Publications:
1.Hu B, Jiang Z, Wang W, Qiu Y, Zhang Z, Liu Y, Li A, Gao X, Liu L, Qian Y, Huang X, Yu F, Kang S, Wang Y, Xie J, Cao S, Zhang L, Wang Y, Xie Q, Kopriva S, Chu C. Nitrate-NRT1.1B-SPX4 cascade integrates nitrogen and phosphorus signalling networks in plants. Nat Plants. 2019 Mar 25. doi: 10.1038/s41477-019-0384-1.
2.Xu W, Wang Y. Sequences, Domain Architectures, and Biological Functions of the Serine/Threonine and Histidine Kinases in Synechocystis sp. PCC 6803. Appl Biochem Biotechnol. 2019 Feb 19. doi: 10.1007/s12010-019-02971-w.
3.Lyu Z, Mao Z, Li Q, Xia Y, Liu Y, He Q, Wang Y, Zhao H, Lu Z, Zhou Q. PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules. EBioMedicine. 2018 Nov 9. pii: S2352-3964(18)30493-6.
4.Li J, Chen T, Huang X, Zhao Y, Wang B, Yin Y, Cui Y, Zhao Y, Zhang R, Wang X, Wang Y, Dai J. Substrate-independent immunomodulatory characteristics of mesenchymal stem cells in three-dimensional culture. PLoS One. 2018 Nov 8;13(11):e0206811.
5.Ge H, Fang L, Huang X, Wang J, Chen W, Zhang Y, Wang X, Sui N, Xu W, He Q, Wang Y, Activation of the Oxidative Pentose Phosphate Pathway is Critical for Photomixotrophic Growth of a hik33-deletion mutant of Synechocystis sp. PCC 6803. Proteomics. 2018 Sep 8:e1800046. doi: 10.1002/pmic.201800046.
6.Han JJ, Yang X, Wang Q, Tang L, Yu F, Huang X, Wang Y, Liu JX, Xie Q. The β5 subunit is essential for intact 26S proteasome assembly to specifically promote plant autotrophic growth under salt stress. New Phytol. 2018 Oct 22. doi: 10.1111/nph.15471.
7.Xu L, Zhang H, Mei M, Du C, Huang X, Li J, Wang Y, Bao S, Zheng H. Phosphorylation of SRSF1 at Tyr-19 promotes cell proliferation in pediatric acute lymphoblastic leukemia. Cancer Sci. 2018 Oct 15. doi: 10.1111/cas.13834. [Epub ahead of print].
8.Zhang F, Wang Y, Wang T, Yao L, Lam SM, Huang X, Fan J, Wang Q, Liu L, Jiang Y, Zhang H, Shi L, Yu M, Shui G, Wang Y, Gao F, Zhang X, Xu Z, cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development. Proc Natl Acad Sci U S A. 2018, 115(40):E9449-E9458
9.Ding L, Yang X, Tian H, Liang J, Zhang F, Wang G, Wang Y, Ding M, Shui G, Huang X. Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. EMBO J. 2018 Jul 26. pii: e97572. doi: 10.15252/embj.201797572. [Epub ahead of print]
10. Peng Y, Chen L, Li S, Zhang Y, Xu R, Liu Z, Liu W, Kong J, Huang X, Wang Y, Cheng B, Zheng L, Li Y. BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis. Nat Commun. 2018 Apr 18;9(1):1522.
11. Green CL, Soltow QA, Mitchell SE, Derous D, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Jones DP, Speakman JR. The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice. Gerontol A Biol Sci Med Sci. 2018 Apr 30. doi: 10.1093/gerona/gly058. [Epub ahead of print]
12. Chen W, Fang L, Huang X, Ge H, Wang J, Wang X, Zhang Y, Sui N, Xu W, and Wang Y. Systematic Identification of Light-Regulated Cold-Responsive Proteome in a Model Cyanobacterium. Journal of Proteomics, 2018,179:100-109.
13. Yan H, Zhao Y, Shi H, Li J, Wang Y, Tang D. BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis. Plant Physiol. 2018 Feb 12. pii: pp.01757.2017. doi: 10.1104/pp.17.01757. [Epub ahead of print]
14. Derous D, Mitchell SE, Wang L, Green CL, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Speakman JR. The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome. Aging (Albany NY). 2017 Jul 31;9(7):1770-1824.
