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  Location: Home >> Faculty >> Developmental Biology
  Developmental Biology

Jianwu Dai

Jianwu Dai,PhD
Professor, and Director, Center for Regenerative Medicine,
Associate Director, State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Tel: 86-10-64805610
Clinical study consultation:
Postdoctoral fellow, animal genetics and stem cell biology, Harvard Medical School,Boston, MA
Ph.D., Cell Biology, Duke University Medical Center, Durham, NC
M.Sc., Biophysics, Beijing Medical University, Beijing, China
B.Sc., Cell Biology, Wuhan University, Wuhan, China
Professional Experience
2003.7-Present   Principle Investigator, Institute of Genetics and Developmental  Biology, Chinese Academy of Sciences
Professional Society Memberships
Medical device technical review specialist of CFDA(China Food and Drug Administration)
Member of Advisory Committee on Biomaterials, Royal Society of Chemistry (RSC)
Vice-chairman and Secretary-general of the Chinese Society for Stem Cell Research (CSSCR)
Member of the Academic Committee of Key laboratory of major diseases in children, Ministry of Education
Editor-in-Chief of Biomedical Materials
Editorial board member of Biomaterials
Editorial board member of Science China Life Sciences
Vice-director member of Regenerative Medicine Translational Research Branch of Genetics Society of China
Awards and Honors
Supported by the “Hundred Talents Program” of Chinese Academy of Sciences
Winner of the National Science Fund for Distinguished Young Scholars
Winner of the Yihai Kerry Excellent Tutor Award, Institute of Genetics and Developmental Biology,2010
Winner of the 2nd Prize Project of the National Sci-Tech Advance Award, “Mechanism and Clinical Application of Myocardial Tissue Repair and Functional Reconstruction after
Myocardial Infarction”, 2012
CCTV Annual Scientific & Technological Innovation Figure, 2014
China Overseas Chinese Contribution Award (Innovation Achievement Award for Regenerative Medicine), All-China Federation of Returned Overseas Chinese, 2016
Advanced Science and Technology Award of Jiangsu Province, 2018

Main research interests
1) Research on the microenvironment of tissue regeneration
2) Research and development of tissues/organs regeneration and repair products
3) Tissues /organs manufacturing
Research Grants
2006-2010  “Research on Self-renewal Regulatory Network of Stem Cells”, National Key Basic Research Program of China (973 Program), Ministry of Science and Technology of China
2010-2012  “Study on the Expression, Function and Regulating Mechanism of OCT4 Isomers“, Major Research plan of the National Natural Science Foundation of
2010-2013  “The Construction of Neural Regeneration Environment“, the State Key Program of National Natural Science Foundation of China
2011-2013  “Safety and Efficacy Evaluation of Collagen-binding VEGF on Porcine Myocardial Injury”, China-Canada (NSFC-CIHR) Health Research Cooperation Project, National Natural Science Foundation of China
2011-2015  “Study on Self-renewal Regulating Network of 3D Stem Cell Culture ”, National Key Basic Research Program of China (973 Program), Ministry of Science and Technology of China
2011-2015  “Stem Cell and Regenerative Medicine” Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
2013-2015  “Cryogenic Cell 3D Reconstruction System for Stem Cell Microenvironment Construction”, Scientific Instrument and Equipment Development Project of Chinese Academy of Sciences
2016-2018  “Tissue and Organ Regeneration and Injury Repair”, Key Programs of the Chinese Academy of Sciences
2016-2021  “Research and Development of Tissue and Organ Regenerative Products on Birth Defects”, National key research and development program, Ministry of Science and Technology of China
2017-2022  “Organ Reconstruction and Manufacturing” Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
2019-2023   “Study on regenerative mechanisms and clinical translation of spinal cord injury repair” National Natural Science Foundation of China ( Major Program)
Representative Achivements
?  Breakthrough the key technology of regenerative medicine. We developed a series of regenerative medical products which had positive effects on endometrium, spinal cord, myocardial and other tissue injury repair. We proposed that the activation and differentiation of endogenous stem cells are an important mechanism for tissue regeneration.
?  Cooperatively developed the biological material scaffold for endometrial regeneration. The scaffold has been investigated in clinical trials and provide an effective treatment for infertile patients with endometrial damage. Jianwu Dai was rated as one of the “2014 CCTV annual scientific and technological innovation figure” because of the progress.
?  The breakthrough in spinal cord injury (SCI) regeneration research. We developed the functional collagen scaffold which can effectively guide neuronal regeneration and promote autonomic motor function recovery in completely transected SCI animals. We started a clinical study of the scaffold in SCI patients in 2015.
Current Lab Members
Staff Members:
Zhao Yannan
Young Investigator
Chen Bing
Associate Professor
Xiao Zhifeng
Associate Professor
Wu Xianming
Associate Professor
Zhang Qi
Assistant Professor
Shi Ya
Hou Xianglin
Li Jiayin
Yin Yanyun
Assistant Engineer
Zhang jiaojiao
Assistant Engineer
Liu Wenbin 
Zhang Quan
Ji Chunnan
Li Panpan
Post-Doctoral Fellow
Xue Xiaoyu  Shu Muya
Ph.D and MS Candidates
Yang Ying  Zhang Haipeng  Fan Yongheng  Jin Chen  Liu Weiyuan  Sun Zheng  Chen Zhenni
Wu Yayu  Quan Rui  Zhao Shuaijing  Han Shuyu
Visiting Researcher
Cui Yi   Zhao Xinhao  Guo Bo    

1.Zou Y, Yin Y, Xiao Z, Zhao Y, Han J, Chen B, Xu B, Cui Y*, Ma X*, Dai, J.* Transplantation of collagen sponge-based three-dimensional neural stem cells cultured in the RCCS system facilitates locomotor functional recovery in spinal cord injury animals. Biomaterials Science. Accepted
2.Zhao X, Wang H, Zou Y, Xue W, Zhuang Y, Gu R, Shen H, Dai, J.* Optimized, visible light-induced crosslinkable hybrid gelatin/hyaluronic acid scaffold promotes complete spinal cord injury repair. Biomed Mater. 2022 Jan 25;17(2).
