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Transcriptional Regulation of Strigolactone Signalling in Arabidopsis
Lei Wang, Bing Wang, Hong Yu, Hongyan Guo, Tao Lin, Liquan Kou, Anqi Wang, Ning Shao, Haiyan Ma, Guosheng Xiong, Xiaoqiang Li, Jun Yang, Jinfang Chu, Jiayang Li
Nature
Abstract
Plant hormones known as strigolactones control plant development and interactions between host plants and symbiotic fungi or parasitic weeds1–4. In Arabidopsis thaliana and rice, the proteins DWARF14 (D14), MORE AXILLARY GROWTH 2 (MAX2), SUPPRESSOR OF MAX2-LIKE 6, 7 and 8 (SMXL6, SMXL7 and SMXL8) and their orthologues form a complex upon strigolactone perception and play a central part in strigolactone signalling5–10. However, whether and how strigolactones activate downstream transcription remains largely unknown. Here we use a synthetic strigolactone to identify 401 strigolactone-responsive genes in Arabidopsis, and show that these plant hormones regulate shoot branching, leaf shape and anthocyanin accumulation mainly through transcriptional activation of the BRANCHED 1, TCP DOMAIN PROTEIN 1 and PRODUCTION OF ANTHOCYANIN PIGMENT 1 genes. We find that SMXL6 targets 729 genes in the Arabidopsis genome and represses the transcription of SMXL6, SMXL7 and SMXL8 by binding directly to their promoters, showing that SMXL6 serves as an autoregulated transcription factor to maintain the homeostasis of strigolactone signalling. These findings reveal an unanticipated mechanism through which a transcriptional repressor of hormone signalling can directly recognize DNA and regulate transcription in higher plants.
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DOI:10.1038/s41586-020-2382-x |
论文题目: |
Transcriptional Regulation of Strigolactone Signalling in Arabidopsis |
英文论文题目: |
Transcriptional Regulation of Strigolactone Signalling in Arabidopsis |
第一作者: |
Lei Wang, Bing Wang, Hong Yu, Hongyan Guo, Tao Lin, Liquan Kou, Anqi Wang, Ning Shao, Haiyan Ma, Guosheng Xiong, Xiaoqiang Li, Jun Yang, Jinfang Chu, Jiayang Li |
英文第一作者: |
Lei Wang, Bing Wang, Hong Yu, Hongyan Guo, Tao Lin, Liquan Kou, Anqi Wang, Ning Shao, Haiyan Ma, Guosheng Xiong, Xiaoqiang Li, Jun Yang, Jinfang Chu, Jiayang Li |
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2020-06-12 |
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Plant hormones known as strigolactones control plant development and interactions between host plants and symbiotic fungi or parasitic weeds1–4. In Arabidopsis thaliana and rice, the proteins DWARF14 (D14), MORE AXILLARY GROWTH 2 (MAX2), SUPPRESSOR OF MAX2-LIKE 6, 7 and 8 (SMXL6, SMXL7 and SMXL8) and their orthologues form a complex upon strigolactone perception and play a central part in strigolactone signalling5–10. However, whether and how strigolactones activate downstream transcription remains largely unknown. Here we use a synthetic strigolactone to identify 401 strigolactone-responsive genes in Arabidopsis, and show that these plant hormones regulate shoot branching, leaf shape and anthocyanin accumulation mainly through transcriptional activation of the BRANCHED 1, TCP DOMAIN PROTEIN 1 and PRODUCTION OF ANTHOCYANIN PIGMENT 1 genes. We find that SMXL6 targets 729 genes in the Arabidopsis genome and represses the transcription of SMXL6, SMXL7 and SMXL8 by binding directly to their promoters, showing that SMXL6 serves as an autoregulated transcription factor to maintain the homeostasis of strigolactone signalling. These findings reveal an unanticipated mechanism through which a transcriptional repressor of hormone signalling can directly recognize DNA and regulate transcription in higher plants. |
英文摘要: |
Plant hormones known as strigolactones control plant development and interactions between host plants and symbiotic fungi or parasitic weeds1–4. In Arabidopsis thaliana and rice, the proteins DWARF14 (D14), MORE AXILLARY GROWTH 2 (MAX2), SUPPRESSOR OF MAX2-LIKE 6, 7 and 8 (SMXL6, SMXL7 and SMXL8) and their orthologues form a complex upon strigolactone perception and play a central part in strigolactone signalling5–10. However, whether and how strigolactones activate downstream transcription remains largely unknown. Here we use a synthetic strigolactone to identify 401 strigolactone-responsive genes in Arabidopsis, and show that these plant hormones regulate shoot branching, leaf shape and anthocyanin accumulation mainly through transcriptional activation of the BRANCHED 1, TCP DOMAIN PROTEIN 1 and PRODUCTION OF ANTHOCYANIN PIGMENT 1 genes. We find that SMXL6 targets 729 genes in the Arabidopsis genome and represses the transcription of SMXL6, SMXL7 and SMXL8 by binding directly to their promoters, showing that SMXL6 serves as an autoregulated transcription factor to maintain the homeostasis of strigolactone signalling. These findings reveal an unanticipated mechanism through which a transcriptional repressor of hormone signalling can directly recognize DNA and regulate transcription in higher plants. |
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Nature |
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Nature |
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其它备注: |
Lei Wang, Bing Wang, Hong Yu, Hongyan Guo, Tao Lin, Liquan Kou, Anqi Wang, Ning Shao, Haiyan Ma, Guosheng Xiong, Xiaoqiang Li, Jun Yang, Jinfang Chu, Jiayang Li. Transcriptional Regulation of Strigolactone Signalling in Arabidopsis. Nature. DOI:10.1038/s41586-020-2382-x. |
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