15. Wang Z, Hou X, Wang Y, Xu A, Cao W, Liao M, Zhang R, Tang J. Ubiquitination of non-lysine residues in the retroviral integrase. Biochem Biophys Res Commun. 2017 Dec 9;494 (1-2):57-62.
16. Duan X, Lu J, Wang H, Liu X, Wang J, Zhou K, Jiang W6, Wang Y, Fang M, Bidirectional factors impact the migration of NK cells to draining lymph node in aged mice during influenza virus infection. Exp Gerontol. 2017, 96:127-137.
17. Zhao L, Cheng D, Huang X, Chen M, Dall’Osto L, Xing J, Gao L, Li L, Wang Y, Bassi R, Peng L, Wang Y, Rochaix JD, Huang F. A Light Harvesting Complex-Like Protein in Maintenance of Photosynthetic Components in Chlamydomonas. Plant Physiol. 2017 Jun 21. pii: pp.01465.2016. doi: 10.1104/pp.16.01465. [Epub ahead of print]
18. Derous D, Mitchell SE, Green CL, Wang Y, Han JDJ, Chen L, Promislow DEL, Lusseau D, Douglas A, Speakman JR. The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue. J Gerontol A Biol Sci Med Sci. 2017 May 27. doi: 10.1093/gerona/glx101. [Epub ahead of print]
19. Ge H, Fang L, Huang X, Wang J, Chen W, Liu Y, Zhang Y, Wang X, Xu W, He Q, and Wang Y. Translating Divergent Environmental Stresses into a Common Proteome Response through Hik33 in a Model Cyanobacterium. Mol Cell Proteomics. 2017, 16:1258-1274.
20. Mitchell SE, Tang Z, Kerbois C, Delville C, Derous D, Green CL, Wang Y, Han JJ, Chen L, Douglas A, Lusseau D, Promislow DE, Speakman JR. The effects of graded levels of calorie restriction: VIII. impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse. Oncotarget. 2017 Feb 11. doi: 10.18632/oncotarget.15294. [Epub ahead of print].
21. Green CL, Mitchell SE, Derous D, Wang Y, Chen L, Han JJ, Promislow DE, Lusseau D, Douglas A, Speakman JR.The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. Aging Cell. 2017 Jan 31. doi: 10.1111/acel.12570. [Epub ahead of print]
22. Niu Y, Dai Z, Liu W, Zhang C, Yang Y, Guo Z, Li X, Xu C, Huang X, Wang Y, Shi YS, Liu JJ. Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. Elife. 2017 Jan 30;6. pii: e20991. doi: 10.7554/eLife.20991. [Epub ahead of print].
23. Miao L, Yuan Y, Cheng F, Fang J, Zhou F, Ma W, Jiang Y, Huang X, Wang Y, Shan L, Chen D, Zhang J.Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish. Development. 2017;144(1):128-138.
24. Ning W, Yu Y, Xu H, Liu X, Wang D, Wang J, Wang Y, Meng W. The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics. Dev Cell. 2016; 39: 61-74.
25. Guan Y, Huang D, Chen F, Gao C, Tao T, Shi H, Zhao S, Liao Z, Lo LJ, Wang Y, Chen J, Peng J. Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3. PLoS Biol. 2016; 14: e1002555.
26. Li Y, Xu M, Ding X, Yan C, Song Z, Chen L, Huang X, Wang X, Jian Y, Tang G, Tang C, Di Y, Mu S, Liu X, Liu K, Li T, Wang Y, Miao L, Guo W, Hao X, Yang C. Protein kinase C controls lysosome biogenesis independently of mTORC1. Nat Cell Biol. 2016; 18: 1065-77.
27. Jia W, Li B, Li S, Liang Y, Wu X, Ma M, Wang J, Gao J, Cai Y, Zhang Y, Wang Y, Li J, Wang Y. Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis. PLoS Biol. 2016; 14: e1002550.