3.Chen Z, Zhang H, Fan C, Zhuang Y, Yang W, Chen Y, Shen H, Xiao Z, Zhao Y*, Li X*, Dai, J.* Adhesive, Stretchable, and Spatiotemporal Delivery Fibrous Hydrogels Harness Endogenous Neural Stem/Progenitor Cells for Spinal Cord Injury Repair. ACS Nano. 2021 Nov 29. doi: 10.1021/acsnano.1c06892.
4.Shen, H., Fan, C., You, Z., Xiao, Z., Zhao, Y*., Dai, J.* (2021). Advances in Biomaterial‐Based Spinal Cord Injury Repair. Advanced Functional Materials, 2110628.
5.Shen H, Xu B, Yang C, Xue W, You Z, Wu X, Ma D, Shao D, Leong K, Dai, J.* A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury. Biomaterials. 2021 Nov 25;280:121279. doi: 10.1016/j.biomaterials.2021.121279
6.Yu Y, Liu X, Zhao Z, Xu Z, Qiao Y, Zhou Y, Qiao H, Zhong J, Dai J, Suo G*. The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice. Front Pharmacol. 2021 Dec 6;12:747223. doi: 10.3389/fphar.2021.747223.
8.Wang Y, Wang G, Hou X, Zhao Y, Chen B, Dai, J.* Sun N. Urethral Tissue Reconstruction Using the Acellular Dermal Matrix Patch Modified with Collagen-Binding VEGF in Beagle Urethral Injury Models. Biomed Res Int. 2021 Oct 15;2021:5502740.
9.Zhang Q, Wu X, Fan Y, Jiang P, Zhao Y, Yang Y, Han S, Xu B, Chen B, Han J, Sun M, Zhao G, Xiao Z, Hu Y, Dai, J.* Single-cell analysis reveals dynamic changes of neural cells in developing human spinal cord. EMBO Rep. 2021 Nov 4;22(11):e52728 doi: 10.15252/embr.202152728
10.Chu Y, Huang L, Hao W, Zhao T, Zhao H, Yang W, Xie X, Qian L, Chen Y, Dai, J.* Long-term stability, high strength, and 3D printable alginate hydrogel for cartilage tissue engineering application. Biomed Mater. 2021 Sep 28;16(6). doi: 10.1088/1748-605X/ac2595
11.Tang F, Tang J, Zhao Y, Zhang J, Xiao Z, Chen B, Han G, Yin N, Jiang X, Zhao C, Cheng S, Wang Z, Chen Y, Chen Q, Song K, Zhang Z, Niu J, Wang L, Shi Q, Chen L, Yang H, Hou S, Zhang S, Dai, J.*. Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold. Sci China Life Sci. 2021 Aug 16. doi: 10.1007/s11427-021-1985-5.
12.Cao Y, Shi Y, Xiao Z, Chen X, Chen B, Yang B, Shu M, Yin Y, Wu S, Yin W, Fu X, Tan J, Zhou Q, Wu Z, Jiang X, Dai, J.*. Contralateral Axon Sprouting but Not Ipsilateral Regeneration Is Responsible for Spontaneous Locomotor Recovery Post Spinal Cord Hemisection. Front Cell Neurosci. 2021 Aug 26;15:730348. doi: 10.3389/fncel.2021.730348.
13.Shu M, Xue X, Nie H, Wu X, Sun M, Qiao L, Li X, Xu B, Xiao Z, Zhao Y, Fan Y, Chen B, Zhang J, Shi Y, Yang Y, Lu F, Dai, J.* Single-cell RNA sequencing reveals Nestin+ active neural stem cells outside the central canal after spinal cord injury. Sci China Life Sci. 2021 May 28. doi: 10.1007/s11427-020-1930-0. Epub ahead of print.
14.Yin W, Xue W, Zhu H, Shen H, Xiao Z, Wu S, Zhao Y, Cao Y, Tan J, Li J, Liu W, Wang L, Meng L, Chen B, Zhao M, Jiang X, Li X, Ren C, Dai, J.* Scar tissue removal-activated endogenous neural stem cells aid Taxol-modified collagen scaffolds in repairing chronic long-distance transected spinal cord injury. Biomater Sci. 2021 May 27. doi: 10.1039/d1bm00449b.
15.Huang L, Chu Y, Zhang L, Liu X, Hao W, Chen Y, Dai, J.* High strength pure chitosan hydrogels via double crosslinking strategy. Biomed Mater. 2021 Jun 28;16(4). doi: 10.1088/1748-605X/ac058c
16.Xue W, Zhang H, Fan Y, Xiao Z, Zhao Y, Liu W, Xu B, Yin Y, Chen B, Li J, Cui Y, Shi Y, Dai, J.* Upregulation of Apol8 by Epothilone D facilitates the neuronal relay of transplanted NSCs in spinal cord injury. Stem Cell Res Ther. 2021 May 26;12(1):300.
