|
dTBC1D7 Regulates Systemic Growth Independently of TSC through Insulin Signaling
Suxia Ren, Zengyi Huang, Yuqiang Jiang, Tao Wang
Journal of Cell Biology
Abstract
The insulin signaling pathway plays key roles in systemic growth. TBC1D7 has recently been identified as the third subunit of the tuberous sclerosis complex (TSC), a negative regulator of cell growth. Here, we used Drosophila as a model system to dissect the physiological function of TBC1D7 in vivo. In mutants lacking TBC1D7, cell and organ growth were promoted, and TBC1D7 limited cell growth in a cell-nonautonomous and TSC-independent manner. TBC1D7 is specifically expressed in insulin-producing cells in the fly brain and regulated biosynthesis and release of insulin-like peptide 2, leading to systemic growth. Furthermore, animals carrying the dTBC1D7 mutation were hypoglycemic, short-lived, and sensitive to oxidative stress. Our findings provide new insights into the physiological function of TBC1D7 in the systemic control of growth, as well as insights into human disorders caused by TBC1D7 mutation.
|
论文编号: |
DOI:10.1083/jcb.201706027 |
论文题目: |
dTBC1D7 Regulates Systemic Growth Independently of TSC through Insulin Signaling |
英文论文题目: |
dTBC1D7 Regulates Systemic Growth Independently of TSC through Insulin Signaling |
第一作者: |
Suxia Ren, Zengyi Huang, Yuqiang Jiang, Tao Wang |
英文第一作者: |
Suxia Ren, Zengyi Huang, Yuqiang Jiang, Tao Wang |
联系作者: |
|
英文联系作者: |
|
外单位作者单位: |
|
英文外单位作者单位: |
|
发表年度: |
2017-12-11 |
卷: |
|
期: |
|
页码: |
|
摘要: |
The insulin signaling pathway plays key roles in systemic growth. TBC1D7 has recently been identified as the third subunit of the tuberous sclerosis complex (TSC), a negative regulator of cell growth. Here, we used Drosophila as a model system to dissect the physiological function of TBC1D7 in vivo. In mutants lacking TBC1D7, cell and organ growth were promoted, and TBC1D7 limited cell growth in a cell-nonautonomous and TSC-independent manner. TBC1D7 is specifically expressed in insulin-producing cells in the fly brain and regulated biosynthesis and release of insulin-like peptide 2, leading to systemic growth. Furthermore, animals carrying the dTBC1D7 mutation were hypoglycemic, short-lived, and sensitive to oxidative stress. Our findings provide new insights into the physiological function of TBC1D7 in the systemic control of growth, as well as insights into human disorders caused by TBC1D7 mutation. |
英文摘要: |
The insulin signaling pathway plays key roles in systemic growth. TBC1D7 has recently been identified as the third subunit of the tuberous sclerosis complex (TSC), a negative regulator of cell growth. Here, we used Drosophila as a model system to dissect the physiological function of TBC1D7 in vivo. In mutants lacking TBC1D7, cell and organ growth were promoted, and TBC1D7 limited cell growth in a cell-nonautonomous and TSC-independent manner. TBC1D7 is specifically expressed in insulin-producing cells in the fly brain and regulated biosynthesis and release of insulin-like peptide 2, leading to systemic growth. Furthermore, animals carrying the dTBC1D7 mutation were hypoglycemic, short-lived, and sensitive to oxidative stress. Our findings provide new insights into the physiological function of TBC1D7 in the systemic control of growth, as well as insights into human disorders caused by TBC1D7 mutation. |
刊物名称: |
Journal of Cell Biology |
英文刊物名称: |
Journal of Cell Biology |
论文全文: |
|
英文论文全文: |
|
全文链接: |
|
其它备注: |
Suxia Ren, Zengyi Huang, Yuqiang Jiang, Tao Wang. dTBC1D7 Regulates Systemic Growth Independently of TSC through Insulin Signaling. Journal of Cell Biology. DOI:10.1083/jcb.201706027 |
英文其它备注: |
|
学科: |
|
英文学科: |
|
影响因子: |
|
第一作者所在部门: |
|
英文第一作者所在部门: |
|
论文出处: |
|
英文论文出处: |
|
论文类别: |
|
英文论文类别: |
|
参与作者: |
|
英文参与作者: |
|
|