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张永清


张永清,博士,研究员,博士生导师

  1991年获北京农业大学(现中国农业大学)博士学位。1992-1993在中国科学院微生物研究所作博士后。1994年在荷兰Wageningen大学作访问学者。1995-1997年在英国剑桥大学作博士后。1998-2003年先后在美国尤他大学和Vanderbilt大学作博士后和访问学者。先后获得美国FRAXA Research Foundation(2001-2002)和 Vanderbilt大学Kennedy Center for Research on Human Development(2003)的研究奖。2005年获国家杰出青年科学基金,2012年获批政府特殊津贴专家。科技部973项目首席。担任多个国际主流期刊的审稿人,中国神经科学学会第四、五届理事,神经发育、衰老与再生分会副会长。Journal of Genetics and Genomics副主编,F1000 Genetics and Genomics评论员,遗传杂志主编。



        张永清研究员的主要研究方向: 以果蝇、非人灵长类猕猴和家犬为实验体系,通过多学科的研究手段包括基因编辑,脑影像和电生理分析以及行为学分析等致力于研究神经突触的发育和功能调控,以及相关重大神经疾病特别是自闭症的分子细胞和神经环路机制。

        主要研究内容包括: 
        1) 以非人灵长类、家犬和果蝇为模式动物研究人类重要神经疾病包括自闭症的分子遗传和神经环路机制,从而为这类疾病的预防和治疗提供理论依据。传统的模式动物果蝇便于分子遗传和信号通路的解析,而大动物模型研究结果则便于临床转化应用。
        2) 以果蝇为材料,用分子、细胞、遗传、发育和神经生物学为主要实验检测手段研究神经系统特别是神经突触的结构和功能调控机制。

主要论著目录: 

 

43,Elsayed Metwally, Guoli Zhao, and Yong Q. Zhang, The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration, Trends Neurosci, 2021, in press
 
42, 任炜, 余山和张永清, 计算行为学研究进展, 科学通报,2021
 
41. Kai Zhao, Huilin Hong, Lu Zhao, Sheng Huang, Ying Gao, Elsayed Metwally, Yuqiang Jiang, Stephan J. Sigrist, Yong Q. Zhang, Postsynaptic cAMP Signalling Regulates the Antagonistic Balance of Glutamate Receptor Subtypes, Development, 2020, 147, dev191874.
 
40. Elsayed Metwally #, Guoli Zhao #, Qifu Wang and Yong Q. Zhang*, Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium, Cell Research, 2020, 0:1–17
 
39. Huilin Hong, Kai Zhao, Shiyan Huang, Sheng Huang, Aiyu Yao, Yuqiang Jiang, Stephan Sigrist, Lu Zhao and Yong Q. Zhang,Structural Remodeling of Active Zones Is Associated with Synaptic Homeostasis,Journal of Neuroscience,2020, 40 (14), 2817-2827 (cover story)
  
38.Hui Zhao#,Qiqi Wang#, Ting Yan, Yu Zhang, Hui-juan Xu, Hao-peng Yu, Zhuchi Tu, Xiangyu Guo, Yong-hui Jiang, Xiao-jiang Li*, Huihui Zhou*, Yong Q. Zhang*.Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates, Translational Psychiatry, (2019) 9:267.
 
37.Mingyue Jia, Danqing Meng, Mo Chen, Tingting Li, Yong Q. Zhang* and Aiyu Yao*, Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation. Journal of Genetics and Genomics ,20;46(1):5-17, 2019
 
36. Yan HuangSheng HuangCoralie Di ScalaQifu WangHans H WandallJacques   FantiniYong Q. Zhang*, The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt , eLife ,2018;7:e38183
 
35.  Elsayed Metwally, Guoli Zhao, Wenhua Li, Qifu Wang and Yong Q. Zhang*, Calcium Activated Calpain Specifically Cleaves Glutamate Receptor IIA but not IIB at the Drosophila Neuromuscular Junction , Journal of Neuroscience, 2019, 2213-17
 
34.  Zhuchi Tu, Hui Zhao, Bang Li, Sen Yan, Lu Wang, Yongjin Tang, Zhujun Li ,Dazhang Bai, Caijuan Li, Yingqi Lin, Yuefeng Li, Jianrong Liu, Hao Xu ,,Xiangyu Guo,  Yong-hui Jiang*, Yong Q Zhang *and Xiao-Jiang Li*,CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms , Human Molecular Genetics, 2019, 28(4),561–571
  
33. Hui Zhao, Yong-hui Jiang, and Yong Q. Zhang. Modeling Autism in Non-human Primates: Opportunities and Challenges. Autism Research 11, 686-694, 2018
 
