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郭伟翔


郭伟翔,博士研究员,博士生导师 
 
        2008年获中国科学院动物研究所博士学位
        2008-2011年在美国新墨西哥州大学从事博士后研究
        2011-2014年在美国威斯康星大学麦迪逊分校从事博士后研究
        2014年 任中国科学院遗传发育所研究员


研究内容:衰老以及中枢神经系统疾病 (如神经退行性疾病和神经发育疾病) 都会引起神经发生的异常。我们实验室着重研究神经干细胞和神经发生的细胞分子机制,以及它们在神经退行性疾病和神经发育疾病的发生机制,从而为这些 疾病的预防和治疗提供理论据。
 
研究组成员
 
工作人员
        王敏 (工程师)
        郭野 (助理工程师)
 
博士后
        刘强 (2020)
 
硕博连读生
        刘英浩 (2015) 罗行 (2016) 王磊 (2016) 徐铭悦 (2017) 申旭宁 (2017) 梁子琦 (2018)闫健菲 (2019)
 
博士研究生
        李志敏 (2019) 秦德哲2021)
  
研究生/博士后奖项
        汤常永 (2018年国家奖学金/2018年振声奖学金/博士)
        邢如晓 (2018年国家奖学金/博士)
        郭野 (2019年 益海嘉里优秀博士后)
 
已毕业的研究生:
        陈旭  (硕士2013-2016) 汤常永 (博士 2015-2018) 王玉晗 (博士 2014-2019) 邢如晓 (硕博 2013-2019)韩秀 (硕博 2014-2021) 席颖颖 (硕士 2018-2021)

代表性论文:*通讯作者)
1. Guo Y, Wu J, Wang M, Wang X, Jian Y, Yang C, Guo W*. The metabolite saccharopine impairs neuronal development by inhibiting the neurotrophic function of glucose-6-phosphate isomerase. J Neurosci. DOI: 10.1523/JNEUROSCI.1459-21.2022. (Featured Research)
 
 
2. Han X, Shen X, Wang M, Wang X, Jian Y, Yang C, Guo W*. Loss of RNA-Binding Protein HuR Leads to Defective Ependymal Cells and Hydrocephalus. J Neurosci. 2022; 42(2):202-219.
 
 
3. Xing R, Zhou H, Jian Y, Li L, Wang M, Liu N, Yin Q, Liang Z, Guo W*, Yang C*. The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion. J. Cell Biol. 2021; 220(8):e202007061.
 
 
4. Zhang B, Wang L, Zhan A, Wang M, Tian L*, Guo W*, Pan Y. Long-term exposure to a hypomagenetic field attenuates adult hippocampal neurogenesis and cognition. Nat. Commun. 2021; 12 (1):1174. (Featured Article)
 
 
5. Tang C*, Guo W*. Implantation of a mini-osmotic pump plus stereotactical injection of retrovirus to study newborn neuron development in adult mouse hippocampus. STAR Protoc. 2021; 2(1):100374.
 
 
6. Wang M, Tang C, Xing R, Liu X, Han X, Liu Y, Wang L, Yang C*, Guo W*. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Mol. Psychiatry. 2021; 26(2):694-709.
 
 
7. Li Y*, Guo W*. Neural Stem Cell Niche and Adult Neurogenesis. Neuroscientist. 2021; 27 (3):235-245.
 
 
8. Zhao Y, He X, Song Z, Guo Y, Zhang Y, Yu H, He Z, Xiong W, Guo W*, Zhu X*. Human antigen R-regulated mRNA metabolism promotes the cell motility of migrating neurons. Development. 2020. 147 (6):dev183509.
 
 
9. Wang Y, Guo Y, Tang C, Han X, Xu M, Sun J, Zhao Y, Zhang Y, Wang M, Cao X, Zhu X, Guo W*. Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis. Cell Rep. 2019. 29 (10): 3101-3117.
 
 
10. Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, Guo S, Zhou Q, Wu N, Chen Y, Chen Y, Song X, Jiang H, Wang Y, Lan Y, Zhou B, Mao L, Li J, Yang H*, Guo W*, Yang X*. Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis. Cell Stem Cell. 2019. 25(6):754-767.
(Preview: Sensing the Environment: Extracellular Lactate Levels Control Adult Neurogenesis. Scandella V. and Knobloch M. 2019. Cell Stem Cell. 25(6):729-731)
 
 
11. Zhou J, Wang X, Wang M, Chang Y, Zhang F, Ban Z, Tang R, Gan Q, Wu S, Guo Y, Zhang Q, Wang F, Zhao L, Jing Y, Qian W, Wang G, Guo W*, Yang C*. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. J. Cell Biol. 2019; 218(2):580-597.
(Spotlight: Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. Leandro J. and Houten SM. 2019; J. Cell Biol. 2018(2):391-392.)
 
 
12. Tang C, Wang M, Wang P, Wang L, Wu Q, Guo W*. Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. Neuron. 2019; 101(1):32-44.
(Preview: Interactive Regulation of Neuronal Development by Hippocampal Stem Cell Niche Populations. LeBelle J. and Kornblum H. 2019. Neuron. 101(1):1-2.)
 
 
13. Guo Y, Chen X, Xing R, Wang M, Zhu X, Guo W*. Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway. Hum. Mol. Genet. 2018; 27(3):475-485.
 
 
14. Liu K, Xing R, Jian Y, Gao Z, Ma X, Sun X, Li Y, Xu M, Wang X, Jing Y, Guo W*, Yang C*, WDR91 is a Rab7 effector required for neuronal development. J. Cell Biol. 2017; 216(10):3307-3321.
(Spotlight: A new Rab7 effector controls phosphoinositide conversion in endosome maturation. Casanova J. and Winckler B. 2017. J. Cell Biol. 216(10): 2995-2997)
 
 
15. Guo Y, He X, Lu Z, Liu L, Song H, Wang X, Xu J, Ju X, Guo W*, Zhu X*. Gβ2 regulates the multipolar-bipolar transition of newborn neurons in the developing neocortex. Cereb. Cortex. 2017; 27(6):3414-3426.
 
 
16. Liu X, Yang Li, Wang X, Xing R, Liu K, Gan Q, Tang C, Gao Z, Jian Y, Luo S, Guo W*, Yang C*, The Beach-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. J. Cell Biol. 2017; 216(5):1301-1320.
 
 
17. Yu H, Sun D, Wang N, Wang M, Lan Y, Fan W, Zhao Y, Guo W*, Zhu X*. Headless Myo10 is a regulator of microtubule stability during neuronal development. J. Neurochem. 2015. 135(2):261-73.
 
 
18. Wang F, Tidei JJ, Polich ED, Gao Y, Zhao H, Perrone-Bizzozero NI*, Guo W*, Zhao X*. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proc. Natl. Acad. Sci. U S A. 2015; 112(36):E4995-5004.
 
 
19. Lai M, Guo Y, Ma J, Yu H, Zhao D, Fan W, Ju X, Sheikh M, Malik Y, Xiong W, Guo W*, Zhu X*. Myosin X regulates neuronal radial migration through interacting with N-cadherin. Front. Cell. Neurosci. 2015; 18; 9:326.