位置:首页 > 研究队伍  


吴青峰


吴青峰,博士,研究员,博士生导师
 
        2005年毕 业于复旦大学获临床医学学士学位,2012年毕业于中国科学院神经科学研究所获理学博士学位。2012-2016年在美国Johns Hopkins University (约翰霍普金斯大学)从事博士后研究。先后获得中国科学院院长特别奖(特等奖)、中国科学院优秀博士毕业论文奖、礼来优秀博士论文奖、细胞生物学青年论坛学术新人奖、人类前沿科学奖(HFSP Postdoctoral Fellowship)、美国马里兰干细胞研究基金奖(MSCRF Fellowship)。


研究方向
 
        哺乳动物大脑基本上由层状结构(如大脑皮层、视网膜等)和核团类结构(丘脑、下丘脑、脑干等)组成,这些神经元的组织结构将直接影响神经信息传递和认知行为。虽然层状结构大脑皮层的组织原则在过去十年里已经得到比较深入的研究,然而学界对核团类结构的空间构架原则所知甚少。我们利用单细胞技术包括单细胞谱系追踪、单细胞测序、单细胞基因敲除等研究发育过程中胚胎神经干细胞的行为,下丘脑和脑干神经元的生成、迁移、连接,以及先天性神经相关疾病的分子细胞机理。
 
        同时,我们也关注成年神经干细胞调控衰老和肥胖症的分子细胞机制,传统的成年神经干细胞定位于亚脑室区(SVZ)和海马颗粒细胞层下区(SGZ),在衰老过程中逐渐衰减;而下丘脑神经干细胞在肥胖症、衰老中发生失调。我们将利用谱系追踪技术关注下丘脑神经干细胞在各种环境下的行为,及其失调对机体代谢的影响;同时关注下丘脑新生神经元的环路整合。

代表性论文:
(10) Qing-Feng Wu, Samuel Z.H. Wong, Candace C. Liu, Christopher Jou, Guo-Li Ming, Hongjun Song, Yasushi Nakagawa. (2017) Deconstructing the cellular basis of thalamic nuclei specification by in vivo clonal analysis. Prepared for submission
 
(9) Qing-Feng Wu, Samuel Z.H. Wong, Candace C. Liu, Christopher Jou, Mai Nakamura, Gerry J. Sun, Michael A. Bonaguidi, Kimberly M. Christian, Yasushi Nakagawa, Guo-li Ming, and Hongjun Song. (2017) Clonal Organization and Production of Diverse Cell Types in Hypothalamus. Prepared for submission
 
(8) Wei D, Gao N, Li L, Zhu JX, Diao L, Huang J, Han QJ, Wang S, Xue H, Wang Q, Wu QF, Zhang X, Bao L. α-Tubulin Acetylation Restricts Axon Overbranching by Dampening Microtubule Plus-End Dynamics in Neurons. (2017) Cereb Cortex, (Epub ahead of print)
 
(7) Yoon KJ, Song G, Qian X, Pan J, Xu D, Rho HS, Kim NS, Habela C, Zheng L, Jacob F, Zhang F, Lee EM, Huang WK, Ringeling FR, Vissers C, Li C, Yuan L, Kang K, Kim S, Yeo J, Cheng Y, Liu S, Wen Z, Qin CF, Wu Q, Christian KM, Tang H, Jin P, Xu Z, Qian J, Zhu H, Song H, Ming GL. Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins. (2017) Cell Stem Cell. (Epub ahead of print)
 
(6) Oh Y, Zhang F, Wang Y, Lee EM, Choi IY, Lim H, Mirakhori F, Li R, Huang L, Xu T, Wu H, Li C, Qin CF, Wen Z, Wu QF, Tang H, Xu Z, Jin P, Song H, Ming GL, Lee G (2017). Zika virus directly infects peripheral neurons and induces cell death. Nat Neurosci, 20(9):1209-1212.
 
(5) Yang L, Dong F, Yang Q, Yang PF, Wu R, Wu QF, Wu D, Li CL, Zhong YQ, Lu YJ, Cheng X, Xu FQ, Chen L, Bao L, Zhang X. (2017) FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7. Neuron, 93(4):806-821
 
(4) Liu H, Wu QF, Li JY, Liu XJ, Li KC, Zhong YQ, Wu D, Wang Q, Lu YJ, Bao L, Zhang X. (2015) Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles. Journal of Molecular Cell Biology, 7(5):466-75
 
(3) Zhang X, Bao L, Yang L, Wu Q, and Li S. (2012) Roles of intracellular fibroblast growth factors in neural development and functions. Sci China Life Sci. 55: 1038-1044. (Review)
 
(2) Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L, Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell, 149(7):1549-64.
 
(1) Liu XJ, Zhang FX, Liu H, Li KC, Lu YJ, Wu QF, Li JY, Wang B, Wang Q, Lin LB, Zhong YQ, Xiao HS, Bao L, Zhang X. (2012) Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. Brain, 135(Pt 2):391-403.