28. Fang L, Ge H, Huang X, Liu Y, Lu M, Wang J, Chen W, Xu W, Wang Y. Trophic Mode-Dependent Proteomic Analysis Reveals Functional Significance of Light-Independent Chlorophyll Synthesis in Synechocystis sp. PCC 6803. Mol Plant. 2017; 10(1):73-85.
30. Guan L, Ma X, Zhang J, Liu JJ, Wang Y, Ding M. The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions. PLoS Genet. 2016; 12: e1006163..
31. Wang Y, Liu L, Zhang H, Fan J, Zhang F, Yu M, Shi L, Yang L, Lam SM, Wang H, Chen X, Wang Y, Gao F, Shui G, Xu Z. Mea6 controls VLDL transport through the coordinated regulation of COPII assembly. Cell Res. 2016; 26: 787-804.
32. Derous D, Mitchell SE, Green CL, Wang Y, Han JD, Chen L, Promislow DE, Lusseau1 D, Speakman JR, Douglas A. The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks. Aging (Albany NY). 2016; 8: 917-32.
33. Chao Q, Gao ZF, Wang YF, Li Z, Huang XH, Wang YC, Mei YC, Zhao BG, Li L, Jiang YB, Wang BC. The proteome and phosphoproteome of maize pollen uncovers fertility candidate proteins. Plant Mol Biol. 2016; 91: 287-304.
34. Mitchell SE, Delville C, Konstantopedos P, Derous D, Green CL, Wang Y, Han JJ, Promislow DE, Douglas A, Chen L, Lusseau D, Speakman JR. The effects of graded levels of calorie restriction: V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse. Oncotarget. 2016; 7: 19147-70.
35. Derous D, Mitchell SE, Green CL, Chen L, Han JJ, Wang Y, Promislow DE, Lusseau D, Speakman JR, Douglas A. The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways. Aging (Albany NY). 2016; 8: 642-63.
36. Wang Z, Li N, Shan J, Gonzalez N, Huang X, Wang Y, Inze D, and Li Y. SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana. Nature Communications. 2016; 7:11192.
37. Wang T, Liang L, Xue Y, Jia PF, Chen W, Zhang MX, Wang YC, Li HJ, Yang WC. A receptor heteromer mediates the male perception of female attractants in plants. Nature. 2016; 536: 360.
38. Zhang B, Wang X, Zhao Z, Wang R, Huang X, Zhu Y, Yuan L, Wang Y, Xu X, Burlingame AL, Gao Y, Sun Y, Tang W. OsBRI1 activates BR signaling by preventing binding between the TPR and kinase domains of OsBSK3 via phosphorylation. Plant Physiol. 2016; 170: 1149-61.
39. Wang J, Yu L, Huang X, Wang Y, Zhao J. Comparative proteome analysis of saccular intracranial aneurysms with iTRAQ quantitative proteomics. J Proteomics. 2016; 130:120-8.
40. Lusseau D, Mitchell SE, Barros C, Derous D, Green C, Chen L, Han JD,
Wang Y, Promislow DE, Douglas A, Speakman JR.
The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction. Sci Rep. 2015; 5:13198.
41. Mitchell SE, Delville C, Konstantopedos P, Derous D, Green CL, Chen L, Han JD, Wang Y, Promislow DE, Douglas A, Lusseau D, Speakman JR. The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse. Oncotarget. 2015; 6:18314-37.
42. Mitchell SE, Tang Z, Kerbois C, Delville C, Konstantopedos P, Bruel A, Derous D, Green C, Aspden RM, Goodyear SR, Chen L, Han JJ, Wang Y, Promislow DE, Lusseau D, Douglas A, Speakman JR. The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse. Oncotarget. 2015;6:15902-30.
43. Mitchell SE, Delville C, Konstantopedos P, Hurst J, Derous D, Green C, Chen L, Han JJ, Wang Y, Promislow DE, Lusseau D, Douglas A, Speakman JR. The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice. Oncotarget. 2015;6:23213-37.
44. Ning DL, Liu KH, Liu CC, Liu JW, Qian CR, Yu Y, Wang YF, Wang YC*, Wang BC. Large-scale comparative phosphoprotein analysis of maize seedling leaves during greening. Planta. 2016; 243(2):501-17(*co-corresponding).
