|
Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA
Junfeng Bi,Wei Wang,Zhonghua Liu,Xiahe Huang,Qingqing Jiang,George Liu,Yingchun Wang,Xun Huang
Cell Metabolism
Abstract
Adipose tissue is central to the regulation of lipid metabolism. Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), one of the most severe lipodystrophy diseases, is caused by mutation of the Seipin gene. Seipin plays an important role in adipocyte differentiation and lipid homeostasis, but its exact molecular functions are still unknown. Here, we show that Seipin physically interacts with the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in both Drosophila and man. SERCA, an endoplasmic reticulum (ER) calcium pump, is solely responsible for transporting cytosolic calcium into the ER lumen. Like dSeipin, dSERCA cell-autonomously promotes lipid storage in Drosophila fat cells. dSeipin affects dSERCA activity and modulates intracellular calcium homeostasis. Adipose tissue-specific knockdown of the ER-to-cytosol calcium release channel ryanodine receptor (RyR) partially restores fat storage in dSeipin mutants. Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis.
|
论文编号: |
DOI:10.1016/j.cmet.2014.03.028 |
论文题目: |
Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA |
英文论文题目: |
Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA |
第一作者: |
Junfeng Bi,Wei Wang,Zhonghua Liu,Xiahe Huang,Qingqing Jiang,George Liu,Yingchun Wang,Xun Huang |
英文第一作者: |
Junfeng Bi,Wei Wang,Zhonghua Liu,Xiahe Huang,Qingqing Jiang,George Liu,Yingchun Wang,Xun Huang |
联系作者: |
|
英文联系作者: |
|
外单位作者单位: |
|
英文外单位作者单位: |
|
发表年度: |
2014-05-07 |
卷: |
|
期: |
|
页码: |
|
摘要: |
Adipose tissue is central to the regulation of lipid metabolism. Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), one of the most severe lipodystrophy diseases, is caused by mutation of the Seipin gene. Seipin plays an important role in adipocyte differentiation and lipid homeostasis, but its exact molecular functions are still unknown. Here, we show that Seipin physically interacts with the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in both Drosophila and man. SERCA, an endoplasmic reticulum (ER) calcium pump, is solely responsible for transporting cytosolic calcium into the ER lumen. Like dSeipin, dSERCA cell-autonomously promotes lipid storage in Drosophila fat cells. dSeipin affects dSERCA activity and modulates intracellular calcium homeostasis. Adipose tissue-specific knockdown of the ER-to-cytosol calcium release channel ryanodine receptor (RyR) partially restores fat storage in dSeipin mutants. Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis. |
英文摘要: |
Adipose tissue is central to the regulation of lipid metabolism. Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), one of the most severe lipodystrophy diseases, is caused by mutation of the Seipin gene. Seipin plays an important role in adipocyte differentiation and lipid homeostasis, but its exact molecular functions are still unknown. Here, we show that Seipin physically interacts with the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in both Drosophila and man. SERCA, an endoplasmic reticulum (ER) calcium pump, is solely responsible for transporting cytosolic calcium into the ER lumen. Like dSeipin, dSERCA cell-autonomously promotes lipid storage in Drosophila fat cells. dSeipin affects dSERCA activity and modulates intracellular calcium homeostasis. Adipose tissue-specific knockdown of the ER-to-cytosol calcium release channel ryanodine receptor (RyR) partially restores fat storage in dSeipin mutants. Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis. |
刊物名称: |
Cell Metabolism |
英文刊物名称: |
Cell Metabolism |
论文全文: |
|
英文论文全文: |
|
全文链接: |
|
其它备注: |
Junfeng Bi,Wei Wang,Zhonghua Liu,Xiahe Huang,Qingqing Jiang,George Liu,Yingchun Wang,Xun Huang. Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA. Cell Metabolism. DOI:10.1016/j.cmet.2014.03.028 |
英文其它备注: |
|
学科: |
|
英文学科: |
|
影响因子: |
|
第一作者所在部门: |
|
英文第一作者所在部门: |
|
论文出处: |
|
英文论文出处: |
|
论文类别: |
|
英文论文类别: |
|
参与作者: |
|
英文参与作者: |
|
|