17.Liu X, Hao M, Chen Z, Zhang T, Huang J, Dai, J.* Zhang Z. 3D bioprinted neural tissue constructs for spinal cord injury repair. Biomaterials. 2021 May;272:120771.
18.Cui Y, Yin Y, Zou Y, Zhao Y, Han J, Xu B, Chen B, Xiao Z, Song H, Shi Y, Xue W, Ma X, Dai, J.*. The Rotary Cell Culture System increases NTRK3 expression and promotes neuronal differentiation and migratory ability of neural stem cells cultured on collagen sponge. Stem Cell Res Ther. 2021 May 21;12(1):298.
19.Xue X, Shu M, Xiao Z, Zhao Y, Li X, Zhang H, Fan Y, Wu X, Chen B, Xu B, Yang Y, Liu W, Liu S, Dai, J.*. Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury. Sci China Life Sci. 2021 Mar 24. doi: 10.1007/s11427-020-1901-4.
20.Xue W, Fan C, Chen B, Zhao Y, Xiao Z, Dai, J.* Direct neuronal differentiation of neural stem cells for spinal cord injury repair. Stem Cells. 2021 Mar 3. doi: 10.1002/stem.3366
21.Liu D, Shu M, Liu W, Shen Y, Long G, Zhao Y, Hou X, Xiao Z, Dai, J.* Li X*. Binary scaffold facilitates in situ regeneration of axons and neurons for complete spinal cord injury repair. Biomater Sci. 2021 Feb 26. doi: 10.1039/d0bm02212h.
22.Liu D, Shen H, Shen Y, Long G, He X, Zhao Y, Yang Z, Dai, J.*, Li X. Dual-Cues Laden Scaffold Facilitates Neurovascular Regeneration and Motor Functional Recovery After Complete Spinal Cord Injury. Adv Healthc Mater. 2021 Mar 19:e2100089. doi: 10.1002/adhm.202100089.
23.Zhang L, Fan C, Hao W, Zhuang Y, Liu X, Zhao Y, Chen B, Xiao Z, Chen Y, Dai, J.* NSCs Migration Promoted and Drug Delivered Exosomes-Collagen Scaffold via a Bio-Specific Peptide for One-Step Spinal Cord Injury Repair. Adv Healthc Mater. 2021 Feb 1:e2001896. doi: 10.1002/adhm.202001896.
24.  Wang, Q., He, X., Wang, B., Pan, J., Shi, C., Li, J., Wang, L., Zhao, Y., Dai, J. *, Wang, D. *,. Injectable collagen scaffold promotes swine myocardial infarction recovery by long-term local retention of transplanted human umbilical cord mesenchymal stem cells. Science China Life Sciences. 2021 Feb;64(2):269-281.
25.Yang, Y., Fan, Y., Zhang, Q., Xiao, Z., Liu, W., Chen, B., Sun, Z., Xue, X., Shu, M., Dai, J.* . Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury. Biomaterials. 2021 Feb;269:120479
26.Zhang H, Xue W, Xue X, Fan Y, Yang Y, Zhao Y, Chen B, Yin Y, Yang B, Xiao Z, Dai, J.*   Spatiotemporal dynamic changes, proliferation, and differentiation characteristics of Sox9-positive cells after severe complete transection spinal cord injury. Exp Neurol. 2021 Mar;337:113556
27.Long G , Liu D , He X , Shen Y , Zhao Y , Hou X , Chen B , OuYang W , Dai, J.*, Li X *. A dual functional collagen scaffold coordinates angiogenesis and inflammation for diabetic wound healing. Biomater Sci. 2020 Nov 21;8(22):6337-6349.
28.Zhang X, Liu Y, Clark KL, Padget AM, Alexander PG, Dai, J., Zhu W*, Lin H*. Mesenchymal stem cell-derived extracellular matrix (mECM): a bioactive and versatile scaffold for musculoskeletal tissue engineering. Biomed Mater. 2020 Dec 23;16(1):012002.
29.He, X., Wang, Q., Zhao, Y., Zhang, H., Wang, B., Pan, J., Li, Jie., Yu. H., Wang, L., Dai, J.* *, Wang, D. *,. Effect of Intramyocardial Grafting Collagen Scaffold With Mesenchymal Stromal Cells in Patients With Chronic Ischemic Heart Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020 Sep 1;3(9):e2016236.
30.Zou, Y., Ma, D., Shen, H. Zhao, Y., Xu, B., Fan, Y., Sun, Z., Chen, B., Xue, W., Shi, Y., Xiao, Z., Gu, R. and Dai, J.*, Aligned collagen scaffold combination with human spinal cord-derived neural stem cells to improve spinal cord injury repair. Biomater. Sci., 2020 Sep 21;8(18):5145-5156.
31.Cui Y., Xu, B., Yin, Y., Chen, B., Zhao, Y., Xiao, Z., Yang, Bin, Shi, Y., Fang,Y., Ma,X., Dai, J.* Collagen particle with collagen-binding bone morphogenetic protein-2 promotes vertebral laminar regeneration in infant rabbits. Biomed Mater. 2020 Jul 21;15(5):055008.
32.Shen, Y., Shen, H., Guo, D., Sun, X., Sun, Y., Hong, N., Wang, X., Xie, C., Zhao, Y., He, Q., Jin, L., Wen, Y., Jiang, B., Yu, C., Zhu, M., Cai, F., Dai, J.* Recent developments in regenerative ophthalmology. Sci China Life Sci. 2020 Oct;63(10):1450-1490
33.Dai, J.  The growth and development of Biomedical Materials. Biomedical Materials. 2020 May 14;15(4):040201.
