神经发生是由神经干细胞分化为神经元的过程。衰老以及中枢神经系统疾病（如神经退行性疾病和神经发育疾病）都会引起神经发生的异常。我们实验室着重研究神经干细胞和神经发生的细胞和分子机制，以及它们在神经退行性疾病和神经发育疾病的发生机制，从而为这些疾病的预防和治疗提供理论依据。
代表性论文：（*通讯作者）
1. Guo Y, Chen X, Xing R, Wang M, Zhu X, Guo W*. Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway. Hum. Mol. Genet. 2017 Dec 1. doi: 10.1093/hmg/ddx417.
2. Liu K, Xing R, Jian Y, Gao Z, Ma X, Sun X, Li Y, Xu M, Wang X, Jing Y, Guo W*, Yang C*, WDR91 is a Rab7 effector required for neuronal development. J. Cell. Biol. 2017; 216(10):3307-3321.
(Spotlight: A new Rab7 effector controls phosphoinositide conversion in endosome maturation. Casanova J. and Winckler B. 2017. J. Cell Biol. 216(10): 2995-2997)
3. Guo Y, He X, Lu Z, Liu L, Song H, Wang X, Xu J, Ju X, Guo W*, Zhu X*. Gβ2 regulates the multipolar-bipolar transition of newborn neurons in the developing neocortex. Cereb Cortex. 2017; 27(6):3414-3426.
4. Liu X, Yang Li, Wang X, Xing R, Liu K, Gan Q, Tang C, Gao Z, Jian Y, Luo S, Guo W*, Yang C*, The Beach-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. J. Cell. Biol. 2017; 216(5):1301-1320.
5. Yu H, Sun D, Wang N, Wang M, Lan Y, Fan W, Zhao Y, Guo W*, Zhu X*. Headless Myo10 is a regulator of microtubule stability during neuronal development. J Neurochem. 2015. 135(2):261-73.
6. Wang F, Tidei JJ, Polich ED, Gao Y, Zhao H, Perrone-Bizzozero NI*, Guo W*, Zhao X*. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proc Natl Acad Sci U S A. 2015; 112(36):E4995-5004.
7. Lai M, Guo Y, Ma J, Yu H, Zhao D, Fan W, Ju X, Sheikh M, Malik Y, Xiong W, Guo W*, Zhu X*. Myosin X regulates neuronal radial migration through interacting with N-cadherin. Front. Cell. Neurosci. 2015; 18;9:326.
8. Guo W, Polich ED, Su J, Gao Y, Christopher DM, Allan AM, Wang M, Wang F, Wang G, Zhao X. Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms. Cell Rep. 2015; 11(10):1651-66.
9. Guo W, Patzlaff EN, Jobe EM, and Zhao X. Isolation of multipotent neural stem/progenitor cells from both the dentate gyrus and subventricular zone of a single adult mouse. Nat. Protoc. 2012; 7(11): 2005-12.
10. Guo W, Murthy AC, Zhang L, Johnson EB, Schaller EG, Allan AM, and Zhao X. Inhibition of GSK3β Improves Hippocampus-Dependent Learning and Rescues Neurogenesis in a Mouse Model for Fragile X Syndrome. Hum. Mol. Genet. 2012; 21(3): 681-91.
11. Guo W, Allan AM, Zong R, Zhang L, Johnson EB, Schaller EG, Murthy AC, Goggin SL, Eisch AJ, Oostra BA, Nelson DL, Jin P, and Zhao X. Ablation of FMRP in Adult Neural Stem Cells Disrupts Hippocampus Dependent Learning. Nat. Med. 2011; 17(5):559-65. (Cover Paper)
12. Guo W, Zhang L, Christopher DM, Teng Z, Fausett SR, Klingensmith J, Jin P, and Zhao X. RNA-binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression. Neuron 2011; 70(5): 924-38.
13. Luo Y#, Shan G#, Guo W# (#, equal contribution), Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, and Zhao X. Fragile X mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet. 2010; 6 (4): e1000898.
