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黄勋


黄勋,博士, 研究员,博士生导师 

        1994年获厦门大学学士学位,1997年获中国科学院微生物研究所硕士学位,2003年获美国加州大学圣克鲁斯分校 (University of California, Santa Cruz) 博士学位,同年进入美国斯坦福大学 (Stanford University) 从事博士后研究。2006年10月起任中国科学院遗传与发育生物学研究所研究员,博士生导师。入选中国科学院百人计划,百人计划终期评估“优秀”;获得中国科学院朱李月华优秀教师奖;获得国家自然科学基金委“国家杰出青年科学基金”、重点项目;科技部“重大科学研究计划”、“973”和中科院先导项目等项目资助。


实验室研究方向:
        脂肪是机体的重要组成成分,除了作为细胞膜主要成份之外,脂类分子也参与了信号通路调节、能量储存,并影响个体生长发育及正常生理功能。脂肪组织是甘油三酯和胆固醇酯的重要储存之处,是机体参与脂类代谢调控最重要的部位。脂类代谢也在胚胎早期发育和非脂肪组织功能执行中起着重要的作用。脂肪代谢异常可能导致出生缺陷、肥胖症、糖尿病、脂营养不良症、生殖缺陷、脂肪肝和动脉粥样硬化等人类重大疾病。
 
        本实验室主要围绕着脂代谢调控研究领域,展开“脂代谢调控与生理”“脂代谢调控与发育进化”两个方向的研究。利用模式动物(果蝇、线虫、小鼠等)体系,系统解析胚胎早期发育和个体不同组织(脂肪组织和神经组织等)中脂代谢调控的分子机制及其所影响动物组织、器官发育的分子细胞机理,为人类脂代谢疾病的发病、致病机理研究提供线索。

主要研究内容:
        1)脂代谢调控与生理:脂代谢调控关键分子的发现及其调控;在细胞、组织和个体层面,脂代谢调控的分子机制;脂代谢调控关键分子影响生理的机理。
        2)脂代谢调控与发育进化:脂代谢调控影响早期胚胎及组织器官发育分子机理;进化中的脂代谢调控。
        3)脂代谢相关疾病的发病、致病机理。
 
 
(具体科研内容请关注实验室英文网页http://english.genetics.cas.cn/huangxun
 
        “脂代谢调控”研究组成员:
        刘忠华 博士 副研究员
        许捷思 博士 助理研究员
        李  霞 硕士 助理研究员
        王  威 学士 工程师
 
在读研究生:丁隆;姚艳;杨晓;杨雷雷;赵雪璠;许梦瑶;苏醒;潘慧敏;朱景林
 
学生获奖情况:
        陈海洋(2010年地奥一等奖);马志国(2011年朱李月华优秀博士生奖);宋松(2011年GSK明日之星奖,2011年朱李月华优秀博士生奖);田嫄(2011年中国科学院院长优秀奖);毕俊峰(2012年中国科学院院长优秀奖,2013年国家奖学金/博士);姚艳(2013年国家奖学金/硕士);刘正隆(2015年国家奖学金/博士);王金铂(2015年地奥一等奖);丁隆(2017年国家奖学金/博士);苏醒(2017年国家奖学金/硕士)。
 
已毕业的研究生:
        陈海洋 (硕博2005-2010,中山大学,教授,青年千人,基金委“优青”);项延会 (博士2006-2010);马志国 (硕博2005-2011,U Mass, Postdoc);王超 (硕博2004-2011, 舒泰神生物制药股份有限公司);田嫄 (硕博2006-2012, 贵州大学, 副教授);葛庆兰 (博士2008-2012);宋松 (硕博2006-2012, Stanford University, Postdoc);刘元 (硕博2008-2014,University of Pennsylvania, Postdoc);毕俊峰 (硕博2007-2014,UCSD, Postdoc);王金铂 (硕博2007-2015,中科院动物所,博士后);刘正隆 (硕博2009-2016, University of Washington, Postdoc);范玮(硕博2010-2017, UTSW, Postdoc)。
 

黄勋实验室发表的文章 (# 通讯作者;*共同第一作者)
30. Lam. S-M., Wang. Z., Li. J., Huang. X. and Shui. G. # (2017) Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival. Redox Biology 12:967-977 PMID: 28499251
 
29. Fan. W., Lam. S-M., Xin. J., Yang. X., Liu. Z., Liu. Y., Wang. Y., Shui. G. and Huang. X. # (2017) Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. PLoS Genetics 13(3):e1006664 PMID: 28273089
 
