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Critical Roles of Soluble Starch Synthase SSIIIa and Granule-Bound Starch Synthase Waxy in Synthesizing Resistant Starch in Rice
Hongju Zhou, Lijun Wang, Guifu Liu, Xiangbing Meng, Yanhui Jing, Xiaoli Shu, Xiangli Kong, Jian Sun, Hong Yu, Steven M. Smith, Dianxing Wu, and Jiayang Li
Proc Natl Acad Sci U S A
Abstract
Changes in human lifestyle and food consumption have resulted in a large increase in the incidence of type-2 diabetes, obesity and colon disease especially in Asia. These conditions are a growing threat to human health, but consumption of foods high in resistant starch (RS) can potentially reduce their incidence. Strategies to increase RS in rice are limited by a lack of knowledge of its molecular basis. Through map-based cloning of a new RS locus in indica rice, we have identified a defective soluble starch synthase gene (SSIIIa) responsible for RS production, and further showed that RS production is dependent on the high-expression of the Waxya allele which is prevalent in indica varieties. The resulting RS has modified granule structure, high amylose, lipid and amylose-lipid complex, and has altered physico-chemical properties. This discovery provides an opportunity to increase RS content of cooked rice especially in the indica varieties which predominate in southern Asia.
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论文编号: |
DOI:10.1073/pnas.1615104113 |
论文题目: |
Critical Roles of Soluble Starch Synthase SSIIIa and Granule-Bound Starch Synthase Waxy in Synthesizing Resistant Starch in Rice |
英文论文题目: |
Critical Roles of Soluble Starch Synthase SSIIIa and Granule-Bound Starch Synthase Waxy in Synthesizing Resistant Starch in Rice |
第一作者: |
Hongju Zhou, Lijun Wang, Guifu Liu, Xiangbing Meng, Yanhui Jing, Xiaoli Shu, Xiangli Kong, Jian Sun, Hong Yu, Steven M. Smith, Dianxing Wu, and Jiayang Li |
英文第一作者: |
Hongju Zhou, Lijun Wang, Guifu Liu, Xiangbing Meng, Yanhui Jing, Xiaoli Shu, Xiangli Kong, Jian Sun, Hong Yu, Steven M. Smith, Dianxing Wu, and Jiayang Li |
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2016-10-24 |
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摘要: |
Changes in human lifestyle and food consumption have resulted in a large increase in the incidence of type-2 diabetes, obesity and colon disease especially in Asia. These conditions are a growing threat to human health, but consumption of foods high in resistant starch (RS) can potentially reduce their incidence. Strategies to increase RS in rice are limited by a lack of knowledge of its molecular basis. Through map-based cloning of a new RS locus in indica rice, we have identified a defective soluble starch synthase gene (SSIIIa) responsible for RS production, and further showed that RS production is dependent on the high-expression of the Waxya allele which is prevalent in indica varieties. The resulting RS has modified granule structure, high amylose, lipid and amylose-lipid complex, and has altered physico-chemical properties. This discovery provides an opportunity to increase RS content of cooked rice especially in the indica varieties which predominate in southern Asia. |
英文摘要: |
Changes in human lifestyle and food consumption have resulted in a large increase in the incidence of type-2 diabetes, obesity and colon disease especially in Asia. These conditions are a growing threat to human health, but consumption of foods high in resistant starch (RS) can potentially reduce their incidence. Strategies to increase RS in rice are limited by a lack of knowledge of its molecular basis. Through map-based cloning of a new RS locus in indica rice, we have identified a defective soluble starch synthase gene (SSIIIa) responsible for RS production, and further showed that RS production is dependent on the high-expression of the Waxya allele which is prevalent in indica varieties. The resulting RS has modified granule structure, high amylose, lipid and amylose-lipid complex, and has altered physico-chemical properties. This discovery provides an opportunity to increase RS content of cooked rice especially in the indica varieties which predominate in southern Asia. |
刊物名称: |
Proc Natl Acad Sci U S A |
英文刊物名称: |
Proc Natl Acad Sci U S A |
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其它备注: |
Hongju Zhou, Lijun Wang, Guifu Liu, Xiangbing Meng, Yanhui Jing, Xiaoli Shu, Xiangli Kong, Jian Sun, Hong Yu, Steven M. Smith, Dianxing Wu, and Jiayang Li. Critical Roles of Soluble Starch Synthase SSIIIa and Granule-Bound Starch Synthase Waxy in Synthesizing Resistant Starch in Rice. Proc Natl Acad Sci U S A. DOI:10.1073/pnas.1615104113 |
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