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王延鹏


王延鹏,博士,青年研究员
        2008年获甘肃农业大学学士学位; 2011年获西北农林科技大学硕士学位;2016年获中国科学院大学博士学位,博士毕业论文获中科院优秀博士论文。2016年至2019年先后在美国马萨诸塞大学医学院和加州大学戴维斯分校从事博士后研究;2019年3月中国科学院遗传与发育生物学研究所青年研究员。2020年入选中科院青促会会员。2021年获国家自然科学基金委“优秀青年基金”资助。


研究方向:
 
        基因组编辑新工具的挖掘和植物基因组编辑递送系统的开发,并利用基因组编辑技术对小麦等作物重要农艺性状的精准改良。

Publications(#共同一作;*共同通讯作者):
1)Zong Y#, Liu Y#, Xue C#, Li B, Li X, Wang Y, Li J, Liu G, Huang X, Cao X*, Gao C*. (2022). An engineered prime editor with enhanced editing efficiency in plants. Nature Biotechnology, doi: 10.1038/s41587-022-01254-w.
 
2)Li S#, Lin D#, Zhang Y#, Deng M#, Chen Y, Lv B, Li B, Lei Y, Wang Y, Zhao L, Liang Y, Liu J, Chen K, Liu Z, Xiao J*, Qiu JL*, Gao C*. (2022) Genome-edited powdery mildew resistance in wheat without growth penalties. Nature, 602(7897):455-460. 
 
3)Luo J., Rouse M.N., Hua L., Li H., Li B., Li T., Zhang W., Gao C., Wang Y*., Dubcovsky J*. and Chen S*. (2021). Identification and characterization of Sr22b, a new allele of the wheat stem rust resistance gene Sr22 effective against the Ug99 race group. Plant Biotechnology Journal, 20(3):554-563.
 
4)Luo G#, Shen L#, Zhao S#, Li R#, Song Y, Song S, Yu K, Yang W, Li X, Sun J., Wang Y, Gao C, Liu D*, Zhang A*. (2021). Genome-wide identification of seed storage protein gene regulators in wheat through coexpression analysis. The Plant journal, 108(6):1704-1720.
 
5)Ma S, Wang M*, Wu J, Guo W, Chen Y, Li G, Wang Y, Shi W, Xia G, Fu D, Kang Z, Ni F*. (2021). WheatOmics: a platform combining multiple omics data to accelerate functional genomics studies in wheat. Molecular Plant, 14(12):1965-1968.
 
6)Li T#, Hu J#, Sun Y, Li B, Zhang D, Li W, Liu J, Li D, Gao C, Zhang Y*, Wang Y*. (2021). Highly efficient heritable genome editing in wheat using an RNA virus and bypassing tissue culture. Molecular Plant, 14(11):1787-1798.
 
7)Lin Q#, Zhu, Z#, Liu G#, Sun C, Lin D, Xue C, Li S, Zhang D, Gao C, Wang Y*, Qiu JL *. (2021). Genome editing in plants with MAD7 nucleaseJournal of Genetics and Genomics, 48(6):444-451. 
 
8)Lin Q#, Jin S#, Zong Y#, Yu H#, Zhu Z, Liu G, Kou L, Wang Y, Qiu JL, Li J*, Gao C*. (2021). High-efficiency prime editing with optimized, paired pegRNAs in plantsNature Biotechnology, 39(8):923-927.
 
9)Luo G, Shen L, Song Y, Yu K, Ji J, Zhang C, Yang W, Li X, Sun J, Zhan K, Cui D, Wang Y, Gao C, Liu D*, Zhang A*. (2021). The MYB family transcription factor TuODORANT1 from Triticum urartu and homolog TaODORANT1 from Triticum aestivum inhibit seed storage protein synthesis in wheatPlant Biotechnology Journal, 19(9):1863-1877. 
 
10)  Jin S#, Fei H#, Zhu Z#, Luo Y#, Liu J, Gao S, Zhang F, Chen YH, Wang Y*, Gao C*. (2020). Rationally designed APOBEC3B cytosine base editors with improved specificity. Molecular Cell, 79(5):728-740.e6.
 
