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程祝宽


程祝宽 男,博士,1966年5月生。研究员,博士生导师。

 

E-mail: zkcheng@genetics.ac.cn; Telephone: 010-64868726

 

        1987年获扬州大学农学系农学学士,1990年获扬州大学农学系作物遗传育种硕士,1999年获中国科学院遗传研究所理学博士,1999年至2002年在美国Wisconsin-Madison大学从事博士后研究。2002年12月入选中国科学院“百人计划”,终期考核为优秀。2003年获国家杰出青年基金资助,现为Chromosome Research杂志编委。主要研究内容包括:



1.植物减数分裂过程的遗传控制
        减数分裂是配子形成过程中进行的一种特殊分裂方式,其特点是染色体复制一次,细胞分裂两次,形成了染色体数目减半的配子。雌雄配子受精形成合子,染色体又恢复到原来的数目。由于减数分裂过程来自父母双方染色体的充分重组和精确分离,在保证物种遗传物质相对稳定的基础上,为有性后代提供了极其丰富的多样性,这也正是借助有性杂交进行遗传选择的基础。减数分裂过程是一极其复杂的生命过程,涉及减数分裂的启动,同源染色体的配对、联会、交换和分离等一系列染色体的变化过程,这些过程受着许多基因的调控,一直成为生物科学研究的热点。我们以水稻作为模式生物,通过正向和反向两种途径,系统研究参与减数分裂过程的基因,了解这些它们的作用网络,为最终解析减数分裂调控的分子机理提供依据。

 

2.水稻花器官发育及种子形成的分子机理
        花器官是植物特有的生殖器官,其遗传与发育受到许多基因的调控。水稻作为单子叶分子生物学研究的模式生物,其花器官与双子叶植物有着质的差别。我们以水稻为模式生物,通过诱发花器官变异的突变体,克隆相关基因,为深入了解单子叶生物花器官形成与发育的分子机理提供证据。

 


回国后发表的主要论文
 
责任作者论文
1.Wang M, Wang KJ, Tang D, Wei CX, Li M, Shen Y, Chi ZC, Gu MH, Cheng ZK (2010). The central element protein ZEP1 of the synaptonemal complex regulates the number of crossovers during meiosis in rice. Plant Cell  doi/10.1105/tpc.109.070789
 
2.Wang KJ, Tang D, Hong LL, Xu WY, Huang J, Li M, Gu MH, Xue YB, Cheng ZK (2010). DEP and AFO regulate reproductive habit in rice. PLoS Genet 6: e1000818.
 
3.Zhu KM, Tang D, Yan CJ, Chi ZC, Yu HX, Chen JM, Liang JS, Gu MH, Cheng ZK (2010). ERECT PANICLE2 encodes a novel protein that regulates panicle erectness in indica rice. Genetics 184: 343-350.
 
4.Hong LL, Qian Q, Zhu KM, Tang D, Huang ZJ, Gao L, Li M, Gu MH, Cheng ZK (2010). ELE restrains empty glumes from developing into lemmas. J. Genet. Genomics 37: 101-114.
 
5.Huang J, Tang D, Shen Y, Qin BX, Hong LL, You AQ, Li M, Wang X, Yu HX, Gu M, Cheng ZK (2010). Activation of gibberellin 2-oxidase 6 decreases active gibberellin levels and creates a dominant semi-dwarf phenotype in rice (Oryza sativa L.). J.Genet. Genomics 37: 23-36.
 
6.Wang KJ, Tang D, Wang M, Lu JF, Yu HX, Liu JF, Qian BX,Gong ZY, Wang X, Chen JM, Gu MH, Cheng ZK (2009). MER3 is required for normal meiotic crossover formation, but not for presynaptic alignment in rice. Journal of Cell Science 122: 2055-2063
 
7.Li M, Xiong GY, Li R, Cui JJ, Tang D, Zhang BC, Pauly M, Cheng ZK and Zhou YH (2009). Rice cellulose synthase-like D4 is essential for normal cell-wall biosynthesis and plant growth. The Plant Journal 60: 1055-1069
 
8.Huang J, Zhang KW, Shen Y, Huang ZJ, Li M, Tang D, Gu MH, Cheng ZK (2009). Identification of a high frequency transposon induced by tissue culture, nDaiZ, a member of the hAT family in rice. Genomics 93: 274-281
 
