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Daily Energy Expenditure Through the Human Life Course
Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama,…Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman, IAEA DLW Database Consortium
Science
Abstract
Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.
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论文编号: |
DOI:10.1126/science.abe5017 |
论文题目: |
Daily Energy Expenditure Through the Human Life Course |
英文论文题目: |
Daily Energy Expenditure Through the Human Life Course |
第一作者: |
Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama,…Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman, IAEA DLW Database Consortium |
英文第一作者: |
Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama,…Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman, IAEA DLW Database Consortium |
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2021-08-13 |
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摘要: |
Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span. |
英文摘要: |
Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span. |
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Science |
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Science |
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Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama,…Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman, IAEA DLW Database ConsortiumDaily Energy Expenditure Through the Human Life Course. Science. DOI:10.1126/science.abe5017 |
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