位置:首页 > 研究队伍  


余泓


教育经历
        2002 - 2006,清华大学,学士
        2006 - 2011,中国科学院遗传与发育生物学研究,博士
 
工作经历
        2011 – 2016,中国科学院遗传与发育生物学研究所,助理研究员
        2017 – 2020,中国科学院遗传与发育生物学研究所,副研究员
        2021 – 今,中国科学院遗传与发育生物学研究所,青年研究员


研究内容
        1. 分子设计育种重要技术与理论体系研究
        2. 重要农艺性状形成的分子机制与品种设计
        3. 野生资源的挖掘与利用

发表论文
(#共同第一作者,*通讯作者/共同通讯作者)
1.Yu, H.#*, Lin, T.#, Meng, X.#, Du, H.#, Zhang, J.#, Liu, G., Chen, M., Jing, Y., Kou, L., Li, X., Gao, Q., Liang, Y., Liu, X., Fan, Z., Liang, Y., Cheng, Z., Chen, M., Tian, Z., Wang, Y., Chu, C., Zuo, J., Wan, J., Qian, Q., Han, B., Zuccolo, A., Wing, R. A., Gao, C.*, Liang, C.*, Li, J.* (2021). A route to de novo domestication of wild allotetraploid rice. Cell 184: 1156-1170.
 
2.Lin, Q.#, Jin, S.#, Zong, Y.#, Yu, H.#, Zhu, Z., Liu, G., Kou, L., Wang, Y., Qiu, J. L., Li, J.*, Gao, C.* (2021). High-efficiency prime editing with optimized, paired pegRNAs in plants. Nat Biotechnol doi: 10.1038/s41587-021-00868-w.
 
3.Ren, J.#, Meng, X.#, Hu, F.#, Liu, Q., Cao, Y., Li, H., Yan, C., Li, J., Wang, K., Yu, H.*, Wang, C.* (2021). Expanding the scope of genome editing with SpG and SpRY variants in rice. Sci China Life Sci doi: 10.1007/s11427-020-1883-5.
 
4.Liu, Q., Jiao, X., Meng, X., Wang, C., Xu, C., Tian, Z., Xie, C., Li, G., Li, J., Yu, H.*, and Wang, K.* (2021). FED: a web tool for foreign element detection of genome-edited organism. Sci China Life Sci 64: 167-170.
 
5.Yu, H., Li, J.* (2021). Short- and long-term challenges in crop breeding. Natl Sci Rev doi: 10.1093/nsr/nwab002.
 
6.Luo, L., He, Y., Li, J., Yu, H.* (2021). Immunopurification of Mitochondria from Arabidopsis. Curr Protoc 1: e34.
 
7.Hu, X.#, Meng, X.#, Li, J., Wang, K.*, and Yu, H.* (2020). Improving the efficiency of the CRISPR-Cas12a system with tRNA-crRNA arrays. Crop J 8: 403-407.
 
8.Xu, Y.#, Meng, X.#, Wang, J., Qin, B., Wang, K., Li, J., Wang, C.*, and Yu, H.* (2020). ScCas9 recognizes NNG protospacer adjacent motif in genome editing of rice. Sci China Life Sci 63: 450-452.
 
9.Yu, H.* (2020). Arabidopsis-like C4 model system. Nat Plants 6: 1076-1077.
 
10.Wang, L.#, Wang, B.#*, Yu, H., Guo, H., Lin, T., Kou, L., Wang, A., Shao, N., Ma, H., Xiong, G., Li, X., Yang, J., Chu, J., and Li, J.* (2020). Transcriptional regulation of strigolactone signalling in Arabidopsis. Nature 583: 277-281.
 
11.Luo, L.#, He, Y.#, Xu, Q.#, Lyu, W., Yan, J., Xin, P., Zhang, D., Chu, J., Li, J., and Yu, H.* (2020). Rapid and specific isolation of intact mitochondria from Arabidopsis leaves. J Genet Genomics 47: 65-68.
 
