2005年毕业于复旦大学获临床医学学士学位，2012年毕业于中国科学院神经科学研究所获理学博士学位。2012-2016年在美国Johns Hopkins University （约翰霍普金斯大学）从事博士后研究。先后获得中国科学院院长特别奖、中国科学院优秀博士学位论文奖、礼来优秀博士毕业论文奖、细胞生物学青年论坛学术新人奖、人类前沿科学奖（HFSP Postdoctoral Fellowship）、美国马里兰干细胞研究基金奖（MSCRF Fellowship）、益海嘉里优秀导师奖、神经细胞生物学青年前沿论坛特邀报告人奖。2018年入选中国科学院脑智卓越中心，2020年入选北京脑科学与类脑研究中心合作研究员。现任中国神经科学学会神经发育与再生分会委员、突触与神经可塑性分会委员、生物物理学会单细胞多组学分会委员和北京细胞生物学会理事。
下丘脑通过调节内分泌、自主神经和行为功能来维持机体内稳态，包括饥饿、睡眠、体温、口渴、昼夜节律、情绪调节、性欲和激素释放等。然而，对于不同脊椎动物的下丘脑发育，包括其模式生成、神经发生和环路组装，我们却知之甚少。我们团队一直致力于开发和应用单细胞分析方法（包括单细胞谱系追踪、单细胞多组学和单细胞遗传操作等），用于研究下丘脑发育过程中神经发生和核团生成过程（Cell Stem Cell, 2021; PLoS Biol, 2018; Cell Regen, 2018;Cell Regen, 2018; Neurosci Bull, 2022）。由于下丘脑神经元种类的多样性、神经元连接的复杂性以及神经元功能的重要性，我们需要付出更多的努力来解码神经元生成和环路组装的过程和机制。。
下丘脑不仅分泌神经递质和神经肽，还分泌神经激素，用以协调大脑和外周器官之间的相互协作。如果下丘脑神经元命运决定和环路组装出现异常，会导致代谢失调和内分泌紊乱等疾病。为探讨下丘脑发育的生理意义，我们主要关注以下三方面的研究：1）调节进食行为和机体代谢的新型神经元亚型；2）中枢性早熟和青春期延迟的细胞机制(Sci Adv, 2022)；3）乳头状颅咽管瘤的遗传病因和病理机制（Nat Commun, 2021; J Endocrinol, 2018）。
神经干细胞的稳态维持对于神经发育和神经再生至关重要，胚胎期神经干细胞的稳态失调可以导致大脑发育异常，出现自闭症、智力障碍等疾病；成年期神经干细胞的稳态失调可以导致精神分裂症、情绪障碍、早衰等疾病。我们利用谱系追踪技术、基因编辑技术等研究在不同生理或病理条件下调控神经干细胞稳态的分子机制（Dev Cell, 2023;Cell Rep, 2020; Cell, 2012）。
代表性论文 (*通讯作者)：
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