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Effects of Dietary Macronutrients and Body Composition on Glucose Homeostasis in Mice
Sumei Hu, Jacques Togo, Lu Wang, Yingga Wu, Dengbao Yang, Yanchao Xu, Li Li, Baoguo Li, Min Li, Jianbo Li, Guanlin Wang, Xueying Zhang, Chaoqun Niu, Mohsen Mazidi, Alex Douglas, John R Speakman
National Science Review
Abstract
As a major health issue, obesity is linked with elevated risk of type 2 diabetes. However, whether disrupted glucose homeostasis is due to altered body composition alone, or dietary macronutrients play an additional role, independent of their impact on body composition, remains unclear. We investigated the associations between macronutrients, body composition, blood hormones and glucose homeostasis. We fed C57BL/6N mice 29 different diets with variable macronutrients for 12 weeks. After 10 weeks, intraperitoneal glucose tolerance tests (ipGTT) were performed. Generalized linear models (GLMs) were generated to evaluate the impacts of macronutrients, body composition and blood hormones on glucose homeostasis. The area under the glucose curve (AUC) was strongly associated with body fat mass, but not dietary macronutrients. AUC was significantly associated with fasting insulin levels. Six genes from transcriptomic analysis of eWAT (epididymal white adipose tissue) and sWAT (subcutaneous white adipose tissue), were significantly associated with AUC. These genes may encode secreted proteins that play important previously unanticipated roles in glucose homeostasis.
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论文编号: |
DOI:10.1093/nsr/nwaa177 |
论文题目: |
Effects of Dietary Macronutrients and Body Composition on Glucose Homeostasis in Mice |
英文论文题目: |
Effects of Dietary Macronutrients and Body Composition on Glucose Homeostasis in Mice |
第一作者: |
Sumei Hu, Jacques Togo, Lu Wang, Yingga Wu, Dengbao Yang, Yanchao Xu, Li Li, Baoguo Li, Min Li, Jianbo Li, Guanlin Wang, Xueying Zhang, Chaoqun Niu, Mohsen Mazidi, Alex Douglas, John R Speakman |
英文第一作者: |
Sumei Hu, Jacques Togo, Lu Wang, Yingga Wu, Dengbao Yang, Yanchao Xu, Li Li, Baoguo Li, Min Li, Jianbo Li, Guanlin Wang, Xueying Zhang, Chaoqun Niu, Mohsen Mazidi, Alex Douglas, John R Speakman |
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2020-08-07 |
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摘要: |
As a major health issue, obesity is linked with elevated risk of type 2 diabetes. However, whether disrupted glucose homeostasis is due to altered body composition alone, or dietary macronutrients play an additional role, independent of their impact on body composition, remains unclear. We investigated the associations between macronutrients, body composition, blood hormones and glucose homeostasis. We fed C57BL/6N mice 29 different diets with variable macronutrients for 12 weeks. After 10 weeks, intraperitoneal glucose tolerance tests (ipGTT) were performed. Generalized linear models (GLMs) were generated to evaluate the impacts of macronutrients, body composition and blood hormones on glucose homeostasis. The area under the glucose curve (AUC) was strongly associated with body fat mass, but not dietary macronutrients. AUC was significantly associated with fasting insulin levels. Six genes from transcriptomic analysis of eWAT (epididymal white adipose tissue) and sWAT (subcutaneous white adipose tissue), were significantly associated with AUC. These genes may encode secreted proteins that play important previously unanticipated roles in glucose homeostasis. |
英文摘要: |
As a major health issue, obesity is linked with elevated risk of type 2 diabetes. However, whether disrupted glucose homeostasis is due to altered body composition alone, or dietary macronutrients play an additional role, independent of their impact on body composition, remains unclear. We investigated the associations between macronutrients, body composition, blood hormones and glucose homeostasis. We fed C57BL/6N mice 29 different diets with variable macronutrients for 12 weeks. After 10 weeks, intraperitoneal glucose tolerance tests (ipGTT) were performed. Generalized linear models (GLMs) were generated to evaluate the impacts of macronutrients, body composition and blood hormones on glucose homeostasis. The area under the glucose curve (AUC) was strongly associated with body fat mass, but not dietary macronutrients. AUC was significantly associated with fasting insulin levels. Six genes from transcriptomic analysis of eWAT (epididymal white adipose tissue) and sWAT (subcutaneous white adipose tissue), were significantly associated with AUC. These genes may encode secreted proteins that play important previously unanticipated roles in glucose homeostasis. |
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National Science Review |
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National Science Review |
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Sumei Hu, Jacques Togo, Lu Wang, Yingga Wu, Dengbao Yang, Yanchao Xu, Li Li, Baoguo Li, Min Li, Jianbo Li, Guanlin Wang, Xueying Zhang, Chaoqun Niu, Mohsen Mazidi, Alex Douglas, John R Speakman. Effects of Dietary Macronutrients and Body Composition on Glucose Homeostasis in Mice. National Science Review. DOI:10.1093/nsr/nwaa177 |
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