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Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation
Shuo Wang, Pengyan Xia7, Yi Chen, Yuan Qu, Zhen Xiong, Buqing Ye, Ying Du, Yong Tian, Zhinan Yin, Zhiheng Xu, Zusen Fan
Cell
Abstract
An emerging family of innate lymphoid cells (termed ILCs) has an essential role in the initiation and regulation of inflammation. However, it is still unclear how ILCs are regulated in the duration of intestinal inflammation. Here, we identify a regulatory subpopulation of ILCs (called ILCregs) that exists in the gut and harbors a unique gene identity that is distinct from that of ILCs or regulatory T cells (Tregs). During inflammatory stimulation, ILCregs can be induced in the intestine and suppress the activation of ILC1s and ILC3s via secretion of IL-10, leading to protection against innate intestinal inflammation. Moreover, TGF-β1 is induced by ILCregs during the innate intestinal inflammation, and autocrine TGF-β1 sustains the maintenance and expansion of ILCregs. Therefore, ILCregs play an inhibitory role in the innate immune response, favoring the resolution of intestinal inflammation.
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论文编号: |
DOI:10.1016/j.cell.2017.07.027 |
论文题目: |
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation |
英文论文题目: |
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation |
第一作者: |
Shuo Wang, Pengyan Xia7, Yi Chen, Yuan Qu, Zhen Xiong, Buqing Ye, Ying Du, Yong Tian, Zhinan Yin, Zhiheng Xu, Zusen Fan |
英文第一作者: |
Shuo Wang, Pengyan Xia7, Yi Chen, Yuan Qu, Zhen Xiong, Buqing Ye, Ying Du, Yong Tian, Zhinan Yin, Zhiheng Xu, Zusen Fan |
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2017-09-30 |
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An emerging family of innate lymphoid cells (termed ILCs) has an essential role in the initiation and regulation of inflammation. However, it is still unclear how ILCs are regulated in the duration of intestinal inflammation. Here, we identify a regulatory subpopulation of ILCs (called ILCregs) that exists in the gut and harbors a unique gene identity that is distinct from that of ILCs or regulatory T cells (Tregs). During inflammatory stimulation, ILCregs can be induced in the intestine and suppress the activation of ILC1s and ILC3s via secretion of IL-10, leading to protection against innate intestinal inflammation. Moreover, TGF-β1 is induced by ILCregs during the innate intestinal inflammation, and autocrine TGF-β1 sustains the maintenance and expansion of ILCregs. Therefore, ILCregs play an inhibitory role in the innate immune response, favoring the resolution of intestinal inflammation. |
英文摘要: |
An emerging family of innate lymphoid cells (termed ILCs) has an essential role in the initiation and regulation of inflammation. However, it is still unclear how ILCs are regulated in the duration of intestinal inflammation. Here, we identify a regulatory subpopulation of ILCs (called ILCregs) that exists in the gut and harbors a unique gene identity that is distinct from that of ILCs or regulatory T cells (Tregs). During inflammatory stimulation, ILCregs can be induced in the intestine and suppress the activation of ILC1s and ILC3s via secretion of IL-10, leading to protection against innate intestinal inflammation. Moreover, TGF-β1 is induced by ILCregs during the innate intestinal inflammation, and autocrine TGF-β1 sustains the maintenance and expansion of ILCregs. Therefore, ILCregs play an inhibitory role in the innate immune response, favoring the resolution of intestinal inflammation. |
刊物名称: |
Cell |
英文刊物名称: |
Cell |
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Shuo Wang, Pengyan Xia7, Yi Chen, Yuan Qu, Zhen Xiong, Buqing Ye, Ying Du, Yong Tian, Zhinan Yin, Zhiheng Xu, Zusen Fan. Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation. Cell. DOI: 10.1016/j.cell.2017.07.027 |
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