28. Tan. S., Cardoso-Moreira. M., Shi. W., Zhang. D., Huang. J., Mao. Y, Jia. H., Zhang. Y., Chen. C., Shao. Y., Leng, L., Liu. Z., Huang. X., Long. M. and Zhang. YE. # (2016) LTR retrotransposons create transcribed retrocopies in metazoans. Genome Research. 26(12):1663-1675 PMID: 27934698
 
27. Pagac. M., Cooper. DE., Qi. Y., Lukmantara. IE., Mak. HY., Wu. Z., Tian. Y., Liu. Z., Lei. M., Du. X., Ferguson. C., Kotevski. D., Sadowski. P., Chen. W., Boroda. S., Harris. TE., Liu. G., Parton. RG., Huang. X., Coleman. RA. and Yang. H. # (2016) SEIPIN regulates lipid droplet expansion and adipocyte development by modulating the activity of glycerol-3-phosphate acyltransferase. Cell Reports 17(6):1546-1559 PMID: 27806294
 
26. Zhang, B. #, Chen, X., Huang, X. # and Yang. X. # (2016) Research advances on animal genetics in China in 2015. Yi Chuan (遗传) 38(6):467-507 PMID: 27655312
 
25. Qi, Y., Kapterian T., Du, X., Ma, Q., Fei, W., Zhang, Y., Huang, X., Dawes, I. and Yang H. # (2016) CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research 57(5):767-80 PMID: 26946540
 
24. Huang, X. # (2015) A lipid pathway for heat adaptation. Sci China (Life Sciences) 58(7):727-728 PMID: 26044402
 
23. Wang, J., Chitturi, J., Ge, Q., Laskova, V., Wang, W., Li X., Ding, M., Zhen, M. # and Huang, X. # (2015) The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development 142:1447-1457 PMID: 25790851
 
22. Bi, J., Wang, W., Liu, Z., Huang, X., Jiang, Q., Liu, G., Wang, Y. and Huang, X. # (2014) Seipin promotes adipose tissue fat storage through the ER Ca2+-ATPase SERCA. Cell Metabolism 19(5):861-871 PMID: 24807223
 
21. Liu, Y., Wang, W., Shui, G. # and Huang, X. # (2014) CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway. PLoS Genetics 10(3):e1004172 PMID: 24603715
 
20. Liu, Z., Li, X., Ge, Q., Ding, M. and Huang, X. # (2014) A lipid droplet-associated GFP reporter-based screen identifies new fat storage regulators in C. elegans. J. Genetics and Genomics 41:305-313 PMID: 24894357
 
19. Zhang, J., Li, X., Jevince, A., Guan, L., Wang, J., Hall, D., Huang, X. # and Ding, M. # (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genetics 9(6):e1003618 PMID: 23825972
 
18. Ma, Z.*, Liu, Z.* and Huang, X. # (2012) Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila. Genetics 190(4):1299-1308 PMID: 22234859
 
17. Zhou, B., Yang, L., Li, S., Huang, J., Chen, H., Hou, L., Wang, J., Green, C., Yan, Z., Huang, X., Kaeberlein, M., Zhu, L., Xiao, H., Liu, Y. and Han, J. # (2012) Midlife gene expressions identify modulators of aging through dietary interventions. PNAS 109(19):E1201-9 PMID: 22509016
 
16. Bi, J. *, Xiang, Y. *, Chen, H., Liu, Z., Gronke, S., Kuhnlein, R. and Huang, X. # (2012) Opposite and redundant roles of the two Drosophila Perilipins in lipid mobilization. Journal of Cell Science 125:3568-77 PMID: 22505614
 
15. Wang, C. and Huang, X. # (2012) Lipid metabolism and Drosophila sperm development. Sci China (Life Sciences) 55(1):35-40 PMID: 22314489
 
14. Wang, C.*, Liu, Z.* and Huang, X. # (2012) Rab32 is important for autophagy and lipid storage in Drosophila. PLoS One 7(2):e32086 PMID: 22348149
 
13. Zhang, P., Na, H., Liu, Z., Zhang, S., Xue, P., Chen, Y., Pu, J., Peng, G., Huang, X., Yang, F., Xie, Z., Xu, T., Xu, P., Ou, G., Zhang, S. and Liu, P. # (2012) Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets. Molecular and Cellular Proteomics 11(8):317-28 PMID: 22493183
 
12. Yue, W., Wang, H., Sun, L., ……Huang, X., Lv, L., Li, T., Zhao, G., Huang, W., Zhang, X., and Zhang D. (2011) Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nature Genetics 43(12):1228-1231 PMID: 22037552
 
