黄勋，男，博士。 研究员，博士生导师。
1994年获厦门大学学士学位，1997年获中国科学院微生物研究所硕士学位，2003年获美国加州大学圣克鲁斯分校(University of California, Santa Cruz)博士学位，同年进入美国斯坦福大学(Stanford University)从事博士后研究。2006年起任中国科学院遗传与发育生物学研究所研究员，百人计划，博士生导师。
研究方向
我们实验室关注脂类代谢、动物发育及人类遗传疾病的分子机制。个体发育是一个相当复杂的，由许多基因精细调节的生物学过程，而发育缺陷可导致疾病。因此，对于发育分子机制的认识不仅具有生物学的意义也可以为研究疾病的发病、致病机制奠定基础。 我们实验室主要有两个研究方向：脂类代谢调控及在发育、疾病中的作用，神经发育和神经疾病的分子机制。
主要研究内容：
1 ）用分子，细胞和遗传学手段研究细胞内脂类代谢调控分子机理，及其参与的发育调控。主要包括脂质储积调控、脂肪酸和胆固醇的代谢调控，及其在动物发育中的功能及人类脂代谢疾病的分子遗传机制研究。 （更多科研内容请关注本实验室英文网页）
2 ）神经发育，特别是神经细胞命运决定及轴突导向的分子调控机理。
课题研究组成员：
刘忠华 博士 助理研究员；
李霞 硕士助理研究员；
王威 学士 工程师
在读研究生
宋松；田嫄；葛庆兰；毕俊峰；王金铂；刘元；刘正隆；范玮
已毕业的研究生：
陈海洋(Carnegie Institute)；项延会(UCSF)；马志国 (U Mass)；王超(北京)
客座学生和博士后招聘信息：
本实验室目前拟招聘1-2名博士后，1-2名客座学生（毕业/学位无论文要求优先）。详情请联系xhuang@genetics.ac.cn
实验室发表文章 (# 通讯作者；*共同第一作者)
1. Huang, X. #, Warren, J. and Gilbert, L. (2008) New players in the regulation of ecdysone biosynthesis. J. Genetics and Genomics 35:1-10 (Review)
2. Chen, H., Ma, Z., Liu, Z., Tian,Y., Xiang, Y., Wang, C., Scott, M. P. and Huang, X. # (2009) Case studies of Ends-Out gene targeting in Drosophila. Genesis 47:305-308
3. Chen, H., Liu, Z. and Huang, X. # (2010) Drosophila models of peroxisomal biogenesis disorder: Peroxins are required for spermatogenesis and very long chain fatty acid metabolism. Human Molecular Genetics 19:494-505
4. Xiang, Y., Liu, Z. and Huang, X. # (2010) br regulates the expression of the ecdysone biosynthesis gene npc1. Developmental Biology 344:800-808
5. Song, S.*, Zhang, B.*, Sun, H., Li, X., Xiang, Y., Liu, Z., Huang, X. #, and Ding, M. # (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics 6(8): e1001056.
6. Ma, Z., Liu, Z. and Huang, X. # (2010) OSBP- and FAN- mediated sterol requirement for spermatogenesis in Drosophila. Development 137, 3775-3784
7. Song, S. *, Ge, Q. * , Wang, J. *, Chen, H., Tang, S., Bi, J., Li, X. , Xie, Q. and Huang, X. # (2011) TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance. J. Genetics and Genomics (Cover story) 38:1-11
8. Wang, C., Ma, Z. Scott, M. P. and Huang, X. # (2011) The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis. Developmental Biology 351:146-155
10. Tian, Y. *, Bi, J. *, Shui, G., Liu, Z., Xiang, Y., Liu, Y., Wenk, M., Yang, H. and Huang, X. # (2011) Tissue-autonomous function of Drosophila Seipin in preventing ectopic lipid droplet formation. PLoS Genetics 7(4): e1001364
11．Fei, W., Shui, G., Zhang, Y., Krahmer, N., Ferguson, C., Kapterian, T., Lin, R., Dawes, I., Brown, A., Li, P., Huang, X., Parton, R., Wenk, M., Walther, T. and Yang, H. # (2011) A role for phosphatidic acid in the formation of "supersized" lipid droplets. PLoS Genetics 7(7): e1002201
12．Yue, W., Wang, H., Sun, L., ……Huang, X., Lv, L., Li, T., Zhao, G., Huang, W., Zhang, X., and Zhang D. (2011) Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nature Genetics 43(12):1228-1231
回国前的工作
1. Zhen, M.,* Huang, X.,* Bamber, B. and Jin, Y. (2000). Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a Ring-H2 finger domain. Neuron 26: 331-343 (* co-first author)
2. Huang, X., Cheng, H-J., Tessier-Lavigne, M. and Jin, Y. (2002). MAX-1, a novel PH/Myth4/FERM domain cytoplasmic protein implicated in Netrin-mediated axon repulsion. Neuron 34: 563-576
3. Huang, X., Huang, P., Robinson, M., Stern, M. and Jin, Y. (2003). UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans. Development 130: 3147-3161
4. Huang, X., Powell-Coffman, J. A. and Jin, Y. (2004). The AHR-1 aryl hydrocarbon receptor and its cofactor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans. Development 131: 819-828
5. Nakata, K., Abrams, B.,Grill, B., Goncharov, A., Huang, X., Chisholm, A.D. and Jin, Y. (2005) Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell 120:407-420
6. Huang, X., Suyama, K., Buchanan, J. A., Zhu, AJ. and Scott, M. P. (2005) A Drosophila model of the Niemann-Pick Type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Development 132:5115-5124
7. Huang, X., Warren, J., Buchanan, J. A., Gilbert, L. and Scott, M. P. (2007) Drosophila Niemann-Pick Type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Development 134:3733-3742
8. Abrams, B., Grill, B., Huang, X. and Jin, Y. (2008) Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions. Dev. Dynamics 237:630-639 |
