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Feedback from Lateral Organs Controls Shoot Apical Meristem Growth by Modulating Auxin Transport
Bihai Shi, Xiaolu Guo, Ying Wang, Yuanyuan Xiong, Jin Wang, Ken-ichiro Hayashi, Jinzhi Lei, Lei Zhang, Yuling Jiao
Developmental Cell
Abstract
Stem cells must balance self-renewal and differentiation; thus, their activities are precisely controlled. In plants, the control circuits that underlie division and differentiation within meristems have been well studied but those that underlie feedback on meristems from lateral organs remain largely unknown. Here we show that long-distance auxin transport mediates this feedback in a non-cell-autonomous manner. A low-auxin zone is associated with the shoot apical meristem (SAM) organization center, and auxin levels negatively affect SAM size. Using computational model simulations, we show that auxin transport from lateral organs can inhibit auxin transport from the SAM through an auxin transport switch, and thus maintain SAM auxin homeostasis and SAM size. Genetic and microsurgical analyses confirmed the model’s predictions. In addition, the model explains temporary change in SAM size of yabby mutants. Our study suggests that the canalization-based auxin flux can be widely adapted as a feedback control mechanism in plants.
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论文编号: |
DOI:10.1016/j.devcel.2017.12.021 |
论文题目: |
Feedback from Lateral Organs Controls Shoot Apical Meristem Growth by Modulating Auxin Transport |
英文论文题目: |
Feedback from Lateral Organs Controls Shoot Apical Meristem Growth by Modulating Auxin Transport |
第一作者: |
Bihai Shi, Xiaolu Guo, Ying Wang, Yuanyuan Xiong, Jin Wang, Ken-ichiro Hayashi, Jinzhi Lei, Lei Zhang, Yuling Jiao |
英文第一作者: |
Bihai Shi, Xiaolu Guo, Ying Wang, Yuanyuan Xiong, Jin Wang, Ken-ichiro Hayashi, Jinzhi Lei, Lei Zhang, Yuling Jiao |
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2018-01-23 |
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摘要: |
Stem cells must balance self-renewal and differentiation; thus, their activities are precisely controlled. In plants, the control circuits that underlie division and differentiation within meristems have been well studied but those that underlie feedback on meristems from lateral organs remain largely unknown. Here we show that long-distance auxin transport mediates this feedback in a non-cell-autonomous manner. A low-auxin zone is associated with the shoot apical meristem (SAM) organization center, and auxin levels negatively affect SAM size. Using computational model simulations, we show that auxin transport from lateral organs can inhibit auxin transport from the SAM through an auxin transport switch, and thus maintain SAM auxin homeostasis and SAM size. Genetic and microsurgical analyses confirmed the model’s predictions. In addition, the model explains temporary change in SAM size of yabby mutants. Our study suggests that the canalization-based auxin flux can be widely adapted as a feedback control mechanism in plants. |
英文摘要: |
Stem cells must balance self-renewal and differentiation; thus, their activities are precisely controlled. In plants, the control circuits that underlie division and differentiation within meristems have been well studied but those that underlie feedback on meristems from lateral organs remain largely unknown. Here we show that long-distance auxin transport mediates this feedback in a non-cell-autonomous manner. A low-auxin zone is associated with the shoot apical meristem (SAM) organization center, and auxin levels negatively affect SAM size. Using computational model simulations, we show that auxin transport from lateral organs can inhibit auxin transport from the SAM through an auxin transport switch, and thus maintain SAM auxin homeostasis and SAM size. Genetic and microsurgical analyses confirmed the model’s predictions. In addition, the model explains temporary change in SAM size of yabby mutants. Our study suggests that the canalization-based auxin flux can be widely adapted as a feedback control mechanism in plants. |
刊物名称: |
Developmental Cell |
英文刊物名称: |
Developmental Cell |
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其它备注: |
Bihai Shi, Xiaolu Guo, Ying Wang, Yuanyuan Xiong, Jin Wang, Ken-ichiro Hayashi, Jinzhi Lei, Lei Zhang, Yuling Jiao. Feedback from Lateral Organs Controls Shoot Apical Meristem Growth by Modulating Auxin Transport. Developmental Cell DOI:10.1016/ j.devcel.2017.12.021 |
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