34.Zhao, G.,  Li, R., Cao, Y., Song, M., Jiang, P., Wu, Q., Zhou, Z., Zhu, H., Wang, H., Dai, H., Liu, D., Yao, S., Lv, H., Wang, L., Dai, J.*, Zhou, Y.*, Hu, Y.* ΔNp63α-induced DUSP4/GSK3β/SNAI1 pathway in epithelial cells drives endometrial fibrosis. Cell Death Dis. 2020 Jun 11;11(6):449.
35.Chen W, Zhang Y, Yang S, Sun J, Qiu H, Hu X, Niu X, Xiao Z, Zhao Y, Zhou Y, Dai, J.*, Chu T*. NeuroRegen Scaffolds Combined with Autologous Bone Marrow Mononuclear Cells for the Repair of Acute Complete Spinal Cord Injury: A 3-Year Clinical Study. Cell Transplant. 2020 Jan-Dec;29:963689720950637.
36.Liu, W., Xu, B., Xue, W., Yang, B., Fan, Y., Chen, B., Xiao, Z., Xue, X., Sun. Z., Shu, M., Zhang. Q., Shi, Y., Zhao, Y.*, Dai. J.* A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair. Biomaterials. 2020; 243:119941.
37.Shen, H., Wu,S., Chen, X., Xu, B., Ma, D., Zhao, Y., Zhuang, Y., Chen, B., Hou, X., Li, J., Cao, Y., Fu, X., Tan, J., Yin, W., Li, J., Meng, L., Shi, Y., Xiao, Z.,* Jiang, X.,* Dai. J.* Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines. Sci China Life Sci, 2020 Dec;63(12):1879-1886.
38.Zou Y., Zhao Y., Xiao Z., Chen B., Ma D., Shen H. *, Gu R. *, Dai. J.*, Comparison of Regenerative Effects of Transplanting Three-dimensional Longitudinal Scaffold Loaded- hMSCs and hNSCs on Spinal Cord Completely Transected Rats. ACS Biomaterials Science & Engineering. 2020, 6, 4, 1909–1919
39.Wang L, Zhao Y, Yang F, Feng M, Zhao Y, Chen X, Mi J, Yao Y, Guan D, Xiao Z, Chen B, Dai. J.* Biomimetic collagen biomaterial induces in situ lung regeneration by forming functional alveolar. Biomaterials. 2020 Apr;236:119825.
40.Shen H, Lin H, Sun AX, Song S, Wang B, Yang Y, Dai. J.*, Tuan RS. Acceleration of chondrogenic differentiation of human mesenchymal stem cells by sustained growth factor release in 3D graphene oxide incorporated hydrogels. Acta Biomater. 2020: 44-55.
41.Ma D, Zhao Y, Huang L, Xiao Z, Chen B, Shi Y, Shen H, Dai. J.*. A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation. Biomaterials. 2020 Jan 31;237:119830.
42.Qiao, Y., Xu, Z., Yu, Y., Hou, S., Geng, J., Xiao, T., Liang, Q., Dong, Q. Mei, Y., Wang, B., Qiao, H., Dai, J.*., Suo, G.*,  Single cell derived spheres of umbilical cord mesenchymal stem cells enhance cell stemness properties, survival ability and therapeutic potential on liver failure. Biomaterials, 2020, 227: 119573.
43.Xue, W., Zhao, Y., Xiao, Z., Wu, X., Ma, D., Han, J., Li, X., Xue, X., Yang, Ying., Fang, Y., Fan, C., Liu, S., Xu, B., Han, S., Chen, B., Zhang, H., Fan, Y., Liu, W., Dong, Q., Dai, J.*. . Epidermal growth factor receptor‐extracellular‐regulated kinase blockade upregulates TRIM32 signaling cascade and promotes neurogenesis after spinal cord injury. Stem Cells.  2020 Jan;38(1).
44.Cui Y., Xu B., Yin Y., Chen B., Zhao Y., Xiao Z., Yang B., Meng Q., Fang Y., Liang Q., Zhou
L., Ma X., Dai, J.*. Repair of lumbar vertebral bone defects by bone particles combined with hUC-MSCs in weaned rabbit. Regenerative Medicine. 2019, 14(10):915-92.
45.Cui Y., Yin Y., Xiao Z., Zhao Y., Chen B., Yang B., Xu B., Song H., Zou Y., Ma X., Dai, J.*. (2019). LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells. Stem Cell Research & Therapy. 2019, 10(1):400.
46.Shi, J., Fan, C., Zhuang, Y., Sun, J., Hou, X., Chen, B., Xiao, Z., Chen, Y., Zhan, Z., Zhao, Y. *, Dai, J.*.. Heparan sulfate proteoglycan promotes fibroblast growth factor-2 function for ischemic heart repair. Biomaterials Science, 2019. 7(12), 5438-5450.
47.Shi, L., Zeng, Y., Zhao, Y., Yang, B., Ossipov, D., Tai, C. W., . Dai, J.*., Xu, C.*, Biocompatible Injectable Magnetic Hydrogel Formed by Dynamic Coordination Network[J]. ACS Appl. Mater. Interfaces 2019, 11, 49, 46233-46240
48.Yang Y., Chen R., Wu X., Zhao Y., Fan Y., Xiao Z., Han J., Sun L., Wang X., Dai, J.*. Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons. Stem Cell Reports. 2019, 13(5):862-876.
women: a pilot study. Sci. China Life Sci.  2019, 62(12): 1617-1629.
