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  Location: Home >> Faculty >> Developmental Biology
  Developmental Biology


Lihui Duan


Education and Appointments 
2006 – 2010 BS in Biology, Huazhong Agricultural University
2010 – 2018 Ph.D. in Neuroscience, Institute of Neuroscience, Chinese Academy of Sciences
2018 – 2022 Postdoctoral fellow in Immunology, University of California, San Francisco


Research Direction
1. Development and Differentiation of the Brain Fibroblasts
2. Interaction between the fibroblasts and the central nervous system
3. The role of fibroblasts in the neuro-immune interactions

Published Works
 
Wolf, E.W., Howard, Z.P., Duan, L., Tam, H., Xu, Y., and Cyster, J.G. (2022). GPR174 signals via G α s to control a CD86-containing gene expression program in B cells. Proceedings of the National Academy of Sciences 119, e2201794119.
 
Liu, D., Duan, L., and Cyster, J.G. (2022a). Chemo‐and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen. Immunological Reviews 306, 25-42.
 
Liu, D., Duan, L., Rodda, L.B., Lu, E., Xu, Y., An, J., Qiu, L., Liu, F., Looney, M.R., and Yang, Z. (2022b). CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. Science 375, eabi5965.
 
Duan, L.*, Liu, D.*, Chen, H., Mintz, M.A., Chou, M.Y., Kotov, D.I., Xu, Y., An, J., Laidlaw, B.J., and Cyster, J.G. (2021). Follicular dendritic cells restrict interleukin-4 availability in germinal centers and foster memory B cell generation. Immunity 54, 2256-2272. e2256. (Highlighted by Nature Immunology)
 
Laidlaw, B.J., Duan, L., Xu, Y., Vazquez, S.E., and Cyster, J.G. (2020). The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. Nature immunology 21, 1082-1093.
 
Duan, L.*, Zhang, X.-D.*, Miao, W.-Y., Sun, Y.-J., Xiong, G., Wu, Q., Li, G., Yang, P., Yu, H., and Li, H. (2018). PDGFRβ cells rapidly relay inflammatory signal from the circulatory system to neurons via chemokine CCL2. Neuron 100, 183-200. e188. (Preview highlight on Neuron)
 
Zhang, S.-X.*, Duan, L.*, He, S.-J., Zhuang, G.-F., and Yu, X. (2017). Phosphatidylinositol 3, 4-bisphosphate regulates neurite initiation and dendrite morphogenesis via actin aggregation. Cell research 27, 253-273.
 
Zhang, S.-X.*, Duan, L.*, Qian, H., and Yu, X. (2016). Actin aggregations mark the sites of neurite initiation. Neuroscience bulletin 32, 1-15.