32. Song Wu, Guangming Gan, Zhiping Zhang, Jie Sun, Qifu Wang, Zhongbao Gao, Meixiang Li, Shan Jin, Juan Huang, Ulrich Thomas, Yong-hui Jiang, Yan Li, Rui Tian, Yong Q. Zhang. A pre-synaptic function of Shank protein in Drosophila. Journal of Neuroscience, 2017, 37, 11592-11604, 2017
 
31.Hui Zhao, Zhuchi Tu, Huijuan Xu, Sen Yan, Huanhuan Yan, Yinghui Zheng, Weili Yang, Jiezhao Zheng, Zhujun Li, Rui Tian, Youming Lu, Xiangyu Guo, Yong-hui Jiang, Xiao-Jiang Li, Yong Q. Zhang. Altered neurogenesis and disrupted expression of synaptic proteins in SHANK3 deficient non-human primate prefrontal cortex. Cell Research, doi:10.1038/cr.2017.95, 2017
 
30. Chuan-Xi Mao, Xue Wen, Shan Jin, and Yong Q. Zhang. Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila. Disease Models and Mechanisms 10, 1245-1252, 2017
 
29. Yan Huang, Sheng Huang, Sin Man Lam, Zhihua Liu, Guanghou Shui, and Yong Q. Zhang. Acsl, the Drosophila ortholog of intellectual disability-related ACSL4, inhibits synaptic growth by altered lipids. Journal of Cell Science 129, 4034-4045, 2016
 
28. Fangfang Jiang, Falong Lu, Peixue Li, Wei Liu, Lu Zhao, Qifu Wang, Xiaofeng Cao, Lei Zhang, and Yong Q. Zhang. Drosophila homolog of FMRP maintains genome integrity by interacting with Piwi. Journal of Genetics and Genomics, 43: 11-24, 2016 (cover story)
 
27.Wenhua Li, Aiyu Yao, Hui Zhi, Kuldeep Kaur, Yong-chuan Zhu, Mingyue Jia, Hui Zhao, Qifu Wang, Shan Jin, Guoli Zhao, Zhi-Qi Xiong, and Yong Q. Zhang. Angelman syndrome protein Ube3a regulates synaptic growth and endocytosis by inhibiting bone morphogenetic protein signaling in Drosophila.[PDF] PLoS Genetics, doi:10.1371/journal.pgen.1006062

26.Guoli Zhao, Yingga Wu, Li Du, Wenhua Li, Ying Xiong, Aiyu Yao, Qifu Wang and Yong Q. Zhang. Drosophila S6 kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor Thickveins. [PDF] PLoS Genet  doi:10.1371/journal.pgen.1004984
 
25. Podufall, J., Tian, R., Knoche, E., Puchkov, D., Walter, A.M., Rosa, S., Quentin, C., Vukoja, A., Jung, N., Lampe, A., Wichmann, C. Bohme, M. Depner, H. Zhang, Y. Q. Schmoranzer, J. Sigrist, S. J. Haucke, V. A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling. Cell Reports 7, 1417-1425, 2014.

24. Zhihua Liu#, Yan Huang#, Wen Hu, Sheng Huang, Qifu Wang, Junhai Han, and Yong Q. Zhang. Drosophila Acyl-CoA synthetase long-chain family member 4 inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.[PDF] Journal of Neuroscience, 34:2785-2796, 2014.

23. Chuan-Xi Mao, Ying Xiong, Zhaohuan Xiong, Qifu Wang, Yong Q. Zhang* and Shan Jin*. Microtubule-severing protein katanin regulates neuromuscular junction development and dendritic elaboration in Drosophila.[PDF] Development, 141:1064-1074, 2014.

22. Wenwen Shi, Yan Chen, Guangming Gan, Dan Wang, Jinqi Ren, Qifu Wang, Zhiheng Xu, Wei Xie, and Yong Q. Zhang.brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing Mad expression.[PDF] Journal of Neuroscience, 33:12352-12363, 2013

21. Lu Zhao, Dan Wang, Qifu Wang, Avital A. Rodal, and Yong Q. Zhang. Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly.[PDF] PLoS Genet (http://www.plosgenetics.org/doi/pgen.1003450)

20. Ying Xiong, Kai Zhao, Jiaxi Wu, Shan Jin and Yong Q. Zhang. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.[PDF] Proc Natl Acad Sci USA, 110(12): 4604-9, 2013。

19. Ethan R. Graf, Vera Valakh, Christina M. Wright, Chunlai Wu, Zhihua Liu, Yong Q. Zhang, and Aaron DiAntonio. RIM Promotes Calcium Channel Accumulation at Active Zones of the Drosophila Neuromuscular Junction. Journal of Neuroscience, 32:16586-16596, 2012

18. Wei Liu,Fangfang Jiang,Xiaolin Bi,and Yong Q.Zhang. Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis.[PDF] Human Molecular Genetics. 21: 4655-4668, 2012