50.Fan, C., Shi, J., Zhuang, Y., Zhang, L., Huang, L., Yang, W., Chen, B., Chen, Y., Xiao, Z., Shen, H., Zhao, Y., Dai, J.*., Myocardial Infarction Responsive Smart Hydrogels Targeting Matrix Metalloproteinase for On-Demand Growth Factor Delivery. Adv. Mater. 2019, 31(40).
51.Liu, D., Li, X., Xiao, Z,. Yin, W., Zhao, Y., Tan, J., Chen, B., Jiang, X., Dai, J.* Different functional bio-scaffolds share similar neurological mechanism to promote locomotor recovery of canines with complete spinal cord injury. Biomaterials. 214:119230, 2019
52.Shen, H., Chen, X., Li, X., Jia, K., Xiao, Z., Dai, J.* Transplantation of adult spinal cord grafts into spinal cord transected rats improves their locomotor function. Sci China Life Sci. 62(6):725-733, 2019
53.Xue, B., Liu, D., Song, M., Zhao, G., Cao, Y., Yan, G., Dai, J.,* Hu, Y. * Leukemia inhibitory factor promotes the regeneration of rat uterine horns with full-thickness injury. Wound Repair Regen. 27(5):477-487, 2019
54.Li, X., Chen, Z., Zhang, H., Zhuang, Y., Shen, H., Chen, Y., Zhao, Y., Chen, B., Xiao, Z., Dai,  J.*Aligned scaffolds with biomolecular gradients for regenerative medicine. Polymers. 197: 20-31, 2019
55.Li, X., Liu, D., Xiao, Z., Zhao, Y., Han, S., Chen, B., Dai, J.* Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation. Biomaterials 197: 20-31, 2019
56.Han S, Yin W, Li X, Wu S, Cao Y, Tan J, Zhao Y, Hou X, Wang L, Ren C, Li J, Hu X, Mao Y, Li G, Li B, Zhang H, Han J, Chen B, Xiao Z, Jiang X, Dai, J.* Pre-Clinical Evaluation of CBD-NT3 Modified Collagen Scaffolds in Completely Spinal Cord Transected Non-Human Primates. J Neurotrauma. 2019 Aug 1;36(15):2316-2324.
57.Liu, S., Xiao, Z., Li, X., Zhao, Y., Wu, X., Han, J., Chen, B., Li, J., Fan, C., Xu, B., Xue, X., Xue, W., Yang, Y., Dai, J.* Vascular endothelial growth factor activates neural stem cells through epidermal growth factor receptor signal after spinal cord injury. CNS Neurosci Ther.  197:20-31, 2019
58.Ding, L., Yan, G., Wang, B., Xu, L., Gu, Y., Ru, T., Cui, X., Lei, L., Liu, J., Sheng, X., Wang, B., Zhang, C., Yang, Y., Jiang, R., Zhou, J., Kong, N., Lu, F., Zhou, H., Zhao, Y., Chen, B., Hu, Y.*, Dai, J.*, Sun, H.* Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility. Sci China Life Sci. 61(12):1554-1565, 2018
59.Li, J., Chen, T., Huang, X., Zhao, Y., Wang, B., Yin, Y., Cui, Y., Zhao, Y., Zhang, R., Wang, X., Wang, Y., Dai, J.* Substrate-independent immunomodulatory characteristics of mesenchymal stem cells in three-dimensional culture. PloS One. 13(11):e0206811. 2018
60.Yin, W., Li, X., Zhao, Y., Tan, J., Wu, S., Cao, Y., Li, J., Zhu, H., Liu, W., Tang, G., Meng, L., Wang, L., Zhu, B., Wang, G., Zhong, M., Liu, X., Xie, D., Chen, B., Ren, C., Xiao, Z., Jiang, X.*, Dai, J.* Taxol-modified collagen scaffolds implantation promotes functional recovery after long-distance spinal cord complete transection in canines. Biomaterials Sci. 6(5):1099-1108. 2018
61.Cui, Y., Yao, Y., Zhao, Y., Xiao, Z., Cao, Z., Han, S., Li, X., Huan, Y., Pan, J.* Dai, J.* Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs. J Tissue Eng Regen Med. 12(5):1285-1296. 2018
62.Hao, Y.*, Ran, Y., Lu, B., Li, J., Zhang, J., Feng, C., Fang, J., Ma, R., Qiao, Z., Dai, X., Xiong, W., Liu, J., Zhou, Q., Hao, J., Li, R.*, Dai, J.* Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells on Canine Radiation-Induced Lung Injury. Int J Radiat Oncol Biol Phys. 102(2):407-416. 2018
63.Cui, Y., Lu, C., Chen, B., Han, J., Zhao, Y., Xiao, Z., Han, S., Pan, J.*, Dai, J.* Restoration of mandibular bone defects with demineralized bone matrix combined with three-dimensional cultured bone marrow-derived mesenchymal stem cells in minipig models. J Mater Sci Mater Med. 29(9):147. 2018
64.Hao, W., Han, J., Chu, Y., Huang, L., Zhuang, Y., Sun, J., Li, X., Zhao, Y., Chen, Y., Dai, J.* Collagen/Heparin Bi-Affinity Multilayer Modified Collagen Scaffolds for Controlled bFGF Release to Improve Angiogenesis In Vivo. Macromol Biosci. e1800086. 2018
65.Li, X., Fan, C., Xiao, Z., Zhao, Y., Zhang, H., Sun, J., Zhuang, Y., Wu, X., Shi, J., Chen, Y., Dai, J.* A collagen microchannel scaffold carrying paclitaxel-liposomes induces neuronal differentiation of neural stem cells through Wnt/β-catenin signaling for spinal cord injury repair. Biomaterials. 183:114-127. 2018
66.Cao, Y., Sun, H., Zhu, H., Zhu, X., Tang, X., Yan, G., Wang, J., Bai, D., Wang, J., Wang, L., Zhou, Q., Wang, H., Dai, C., Ding, L., Xu, B., Zhou, Y., Hao, J., Dai, J.*, Hu, Y.* Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther. 9(1):192. 2018
