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Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice
Penggen Duan,Shen Ni,Junmin Wang,Baolan Zhang,Ran Xu,Yuexing Wang,Hongqi Chen,Xudong Zhu & Yunhai Li
Nature Plants
Abstract
An increase in grain yield is crucial for modern agriculture1. Grain size is one of the key components of grain yield in rice and is regulated by quantitative trait loci (QTLs)2,3. Exploring new QTLs for grain size will help breeders develop elite rice varieties with higher yields3,4. Here, we report a new semi-dominant QTL for grain size and weight (GS2) in rice, which encodes the transcription factor OsGRF4 (GROWTH-REGULATING FACTOR 4) and is regulated by OsmiR396. We demonstrate that a 2 bp substitution mutation in GS2 perturbs OsmiR396-directed regulation of GS2, resulting in large and heavy grains and increased grain yield. Further results reveal that GS2 interacts with the transcription coactivitors OsGIF1/2/3, and overexpression of OsGIF1 increases grain size and weight. Thus, our findings define the regulatory mechanism of GS2, OsGIFs and OsmiR396 in grain size and weight control, suggesting this pathway could be used to increase yields in crops.
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论文编号: |
DOI:10.1038/nplants.2015.203 |
论文题目: |
Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice |
英文论文题目: |
Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice |
第一作者: |
Penggen Duan,Shen Ni,Junmin Wang,Baolan Zhang,Ran Xu,Yuexing Wang,Hongqi Chen,Xudong Zhu & Yunhai Li |
英文第一作者: |
Penggen Duan,Shen Ni,Junmin Wang,Baolan Zhang,Ran Xu,Yuexing Wang,Hongqi Chen,Xudong Zhu & Yunhai Li |
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2015-12-22 |
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摘要: |
An increase in grain yield is crucial for modern agriculture1. Grain size is one of the key components of grain yield in rice and is regulated by quantitative trait loci (QTLs)2,3. Exploring new QTLs for grain size will help breeders develop elite rice varieties with higher yields3,4. Here, we report a new semi-dominant QTL for grain size and weight (GS2) in rice, which encodes the transcription factor OsGRF4 (GROWTH-REGULATING FACTOR 4) and is regulated by OsmiR396. We demonstrate that a 2 bp substitution mutation in GS2 perturbs OsmiR396-directed regulation of GS2, resulting in large and heavy grains and increased grain yield. Further results reveal that GS2 interacts with the transcription coactivitors OsGIF1/2/3, and overexpression of OsGIF1 increases grain size and weight. Thus, our findings define the regulatory mechanism of GS2, OsGIFs and OsmiR396 in grain size and weight control, suggesting this pathway could be used to increase yields in crops. |
英文摘要: |
An increase in grain yield is crucial for modern agriculture1. Grain size is one of the key components of grain yield in rice and is regulated by quantitative trait loci (QTLs)2,3. Exploring new QTLs for grain size will help breeders develop elite rice varieties with higher yields3,4. Here, we report a new semi-dominant QTL for grain size and weight (GS2) in rice, which encodes the transcription factor OsGRF4 (GROWTH-REGULATING FACTOR 4) and is regulated by OsmiR396. We demonstrate that a 2 bp substitution mutation in GS2 perturbs OsmiR396-directed regulation of GS2, resulting in large and heavy grains and increased grain yield. Further results reveal that GS2 interacts with the transcription coactivitors OsGIF1/2/3, and overexpression of OsGIF1 increases grain size and weight. Thus, our findings define the regulatory mechanism of GS2, OsGIFs and OsmiR396 in grain size and weight control, suggesting this pathway could be used to increase yields in crops. |
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Nature Plants |
英文刊物名称: |
Nature Plants |
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Penggen Duan,Shen Ni,Junmin Wang,Baolan Zhang,Ran Xu,Yuexing Wang,Hongqi Chen,Xudong Zhu & Yunhai Li. Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice. Nature Plants. DOI:10.1038/nplants.2015.203 |
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