12.Wang, L.#, Xu, Q.#, Yu, H., Ma, H., Li, X., Yang, J., Chu, J., Xie, Q., Wang, Y., Smith, S.M., Li, J., Xiong, G.*, and Wang, B.* (2020). Strigolactone and karrikin signaling pathways elicit ubiquitination and proteolysis of SMXL2 to regulate hypocotyl elongation in Arabidopsis thaliana. Plant Cell 32: 2251-2270.
 
13.Zhao, Y.#, Yu, H.#, Zhou, J.M., Smith, S.M.,* and Li, J.* (2020). Malate circulation: linking chloroplast metabolism to mitochondrial ROS. Trends Plant Sci 25: 446-454.
 
14.Wang, C.#, Yu, H.#, Huang, J.#, Wang, W.#, Faruquee, M., Zhang, F., Zhao, X., Fu, B., Chen, K., Zhang, H., Tai, S., Wei, C., McNally, K., Alexandrov, N., Gao, X., Li, J., Li, Z., Xu, J.* and Zheng, T.* (2020). Towards a deeper haplotype mining of complex traits in rice with RFGB v2.0. Plant Biotechnol J 18: 14-16.
 
15.Song, J.#, Zhang, S.#, Wang, X., Sun, S., Liu, Z., Wang, K., Wan, H., Zhou, G., Li, R., Yu, H., and Cui, X.* (2020). Variations in both FTL1 and SP5G, two tomato FT paralogs, control day-neutral flowering. Mol Plant 13: 939-942.
 
16.Wang, Y.#, Shang, L.#, Yu, H.#, Zeng, L.#, Hu, J., Ni, S., Rao, Y., Li, S., Chu, J., Meng, X., Wang, L., Hu, P., Yan, J., Kang, S., Qu, M., Lin, H., Wang, T., Wang, Q., Hu, X., Chen, H., Wang, B., Gao, Z., Guo, L., Zeng, D., Zhu, X., Xiong, G.*, Li, J.*, and Qian, Q.* (2020). A strigolactone biosynthesis gene contributed to the Green Revolution in rice. Mol Plant 13: 923-932.
 
17.Luo, L#., He, Y.#, Zhao, Y.#, Xu, Q., Wu, J., Ma, H., Guo, H., Bai, L., Zuo, J., Zhou, J.M., Yu, H.* and Li, J.* (2019). Regulation of mitochondrial NAD pool via NAD+ transporter 2 is essential for matrix NADH homeostasis and ROS production 8in Arabidopsis. Sci China Life Sci 62: 991-1002.
 
18.Guo, T., Yu, H., Qiu, J., Li, J., Han, B. and Lin, H.* (2019). Advances in rice genetics and breeding by molecular design in China. Sci Sin Vitae 49: 1185-1212.
 
19.Wang, J.#, Meng, X.#, Hu, X.#, Sun, T., Li, J., Wang, K.* and Yu, H.* (2019). xCas9 expands the scope of genome editing with reduced efficiency in rice. Plant Biotechnol J 17: 709-711.
 
20.Shao, G.#, Lu, Z.#, Xiong, J., Wang, B., Jing, Y., Meng, X., Liu, G., Ma, H., Liang, Y., Chen, F., Wang, Y., Li, J. and Yu, H.* (2019). Tiller bud formation regulators MOC1 and MOC3 cooperatively promote tiller bud outgrowth by activating FON1 expression in rice. Mol Plant 12: 1090-1102.
 
21.Duan, J.#, Yu, H.#, Yuan, K., Liao Z., Meng, X., Jing, Y., Liu, G., Chu, J., and Li, J.* (2019). Strigolactone promotes cytokinin degradation through transcriptional activation of CYTOKININ OXIDASE/DEHYDROGENASE 9 in rice. Proc Natl Acad Sci USA 116: 14319-14324.
 