67.Liu, W., Xie, Y., Gao, T., Huang, F., Wang, L., Ding, L., Wang, W., Liu, S., Dai, J.*, Wang, B.* Reflection and observation: cell-based screening failing to detect HBV in HUMSCs derived from HBV-infected mothers underscores the importance of more stringent donor eligibility to reduce risk of transmission of infectious diseases for stem cell-based medical products. Stem Cell Res Ther. 9(1):177. 2018
68.Chen, X., Fan, Y., Xiao, Z., Li, X., Yang, B., Zhao, Y., Hou, X., Han, S., Dai, J.* Promotion of transplanted collagen scaffolds combined with brain-derived neurotrophic factor for axonal regeneration and motor function recovery in rats after transected spinal cord injury. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 32(6):650-659. 2018
69.Li, J., Li, X., Xiao, Z., Dai, J.* Review of the regeneration mechanism of complete spinal cord injury. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 32(6):641-649. 2018
70.Guan, D., Mi, J., Chen, X., Wu, Y., Yao, Y., Wang, L., Xiao, Z., Zhao, Y., Chen, B., Dai, J.* Lung endothelial cell-targeted peptide guided bFGF promotes the regeneration afterradiation induced lung injury. Biomaterials. 184:10-19. 2018
71.Chen, X., Zhao, Y., Li, X., Xiao, Z., Yao, Y., Chu, Y., Farkas, B., Romano, I., Brandi, F., Dai, J.* Functional multichannel Poly(Propylene Fumarate)-collagen scaffold with collagen-binding neurotrophic factor 3 promotes neural regeneration after transected spinal cord injury. Adv Healthc Mater. 7(14):e1800315. 2018
72.Fan, C., Li, X., Zhao, Y., Xiao, Z., Xue, W., Sun, J., Li, X., Zhuang, Y., Chen, Y., Dai, J.* Cetuximab and Taxol co-modified collagen scaffolds show combination effects for the repair of acute spinal cord injury. Biomater Sci. 6(7):1723-1734. 2018
73.Li, X., Yang, B., Xiao, Z., Zhao, Y., Han, S., Yin, Y., Chen, B., Dai, J.* Comparison of subacute and chronic scar tissues after complete transected spinal cord injury. Experimental Neurology. 306:132-137. 2018
74.Li, L., Chen, B., Yan, H., Zhao, Y., Lou, Z., Li, J., Fu, B., Zhu, X., McManus, D.P., Dai, J.*, Jia, W. Three-dimensional hepatocyte culture system for the study of Echinococcus multilocularis larval development. PLoS Negl Trop Dis. 12(3):e0006309. 2018
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168.  Huang, X., Li, X., Wang, Q., Dai, J.Hou, J.*, Chen, L.* Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates. Biomaterials. 34(26):6139-46. 2013
169.  Han, J., Chen, L., Luo, G., Dai, B., Wang, X., Dai, J.*. Three-dimensional culture may promote cell reprogramming. Organogenesis. 9:118-120. 2013
170.  Jiang, Y., Chen, B., Liu, Y., Zhufu, Z., Yan, X., Hou, X., Dai, J.*, Tan, Q*. Effect of collagen scaffold with adipose-derived stromal vascular fraction cells on diabetic wound healing: A study in a diabetic porcine model. Tissue Engineering and Regenerative Medicine. 10(4):192-199. 2013
171.  Du, M., Zhu, Y., Yuan, L., Liang, H., Mou, C., Li, X., Sun, J., Zhuang, Y., Zhang, W., Shi, Q., Chen, B., Dai, J.* Assembled 3D cell niches in chitosan hydrogel network to mimic extracellular matrix. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 434: 78–87. 2013
172.  Guan, J., Zhu, Z., Robert Zhao C., Xiao, Z., Wu, C., Han, Q., Chen, L., Tong, W., Zhang, J., Han, Q., Gao, J., Feng, M., Bao, X., Dai, J.*, Wang, R.* Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats. Biomaterials. 34(24):5937-5946. 2013
173.  Su, G., Zhao, Y., Wei, J., Xiao, Z., Chen, B., Han, J., Chen, L., Guan, J., Wang, R., Dong, Q., Dai, J. * Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces. Biomaterials. 34(24): 5897-5906. 2013
174.  Liu, X., Li, X., Zhou, L., Li, S., Sun, J., Wang, Z., Gao, Y., Jiang, Y., Lu, H., Wang, Q., Dai, J. * Effects of simvastatin-loaded polymeric micelles on human osteoblast-like MG-63 cells. Colloids Surf B Biointerfaces.102:420-7. 2013
175.  Li, X., Xiao, Z., Han, J., Chen, L., Xiao, H., Ma, F., Hou, X., Li, X., Sun, J., Ding, W., Zhao, Y., Chen, B., Dai, J.* Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair. Biomaterials. 34(21):5107-16. 2013
176.  Tan, Q., Chen, B., Yan, X., Lin, Y., Xiao, Z., Hou, X., Dai, J.* Promotion of diabetic wound healing by collagen scaffold with collagen-binding vascular endothelial growth factor in diabetic rat model. Journal of Tissue Engineering and Regenerative Medicine. 8(3):195-201. 2013
