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丁梅


丁梅,博士, 研究员,博士生导师
 
    1995年厦门大学学士, 2004年美国加州大学圣克鲁斯分校(University of California, Santa Cruz)获博士学位,2004至2008年美国斯坦福大学(Stanford University)博士后。2008年任中国科学院遗传与发育生物学研究所研究员,百人计划,博士生导师。


主要研究方向
     人类感知、学习、记忆、思维、情绪均依赖于神经系统正确的信号传导。然而,神经系统信号传导究竟如何发生,是什么机制确保信息传导的连贯性和精确性并不清楚。本实验室立足基础,以秀丽隐杆线虫为模式,综合利用分子生物学,遗传学,活体成像,生物化学等多种研究手段, 系统探索神经系统发育的分子机制。主要研究内容包括:轴突定向生长,神经细胞特异性识别,突触形成与稳态调控。

发表论文(# 为通讯作者):
1. Guan L*, Ma X*, Zhang J, Liu J, Wang Y, Ding M#. The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions. PLoS Genetics (DOI:10.1371/journal.pgen.1006163).
 
2.Wu J, Cheng Y, Wang J, Chen L, Ding M, and Wu J.(2015) Structural insight into the mechanism of synergic autoinhibition of SAD kinases. Nature Communications (DOI:10.1038/ncomms9953). 
 
3. Cheng Y*, Wang J*, WangY, and Ding M#. (2015) Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. eLife (DOI:10.7554/eLife.05118).
 
4. Wang J, Chitturi J, Ge Q, Laskova V, Wang W, Li X, Ding M, Zhen M# and Huang X#. (2015) The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development 142:1447-1457
 
5. Qin J, Liang J, and Ding M#. (2014) Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons. Journal of Neuroscience 34(31):10311-10324.
 
6. Zhang J, Li X, Jevince AR, Guan L, Wang J, Hall DH, Huang X #, and Ding M#. (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genetics 9(6): e1001056.
 
7. Song S*, Zhang B*, Sun H, Li X, Xiang Y, Liu Z, Huang X #, and Ding M#. (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics 6(8): e1003618.
 
8. Ding M # and Shen K. (2008) The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessay 30: 1075-1083.
 
9. Ding M, King RS, Berry EC, Wang Y, Hardin J, and Chisholm AD. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PloS One 3: e3346.
 
10. Ding M, Chao D, Wang G, Shen K. (2007) Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science 317, 947-951.
 
11. Ding M, Woo WM, Chisholm AD. (2004) The cytoskeleton and epidermal morphogenesis in C. elegans. Exp Cell Res 301:84-90.
 
12. Ding M, Goncharov A, Jin Y, Chisholm AD. (2003) C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development 130:5791-5801.
 
13. Chin-Sang ID, Moseley SL, Ding M, Harrington RJ, George SE, Chisholm AD. (2002). The divergent C. elegans ephrin EFN-4 functions in embryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor. Development 129:5499-5510.
 
14. Chin-Sang ID, George SE, Ding M, Moseley SL, Lynch AS, Chisholm AD. (1999) The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans. Cell 99:781-790