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SEUSS Integrates Transcriptional and Epigenetic Control of Root Stem Cell Organizer Specification
Huawei Zhai, Xiaoyue Zhang, Yanrong You, Lihao Lin, Wenkun Zhou, and Chuanyou Li
The EMBO Journal
Abstract
Proper regulation of homeotic gene expression is critical for stem cell fate in both plants and animals. In Arabidopsis thaliana, the WUSCHEL (WUS)-RELATED HOMEOBOX 5 (WOX5) gene is specifically expressed in a group of root stem cell organizer cells called the quiescent center (QC) and plays a central role in QC specification. Here, we report that the SEUSS (SEU) protein, homologous to the animal LIM-domain binding (LDB) proteins, assembles a functional transcriptional complex that regulates WOX5 expression and QC specification. SEU is physically recruited to the WOX5 promoter by the master transcription factor SCARECROW. Subsequently, SEU physically recruits the SET domain methyltransferase SDG4 to the WOX5 promoter, thus activating WOX5 expression. Thus, analogous to its animal counterparts, SEU acts as a multi-adaptor protein that integrates the actions of genetic and epigenetic regulators into a concerted transcriptional program to control root stem cell organizer specification.
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论文编号: |
DOI:10.15252/embj.2020105047 |
论文题目: |
SEUSS Integrates Transcriptional and Epigenetic Control of Root Stem Cell Organizer Specification |
英文论文题目: |
SEUSS Integrates Transcriptional and Epigenetic Control of Root Stem Cell Organizer Specification |
第一作者: |
Huawei Zhai, Xiaoyue Zhang, Yanrong You, Lihao Lin, Wenkun Zhou, and Chuanyou Li |
英文第一作者: |
Huawei Zhai, Xiaoyue Zhang, Yanrong You, Lihao Lin, Wenkun Zhou, and Chuanyou Li |
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2020-09-15 |
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摘要: |
Proper regulation of homeotic gene expression is critical for stem cell fate in both plants and animals. In Arabidopsis thaliana, the WUSCHEL (WUS)-RELATED HOMEOBOX 5 (WOX5) gene is specifically expressed in a group of root stem cell organizer cells called the quiescent center (QC) and plays a central role in QC specification. Here, we report that the SEUSS (SEU) protein, homologous to the animal LIM-domain binding (LDB) proteins, assembles a functional transcriptional complex that regulates WOX5 expression and QC specification. SEU is physically recruited to the WOX5 promoter by the master transcription factor SCARECROW. Subsequently, SEU physically recruits the SET domain methyltransferase SDG4 to the WOX5 promoter, thus activating WOX5 expression. Thus, analogous to its animal counterparts, SEU acts as a multi-adaptor protein that integrates the actions of genetic and epigenetic regulators into a concerted transcriptional program to control root stem cell organizer specification. |
英文摘要: |
Proper regulation of homeotic gene expression is critical for stem cell fate in both plants and animals. In Arabidopsis thaliana, the WUSCHEL (WUS)-RELATED HOMEOBOX 5 (WOX5) gene is specifically expressed in a group of root stem cell organizer cells called the quiescent center (QC) and plays a central role in QC specification. Here, we report that the SEUSS (SEU) protein, homologous to the animal LIM-domain binding (LDB) proteins, assembles a functional transcriptional complex that regulates WOX5 expression and QC specification. SEU is physically recruited to the WOX5 promoter by the master transcription factor SCARECROW. Subsequently, SEU physically recruits the SET domain methyltransferase SDG4 to the WOX5 promoter, thus activating WOX5 expression. Thus, analogous to its animal counterparts, SEU acts as a multi-adaptor protein that integrates the actions of genetic and epigenetic regulators into a concerted transcriptional program to control root stem cell organizer specification. |
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The EMBO Journal |
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The EMBO Journal |
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Huawei Zhai, Xiaoyue Zhang, Yanrong You, Lihao Lin, Wenkun Zhou, and Chuanyou Li. SEUSS Integrates Transcriptional and Epigenetic Control of Root Stem Cell Organizer Specification. The EMBO Journal. DOI:10.15252/embj.2020105047 |
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