22.Liao, Z.#, Yu, H.#, Duan, J., Yuan, K., Yu, C., Meng, X., Kou, L., Chen, M., Jing, Y., Liu, G., Smith, S., and Li, J.* (2019). SLR1 inhibits MOC1 degradation to coordinate tiller number and plant height in rice. Nat Commun 8:14789.
 
23.Zhang, S.#, Yu, H.#, Wang, K.#, Zheng, Z.#, Liu, L., Xu, M., Jiao, Z., Li, R., Liu, X., Li, J., and Cui, X.* (2018). Detection of major loci associated with the variation of 18 important agronomic traits between Solanum pimpinellifolium and cultivated tomatoes. Plant J 95: 312-323
 
24.Wang, Q.#, Nian, J.#, Xie, X.#, Yu, H., Zhang, J., Bai, J., Dong, G., Hu, J., Bai, B., Chen, L., Xie, Q., Feng, J., Yang, X., Peng, J., Chen, F., Qian, Q.*, Li, J.*, and Zuo, J.* (2018). Genetic variations in ARE1 mediate grain yield by modulating nitrogen utilization in rice. Nat Commun 9: 735.
 
25.陈明江, 刘贵富, 余泓, 王冰, 李家洋* (2018). 水稻高产优质的分子基础与品种设计. 科学通报 63: 1276-1289.
 
26.Wang, W.#, Mauleon, R.#, Hu, Z.#, Chebotarov, D.#, Tai, S#., Wu, Z.#, Li, M.#, Zheng, T.#, Fuentes, R.#, Zhang, F.#, Mansueto, L.#, Copetti, D.#, Sanciangco, M., Palis, K., Xu, J., Sun, C., Fu, B., Zhang, H., Gao, Y., Zhao, X., Shen, F., Cui, X., Yu, H., Li, Z., Chen, M., Detras, J., Zhou, Y., Zhang, X., Zhao, Y., Kudrna, D., Wang, C., Li, R., Jia, B., Lu, J., He, X., Dong, Z., Xu, J., Li, Y., Wang, M., Shi, J., Li, J., Zhang, D., Lee, S., Hu, W., Poliakov, A., Dubchak, I., Ulat, V., Borja, F., Mendoza, J., Ali, J., Li, J., Gao, Q., Niu, Y., Yue, Z., Naredo, M., Talag, J., Wang, X., Li, J., Fang, X., Yin, Y., Glaszmann, J., Zhang, J., Li, J., Hamilton, R., Wing, R.*, Ruan, J.*, Zhang, G.*, Wei, C.*, Alexandrov, N.*, McNally, K.*, Li, Z.*, and Leung, H.* (2018). Genomic variation in 3,010 diverse accessions of Asian cultivated rice. Nature 557: 43-49.
 
27.Lin, T.#, Xu, X.#, Ruan, J.#, Liu, S., Wu, S., Shao, X., Wang, X., Gan, L., Qin, B., Yang, Y., Cheng, Z., Yang, S., Zhang, Z., Xiong, G., Huang, S., Yu, H.*, and Li, J.* (2018). Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis. Natl Sci Rev 5: 78-87.
 
28.Bai, S., Yu, H., Wang, B., and Li, J.* (2018). Retrospective and perspective of rice breeding in China. J Genet Genomics 45: 603-612.
 
29.Wang, J.#*, Zhou, L.#, Shi, H.#, Chern, M.#, Yu, H.#, Yi, H., He, M., Yin, J., Zhu, X., Li, Y., Li, W., Liu, J., Wang, J., Chen, X., Qing, H., Wang, Y., Liu, G., Wang, W., Li, P., Wu, X., Zhu, L., Zhou, J., Ronald, P., Li, S., Li, J.*, and Chen, X.* (2018). A single transcription factor promotes both yield and immunity in rice. Science 361: 1026-1028.
 