17. Zhihua Liu, Yan Huang, Yi Zhang, Di Chen, and Yong Q. Zhang*. Drosophila acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission.[PDF] Journal of Neuroscience,31(6):2052-2063,2011

16. Aiyu Yao, Shan Jin, Xinhai Li, Zhihua Liu, Xuehua Ma, Jing Tang, and Yong Q. Zhang*. Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria.[PDF] Human Molecular Genetics, 20(1):51-63,2011

15. Haiying Zhang, Ling Tian, Stephen Tobe, Ying Xiong, Songyan Wang, Xinda Lin, Yanan Liu, William Bendena, Sheng Li, and Yong Q Zhang*. Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene.[PDF]  Biochemical and Biophysical Research Communications, 401: 182-187, 2010

14. Zhiwei Liu, Yan Chen, Dan Wang, Songyan Wang, Yong Q. Zhang*. Distinct pre- and postsynaptic dismantling processes of Drosophila neuromuscular junctions during metamorphosis,[PDF] Journal of Neuroscience, 30: 11624-11634, 2010. Commented on in Faculty of 1000 at http://f1000.com/5488963

13. Dan Wang, Lijun Zhang, Guoli Zhao, Gudrun Wahlstr?m, Tapio I. Heino, Jiong Chen*, and Yong Q. Zhang*. Drosophila twinfilin is required for cell migration and synaptic endocytosis . [PDF] Journal of Cell Science, 123: 1546-1556, 2010

12. Shan Jin, Luyuan Pan, Zhihua Liu, Qifu Wang, Zhiheng Xu, and Yong Q. Zhang. Drosophila tubulin chaperone E functions at neuromuscular synapses and is required for microtubule network formation.[PDF] Development, 136: 1571-1581, 2009

11. Simon P. Reeve #, Xinda Lin# (co-first author), Bahar H. Sahin, Fangfang Jiang, Aiyu Yao, Zhihua Liu, Hui Zhi, Kendal Broadie, Wei Li, Angela Giangrande, Bassem A. Hassan, Yong Q. Zhang. Mutational analysis establishes a critical role for the N terminus of Fragile X mental retardation protein FMRP. [PDF]  Journal of Neuroscience, 28(12):3221-3226, 2008

10. Feng Gu, Hai-Yin Zhang, Shao-Yi Hu, Shang-Zhi Huang, Xu Ma, Yong Q. Zhang. Erectile dysfunction in Fragile X patients.[PDF] Asian J Androl, 8: 483-487, 2006

9. Yong Q. Zhang and Kendal Broadie. Fathoming fragile X in fruit flies .[PDF] Trends in Genetics, 21(1): 37-45, 2005

8. Yong Q. Zhang, David Friedman, Zhe Wang, Elvin Woodruff III, Luyuan Pan, Janis O’Donnell and Kendal Broadie, Protein Expression Profiling of the Drosophila Fragile X Mutant Brain Reveals Upregulation of Monoamine Synthesis.[PDF] Molecular and Cellular Proteomics, 4(3): 278-290, 2005

7. Luyuan Pan, Yong Q. Zhang, Elvin Woodruff and Kendal Broadie . The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation . [PDF]Current Biology 14: 1863-1870, 2004

6. Yong Q. Zhang, Heinrich J. G. Matthies, Joel Mancuso, Hillary K. Andrews, Elvin Woodruff, III, David Friedman and Kendal Broadie. The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis .[PDF] Developmental Biology 270(2): 290-307, 2004

5. Hillary Andrews, Yong Zhang, Nick Trotta and Kendal Broadie. Drosophila Sec10 is required for hormone secretion but not general exocytosis or neurotransmission .[PDF] Traffic 3(12): 906-921, 2002

4. Yong Zhang, Christopher Rodesch and Kendal Broadie. A living synaptic vesicle marker: s ynaptotagmin-GFP.[PDF] Genesis: the journal of genetics and development 34: 142-145, 2002

3. Yong Zhang, Adina M. Bailey, Heinrich J. G. Matthies, Robert B. Renden, Mark A. Smith, Sean D. Speese, Gerald M. Rubin and Kendal Broadie. Drosophila fragile X related gene regulates the MAP1B homolog Futsch to control synaptic structure and function.[PDF] Cell 107: 591-603, 2001

2. Yong Zhang, David Featherstone, Warren Davis, Emma Rushton and Kendal Broadie. Drosophila D-Titin is required for myoblast fusion and skeletal muscle striation.[PDF] Journal of Cell Science 113: 3101-3115, 2000

1. Yong Zhang, John Roote, Saverio Brogna, Andrew W. Davis, Daniel A. Barbash, David Nash and Michael Ashburner. stress sensitive B encodes an adenine nucleotide translocase in Drosophila melanogaster.[PDF] Genetics 153 (2): 891-903, 1999