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  Location: Home >> Faculty >> Center for Genome Biology
  Center for Genome Biology


Jianmin Zhou
Education
Ph.D., Horticulture, Purdue University, 1994.         
M.S., Institute of Genetics, Academia Sinica, Beijing, China, 1987.
B.S., Department of Biology, Sichuan University, Chengdu, China, 1984.
 
Professional Experience
Principal Investigator, Institute of Genetics and Developmental Biology, CAS, 2012-present.
Investigator, National Institute of Biological Sciences, Beijing, 2010-2012
Associate Investigator, National Institute of Biological Sciences, Beijing, 2004-2010
Associate Professor of Plant Pathology, Kansas State University, 2002 – 2005.
Assistant Professor of Plant Pathology, Kansas State University, 1997 – 2002.
Post-Doctoral Associate, Purdue University, 1994 - 1997
 
Other Professional Activities
Review Editor, eLife, 2016-present
Editor，Current Protocols in Plant Biology, 2015-present
Section Editor, PLoS Pathogens, 2014-present
Associate Editor, PLoS Pathogens, 2011-2013
Editor, Mol Plant, 2006-present
Board of Directors, International Society of Molecular Plant-Microbe Interactions, 2016-present
 


Research Interest
Like animals, plants are equipped to detect invading microbial pathogens through specialized immune receptors and trigger robust immune responses. A major interest in the lab is to understand the molecular basis of pathogen-recognition and signal transduction pathways leading to plant disease resistance. Pathogenic microbes are capable of delivering a variety of virulence proteins into the host cell. These proteins can suppress plant immunity, modulate cellular processes, and assist pathogen progression in plants. Understanding how these proteins manipulate host cellular processes is major focus in the lab
Selected publications
Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang HW, Zhou JM, Chai J.
Science. 2019 Apr 5;364(6435). pii: eaav5870. doi: 10.1126/science.aav5870.
 
Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW, Zhou JM, Chai J.
Science. 2019 Apr 5;364(6435). pii: eaav5868. doi: 10.1126/science.aav5868.
 
Zhao Y, Liang X, Zhou JM.
F1000Res. 2018 Oct 11;7. pii: F1000 Faculty Rev-1633. doi: 10.12688/f1000research.15761.1. eCollection 2018. Review.
 
Zhang M, Chiang YH, Toru？o TY, Lee D, Ma M, Liang X, Lal NK, Lemos M, Lu YJ, Ma S, Liu J, Day B, Dinesh-Kumar SP, Dehesh K, Dou D, Zhou JM, Coaker G.
Cell Host Microbe. 2018 Sep 12;24(3):379-391.e5. doi: 10.1016/j.chom.2018.08.007.
 
Wang J, Zhou L, Shi H, Chern M, Yu H, Yi H, He M, Yin J, Zhu X, Li Y, Li W, Liu J, Wang J, Chen X, Qing H, Wang Y, Liu G, Wang W, Li P, Wu X, Zhu L, Zhou JM, Ronald PC, Li S, Li J, Chen X.
Science. 2018 Sep 7;361(6406):1026-1028. doi: 10.1126/science.aat7675.
 
Zhou Z, Bi G, Zhou JM.
Curr Protoc Plant Biol. 2018 Mar;3(1):42-50. doi: 10.1002/cppb.20066.
 
Rao S, Zhou Z, Miao P, Bi G, Hu M, Wu Y, Feng F, Zhang X, Zhou JM.
Plant Physiol. 2018 Aug;177(4):1679-1690. doi: 10.1104/pp.18.00486. Epub 2018 Jun 15.
 
Bi G, Zhou Z, Wang W, Li L, Rao S, Wu Y, Zhang X, Menke FLH, Chen S, Zhou JM.
Plant Cell. 2018 Jul;30(7):1543-1561. doi: 10.1105/tpc.17.00981. Epub 2018 Jun 5.
 
Liang X, Zhou JM.
Annu Rev Plant Biol. 2018 Apr 29;69:267-299. doi: 10.1146/annurev-arplant-042817-040540.
 
Zheng X, Kang S, Jing Y, Ren Z, Li L, Zhou JM, Berkowitz G, Shi J, Fu A, Lan W, Zhao F, Luan S.
Plant Cell. 2018 May;30(5):1132-1146. doi: 10.1105/tpc.17.00701. Epub 2018 Apr 30.
 