30.余泓, 王冰, 陈明江, 刘贵富, 李家洋* (2018). 水稻分子设计育种发展与展望. 生命科学 30: 1032-1037.
 
31.Zhang, N.#, Yu, H.#, Yu, H.#, Cai, Y., Huang, L., Xu, C., Xiong, G., Meng, X., Wang, J., Chen, H., Liu, G., Jing, Y., Yuan, Y., Liang, Y., Li, S., Smith, S., Li, J., and Wang, Y.* (2018). A core regulatory pathway controlling rice tiller angle mediated by the LAZY1-dependent asymmetric distribution of auxin. Plant Cell 30: 1461-1475.
 
32.Zhao, Y.#, Luo, L.#, Xu, J.#, Xin, P., Guo, H., Wu, J., Bai, L., Wang, G., Chu, J., Zuo, J., Yu, H.*, Huang, X.*, and Li, J.* (2018). Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana. Cell Res 28: 448-461.
 
33.Zhang, L.#, Yu, H.#, Ma, B., Liu, G., Wang, J., Wang, J., Gao, R., Li, J., Liu, J., Xu, J., Zhang, Y., Li, Q., Huang, X., Xu, J., Li, J., Qian, Q., Han, B., He, Z.*, and Li, J.* (2017). A natural tandem array alleviates epigenetic repression of IPA1 and leads to superior yielding rice. Nat Commun 8: 14789.
 
34.Hu, Q.#, He, Y.#, Wang, L., Liu, S., Meng, X., Liu, G., Jing, Y., Chen, M., Song, X., Jiang, L., Yu, H., Wang, B., Li, J.* (2017). DWARF14, A Receptor Covalently Linked with the Active Form of Strigolactones, Undergoes Strigolactone-Dependent Degradation in Rice. Front Plant Sci 8: 1935.
 
35.Ma, H .#, Duan, J.#, Ke, J#., He, Y., Gu, X., Xu, T., Yu, H., Wang, Y., Joseph S.Brunzelle, Jiang, Y., Scott B.Rothbart, H.Eric Xu*, Li, J.*, and Karsten Melcher* (2017). A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv 3: e1601217.
 
36.Wang, J.#, Yu, H.#, Xiong, G., Lu, Z., Jiao, Y., Meng, X., Liu, G., Chen, X., Wang, Y.*, and Li, J.* (2017). Tissue-Specific ubiquitination by IPA1 INTERACTING PROTEIN1 modulates IPA1 protein levels to regulate plant architecture in rice. Plant Cell 29: 697-707.
 
37.Fang, C.#, Ma, Y.#, Wu, S.#, Liu, Z., Wang, Z., Yang, R., Hu, G., Zhou, Z., Yu, H., Zhang, M., Pan, Y., Zhou, G., Ren, H., Du, W., Yan, H., Wang, Y., Han, D., Shen, Y., Liu, S., Liu, T., Zhang, J., Qin, H., Yuan, J., Yuan, X., Kong, F., Liu, B., Li, J., Zhang, Z.*, Wang, G.*, Zhu, B.*, Tian, Z.* (2017). Genome-wide association studies dissect the genetic networks underlying agronomical traits in soybean. Genome Biol 18: 161.
 
38.Meng, X.#, Yu, H.#, Zhang, Y., Zhuang, F., Song, X., Gao, S., Gao, C.*, and Li, J.* (2017). Construction of a Genome-Wide mutant library in rice using CRISPR/Cas9. Mol Plant 10: 1238-1241
 
39.Song, X.#, Lu, Z.#, Yu, H.#, Shao, G., Xiong, J., Meng, X., Jing, Y., Liu, G., Xiong, G., Duan, J., Yao, X., Liu, C., Li, H., , Wang, Y., and Li, J.* (2017). IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice. Cell Res 27: 1128-1141
 
40.Qiu, Z.#, Li, R.#, Zhang, S.#, Wang, K., Xu, M., Li, J., Du, Y.*, Yu, H.*, and Cui, X.* (2016). Identification of Regulatory DNA Elements Using Genome-wide Mapping of DNase I Hypersensitive Sites during Tomato Fruit Development. Mol Plant 9: 1168-1182.
 
