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Barbara McClintock's Unsolved Chromosomal Mysteries: Parallels to Common Rearrangements and Karyotype Evolution
James A. Birchler, Fangpu Han
The Plant Cell
Abstract
Two obscure studies on chromosomal behavior by Barbara McClintock are revisited in light of subsequent studies and evolutionary genomics of chromosome number reduction. The phenomenon of deficiency recovery in which adjacent genetic markers lost in the zygote reappear in later developmental sectors is discussed in light of de novo centromere formation on chromosomal fragments. Secondly, McClintock described a small chromosome, which she postulated carried an “X component” that fostered specific types of chromosomal rearrangements mainly involving centromere changes and attachments to the termini of chromosomes. These findings are cast in the context of subsequent studies on centromere misdivision, the tendency of broken fragments to join chromosome ends and the realization from genomic sequences that nested chromosomal insertion and end-to-end chromosomal fusions are common features of karyotype evolution. Together these results suggest a synthesis that centromere breaks, inactivation, and de novo formation together with telomeres - acting under some circumstances as double strand DNA breaks that join with others - is the underlying basis of these chromosomal phenomena.
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论文编号: |
DOI:10.1105/tpc.17.00989 |
论文题目: |
Barbara McClintock's Unsolved Chromosomal Mysteries: Parallels to Common Rearrangements and Karyotype Evolution |
英文论文题目: |
Barbara McClintock's Unsolved Chromosomal Mysteries: Parallels to Common Rearrangements and Karyotype Evolution |
第一作者: |
James A. Birchler, Fangpu Han |
英文第一作者: |
James A. Birchler, Fangpu Han |
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2018-03-16 |
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摘要: |
Two obscure studies on chromosomal behavior by Barbara McClintock are revisited in light of subsequent studies and evolutionary genomics of chromosome number reduction. The phenomenon of deficiency recovery in which adjacent genetic markers lost in the zygote reappear in later developmental sectors is discussed in light of de novo centromere formation on chromosomal fragments. Secondly, McClintock described a small chromosome, which she postulated carried an “X component” that fostered specific types of chromosomal rearrangements mainly involving centromere changes and attachments to the termini of chromosomes. These findings are cast in the context of subsequent studies on centromere misdivision, the tendency of broken fragments to join chromosome ends and the realization from genomic sequences that nested chromosomal insertion and end-to-end chromosomal fusions are common features of karyotype evolution. Together these results suggest a synthesis that centromere breaks, inactivation, and de novo formation together with telomeres - acting under some circumstances as double strand DNA breaks that join with others - is the underlying basis of these chromosomal phenomena. |
英文摘要: |
Two obscure studies on chromosomal behavior by Barbara McClintock are revisited in light of subsequent studies and evolutionary genomics of chromosome number reduction. The phenomenon of deficiency recovery in which adjacent genetic markers lost in the zygote reappear in later developmental sectors is discussed in light of de novo centromere formation on chromosomal fragments. Secondly, McClintock described a small chromosome, which she postulated carried an “X component” that fostered specific types of chromosomal rearrangements mainly involving centromere changes and attachments to the termini of chromosomes. These findings are cast in the context of subsequent studies on centromere misdivision, the tendency of broken fragments to join chromosome ends and the realization from genomic sequences that nested chromosomal insertion and end-to-end chromosomal fusions are common features of karyotype evolution. Together these results suggest a synthesis that centromere breaks, inactivation, and de novo formation together with telomeres - acting under some circumstances as double strand DNA breaks that join with others - is the underlying basis of these chromosomal phenomena. |
刊物名称: |
The Plant Cell |
英文刊物名称: |
The Plant Cell |
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其它备注: |
James A. Birchler, Fangpu Han. Barbara McClintock’s Unsolved Chromosomal Mysteries: Parallels to Common Rearrangements and Karyotype Evolution. The Plant Cell. DOI:10.1105/tpc.17.00989 |
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