177.  Li, N., Zhang, Q., Gao, S., Song, Q., Huang, R., Wang, L., Liu, L., Dai, J.* Tang, M.*, Cheng, G.* Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci. Rep. 3:1604. 2013
178.  Su, G., Zhao, Y., Wei, J., Han, J., Chen, L., Xiao, Z., Chen, B., Dai, J. * The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties. Biomaterials. 34(13):3215-22. 2013
179.  Yi, P., Chen, G., Zhang, H., Tian, F, Tan, B., Dai, J., Wang, Q.,* Deng, Z.* Magnetic resonance imaging of Fe3O4@SiO2-labeled human mesenchymal stem cells in mice at 11.7 T. Biomaterials. 4(12):3010-9. 2013
180.  Han, J., Xiao, Z., Chen, L., Chen, B., Li, X., Han, S., Zhao, Y., Dai, J.* Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway. Biomaterials. 34(8):1921-8. 2013
181.  Cao, J., Xiao, Z., Jin, W., Chen, B., Meng, D., Ding, W., Han, S., Hou, X., Zhu, T., Yuan, B., Wang, J., Liang, W., Dai, J.* Induction of rat facial nerve regeneration by functional collagen scaffolds. Biomatierials. 34(4):1302-10. 2013
183.  Chen, W., Cao, Y., Liu, M., Zhao, Q., Huang, J., Zhang, H., Deng, Z., Dai, J., Williams, DF., Zhang, Z. * Rotavirus capsid surface protein VP4-coated Fe3O4 nanoparticles as a theranostic platform for cellular imaging and drug delivery. Biomaterials. 33(31):7895-902. 2012
184.  Han, S., Zhao, Y., Xiao, Z., Han, J., Chen, B., Chen, L.  Dai, J. * The three-dimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells. J Genet Genomics. 39(12):633-41. 2012
185.  Li, Q., Tao, L., Chen, B., Ren, H., Hou, X., Zhou, S., Zhou, J., Sun, X., Dai, J. *, Ding, Y. * Extrahepatic bile duct regeneration in pigs using collagen scaffolds loaded with human collagen-binding bFGF. Biomaterials. 33(17):4298-308. 2012
186.  Cui, Y., Xiao, Z., Han, J., Sun, J., Ding, W., Zhao, Y., Chen, B., Li, X., Dai, J.* MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin. BMC Neurosci.;13(1):116. 2012
187.  Gao, Y., Wei, J., Han, J., Wang, X., Su, G., Zhao, Y., Chen, B., Xiao, Z., Cao, J., Dai, J. *  The novel function of OCT4B isoform-265 in genotoxic stress. Stem Cells. 30(4):665-72. 2012
188.  Chen, B., Xiao, Z., Shi, C., Dai, J.* Collagen-based Functional Biomaterials for Tissue Regeneration. Regenerative Medicine in China, S. Sanders Ed. A Sponsored supplement to Science (Science/AAAS, Washington, DC, 2012):43-5. Science 336(6080): 497. 2012
189.  Lin, N., Li, X., Song, T., Wang, J., Meng, K., Yang, J., Hou, X., Dai, J.*, Hu, Y. The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury. Biomaterials. 33(6):1801-7. 2012
191.  Guan, J., Tong, W., Ding, W., Du, S., Xiao, Z., Han, Q., Zhu, Z., Bao, X., Shi. X., Wu, C., Cao, J., Yang, Y., Ma, W., Li, G., Yao, Y., Gao, J., Wei, J., Dai, J.*, Wang, R.* Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model. Biomaterials. 33(5):1386-95. 2012
192.  Chen, L., Xiao, Z., Meng, Y., Zhao, Y., Han, J., Su, G., Chen, B., Dai, J.* The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs. Biomaterials. 33(5):1437-44. 2012
193.  Gao, J., Liu, J., Gao, Y., Wang, C., Zhao, Y., Chen, B., Xiao, Z., Miao, Q., Dai, J.* A Myocardial Patch Made of Collagen Membranes Loaded with Collagen-Binding Human Vascular Endothelial Growth Factor Accelerates Healing of the Injured Rabbit Heart. Tissue Engineering Part A. 17(21-22):2739-47. 2011
194.  Li, X., Sun, H., Lin, N., Hou, X., Wang, J., Zhou, B., Xu, P., Xiao, Z., Chen, B., Dai, J. *, Hu, Y.* Regeneration of uterine horns in rats by collagen scaffolds loaded with collagen-binding human basic fibroblast growth factor. Biomaterials. 32(32):8172-81. 2011
195.  Han, Q., Li. B., Feng, H., Xiao, Z., Chen, B., Zhan, Y., Huang, J. and Dai, J.* The promotion of cerebral ischemia recovery in rats by laminin-binding BDNF. Biomaterials. 32(22):5077-85. 2011
196.  Cao, J., Sun, C.*, Zhao, H., Xiao, Z., Chen, B., Gao, J., Zheng, T., Wu, W., Wu, S., Wang, J., Dai, J.* The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats. Biomaterials. 32(16):3939-48. 2011
197.  Fan, J., Zhang, H., He, J., Xiao, Z., Chen, B., Jiang, X.*, Dai, J.*, Xu, R.* Neural regrowth induced by PLGA nerve conduits and neurotrophin-3 in rats with complete spinal cord transaction. JBMRB. 97(2):271-7. 2011
198.  Han, Q., Jin, W., Xiao, Z., Huang, J., Ni, H., Kong, J., Wu, J., Chen B., Liang, W., Dai, J.* The promotion of neurological recovery in an intracerebral hemorrhage model using fibrin-binding brain derived neurotrophic factor. Biomaterials. 32(12):3244-52. 2011