11. Wang, C., Ma, Z. Scott, M. P. and Huang, X. # (2011) The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis. Developmental Biology 351:146-155 PMID: 21215267
 
10. Tuxworth, RI., Chen, H., Vivancos, V., Carvajal, N., Huang, X. and Tear G. # (2011) The Batten disease gene CLN3 is required for the response to oxidative stress. Human Molecular Genetics 20:2037-47 PMID: 21372148
 
9. Tian, Y. *, Bi, J. *, Shui, G., Liu, Z., Xiang, Y., Liu, Y., Wenk, M., Yang, H. and Huang, X. # (2011) Tissue-autonomous function of Drosophila Seipin in preventing ectopic lipid droplet formation. PLoS Genetics 7(4):e1001364 PMID: 21533227
 
8.Fei, W., Shui, G., Zhang, Y., Krahmer, N., Ferguson, C., Kapterian, T., Lin, R., Dawes, I., Brown, A., Li, P., Huang, X., Parton, R., Wenk, M., Walther, T. and Yang, H. # (2011) A role for phosphatidic acid in the formation of “supersized” lipid droplets. PLoS Genetics 7(7):e1002201 PMID: 21829381
 
7. Song S.*, Ge Q.* , Wang J.*, Chen H., Tang S., Bi J., Li X., Xie Q. and Huang X.# (2011) TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance. J. Genetics and Genomics 38:1-11 (Cover story) PMID: 21338947
 
6. Chen, H., Liu, Z. and Huang, X. # (2010) Drosophila models of peroxisomal biogenesis disorder: Peroxins are required for spermatogenesis and very long chain fatty acid metabolism. Human Molecular Genetics 19:494-505 PMID: 19933170
 
5. Xiang, Y., Liu, Z. and Huang, X. # (2010) br regulates the expression of the ecdysone biosynthesis gene npc1. Developmental Biology 344:800-808 PMID: 20621708
 
4. Song, S.*, Zhang, B.*, Sun, H., Li, X., Xiang, Y., Liu, Z., Huang, X. # and Ding, M. # (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics 6(8):e1001056. PMID: 20711352
 
3. Ma, Z., Liu, Z. and Huang, X. # (2010) OSBP- and FAN- mediated sterol requirement for spermatogenesis in Drosophila. Development 137:3775-3784 PMID: 20943709
 
2.Chen, H., Ma, Z., Liu, Z., Tian,Y., Xiang, Y., Wang, C., Scott, M. P. and Huang, X.# (2009) Case studies of Ends-Out gene targeting in Drosophila. Genesis 47:305-308 PMID: 19298016
 
1. Huang, X.,# Warren, J. and Gilbert, L.# (2008) New players in the regulation of ecdysone biosynthesis. J. Genetics and Genomics 35:1-10 PMID: 18222403
 
Huang Xun’s Publications during PhD and Postdoc (1997-2006)
8. Abrams, B., Grill, B., Huang, X. and Jin, Y. (2008) Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions. Developmental Dynamics 237:630-639 PMID: 18224716
 
7. Huang, X., Warren, J., Buchanan, J. A., Gilbert, L. and Scott, M. P. (2007) Drosophila Niemann-Pick Type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Development 134:3733-3742 PMID: 17804599
 
6. Huang, X., Suyama, K., Buchanan, J. A., Zhu, AJ. and Scott, M. P. (2005) A Drosophila model of the Niemann-Pick Type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Development 132:5115-5124 PMID: 16221727
 
5. Nakata, K., Abrams, B.,Grill, B., Goncharov, A., Huang, X., Chisholm, A.D. and Jin, Y. (2005) Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell 120:407-420 PMID: 15707898
 
4. Huang, X., Powell-Coffman, J. A. and Jin, Y. (2004). The AHR-1 aryl hydrocarbon receptor and its cofactor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans. Development 131:819-828 PMID: 14757639
 
3. Huang, X., Huang, P., Robinson, M., Stern, M. and Jin, Y. (2003). UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans. Development 130:3147-3161 PMID: 12783787
 
2. Huang, X., Cheng, H-J., Tessier-Lavigne, M. and Jin, Y. (2002). MAX-1, a novel PH/Myth4/FERM domain cytoplasmic protein implicated in Netrin-mediated axon repulsion. Neuron 34:563-576 PMID: 12062040
 
1. Zhen, M.,* Huang, X.,* Bamber, B. and Jin, Y. (2000). Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a Ring-H2 finger domain. Neuron 26:331-343 (* co-first author) PMID: 10839353