45. Bai C, Guo P, Zhao Q, Lv Z, Zhang S, Gao F, Gao L, Wang Y, Tian Z, Wang J, Yang F, Liu C. Protomer roles in Chloroplast Chaperonin Assembly and Function. Mol Plant. 2015;8(10):1478-92.
46. Gao L, Wang J, Ge H, Fang L, Zhang Y, Huang X,
Wang Y. Toward the complete proteome of Synechocystis sp. PCC 6803.
Photosynth Res,
2015, 126:203-19.
47. Hu J, Huang X, Chen L, Sun X, Lu C, Zhang L, Wang Y, Zuo J. Site-specific nitrosoproteomic identification of endogenously S-nitrosylated proteins in Arabidopsis. Plant Physiol, 2015;167:1731-46.
48. Gao L, Ge H, Huang X, Liu K, Zhang Y, Xu W, and Wang Y. Systematically Ranking the Tightness of Membrane Association for Peripheral Membrane Proteins. Mol Cell Proteomics, 2015;14:340-53.
49. Yin P, Tu Z, Yin A, Zhao T, Yan S, Guo X, Chang R, Zhang L, Hong Y, Huang X, Zhou J, Wang Y, Li S, Li XJ. Aged Monkey Brains Reveal the Role of Ubiquitin-Conjugating Enzyme UBE2N in the Synaptosomal Accumulation of Mutant Huntingtin. Hum Mol Genet, 2015; 24:1350-62.
50. Gao L, Huang X, Ge H, Zhang Y, Kang Y, Fang L, Liu K, Wang Y. Profiling and Compositional Analysis of the Exoproteome of Synechocystis sp. PCC 6803. J Metabol Sys Biol, 2014;1(1): 8.
51. Liu K, Zhang J, Fu B, Xie H, Wang Y, Qian X. Evaluation of empirical rule of linearly correlated peptide selection (ERLPS) for proteotypic peptide-based quantitative proteomics. Proteomics, 2014;14:1593-603.
52. Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, Wang Y, Huang X. Seipin promotes adipose tissue fat storage through the ER Ca2？-ATPase SERCA. Cell Metab, 2014;19:861-71.
53. Li L, Li M, Yu L, Zhou Z, Liang X, Liu Z, Cai G, Gao L, Zhang X, Wang Y, Chen S, Zhou JM. The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity. Cell Host Microbe, 2014;15:329-38.
54. Gao L, Shen C, Liao L, Huang X, Liu K, Wang W, Guo L, Jin W，Huang F, Xu W, and Wang Y. Functional proteomic discovery of Slr0110 as a central regulator of carbohydrate metabolism in Synechocystis sp. PCC6803. Mol Cell Proteomics, 2014;13:204-19.
55. Chen D, Jian Y, Liu X, Zhang Y, Liang J, Qi X, Du H, Zou W, Chen L, Chai Y, Ou G, Miao L, Wang Y, Yang C. Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genet, 2013; 9(5):e1003517.
56. Zhai Q, Yan L, Tan D, Chen R, Sun J, Gao L, Dong MQ, Wang Y, Li C. Phosphorylation-coupled proteolysis of the transcription factor MYC2 is important for jasmonate-signaled plant immunity. PLoS Genet, 2013; 9(4):e1003422.
57. Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke RL, KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res, 2012, 72: 2554-64.
58. Wang Y, and Klemke R. Proteomics method for identification of pseudopodium phosphotyrosine proteins. Methods Mol Biol, 2012;757:349-65.
59. Xu W, Wang Y*, Taylor E, Laujac A, Gao L, Savikhin S, Chitnis PR. Mutational analysis of photosystem I of Synechocystis sp. PCC 6803: the role of four conserved aromatic residues in the j-helix of PsaB. PLoS One, 2011;6(9):e24625 (*co-corresponding).
60. Wang Y, Yang F, Fu Y, Huang X, Wang W, Jiang X, Gritsenko MA, Zhao R, Monore ME, Pertz OC, Purvine SO, Orton DJ, Jacobs JM, Camp DG 2nd, Smith RD, Klemke RL. Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem. 2011; 286:18190-201.