11)  Li C, Zong Y, Jin S, Zhu H, Lin D, Li S, Qiu JL, Wang Y*, Gao C*. (2020). SWISS: multiplexed orthogonal genome editing in plants with a Cas9 nickase and engineered CRISPR RNA scaffolds. Genome Biology, 21(1):141.
 
12)Lin Q#, Zong Y#, Xue C#, Wang S, Jin S, Zhu Z, Wang Y, Anzalone AV, Raguram A, Doman JL, Liu DR, Gao C*. (2020). Prime genome editing in rice and wheat. Nature Biotechnology38(5):582-585.
 
13)  Si X, Zhang H, Wang Y, Chen K, Gao C*. (2020). Manipulating gene translation in plants by CRISPR-Cas9-mediated genome editing of upstream open reading frames. Nature Protocols, 15(2):338-363.
 
14)Chen K#Wang Y#, Zhang R, Zhang H, Gao C*. (2019) CRISPR/Cas genome editing and precision plant breeding in agriculture. Annual Review of Plant Biology, 70:667-697.
 
15)Jin S#, Zong Y#, Gao Q#, Zhu Z, Wang Y, Qin P, Liang C, Wang D, Qiu JL, Zhang F, Gao C*. (2019). Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science, 364(6437):292-295.
 
16)Zong Y#, Song Q#, Li C, Jin S, Zhang D, Wang Y, Qiu JL, Gao C*. (2018). Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A. Nature Biotechnology, 36(10):950-953.
 
17)Li C#, Zong Y#, Wang Y#Jin S, Zhang D, Song Q, Zhang R, Gao C*. (2018). Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion. Genome Biology, 19(1):59.
 
18)Zong Y#Wang Y#, Li C, Zhang R, Chen K, Ran Y, Qiu JL, Wang D, Gao C*. (2017). Precise base editing in rice, wheat and maize with a Cas9- cytidine deaminase fusion. Nature Biotechnology, 35(5):438-440.
 
19)   Wang Y, Zong Y, Gao C*. (2017). Wheat genome editing by sequence-specific nucleases. Methods in Molecular Biology, P169-186. DOI 10.1007/978-1-4939-7337-8.
 
20)Liang Z , Chen K, Li T, Zhang Y, Wang Y, Zhao Q, Liu J, Zhang H, Liu C, Ran Y, Gao C*. (2017). Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes. Nature Communications, 8:14261.
 
21)Gil-Humanes J, Wang Y, Liang Z, Shan Q, Ozuna C. V, Sanchez-Leon S, Baltes N. J, Starker C, Barro F, Gao C, Voytas D. F*. (2016). High-efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9. The Plant Journal, 89(6):1251-1262.
 
22)Zhang Y, Liang Z, Zong Y, Wang Y, Liu J, Chen K, Qiu J, Gao C*. (2016). Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA. Nature Communications, 7:12617.
 
23)Ji X, Zhang H, Zhang Y, Wang Y and Gao C*. (2015). Establishing a CRISPR–Cas-like immune system conferring DNA virus resistance in plants. Nature Plants. 1:15144.
 
24)   Wang Y#, Cheng X#, Shan Q, Zhang Y, Liu J, Gao C*, Qiu JL*. (2014). Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew. Nature Biotechnology, 32(9):947-951.
 
25)Shan Q, Wang Y, Li J, Gao C*. (2014). Genome editing in rice and wheat using the CRISPR/Cas system. Nature Protocols. 9(10):2395-2410.
 
26)Shan Q#Wang Y#, Li J#, Zhang Y, Chen K. Liang Z, Zhang K, Liu J, Xi J.J, Qiu JL*, Gao C*. (2013). Targeted genome modification of crop plants using a CRISPR-Cas system. Nature Biotechnology, 31(8):686-688.
 
27)Shan Q#Wang Y#, Chen K#, Liang Z, Li J, Zhang Y, Zhang K, Liu J, Voytas D.F, Zheng X, Zhang Y, Gao C*. (2013). Rapid and efficient gene modification in rice and brachypodium using TALENs. Molecular Plant, 6(4):1365-1368.