., Chang, Y., Zhao, T., Schranz, M.E., and Wang, G*. (2015). Nicotinate O-glucosylation is an evolutionarily metabolic trait important for seed germination under stress conditions in Arabidopsis thaliana. Plant Cell 27, 1907-1924.
 
29.   Chen, Q., Fan, D., and Wang, G*. (2015) Heteromeric geranyl(geranyl) diphosphate synthase is involved in monoterpene biosynthesis in Arabidopsis flowers. Mol Plant 81434-1437.
 
30.   Wang, B., Chu, J., Yu, T., Xu, Q., Sun, X., Yuan, J., Xiong, G., Wang, G., Wang, Y., and Li, J*. (2015). Tryptophan-independent auxin biosynthesis contributes to early embryogenesis in Arabidopsis. Proc Natl Acad Sci USA 112, 4821-4826.
 
31.   Li, H., Ban, Z., Qin, H., Ma, L., King, A.J., and Wang, G*. (2015). A heteromeric membrane-bound prenyltransferase complex from Humulus lupulus catalyzes three sequential aromatic prenylations in the bitter acid pathway. Plant Physiol 167, 650-659.
 
32.   Wang, G*. (2015). LC-MS in Plant Metabolomics. In Qi X eds. Plant Metabolomics: Methods and Applications. Springer Netherlands, pp 45-61
 
33.   Wang, G*. (2015). Applications of LC-MS in Plant Metabolomics. In Qi X eds. Plant Metabolomics: Methods and Applications. Springer Netherlands, pp 213-226
 
34.   Wang, G*. (2014). Recent progress in secondary metabolism of plant glandular trichomes. Plant Biotech 31, 353-361.
 
35.   Xu, F., Fang, J., Ou, S., Gao, S., Zhang, F., Du, L., Xiao, Y., Wang, H., Sun, X., Chu, J., Wang, G., and Chu, C*. (2014). Variations in CYP78A1 coding region influence grain size and yield in rice. Plant Cell Enviro 38, 800-811.
 
36.   Song, Q., Li, Q., Liu, Y., Zhang, F., Ma, B., Zhang, W., Man, W., Du, W., Wang, G., Chen, S., Zhang, J*. (2013). Soybean GmbZIP123 gene enhances lipid content in the seeds of transgenic Arabidopsis plants. J Exp Bot 64, 4329-4341.
 
37.   Zhao, N., Wang, G., Norris, A., Chen, X., and Chen, F*. (2013). Studying plant secondary metabolism in the age of genomics. Crit Rev Plant Sci 32, 369–382.
 
38.   Yu, S., Cao, L., Zhou C., Zhang T., Lian, H., Sun, Y., Wu, J., Huang, J., Wang, G., and Wang J*. (2013). Sugar is an endogenous cue for juvenile-to-adult phase transition in plants. eLife 2, e00269.
 
39.   Xu, H., Zhang, F., Liu, B., Huhman, DV., Sumner, LW, Dixon, RA and Wang, G*. (2013). Characterization of the formation of branched short-chain fatty acid:CoAs for bitter acid biosynthesis in hop glandular trichomes. Mol Plant 6, 1301–1317.
 
40.   Yu, H., Zhang, F., Wang, G., Liu, Y., and Liu, D*. (2013) Partial deficiency of isoleucine impairs root development and alters transcript levels of the genes involved in branched-chain amino acid and glucosinolate metabolism in Arabidopsis. J Exp Bot 64, 599-612.
 
41.   Yu, H., Du, X., Zhang, F., Hu, Y., Liu, S., Jiang, X., Wang, G., and Liu, D*. (2012). A mutation in the E2 subunit of the mitochondrial pyruvate dehydrogenase complex in Arabidopsis reduces plant organ size and enhances the accumulation of amino acids and intermediate products of the TCA cycle. Planta 236, 387-399.
 