Liang X, Ma M, Zhou Z, Wang J, Yang X, Rao S, Bi G, Li L, Zhang X, Chai J, Chen S, Zhou JM.
Cell Res. 2018 May;28(5):529-543. doi: 10.1038/s41422-018-0027-5. Epub 2018 Mar 15.
 
Wang J, Grubb LE, Wang J, Liang X, Li L, Gao C, Ma M, Feng F, Li M, Li L, Zhang X, Yu F, Xie Q, Chen S, Zipfel C, Monaghan J, Zhou JM.
Mol Cell. 2018 Feb 1;69(3):493-504.e6. doi: 10.1016/j.molcel.2017.12.026. Epub 2018 Jan 18.
 
Qi J, Wang J, Gong Z, Zhou JM.
Curr Opin Plant Biol. 2017 Aug;38:92-100. doi: 10.1016/j.pbi.2017.04.022. Epub 2017 May 13. Review.
 
Dingzhong Tang*, Guoxun Wang, and Jian-Min Zhou* (2017). Receptor kinases in plant pathogen interactions: more than pattern recognition. Plant Cell (invited review), doi: 10.1105/tpc.16.00891.

Guozhi Bi and Jian-Min Zhou* (2017). MAP kinase signaling pathways: a hub of plant-microbe interactions. Cell Host Microbe (commentary), 21: 270-273.

Lei Li*, Panya Kim, Liping Yu, Gaihong Cai, She Chen, James R Alfano, and Jian-Min Zhou* (2016). Activation-dependent destruction of a co-receptor by a Pseudomonas syringae effector dampens plant immunity. Cell Host Microbe, 20: 504-514.

Jian-Min Zhou* (2016). Plant pathology: a life and death struggle in rice blast disease. Curr Biol. (commentary), 26: R843-845.

Xiangxiu Liang, Pingtao Ding, Keihui Lian, Jinlong Wang, Miaomiao Ma, Lin Li, Lei Li, Meng Li, Xiaojuan Zhang, She Chen, Yuelin Zhang*, Jian-Min Zhou* (2016).  Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor. eLife, DOI: 10.7554/eLife.13568

Dingzhong Tang* and Jian-Min Zhou* (2016). PEPRs spice up plant immunity. EMBO J. (commentary), 35: 4-5.

Guoxun Wang, Brice Roux, Feng Feng, Endrick Guy, Lin Li, Nannan Li, Xiaojuan Zhang, Martine Lautier, Marie-Franc oise Jardinaud, Matthieu Chabannes, Matthieu Arlat, She Chen, Chaozu He, Laurent D. No？l*, and Jian-Min Zhou* (2015). The Decoy substrate of a pathogen effector and a pseudokinase specify pathogen-induced modified-self recognition and immunity in plants. Cell Host Microbe, 18: 285-295.

Zhaoyang Zhou, Yujiao Wu, Yongqing Yang, Minmin Du, Xiaojuan Zhang, Yan Guo, Chuanyou Li, and Jian-Min Zhou* (2015). An Arabidopsis plasma membrane proton ATPase modulates JA signaling and is exploited by the Pseudomonas syringae effector protein AvrB for stomatal invasion. Plant Cell, 27: 2032-2041.

Meng Li, Xiqing Ma, Yi-Hsuan Chiang, Koste A Yadeta, Pengfei Ding, Liansai Dong, Yan Zhao, Xiuming Li, Yufei Yu, Ling Zhang, Qian-Hua Shen, Bin Xia, Gitta Coaker, Dong Liu*, Jian-Min Zhou* (2014). Proline isomerization of the immune receptor-interacting protein RIN4 by a cyclophilin inhibits effector-triggered immunity. Cell Host Microbe, 16: 473-483.

Lei Li, Meng Li, Liping Yu, Zhaoyang Zhou, Xiangxiu Liang, Zixu Liu, Gaihong Cai, Liyan Gao, Xiaojuan Zhang, Yingchun Wang, She Chen, and Jian-Min Zhou* (2014). The FLS2-Associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity. Cell Host Microbe, 15: 329-338.

Yadong Sun, Lei Li, Alberto P. Macho, Zhifu Han*, Cyril Zipfel, Jian-Min Zhou*, and Jijie Chai* (2013). Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science, 342: 624-628.