199.  Shi, C., Li, Q., Zhao, Y., Chen, W., Chen, B., Xiao, Z., Lin, H., Nie, L., Wang, D., Dai, J.*. Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration. Biomaterials. 32(10):2508-2515. 2011
200.  Shi, C., Chen, W., Zhao, Y., Chen, B., Xiao, Z., Wei, Z., Hou, X., Tang, J., Wang, Z., Dai, J.* Regeneration of full-thickness abdominal wall defects in rats using collagen scaffolds loaded with collagen-binding basic fibroblast growth factor. Biomaterials. 32(3): 753-9. 2011
201.  He, Q., Zhao, Y., Chen, B., Xiao, Z., Zhang, J., Chen, L., Chen, W., Deng, F.*, Dai, J.* Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. Acta Biomaterialia. 7(3):1084-1093. 2011
202.  Zhang, J., Wang, X., Chen, B., Xiao, Z., Li, W., Lu, Y., Dai, J.*. The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development. Oncology Letters. 1(3): 457-463. 2010
203.  Cao, J., Xiao, Z., Chen, B., Gao, Y., Shi, C., Wang, J., Dai, J.* Differential effects of recombinant fusion proteins TAT-OCT4 and TAT-NANOG on adult human fibroblasts. Frontiers in Biology. 5 (5): 424-430. 2010
204.  Han, Q., Jin, W., Xiao, Z., Ni, H., Wang, J., Kong, J., Wu, J., Liang, W., Chen, L., Zhao, Y., Chen, B., and Dai, J.* The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody. Biomaterials. 31(35):9212-20. 2010
205.  Liang, W., Han, Q., Jin, W., Xiao, Z., Huang, J., Ni, H., Chen, B., Kong, J., Wu, J., Dai, J.* The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF. Biomaterials. 31(33):8634-41. 2010
206.  Yan, X., Chen, B., Lin, Y., Li, Y., Xiao, Z., Hou, X., Tan, Q.* and Dai, J.* Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model. Diabetes Research and Clinical Practice. 90(1):66-72. 2010
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208.  Dai, J., Gao, S. Stem cell research is coming of age in China. J Genet Genomics. 37(7):413. 2010
209.  Gao, Y., Wang, X., Han, J., Xiao, Z., Chen, B., Su, G., Dai, J.*. The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B. J Genet Genomics. 37(7):461-5. 2010
210.  Chen, W., Shi, C., Yi, S., Chen, B., Zhang, W., Fang, Z., Wei, Z., Jiang, S., Sun, X., Hou, X., Xiao, Z., Ye, G., Dai, J.* Bladder regeneration by collagen scaffolds with collagen binding human basic fibroblast growth factor. J Urol. 183(6):2432-9. 2010
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212.  Zhang, W., Wang, X., Xiao, Z., Liu, W., Chen, B., Dai, J.* Mapping of the minimal internal ribosome entry site element in the human embryonic stem cell gene OCT4B mRNA. Biochem Biophys Res Commun. 394(3):750-4. 2010
213.  Ma, J., Meng, Y., Kwiatkowski, D.J., Chen, X., Peng, H., Sun, Q., Zha, X., Wang, F., Wang, Y., Jing, Y., Zhang, S., Chen, R., Wang, L., Wu, E., Cai, G., Malinowska-Kolodziej, I., Liao, Q., Liu, Y., Zhao, Y., Sun, Q., Xu, K., Dai, J., Han, J., Wu, L., Zhao, R.C., Shen, H., Zhang, H. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest. 120(1):103-14. 2010
214.  Chen, L., He, Z., Chen, B., Yang, M., Zhao, Y., Sun, W., Xiao, Z., Zhang, J., Dai, J.* Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold. J Mater Sci Mater Med. 21(1):309-17. 2010
215.  Gao, Y., Wang, B., Xiao, Z., Chen, B., Han, J., Wang, X., Zhang, J., Gao, S., Zhao, Y., Dai, J.* Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells. Stem Cells Dev. 19(1):53-60. 2010
216.  Sun, W., Lin, H., Chen, B., Zhao, W., Zhao, Y., Xiao, Z., Dai, J.* Collagen scaffolds loaded with collagen-binding NGF-beta accelerate ulcer healing. J Biomed Mater Res A. 92(3):887-95. 2010
217.  Zhao, Y., Zhang, J., Wang, X., Chen, B., Xiao, Z., Shi, C., Wei, Z., Hou, X., Wang, Q., Dai, J.* The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies. J Controlled Release. 141(1):30-7. 2010
218.  Chen, L., He, Z., Chen, B., Zhao, Y., Sun, W., Xiao, Z., Zhang, J., Yang, M., Gao, Z., Dai, J.* Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization. Biomacromolecules. 10(12):3193-8. 2009
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225.  Gao, Y., Xiao, Z., Chen, B., Wang, B., Han, J., Zhao, Y., Zhang, J., Dai, J.* Effect of different regions of Nogo-A on the differentiation of neural progenitors. Neurosci Lett. 458(3):132-5. 2009
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229.  Sun, B., Chen, B., Zhao, Y., Sun, W., Chen, K., Zhang, J., Wei, Z., Xiao, Z., Dai, J.* Crosslinking heparin to collagen scaffolds for the delivery of human platelet-derived growth factor. J Biomed Mater Res B Appl Biomater. 91(1):366-72. 2009
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