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Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus
Hao Wang,Yefeng Yuan,Zhao Zhang,Hui Yan,Yaqin Feng and Wei Li
THE JOURNAL OF BIOLOGICAL CHEMISTRY
Abstract
DTNBP1 (dystrobrevin-binding protein 1) which encodes dysbindin-1 is one of the leading susceptibility genes for schizophrenia. Both dysbindin-1B and 1C isoforms are decreased but the 1A isoform is unchanged in schizophrenic hippocampal formation, suggesting dysbindin-1 isoforms may have distinct roles in schizophrenia. We found that mouse dysbindin-1C, but not 1A, is localized in the hilar glutamatergic mossy cells of the dentate gyrus. The maturation rate of newborn neurons in sandy (sdy) mice, in which both dysbindin-1A and 1C are deleted, is significantly delayed when compared with that in wild-type mice, or with that in muted (mu) mice in which dysbindin-1A is destabilized but 1C is unaltered. Dysbindin-1C deficiency leads to a decrease in mossy cells, which causes the delayed maturation of newborn neurons. This suggests that dysbindin-1C, rather than 1A, regulates adult hippocampal neurogenesis in a non-cell autonomous manner.
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论文编号: |
DOI:10.1074/jbc.M114.590927 |
论文题目: |
Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus |
英文论文题目: |
Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus |
第一作者: |
Hao Wang,Yefeng Yuan,Zhao Zhang,Hui Yan,Yaqin Feng and Wei Li |
英文第一作者: |
Hao Wang,Yefeng Yuan,Zhao Zhang,Hui Yan,Yaqin Feng and Wei Li |
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2014-08-30 |
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摘要: |
DTNBP1 (dystrobrevin-binding protein 1) which encodes dysbindin-1 is one of the leading susceptibility genes for schizophrenia. Both dysbindin-1B and 1C isoforms are decreased but the 1A isoform is unchanged in schizophrenic hippocampal formation, suggesting dysbindin-1 isoforms may have distinct roles in schizophrenia. We found that mouse dysbindin-1C, but not 1A, is localized in the hilar glutamatergic mossy cells of the dentate gyrus. The maturation rate of newborn neurons in sandy (sdy) mice, in which both dysbindin-1A and 1C are deleted, is significantly delayed when compared with that in wild-type mice, or with that in muted (mu) mice in which dysbindin-1A is destabilized but 1C is unaltered. Dysbindin-1C deficiency leads to a decrease in mossy cells, which causes the delayed maturation of newborn neurons. This suggests that dysbindin-1C, rather than 1A, regulates adult hippocampal neurogenesis in a non-cell autonomous manner. |
英文摘要: |
DTNBP1 (dystrobrevin-binding protein 1) which encodes dysbindin-1 is one of the leading susceptibility genes for schizophrenia. Both dysbindin-1B and 1C isoforms are decreased but the 1A isoform is unchanged in schizophrenic hippocampal formation, suggesting dysbindin-1 isoforms may have distinct roles in schizophrenia. We found that mouse dysbindin-1C, but not 1A, is localized in the hilar glutamatergic mossy cells of the dentate gyrus. The maturation rate of newborn neurons in sandy (sdy) mice, in which both dysbindin-1A and 1C are deleted, is significantly delayed when compared with that in wild-type mice, or with that in muted (mu) mice in which dysbindin-1A is destabilized but 1C is unaltered. Dysbindin-1C deficiency leads to a decrease in mossy cells, which causes the delayed maturation of newborn neurons. This suggests that dysbindin-1C, rather than 1A, regulates adult hippocampal neurogenesis in a non-cell autonomous manner. |
刊物名称: |
THE JOURNAL OF BIOLOGICAL CHEMISTRY |
英文刊物名称: |
THE JOURNAL OF BIOLOGICAL CHEMISTRY |
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Hao Wang,Yefeng Yuan,Zhao Zhang,Hui Yan,Yaqin Feng and Wei Li. Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus. THE JOURNAL OF BIOLOGICAL CHEMISTRY. DOI:10.1074/jbc.M114.590927 |
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