Zixu Liu, Ying Wu, Fang Yang, Yiyue Zhang, She Chen, Qi Xie, Xingjun Tian*, and Jian-Min Zhou* (2013). BIK1 interacts with PEPRs to mediate ethylene-induced immunity. PNAS, 110: 6205-6210.

Daolong Dou and Jian-Min Zhou (2012). Phytopathogen effectors subverting host immunity: different foes, similar battleground. Cell Host Micrbe (invited review), 12, 484-495.

Feng Feng and Jian-Min Zhou (2012). Plant-bacterial pathogen interactions mediated by type III effectors. Curr. Opin. Plant Biol. (invited review), doi: 10.1016/j.pbi.2012.03.004.

Feng Feng, Fan Yang, Wei Rong, Xiaogang Wu, Jie Zhang, She Chen, Chaozu He, and Jian-Min Zhou (2012). A Xanthomonas uridine 5’-monophosphate transferase inhibits plant immune kinases. Nature, 485, 114-118.

Tingting Xiang, Na Zong, Jie Zhang, Jinfeng Chen, Mingsheng Chen, and Jian-Min Zhou (2011). BAK1 is not a target of the Pseudomonas syringae effector AvrPto. MPMI, 24, 100-107.

Jie Zhang and Jian-Min Zhou (2010). Plant innate immunity triggered by microbial molecular signatures. Molecular Plant (invited review), 5, 783-793.

Yujing Wang, Jifeng Li, Shuguo Hou, Xingwei Wang, Yuan Li, Dongtao Ren, She Chen, Xiaoyan Tang, and Jian-Min Zhou (2010). A Pseudomonas syringae ADP-Ribosyltransferase inhibits Arabidopsis Mitogen-Activated Protein Kinase Kinases. Plant Cell, 22, 2033-2044.

Jie Zhang, Wei Li, Tingting Xiang, Zixu Liu, Kristin Laluk, Xiaojun Ding, Yan Zou, Minghui Gao, Xiaojuan Zhang, She Chen, Tesfaye Mengiste, Yuelin Zhang, and Jian-Min Zhou. (2010). Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host & Microbe, 7, 290-301.

Yan Li, QingQing Zhang, Jiangguang Zhang, Liang Wu, Yijun Qi, and Jian-Min Zhou. (2010). Identification of miRNAs involved in Pathogen-Associated Molecular Pattern-triggered plant innate immunity. Plant Physiol., 152, 2222-231.

Cui, H., Wang, Y., Xue, L., Chu, J., Yan, C., Fu, J., Chen, M., Innes, R.W., and Zhou, J.-M. (2010). Pseudomonas syringae effector protein AvrB perturbs Arabidopsis hormone signaling by activating MAP KINASE 4. Cell Host & Microbe, 7, 164-175.

Huamin Chen, Li Xue, Satya Chintamanani, Hugo Germain, Huiqiong Lin, Haitao Cui, Run Cai, Jianru Zuo, Xiaoyan Tang,  Xin Li, Hongwei Guo, and Jian-Min Zhou (2009).  ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE 3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity. Plant Cell, 25, 2527-2540.

Haitao Cui, Tingting Xiang, and Jian-Min Zhou (2009).  Plant immunity: A lesson from pathogenic bacterial effector proteins. Cellular Microbiology (invited review), 11, 1453-1461.

Huamin Chen, Yan Zou, Yulei Shang, Huiqiong Lin, Yujing Wang, Run Cai, Xiaoyan Tang, and Jian-Min Zhou (2008). Firefly luciferase complementation imaging assay for protein-protein interactions in plants. Plant Physiol. 146: 368-376.

Jian-Min Zhou and Jijie Chai (2008). Plant pathogenic bacterial type III effectors subdue host responses. Curr Opin Microbiol (invited review), 11, 179-185.

Linjie Chen, Huayi Wang, Jie Zhang, Lichuan Gu, Niu Huang, Jian-Min Zhou, and Jijie Chai (2008). Structural basis for the catalytic mechanism of phosphothreonine lyase. Nat Struct Mol Biol, 15, 101-102.

Tingting Xiang, Na Zong, Yan Zou, Yong Wu, Jie Zhang, Weiman Xing, Yan Li, Xiaoyan Tang, Lihuang Zhu, Jijie Chai, and Jian-Min Zhou (2008). Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol, 18, 74-80.