9.Zhang DF, Yang QY, Ding Y, Cao XF, Xue YB, Cheng ZK (2008) Cytological Characterization of the Tandem Repetitive Sequences and Their Methylation Status in the Antirrhinum majus Genome. Genomics 92: 107–114
 
10.Yu HX, Wang X, Gong ZY, Tang D, Gu MH, Cheng ZK (2008) Generating of rice OsCENH3-GFP transgenic plants and their genetic applications. Chinese Science Bulletin 53: 2981-2988
 
11.Cui JJ, Fan SC, Shao T, Huang ZJ, Zheng DL, Tang D, Li M, Qian Q, Cheng ZK (2007). Characterization and fine mapping of the ibf mutant in rice. J. Integr. Plant Biol. 49: 678−685
 
12.Tang XM, Bao WD, Zhang WL, Cheng ZK (2007). Identification of chromosomes from multiple rice genomes using a universal molecular cytogenetic marker system. J. Integr. Plant Biol. 49: 953−960
 
13.Zhang KW, Qian Q, Huang ZJ, Wang YQ, Li M, Hong LL, Zheng DL, Gu MH, Chu CC, and Cheng ZK (2006). GOLD HULL AND INTERNODE2 (GH2) encodes a primarily multifunctional cinnamyl-alcohol dehydrogenase (CAD) in Oryza sativa.Plant Physiol. 140: 972-983
 
14.Bao WD, Zhang WL, Yang QY, Zhang Y, Han B, Gu MH, Xue YB, and Cheng ZK (2006). Diversity of centromeric repeats in two closely related wild rice species, O. officinalis and O. rhizomatis. Mol. Gen. Genomics 275: 421-430
 
15.Zhang WL, Yi CD, Bao WD, Liu B, Cui JJ, Yu HX, Cao XF, Gu MH, Liu M, and Cheng ZK (2005). The transcribed 165bp CentO satellite is the major functional centromeric element in the wild rice species Oryza punctata. Plant Physilol. 139: 306-315
 
16.Zhang DF, Yang QY, Bao WD, Zhang Y, Han B, Xue YB and Cheng ZK (2005). Molecular cytogenetic characterization of the Antirrhinum majus genome. Genetics 169: 325-335
 
合作论文
1.Lu F, Ammiraju J.S.S., Sanyal A., Zhang SL, Song RT, Chen JF, Li GS, Sui Y, Song X, Cheng ZK, de Oliveira A.C., Bennetzen  J.L., Jackson S.A., Wing R.A., Chen MS (2009). Comparative sequence analysis of MONOCULM1-orthologous regions in 14 Oryza genomes. PNAS 106: 2071-2076
 
2.Gao DY, Gill N, Kim HR, Walling JG, Zhang WL, Fan CZ, Yu YS, Ma JX, Miguel PS, Jiang N, Cheng ZK, Wing RA, Jiang JM and Jackson SA (2009). A lineage-specific centromere retro- transposon in Oryza brachyantha. The Plant Journal 60: 820-831
 
3.Shang JJ, Tao Y, Chen XW, Zou Y, Lei CL, Wang J, Li XB, Zhao XF, Zhang MJ, Lu ZK, Xu JC, Cheng ZK, Wan JM and Zhu LH (2009). Identification of a new rice blast resistance gene, Pid3, by genome wide comparison of paired-nucleotide-bindingsite–Leucine-rich repeat genes and their pseudogene alleles between the two sequenced rice genomes. Genetics 182: 1303-1311
 
4.Cheng XD, Zhang DF, Cheng ZK, Keller B, Ling HQ (2009). A new family of Ty1-copia-Like retrotransposons originated in the tomato genome by a recent horizontal transfer event. Genetics 181: 1183-1193
 
5.Xue YB, Zhang YJ, Yang QY, Li Q, Cheng ZK, Dickinson, H G (2009). Genetic features of a pollen-part mutation suggest an inhibitory role for the Antirrhinum pollen self-incompatibility determinant. Plant Mol. Biol. 70: 499-509
 
6.Mueller L. A., et al. (2009). A Snapshot of the Emerging Tomato Genome Sequence. Plant Genome 2: 78-92
 
7.Chen SH, Yang Y, Shi WW, Ji Q, He F, Zhang ZD, Cheng ZK, Liu XN, Xu ML (2008). Badh2, encoding betaine aldehyde dehydrogenase, inhibits the biosynthesis of 2-acetyl-1-pyrroline, a major component in rice fragrance. Plant Cell 20: 1850-1861
 
