陈良标，博士，研究员，博士生导师.
1988 年毕业于杭州大学生物系细胞生物学专业，1991年获中国科学院发育生物学研究所理学硕士学位，1993和1996年从美国University of Illinois at Urbana-Champaign 获生理学硕士和分子生理学博士学位，1997至1999年在美国National Institutes of Health做博士后研究，2000至2001年服务于美国生物信息公司Doubletwist Inc.，从事生物信息数据库工作, 2001年回国，2004年6月入选中科院"百人计划", 2006年获国家杰出青年基金。
陈良标创新小组的主要研究方向是进化基因组学，以及干细胞的分子特征。
一．极端环境下的基因组进化
生活在地球两极的鱼类在千万年的寒冷环境中进化出了许多新的基因和特殊的生理机制以适应寒冷的极地环境。我们通过比较基因组学和分子生物学的研究手段揭示极端寒冷环境下基因组的进化规律以及细胞对严寒适应的分子基础。
二．肿瘤干细胞发生的表观遗传机制
分析胚胎干细胞和肿瘤干细胞的基因表达谱和蛋白质谱、发掘控制肿瘤干细胞发生和分化的表观遗传因子，并揭示其功能。
实验室工作人员：曹立雪 (博士，助理研究员)，郑英慧（博士，助理研究员）， 沈玉 (学士，实验师)
博士后：杨若琳，邓成
在读研究生： 叶桦，胡鹏，陈淑娥，黄圣健，杨娜
KEY PUBLICATIONS
1. Deng C, Cheng CH, Ye H, He XM, Chen L*. (2010). Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc. Natl. Acad. Sci. USA. In Press.
2. Wu R, Xu C, Jin F, Tan Z, Gu B, Chen L, Yao X, Zhang M. (2010). Derivation,characterization and differentiation of a new human embryonic stem cell line from a Chinese hatched blastocyst assisted by a non-contact laser system. Hum Cell. 23(3):89-102.
3. Gu B, Zhang J, Chen Q, Tao B, Wang W, Zhou Y, Chen L, Liu Y, Zhang M. (2010). Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Biochem Biophys Res Commun. 394(2):418-23.
4. Zhou L, Cai M, Ling XB,Wang Q, Lau K, Zhao JJ, Schilling J, Chen L*.(2009). Tumor associated proteome and peptidome analyses for multiclass cancer discrimination. Clinical Proteomics 5:163-169
5. Xie C, Huang H, Wei S, Song L, Zhang J, Ritchie R, Chen L, Zhang M and Chen Y.(2009) A Comparison of Murine Smooth Muscle Cells Generated from Embryonic versus Induced Pluripotent Stem Cells. Stem cells and Development. 18:741-8.
6. Dai Z, Chen Z, Ye H, Wang Y, Peng S and Chen L.* (2009). Characterization of microRNAs in cephalochordates reveals a correlation between miRNA repertoire homology and morphological similarity in chordate evolution. Evolution and Development. 11:1,41-49.
7. Chen Z#, Cheng CH#, Zhang J# (# co-first authors), Cao L, Chen L, Zhou L, Jin Y, Ye H, Deng C, Dai Z, Xu Q, Hu P, Sun S, Shen Y, and Chen L*. (2008). Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fishes. Proc. Natl. Acad. Sci. USA. 105:12944-12949.
8. Zhang J, Dend C, Wang J. and Chen L*. (2009). Characterization of a two-domain antifreeze protein gene in Antarctic eelpout Lycodichthyus dearborni. Polar Biol. 32(1): 35-40.
9. Xu Q#, Cheng CH#, Hu P# (# co-first authors) , Ye H, Chen Z, Cao L, Chen L, Shen Y, Chen L*. (2008). Adaptive evolution of hepcidin genes in antarctic notothenioid fishes. Mol. Biol. Evol. 25(6):1099-112.
10. Chen L, Cao L, Zhou L, Jing Y, Chen Z, Deng C, Shen Y, Chen L* (2007). Trehalose as a good candidate for enriching full-length cDNAs in cDNA library construction. J. Biotech. 127: 402-407
11. Zuozhou Chen, Weilin Wang, Xuefeng Bruce Ling, Jane Jijun Liu and Liangbiao Chen* (2006). GO-Diff: Mining functional differentiation between EST-based transcriptomes. BMC Bioinformatics. 2006, 7:72
12. Huarong Huang, Xiaoli Zhao, Liangbiao Chen, Chao Xu, Xing Yao, Yongliang Lu, Licheng Dai, Ming Zhang (2006).Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochem. Biophys. Res. Comm., 351: 321-327
13. Jane Jijun Liu, Gene Cutler, Wuxiong Li, Zheng Pan, Sihua Peng,Tim Hoey, Liangbiao Chen and Xuefeng Bruce Ling (2005). Multiclass cancer classification and biomarker discovery using GA-based algorithms. Bioinformatics. 21: 2691-7
14. Zuozhou Chen, Chenghai Xue, Sheng Zhu, Fengfeng Zhou, Xuefeng Bruce Ling, Guoping Liu, Liangbiao Chen* (2005). GoPipe: Streamlined Gene Ontology Annotation for Batch Anonymous Sequences with Statistics. Prog. Biochem. Biophys. 32(2): 187-191.
15. Sihua Peng, Qianghua Xu, Xuefeng Bruce Ling, Xiaoning Peng, Wei Du, Liangbiao Chen* (2003). Molecular classification of cancer types from microarray data using the combination of Genetic Algorithms and Support Vector Machines. FEBS Letters, 555:358-62.
16. Shuyu Li, Gene Cutler, Jane Jijun Liu, Timothy Hoey, Liangbiao Chen, Peter G. Schultz, Jiayu Liao, Xuefeng Bruce Ling (2003). A Comparative Analysis Of HGSC and Celera Human Genome Assemblies and Gene Sets. Bioinformatics. 19(13):1597-605.
17. Chi-Hing C. Cheng, Liangbiao Chen, Thomas Near, Yumi Jin (2003). Functional antifreeze glycoprotein genes in temperate-water New Zealand nototheniid fish infer an Antarctic origin. Mol. Biol. Evol. 20(11):1897-908.
18. Chi-Hing C. Cheng and Liangbiao Chen. (1999). Evolution of Antifreeze Glycoprotein. Nature. 401:443-444.
19. Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng (1997). Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish. Proc. Natl. Acad. Sci. USA. 94:3811-3816.
20. Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng (1997). Convergent evolution of antifreeze glycoproteins in Antarctic notothenioid fish and Arctic cod. Proc. Natl. Acad. Sci. USA. 94:3817-3822.
21. SH Hahm, Liangbiao Chen, C Patel, J Erickson, TI Bonner, Eberhard Weihe, K. -H. Schafer, Lee E. Eiden (1998). Upstream sequencing and functional characterization of the human cholinergic gene locus. J. Mol. Neurosci.. 9(3): 223-236.
22. Berkhard Schutz, Liangbiao Chen, K. -H. Schafer, Eberhard Weihe, Lee E. Eiden (2000). Somatomotor neuron-specific expression of the cholinergic gene locus in transgenic mice. Neuroscience. 96(4): 707-722. |