41.Zhou, H.#, Wang, L.#, Liu, G.#, Meng, X., Jing, Y., Shu, X., Kong, X., Sun, J., Yu, H., Smith, S.M., Wu, D., and Li, J.* (2016). Critical roles of soluble starch synthase SSIIIa and granule-bound starch synthase Waxy in synthesizing resistant starch in rice. Proc Natl Acad Sci USA 113: 12844-12849.
 
42.Zheng, T.#, Yu, H.#, Zhang, H.#, Wu, Z.#, Wang, W.#, Tai, S., Chi, L., Ruan, J., Wei, C., Shi, J., Gao, Y., Fu, B., Zhou, Y., Zhao, X., Zhang, F., McNally, K., Li, Z., Zhang, G., Li, J., Zhang, D., Xu, J.*, Li, Z.* (2015). Rice functional genomics and breeding database (RFGB)-3K-rice SNP and InDel sub-database. Chin Sci Bull 60: 367.
 
43.Yu, H., Li, J.* (2015). Plant and animal organelles in cell death. Oncotarget 6: 13852-13853.
 
44.Wang, Y.#, Xiong, G.#, Hu, J.#, Jiang, L., Yu, H., Xu, J., Fang, Y., Zeng, L., Xu, E., Xu, J., Ye, W., Meng, X., Liu, R., Chen, H., Jing, Y., Wang, Y., Zhu, X.*, Li, J.*, Qian, Q.* (2015). Copy number variation at the GL7 locus contributes to grain size diversity in rice. Nat Genet 47: 944-948.
 
45.Wu, J.#, Sun, Y.#, Zhao, Y., Zhang, J., Luo, L., Li, M., Wang, J., Yu, H., Liu, G., Yang, L., Xiong, G., Zhou, J. M., Zuo, J., Wang, Y., Li, J.* (2015). Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species. Cell Res 25: 621-633.
 
46.Wang, C.*, Li, X., Chen, P., Wang, A., Zhou, X., Yu, H. (2015). Heterogeneous Cloud Framework for Big Data Genome Sequencing. IEEE/ACM Trans. Comput. Biol. Bioinform. 12: 166-178.
 
47.Jiang, L.#, Liu, X.#, Xiong, G.#, Liu, H.#, Chen, F., Wang, L., Meng, X., Liu, G., Yu, H., Yuan, Y., Yi, W., Zhao, L., Ma, H., He, Y., Wu, Z., Melcher, K., Qian, Q., Xu, H. E.*, Wang, Y.*, Li, J.* (2013). DWARF 53 acts as a repressor of strigolactone signalling in rice. Nature 504: 401-405.
 
48.Lu, Z.#, Yu, H.#, Xiong, G.#, Wang, J., Jiao, Y., Liu, G., Jing, Y., Meng, X., Hu, X., Qian, Q., Fu, X., Wang, Y., Li, J.* (2013). Genome-wide binding analysis of the transcription activator ideal plant architecture 1 reveals a complex network regulating rice plant architecture. Plant Cell 25: 3743-3759.
 
49.Huang, J., Liu, Y., Zhang, W., Yu, H., Han, J. D.* (2011). eResponseNet: a package prioritizing candidate disease genes through cellular pathways. Bioinformatics 27: 2319-2320.
 
50.Yu, H.#, Huang, J.#, Qiao, N., Green, C., Han, J.* (2010). Evaluating diabetes and hypertension disease causality using mouse phenotypes. BMC syst biol 4: 97.
 
51.Yu, H.#, Zhu, S.#, Zhou, B.#, Xue, H., Han, J.* (2008). Inferring causal relationships among different histone modifications and gene expression. Genome Res 18: 1314-1324.