8.Yan S, Yan CJ, Zeng XH, Yang YC, Fang YW, Tian CY, Sun YW, Cheng ZK, Gu MH (2008).  ROLLED LEAF 9, encoding a GARP protein, regulates the leaf abaxial cell fate in rice. Plant Mol. Biol. 68: 239–250
 
9.Fang J, Chai CL, Qian Q, Li CL, Tang JY, Sun L, Huang ZJ, Guo XL, Sun CH, Liu M, Zhang Y, Lu QT, Wang YQ, Lu CM, Han B, Chen F, Cheng ZK, Chu CC (2008). Mutations of genes in synthesis of the carotenoid precursors of ABA lead to preharvest sprouting and photo-oxidation in rice. The Plant Journal 54: 177-189
 
10.Ding Y, Wang X, Su L, Zhai JX, Cao SY, Zhang DF, Liu CY, Bi YP, Qian Q, Cheng ZK, Chu CC, Cao XF (2007). SDG714, a Histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. Plant Cell 19: 9-22
 
11.Yang QY, Zhang DF, Li Q, Cheng ZK, Xue YB (2007). Heterochromatic and Genetic Features are Consistent with Recombination Suppression of The Self-Incompatibility Locus in Antirrhinum. The Plant Journal 51: 140–151
 
12.Tang YL, Wen XG, Lu QT, Yang ZP, Cheng ZK, Lu CM (2007). Heat stress induces an aggregation of the light-harvesting complex of photosystem II in spinach plants. Plant Physiol. 143: 629-638
 
13.Jiang L, Zhang W, Xia Z, Jiang G, Qian Q, Li A, Cheng ZK, Zhu L, Mao L, Zhai W. A paracentric inversion suppresses genetic recombination at the FON3 locus with breakpoints corresponding to sequence gaps on rice chromosome 11L. Mol. Gen. Genomics 2007, 277: 263-272
 
14.Li L, Wang XF, Stolc V, Li XY, Zhang DF, Su N, Tongprasit W, Li SG, Cheng ZK, Wang J and Deng XW.(2006) Genome-wide transcription analyses in rice using tiling microarrays. Nature Genetics 38: 124 – 129
 
15.Wang Y, Tang XM, Cheng ZK, Mueller L, Giovannoni J and Tanksley SD (2006) Euchromatin and pericentromeric heterochromatin: Comparative composition in the tomato genomeGenetics 172: 2529-2540
 
16.Mueller L. A., et al. (2005) The Tomato Sequencing Project, the first cornerstone of the International Solanaceae Project (SOL). Comparative and Functional Genomics 6: 153–158.
 
17.Jiao YL, Jia PX, Wang XF, Su N, Yu SL, Zhang DF, Ma LG, Feng Q, Jin ZQ, Li L, Xue YB, Cheng ZK, Zhao HY, Han B, and Deng XW (2005). A Tiling Microarray Expression Analysis of Rice Chromosome 4 Suggests a Chromosome-Level Regulation of Transcription. Plant Cell 17: 1641-1657
 
18.Lee HR, Zhang WL, Langdon T, Jin WW, Yan HH, Cheng ZK, and Jiang JM (2005). ChIP cloning reveals rapid evolutionary patterns of centromeric DNA in Oryza species. PNAS 102: 11793-11798
 
19.Nagaki K, Neumann P, Zhang DF, Ouyang S, Buell CR, Cheng ZK, and Jiang JM (2005). Structure, divergence, and distribution of the CRR centromeric retrotransposon family in rice. Molecular Biology and Evolution 22: 845-855
 
20.Guyot R, Cheng XD, Su Y, Cheng ZK, Schlagenhauf E, Keller B and Ling HQ (2005). Complex Organization and Evolution of the Tomato, Pericentromeric Region at the FER Gene Locus1. Plant Physilol. 138: 1205-1215
 
21.Nagaki K., Cheng, ZK, Ouyang S., Talbert P.B., Kim M., Jones K.M., Henikoff S., Buell C.R., Jiang JM (2004). Sequencing of a rice centromere uncovers active genes. Nature Genet. 36: 138-145
 
22.Zhang Y, Huang YC, Zhang L, Li Y, Lu TT, Lu YQ, Feng Q, Zhao Q, Cheng ZK, Xue YB, Rod A. Wing and Han B (2004). Structural features of the rice chromosome 4 centromere. Nucleic Acids Research  32: 2023-2030