61. Wang Y, Yang F, Gritsenko MA, Wang Y, Clauss T, Liu T, Shen Y, Monroe ME, Lopez-Ferrer D, Reno T, Moore RJ, Klemke RL, Camp DG 2nd, Smith RD. Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells. Proteomics, 2011;11:2019-26.
62. Yang F, Waters KM, Miller JH, Gritsenko MA, Zhao R, Du X, Livesay EA, Purvine SO, Monroe ME, Wang Y, Camp DG 2nd, Smith RD, Stenoien DL. Phosphoproteomics Profiling of Human Skin Fibroblast Cells Reveals Pathways and Proteins Affected by Low Doses of Ionizing Radiation. PLos One, 2010;5: e14152.
63. Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR 3rd, Klemke RL. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. Proc Natl Acad Sci U S A, 2010; 107(24):10920-5.
64. Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, Jin Y, Klemke RL, Sauder JM, Burley SK. Structures of PHR Domains from Mus musculus Phr1 (Mycbp2) Explain the Loss-of-Function Mutation (Gly1092 → Glu) of the C. elegans Ortholog RPM-1. J Mol Biol, 2010;397(4):883-92.
65. Wang Y*, Xu W*, Chitnis PR. Identification and bioinformatic analysis of the thylakoid membrane proteome of Synechocystis sp. PCC6803. Proteome Science, 2009, 7: 11. (*corresponding author).
66. Ding SJ*, Wang Y*, Jacobs JM, Qian WJ, Yang F, Tolmachev AV, Du X, Wang W, Moore RJ, Monroe ME, Purvine SO, Waters K, Heibeck TH, Adkins JN, Camp DG 2nd, Klemke RL, Smith RD. Quantitative Phosphoproteome Analysis of Lysophosphatidic Acid induced chemotaxis using Dual-step 18O Labeling Coupled with Immobilized Metal Affinity Chromatography. J Proteome Res, 2008;7:4215-24. (*co-first authors).
67. Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, Clauss TR, Anderson DJ, Liu T, Auberry KJ, Camp DG 2nd, Smith RD, Klemke RL. Spatial Mapping of the Neurite and Soma Proteomes Reveals a Functional Cdc42/Rac Regulatory Network. Proc Natl Acad Sci U S A, 2008;105:1931-1936.
68. Wang Y and Klemke RL. PhosphoBlast: A Computational Tool for Comparing Phosphoprotein Signatures among Large Datasets. Mol Cell Proteomics, 2008;7: 145-162.
69. Wang Y, Ding SJ, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG 2nd, Smith RD, Klemke RL. Methods for Pseudopodia Purification and Proteomics Analysis. Sci. STKE, 2007; pl4.
70. Wang Y, Ding SJ, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG 2nd, Smith RD, Klemke RL. Profiling Signaling Polarity in Chemotactic Cells. Proc Natl Acad Sci U S A, 2007;104: 8328-8333.
71. Wang Y, and Klemke RL. Biochemical Purification of Pseudopodia from Migratory Cells. Methods Mol Biol, 2007;370:55-66.
72. Wang Y, Hanley R and Klemke RL. Computational methods for comparison of large genomic and proteomic datasets reveals protein markers of metastatic cancer. J Proteome Res, 2006; 5: 907-15.
73. Harvey D, Wang Y, Chitnis PR, Kothari SC. Computational Opportunities in Proteomics Research: Automation in data processing and analysis. High Performance Computing Conference (HPC 2002), December 16-19 in Banglore, India.
74. Xu W, Tang H, Wang Y, Chitnis PR. Proteins of the cyanobacterial photosystem I. Biochimica Biophysica Acta, 2001; 1507: 32-40.
75. Hou JM, Boichenko VA, Wang YC, Chitnis PR, Mauzerall D. Thermodynamics of electron transfer in oxygenic photosynthetic reaction center: a photoacoustic study revealed a similarity to bacterial reaction centers on electron transfer in photosystem I in both volume change and entropy. Biochemistry, 2001; 40: 7109-7116.
76. Wang Y, Sun J, Chitnis PR. Proteomic study of the peripheral proteins from thylakoid membranes of the cyanobacterium Synechocystis sp. PCC 6803. Electrophoresis, 2000;21: 1746-1754.