Weiman Xing, Yan Zou, Qun Liu, Jianing Liu, Xi Luo, Qingqiu Huang, She Chen, Lihuang Zhu, Ruchang Bi, Quan Hao, Jia-Wei Wu, Jian-Min Zhou, and Jijie Chai (2007). Structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature, 449, 243-247.

Jie Zhang, Feng Shao, Yan Li, Haitao Cui, Linjie Chen, Hongtao Li, Yan Zou, Chengzu Long, Lefu Lan, Jijie Chai, She Chen, Xiaoyan Tang, and Jian-Min Zhou (2007). A Pseudomonas syringae Effector Inactivates MAPKs to Suppress PAMP-Induced Immunity. Cell Host & Microbe, 1,175-185.

Hongtao Li, Hao Xu, Yan Zhou, Jie Zhang, Chengzu Long, Shuqin Li, She Chen, Jian-Min Zhou, Feng Shao (2007). The phosphothreonine lyase activity of a bacterial type III effector family. Science 315, 1000-1003.

Yulei Shang, Xinyan Li, Haitao Cui, Ping He, Roger Thilmony, Satya Chintamanani, Julie Zwiesler-Vollick, Suresh Gopalan, Xiaoyan Tang, and Jian-Min Zhou (2006). RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB. PNAS, 103, 19200-19205.

Xiaoyan Tang and Jian-Min Zhou (2006). Regulation of the type III secretion system in phytopathogenic bacteria. MPMI (review), 19, 1159-1166.

Xinyan Li, Huiqiong Lin, Weiguo Zhang, Yan Zou, Jie Zhang, Xiaoyan Tang, and Jian-Min Zhou (2005). Flagellin induces innate immunity in nonhost interactions that is suppressed by Pseudomonas syringae effectors. PNAS, 102, 12990-12995.

Fangming Xiao, S. Mark Goodwin, Yanmei Xiao, Zhaoyu Sun, Douglas Baker, Xiaoyan Tang, Matthew A. Jenks, and Jian-Min Zhou (2004) Arabidopsis CYP86A2 represses Pseudomonas syringae type III genes and is required for cuticle development. EMBO J., 23, 2903-2913.

Ping He, Satya Chintamanani, Zhongying Chen, Lihuang Zhu, Barbara N. Kunkel, James R. Alfano, Xiaoyan Tang, and Jian-Min Zhou (2004). Activation of a COI1-dependent pathway in Arabidopsis by Pseudomonas syringae type III effectors and coronatine. The Plant Journal, 37, 589-602. 

Li Kang, Jianxiong Li, Tiehan Zhao, Fangming Xiao, Xiaoyan Tang, Roger Thilmony, ShengYang He, and Jian-Min Zhou (2003). Interplay of the Arabidopsis nonhost resistance gene NHO1 with bacterial virulence. PNAS, 100, 3519-3524.

Ping He, Bernd Friebe, Bikram Gill, and Jian-Min Zhou (2003). Allopolyploidy alters gene expression in the highly stable hexaploid wheat. Plant Molecular Biology, 52, 401-414.

Thara Venkatappa, John Fellers, and Jian-Min Zhou (2003). In planta induced genes of Puccinia triticina. Molecular Plant Pathology, 4, 51-56.

Fangming Xiao, Ming Lu, Tiehan Zhao, Xiaoyan Tang, and Jian-Min Zhou (2003). Pto mutants differentially activate Prf-dependent, AvrPto-independent resistance and gene-for-gene resistance. Plant Physiology, 131, 1239-1249.

Fang-Ming Xiao, Xiaoyan Tang, and Jian-Min Zhou (2001). Expression of 35S::Pto globally activates defense gene expression in tomato plants. Plant Physiology, 126, 1637-1645.

Ming Lu, Xiaoyan Tang, and Jian-Min Zhou. (2001) Arabidopsis NHO1 is required for general resistance against Pseudomonas bacteria. Plant Cell, 13, 437-447.

Libo Shan, Venkatappa Thara, Gregory Martin, Jian-Min Zhou, and Xiaoyan Tang (2000). The Pseudomonas AvrPto protein is differentially recognized by tomato and tobacco and is localized to the plant plasma membrane.  Plant Cell, 12, 2323-2338.
 
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