位置:首页 > 研究队伍  


许操


许操,男,博士,研究员,博士生导师。
        2001-2005: 山东农业大学,学士;2005-2012: 中国科学院遗传与发育生物学研究所,博士;2013-2017: 美国冷泉港实验室(Cold Spring Harbor Laboratory), 博士后;入选国家高层次人才计划于2017年8月入职中国科学院遗传与发育生物学研究所,任研究员。2017年11月入选中国科学院-英国约翰英纳斯中心植物和微生物科学联合研究中心(Chinese Academy of Sciences-John Innes Centre, CEPAMS),研究员。
 
        实验室围绕发育可塑性、系统稳健性与环境适应性这一内在联系与统一的生物学主题,主要从小肽信号与细胞通讯,蛋白质相分离与生命系统稳健性,基因编辑与作物重新驯化及定向进化等方面开展研究,认知上述生物学主题内在联系与统一的基本规律。


研究方向
 
        小肽信号(Peptide signaling) 与细胞通讯
        植物的生长发育依赖于细胞间的通讯和对话,作为可以在细胞间穿梭的信号分子,小肽信号通过控制细胞通讯决定植物的生长发育和对环境的响应。我们将运用新的策略发掘未知的小肽信号,鉴定其受体并深入研究它们调控发育与环境适应性的分子机制。
 
        蛋白质相分离(Protein phase separation)生命系统稳健性(Robustness)
        生命系统(Living system)所具有的稳健性使其具有强大的生命力以应对内在的遗传突变和外在的环境胁迫。植物会通过基因冗余、基因和蛋白网络的重新整合等策略启动“应急预案”以应对内在和外在的胁迫,从而实现系统稳健性。生物演化在细胞水平上的一个重要体现便是从相对均一的细胞质环境进化出多样化的细胞器结构,不同生物反应以一种时空特异性的方式在不同的细胞器内有序发生从而决定着细胞的命运。某些蛋白质或者核酸分子可以通过多价相互作用发生相位分离,在原本均一的环境中产生物理、化学性质不同的另一相,形成无膜细胞器或者细胞结构。我们将使用番茄作为研究模式,揭示相分离调控植物生命系统实现稳健性和发育可塑性的分子机制。
 
        作物设计与创造
        基于对作物进化、驯化规律和植物发育可塑性以及生命系统稳健性的认识,使用多重组学、合成生物学和基因编辑技术加速现有作物的驯化和改良;同时从自然界遴选野生植物,进行重新驯化,创造适应自然环境变化,面向国家重大需求的战略资源作物和面向人民生命健康的全新智能作物。
 

近期发表文章(**Corresponding author, *Co-first author)
 
Xiaozhen Huang*, Nan Xiao*, Yue Xie, Lingli Tang, Yueqin Zhang, Yuan Yu, Cao Xu (2021) Transcriptional condensates formed by phase-separated ALOG family proteins control shoot meristem maturation for flowering. BioRxiv. DOI: https://doi.org/10.1101/2021.03.18.435998.
 
Xiaozhen Huang*, Shudong Chen*, Weiping Li, Lingli Tang, Yueqin Zhang, Ning Yang, Yupan Zou, Xiawan Zhai, Nan Xiao, Wei Liu, Pilong Li**, Cao Xu** (2021) ROS regulated reversible protein phase separation synchronizes plant flowering. Nature Chemical Biology.  DOI: https://doi.org/10.1038/s41589-021-00739-0 (Featured Article, Highlighted by Nature Chemical Biology, Feb. 25. 2021)
 
Lichan Tu*, Ping Su*, Zhongren Zhang*, Linhui Gao, Jiadian Wang, Tianyuan Hu, Jiawei Zhou, Yifeng Zhang, Yujun Zhao, Yuan Liu, Yadi Song, Yuru Tong, Yun Lu, Jian Yang, Cao Xu, Meirong Jia, Reuben J. Peters, Luqi Huang** & Wei Gao**. Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis. Nature Communications. 11: 971 (2020)
 
Daniel Rodriguez-Leal*, Cao Xu*, Choon-Tak Kwon, Cara Soyars, Edgar Demesa-Arevalo, Jarrett Man, Lei Liu, Zachary H. Lemmon, Daniel S. Jones, Joyce Van Eck, David P. Jackson**, Madelaine E. Bartlett**, Zachary L. Nimchuk** and Zachary B. Lippman**. Evolution of buffering in a genetic circuit controlling plant stem cell proliferation. (2019). Nature Genetics, 51(5) 786~792 (Highlighted by Nature Genetics 51, 770–771, 2019)
 
Tingdong Li*, Xinping Yang*, Yuan Yu*, Xiaomin Si, Xiawan Zhai, Huawei Zhang, Wenxia Dong, Caixia Gao** & Cao Xu** (2018) Domestication of wild tomato is accelerated by genome editing. Nature Biotechnology. doi:10.1038/nbt.4273 (Highlighted by Nature, Oct. 2. 2018)
 
Xiaozhen Huang, Lingli Tang, Yuan Yu, Justin Dalrymple, Zachary B. Lippman** & Cao Xu** (2018) Control of flowering and inflorescence architecture in tomato by synergistic interactions between ALOG transcription factors.
Journal of Genetics and Genomics. doi: 10.1016/j.jgg.2018.03.008.
 
Ning Zhang*, Hong Yu*, Hao Yu*, Yueyue Cai, Linzhou Huang, Cao Xu, Guosheng Xiong, Xiangbing Meng, Jiyao Wang, Haofeng Chen, Guifu Liu, Yanhui Jing, Yundong Yuan, Yan Liang, Shujia Li, Steven M Smith, Jiayang Li, and Yonghong Wang** (2018) A core regulatory pathway controlling rice tiller angle mediated by the LAZY1-dependent asymmetric distribution of auxin. Plant Cell. doi: 10.1105/tpc.18.00063.
 
Cao Xu, Soon Ju Park, Joyce Van Eck, and Zachary B. Lippman** (2016) Control of inflorescence architecture in tomato by BTB/POZ transcriptional regulators. Genes & Development. 30(18): 2048- 2061. (Recommended by F1000 Prime)
 
Cao Xu*, Katie L. Liberatore*, Cora A MacAlister, Zejun Huang, Yi-Hsuan Chu, Ke Jiang, Christopher Brooks, Mari Ogawa-Ohnishi, Guangyan Xiong, Markus Pauly, Joyce Van Eck, Yoshikatsu Matsubayashi, Esther van der Knaap & Zachary B Lippman** (2015) A cascade of arabinosyltransferases controls shoot meristem size in tomato. Nature Genetics. 47(7): 784-792. (Featured on the cover, Highlighted by Nature Genetics 47, 698–699 (2015), by Science, May. 25, 2015, Recommended by F1000 Prime)
 
Cao Xu*, Yonghong Wang*, Yanchun Yu*, Jingbo Duan, Zhigang Liao, Guosheng Xiong, Xiangbing Meng, Guifu Liu, Qian Qian** & Jiayang Li** (2012) Degradation of MONOCULM 1 by APC/CTAD1 regulates rice tillering. Nature Communications. 3:750.