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OsMTOPVIB Promotes Meiotic DNA Double-Strand Break Formation in Rice
Zhihui Xue, Yafei Li, Lei Zhang, Wenqing Shi, Chao Zhang, Mengshi Feng, Fanfan Zhang, Ding Tang, Hengxiu Yu, Minghong Gu, Zhukuan Cheng
Molecular Plant
Abstract
We identified the rice member of MTOPVIB/TOPOVIBL protein family and designated OsMTOPVIB. In the OsmtopVIB mutant, neither γH2AX nor OsDMC1 is properly loaded. Nevertheless, DSB repair defects in Osrad51c and Oshus1 are abolished in the OsmtopVIB background. These results reveal that OsMTOPVIB is required for DSB formation in rice meiosis. OsMTOPVIB interacts with OsSPO11-1 and OsSPO11-2, indicating that meiotic DSB is generated by a heterodimer as archaeal TopVIA/TopVIB
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DOI:10.1016/j.molp.2016.07.005 |
论文题目: |
OsMTOPVIB Promotes Meiotic DNA Double-Strand Break Formation in Rice |
英文论文题目: |
OsMTOPVIB Promotes Meiotic DNA Double-Strand Break Formation in Rice |
第一作者: |
Zhihui Xue, Yafei Li, Lei Zhang, Wenqing Shi, Chao Zhang, Mengshi Feng, Fanfan Zhang, Ding Tang, Hengxiu Yu, Minghong Gu, Zhukuan Cheng |
英文第一作者: |
Zhihui Xue, Yafei Li, Lei Zhang, Wenqing Shi, Chao Zhang, Mengshi Feng, Fanfan Zhang, Ding Tang, Hengxiu Yu, Minghong Gu, Zhukuan Cheng |
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2016-07-28 |
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摘要: |
We identified the rice member of MTOPVIB/TOPOVIBL protein family and designated OsMTOPVIB. In the OsmtopVIB mutant, neither γH2AX nor OsDMC1 is properly loaded. Nevertheless, DSB repair defects in Osrad51c and Oshus1 are abolished in the OsmtopVIB background. These results reveal that OsMTOPVIB is required for DSB formation in rice meiosis. OsMTOPVIB interacts with OsSPO11-1 and OsSPO11-2, indicating that meiotic DSB is generated by a heterodimer as archaeal TopVIA/TopVIB |
英文摘要: |
We identified the rice member of MTOPVIB/TOPOVIBL protein family and designated OsMTOPVIB. In the OsmtopVIB mutant, neither γH2AX nor OsDMC1 is properly loaded. Nevertheless, DSB repair defects in Osrad51c and Oshus1 are abolished in the OsmtopVIB background. These results reveal that OsMTOPVIB is required for DSB formation in rice meiosis. OsMTOPVIB interacts with OsSPO11-1 and OsSPO11-2, indicating that meiotic DSB is generated by a heterodimer as archaeal TopVIA/TopVIB |
刊物名称: |
Molecular Plant |
英文刊物名称: |
Molecular Plant |
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其它备注: |
Zhihui Xue, Yafei Li, Lei Zhang, Wenqing Shi, Chao Zhang, Mengshi Feng, Fanfan Zhang, Ding Tang, Hengxiu Yu, Minghong Gu, Zhukuan Cheng. OsMTOPVIB Promotes Meiotic DNA Double-Strand Break Formation in Rice. Molecular Plant. DOI:10.1016/j.molp.2016.07.005 |
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