论文编号: |
DOI:10.1038/cr.2015.64 |
论文题目: |
Targeted genome editing in primate embryos |
英文论文题目: |
Targeted genome editing in primate embryos |
第一作者: |
Xiangyu Guo and Xiao-Jiang Li |
英文第一作者: |
Xiangyu Guo and Xiao-Jiang Li |
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2015-06-05 |
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摘要: |
Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases. |
英文摘要: |
Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases. |
刊物名称: |
Cell Research |
英文刊物名称: |
Cell Research |
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其它备注: |
Xiangyu Guo and Xiao-Jiang Li. Targeted genome editing in primate embryos. Cell Research. DOI:10.1038/cr.2015.64 |
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