42.   Liu, X., … Wang, G., … Li, C*. (2012). Activation of the jasmonic acid pathway by depletion of the hydroperoxide lyase OsHPL3 reveals crosstalk between the HPL and AOS branches of the oxylipin pathway in rice. PLoS One 7, e50089.
 
43.   Wu, H.J., … Wang, G.D., … Xie, Q*. (2012). Insights into salt tolerance from the genome of Thellungiella salsuginea. Proc Natl Acad Sci USA 109, 12219-12224.
 
44.   Li, C., Wang, Y., Liu, L., Hu, Y., Zhang, F., Mergen, S., Wang, G., Schl?ppi, M. R., and Chu, C*. (2011). A rice plastidial nucleotide sugar epimerase is involved in galactolipid biosynthesis and improves photosynthetic efficiency. PLoS Genet 7, e1002196.
 
45.   Tan, H., Yang, X., Zhang, F., Zheng, X., Qu, C., Mu, J., Fu, F., Li, J., Guan, R., Zhang, H., Wang, G. and Zuo, J*. (2011). Enhanced seed oil production in canola by conditional expression of brassica napus LEAFY COTYLEDON1 (BnLEC1) and LEC1-LIKE (BnL1L) in developing seeds. Plant Physiol 156, 1577-1588.
 
46.   Dai, X., Wang, G., Yang, DS., Tang, Y., Broun, P., Marks, MD., Sumner, LW., Dixon, RA, and Zhao PX*. (2010). TrichOME: a comparative omics database for plant trichomes. Plant Physiol 152, 44-54.
 
47.   Wang, G., and Dixon, RA*. (2009). Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis. Proc. Natl. Acad. Sci. USA. 106, 9914-9919.
 
48.   Wang, G.#, Tian, L.#, Aziz, N., Broun, P., Dai, X., He, J., King, A., Zhao, PX., and Dixon, RA*. (2008). Terpene biosynthesis in glandular trichomes of hop. Plant Physiol 148, 1254-1266.
 
49.   Wang, G., and Pichersky, E*. (2007). Nicotinamidase participates in the salvage pathway of NAD biosynthesis in Arabidopsis. Plant J 49, 1020-1029.
 
50.   Wang, G., and Chen, X*. (2007). Detoxification of soil phenolic pollutants by plant secretory enzyme. In Methods in Biotechnology Vol. 23: Phytoremediation: Methods and Reviews, (Neil, W. ed.), page 49-57. Humana Press.
 
51.   Iijima, Y., Wang, G., Fridman, E., and Pichersky, E*. (2006). Analysis of the enzymatic formation of citral in the glands of sweet basil. Arch. Biochem. Biophys. 448, 141-149.
 
52.   Yang. Y., Varbanova, M., Ross, J., Wang, G., Cortes, D., Fridman, E., Shulaev, V., Noel, J.P., Pichersky, E*. (2005). Methylation and demethylation of plant signal molecules. In Recent Advances in Phytochemistry, Vol. 40. page 253-270. Oxford: Elsevier Science.
 
53.   Wang, G., Li, Q., Luo, B., and Chen, X*. (2004). Ex planta phytoremediation of trichlorophenol and phenolic allelochemicals via an engineered secretory laccase. Nat Biotechnol 22, 893-897.
 
54.   Wang, G., and Chen, X*. (2003). Laccase: properties, catalytic mechanism and applicability. Chinese Bulletin of Botany 20, 469-475.
 
55.   Luo, P., Wang, Y, Wang, G., Essenberg, M., and Chen, X*. (2001). Molecular cloning and functional identification of (+)-delta-cadinene-8-hydroxylase, a cytochrome P450 mono-oxygenase (CYP706B1) of cotton sesquiterpene biosynthesis. Plant J 28, 95-104.
 
56.   Luo, P., Wang, G., and Chen, X*. (2001). Isolation and expression analysis of two cDNA encoding C4H homologues from Gossypium arboretum. Acta Botanica Sinica 43, 77-81.
 
Updated on 01-14-2022