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张建


张建
 
        1988年获四川大学学士;
        1996年获University of Miami 博士学位;
        1997-1999年,University of Miami 和Genentech Inc. 博士后;
        2002年入选中科院“百人计划”;
        2004年获得国家杰出青年科学基金


脊椎动物发育生物学
我们实验室对发育生物学中的重要问题感兴趣,目前主要研究方向: 1)早期胚胎发育的调控(如:原始生殖细胞发生);2)小鼠细胞谱系建立和维持。实验用模式动物包括斑马鱼,非洲爪蛙,和小鼠。我们在研究中广泛运用遗传学,细胞生物学,生物化学的方法。
 
 

 
已毕业博士研究生(毕业年份和毕业后去向):
 
        张  磊(2008,葛兰素史克(GSK)中国公司,科学家)
        祝冬梅(2008,德国Freiburg University,博士后)
        张  伟(2009,美国 Baylor college of Medicine,博士后)
        徐素宏(2009,美国 Univ. of California San Diego, 博士后)
        王华伟(2011,美国 Univ. of California San Diego, 博士后)
        刘  超(2011,美国 Univ. of California San Diego, 博士后)
        苏文静(2013,美国 Memorial Sloan Kettering Cancer Center,博士后)
        程  峰(2014,美国 Univ. of California San Francisco, 博士后)
        马为锐(2015,美国 Memorial Sloan Kettering Cancer Center,博士后)
 
        欢迎有志于生物学研究的研究生、本科生和技术人员加入我们的团队。
 
        诚招2名实验室工作人员(小鼠胚胎操作一人,斑马鱼发育一人)工资和其它待遇从优工作地点: 云南省昆明市云南大学,并在北京和南京接受培训。 有兴趣者请将简历以及已发表论文或者即将发表论文PDF文件发至: jianzhang84@genetics.ac.cn

代表性论文:
 
Cheng F, Miao L, Wu Q, Gong X, Xiong J*, Zhang J*. (2016) Vinculin b deficiency causes epicardial hyperplasia and coronary vessel disorganization in zebrafish. Development 2016 Aug 30. pii: dev.132936.
 
Fang J, Wang H, Miao L, Kuang X, Ma W, Wang C, Zhang J*, Xia G*. (2016) Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Biol Reprod. 2016 Aug 10. pii: biolreprod.116.138941
 
Kuang X, Liu C, Fang J, Ma W, Zhang J*, Cui S*. (2016) The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development. FEBS Lett. 590(14):2076-85
 
Yuan Y., Zhang J.*, Zhou Q*. (2016) Overexpression of Jak1 activating mutants in hepatocytes is insufficient to generate hepatocellular carcinoma in zebrafish. J Genet Genomics. 43(2):99-102.
 
Ma WR, Zhang J*. (2015) Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death. Development 142(4):763-73.
 
Zhu, G., Li, Y., Zhu, F., Wang, T., Jin, W., Mu, W., Lin, W., Tan, W., Li, W., R. Street, C., Peng, S., Zhang, J., Feng, Y., Warren, S., Sun, Q.*, Jin, P.* and Chen, D.* (2014) Coordination of Engineered Factors with TET1/2 Promotes Early-Stage Epigenetic Modification during Somatic Cell Reprogramming. Stem Cell Reports 2(3):253-61
 
Su W, Fang J, Cheng F, Liu C, Zhou F, Zhang J*. (2013) RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development. Proc Natl Acad Sci USA 110(5):1720-5.
 
Liu C, Ma W, Su W, Zhang J*. (2012) Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish. Development 139(24):4591-600.
 
Wang HW, Fang JS, Kuang X, Miao LY, Wang C, Xia GL, King ML, Zhang J*.(2012) Activity of long-chain acyl-CoA synthetase is required for maintaining meiotic arrest in Xenopus laevis. Biol. Reprod. 87(3):74.
 
Xu S, Cheng F, Liang J, Wu W, Zhang J*.(2012) Maternal xNorrin, a Canonical Wnt Signaling Agonist and TGF-b Antagonist, Controls Early Neuroectoderm Specification in Xenopus. PLOS Biol. 10(3): e1001286. doi:10.1371/journal.pbio.1001286
 
Zhang L, Kuang X, Zhang J.* (2011) Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1), may function as a NgR1 co-receptor for Nogo-66. J Genet Genomics. 38(11):515-23.
 
Wang Y, Chen J, Hu JL, Wei XX, Qin D, Gao J, Zhang L, Jiang J, Li JS, Liu J, Lai KY, Kuang X, Zhang J, Pei D, Xu GL. (2011) programming of mouse and human somatic cells by high-performance engineered factors. EMBO Rep. 12(4):373-8
 
Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG. (2010) Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat. Cell Biol. 12(8):781-90.
 
Zhang L, Zheng S, Wu H, Wu Y, Liu S, Fan M, Zhang J*. (2009) Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. J. Neurosci. 29(19):6348-52.
 
Zhu D, Fang J, Li Y, Zhang J*. (2009) Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation.PLOS One. 4(11):e7684.
Zhang J.* (2004) A new trick to tune down TGF-beta signal. Cell Research 14(5):439-40.
 
Zhou Y., Zhang J., King M. L. (2004) Polarized distribution of mRNAs encoding a putative LDL receptor adaptor protein, xARH (autosomal recessive hypercholesterolemia) in Xenopus oocytes. Mechanism of Development 121:1249-58.
 
Mamidipudi V., Zhang J., Lee K., and Cartwright CA. (2004) RACK1 regulates G1/S progression by suppressing Src kinase activity. Mol. Cell. Biol. 24: 6788-98.
 
Zhou Y., Zhang J., King M. L. (2003) Xenopus ARH couples lipoprotein receptors with the AP-2 complex in oocytes and embryos and is required for vitellogenesis. J. Biol. Chem. 278: 44584-92
 
Zhang, J., Rosenthal, A., de Sauvage F. J., and Shivdasani, R. A. (2001). Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev. Biol. 229: 188-202.
 
Zhang, J., Houston, D.W., King, M. L., Payne, C., Wylie, C., and Heasman, J. (1998) The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. Cell 94, 515-524.
 
Houston, D.W., Zhang, J., Maines, J.Z., Wasserman, S.A., and King, M.L. (1998) A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologues of Drosophila boule. Development 125, 171-180.
 
Zhang, J. and King, M.L. (1996) Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcriptional factor involved in dorsal/ventral patterning. Development 122, 4119-4129.