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Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction
Yun Yang,Chunying Shi,Xianglin Hou,Yannan Zhao,Bing Chen,Bo Tan,Zongwu Deng,Qingguo Li,Jianzhou Liu,Zhifeng Xiao,Qi Miao and Jianwu Dai
Journal of Controlled Release
Abstract
Vascular endothelial growth factor (VEGF) promotes angiogenesis and improves cardiac function after myocardial infarction (MI). However, the non-targeted delivery of VEGF decreases its therapeutic efficacy due to an insufficient local concentration in the ischemic myocardium. In this study, we used a specific peptide to modify VEGF and determined that this modified VEGF (IMT-VEGF) localized to the ischemic myocardium through intravenous injection by interacting with cardiac troponin I (cTnI). When IMT-VEGF was used to mediate cardiac repair in a rat model of ischemia–reperfusion (I–R) injury, we observed a decreased scar size, enhanced angiogenesis and improved cardiac function. Moreover, an alternative treatment using the repeated administration of a low-dose IMT-VEGF also promoted angiogenesis and functional recovery. The therapeutic effects of IMT-VEGF were further confirmed in a pig model of MI as the result of the conserved properties of its interacting protein, cTnI. These results suggest a promising therapeutic strategy for MI based on the targeted delivery of IMT-VEGF.
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论文编号: |
DOI:10.1016/j.jconrel.2015.06.036 |
论文题目: |
Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction |
英文论文题目: |
Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction |
第一作者: |
Yun Yang,Chunying Shi,Xianglin Hou,Yannan Zhao,Bing Chen,Bo Tan,Zongwu Deng,Qingguo Li,Jianzhou Liu,Zhifeng Xiao,Qi Miao and Jianwu Dai |
英文第一作者: |
Yun Yang,Chunying Shi,Xianglin Hou,Yannan Zhao,Bing Chen,Bo Tan,Zongwu Deng,Qingguo Li,Jianzhou Liu,Zhifeng Xiao,Qi Miao and Jianwu Dai |
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2015-07-08 |
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摘要: |
Vascular endothelial growth factor (VEGF) promotes angiogenesis and improves cardiac function after myocardial infarction (MI). However, the non-targeted delivery of VEGF decreases its therapeutic efficacy due to an insufficient local concentration in the ischemic myocardium. In this study, we used a specific peptide to modify VEGF and determined that this modified VEGF (IMT-VEGF) localized to the ischemic myocardium through intravenous injection by interacting with cardiac troponin I (cTnI). When IMT-VEGF was used to mediate cardiac repair in a rat model of ischemia–reperfusion (I–R) injury, we observed a decreased scar size, enhanced angiogenesis and improved cardiac function. Moreover, an alternative treatment using the repeated administration of a low-dose IMT-VEGF also promoted angiogenesis and functional recovery. The therapeutic effects of IMT-VEGF were further confirmed in a pig model of MI as the result of the conserved properties of its interacting protein, cTnI. These results suggest a promising therapeutic strategy for MI based on the targeted delivery of IMT-VEGF. |
英文摘要: |
Vascular endothelial growth factor (VEGF) promotes angiogenesis and improves cardiac function after myocardial infarction (MI). However, the non-targeted delivery of VEGF decreases its therapeutic efficacy due to an insufficient local concentration in the ischemic myocardium. In this study, we used a specific peptide to modify VEGF and determined that this modified VEGF (IMT-VEGF) localized to the ischemic myocardium through intravenous injection by interacting with cardiac troponin I (cTnI). When IMT-VEGF was used to mediate cardiac repair in a rat model of ischemia–reperfusion (I–R) injury, we observed a decreased scar size, enhanced angiogenesis and improved cardiac function. Moreover, an alternative treatment using the repeated administration of a low-dose IMT-VEGF also promoted angiogenesis and functional recovery. The therapeutic effects of IMT-VEGF were further confirmed in a pig model of MI as the result of the conserved properties of its interacting protein, cTnI. These results suggest a promising therapeutic strategy for MI based on the targeted delivery of IMT-VEGF. |
刊物名称: |
Journal of Controlled Release |
英文刊物名称: |
Journal of Controlled Release |
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Yun Yang,Chunying Shi,Xianglin Hou,Yannan Zhao,Bing Chen,Bo Tan,Zongwu Deng,Qingguo Li,Jianzhou Liu,Zhifeng Xiao,Qi Miao and Jianwu Dai. Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction. Journal of Controlled Release. DOI:10.1016/j.jconrel.2015.06.036 |
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