Danhua Jiang

 

 

 

 

The dynamics of chromatin and epigenetic information it carries regulate chromatin function and the “reading” of genetic information. Using the model plant Arabidopsis thaliana and crop species, we study the chromatin regulatory mechanisms and their impact on plant environmental responses. One of our special interests is the role of histone variants in plant chromatin regulation.

 

Improving crop stress tolerance is critical for stabilized food production. We use an emerging C4 model crop Setaria italica, which is highly efficient in water and nutrient use and shows strong tolerant in abiotic stresses to investigate the genetic and molecular basis of its stress response. The genetic resources obtained will be applied to improve stress tolerance in closely related crop species such as maize and sorghum.

 

(Please refer to Google Scholar for the full list of publications

https://scholar.google.com/citations?user=ZzvFigEAAAAJ&hl=en)

 

Zhao T*, Lu J*, Zhang H*, Xue M, Pan J, Ma L, Berger F, Jiang D. Histone H3.3 deposition in seed is essential for the post-embryonic developmental competence in Arabidopsis. Nature Communications, 2022, 13: 7728.

 

Pan J*, Zhang H*, Zhan Z, Zhao T, Jiang D. A REF6-dependent H3K27me3-depleted state facilitates gene activation during germination in Arabidopsis. Journal of Genetics and Genomics, 2022, https://doi.org/10.1016/j.jgg.2022.09.001.

 

Zhang H*, Li X*, Song R*, Zhan Z*, Zhao F, Li Z, Jiang D. Cap-binding complex assists RNA polymerase II transcription in plant salt stress response. Plant Cell & Environment, 2022, 45: 2780-2793.

 

Xue M, Zhang H, Zhao F, Zhao T, Li H, Jiang D. The INO80 chromatin remodeling complex promotes thermomorphogenesis by connecting H2A.Z eviction and active transcription in Arabidopsis. Molecular Plant, 2021, 14: 1799-1813

 

Zhao F, Zhang H, Zhao T, Li Z, Jiang D. The histone variant H3.3 promotes the active chromatin state to repress flowering in Arabidopsis. Plant Physiology, 2021, 186: 2051-2063.

 

Borg M*, Jiang D*, Berger F. Histone variants take center stage in shaping the epigenome. Current Opinion in Plant Biology, 2021, 61: 101991.

 

Jiang D*, Borg M*, Lorkovic ZJ, Montgomery S, Osakabe A, Yelagandula R, Axelsson E, Berger F. The evolution and functional divergence of the histone H2B family in plants. Plos Genetics, 2020, 16: e1008964.

 

Zhao T, Zhan Z, Jiang D. Histone modifications and their regulatory roles in plant development and environmental memory. Journal of Genetics and Genomics, 2019, 46: 467-476.

 

Li Z*, Jiang D*, He Y. FRIGIDA establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production. Nature Plants, 2018, 4: 836-846.

 

Jiang D, Berger F. DNA replication-coupled histone modification maintains Polycomb gene silencing in plants. Science, 2017, 357: 1146-1149.

 

Jiang D, Berger F. Histone variants in plant transcriptional regulation. Biochimica et Biophysoca Acta (BBA)-Gene Regulatory Mechanisms, 2017, 1: 123-130.

 

Li Z*, Jiang D*, Fu X, Luo X, Liu R, He Y. Intergration of histone methylations with RNA processing by the nuclear mRNA cap binding complex. Nature Plants, 2016, 2: 16015.

 

Gu X*, Jiang D*, Yang W*, Jacob Y, Michaels S, He Y. Arabidopsis homologs of retinoblastoma-associated protein 46/48 associate with a histone deacetylase to act redundantly in chromatin silencing. Plos Genetics, 2011, e1002366.

 

Jiang D, Kong N, Gu X, Li Z, He Y. Arabidopsis COMPASS-like complexes mediate histone H3 lysine 4 trimethylation to control the floral transition and plant development. Plos Genetics, 2011, e1001330.

 

Jiang D, Gu X, He Y. Establishment of the winter-annual growth habit via FRIGIDA-mediated histone methylation at FLOWERING LOCUS C in Arabidopsis. Plant Cell, 2009, 21: 1733-1746.

 

Jiang D, Wang Y, Wang Y, He Y. Rerpression of the FLOWERING LOCUS C and FLOWERING LOCUS T by the Arabidopsis polycomb repressive complex 2 components. Plos ONE, 2008, 3: e3404.

 

Jiang D*, Yang W*, He Y, Amasino RM. Arabidopsis relatives of human histone-lysine specific demethylase 1 repress expression FWA and FLOWERING LOCUS C and thus promote floral transition. Plant Cell, 2007, 19: 2975-2987.