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丁梅


丁梅,博士, 研究员,博士生导师
 
    1995年厦门大学学士, 2004年美国加州大学圣克鲁斯分校(University of California, Santa Cruz)获博士学位,2004至2008年美国斯坦福大学(Stanford University)博士后。2008年起任中国科学院遗传与发育生物学研究所研究员,博士生导师,国家自然科学基金委“国家优秀青年科学基金”获得者。


主要研究方向
     人类感知、学习、记忆、思维、情绪均依赖于神经系统正确的信号传导。然而,神经系统信号传导究竟如何发生,是什么机制确保信息传导的连贯性和精确性并不清楚。本实验室综合利用分子生物学,遗传学,活体成像,生物化学等多种研究手段,系统探索神经系统发育的分子机制。主要研究内容包括:轴突定向生长,神经元靶细胞特异识别,突触形成与稳态调控。

发表论文(*为通讯作者):
Guan L#, Yang Y#, Jing Liang L#, Miao Y, Shang A, Wang B, Wang Y, Ding M*. (2022). ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Traffic doi: 10.1111/tra.12830. Online ahead of print.
 
Cong D#,  Ren J#, Zhou Y, Wang S, Liang J, Ding M* Feng W*. (2021) Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A. PLoS Genetics doi: 10.1371/journal.pgen.1009940.
 
Xu J#, Chen S#, Wang W, Lam S-M, Xu Y, Zhang S, Pan H, Liang J, Huang X, Wang Y, Li T, Jiang Y, Wang Y, Ding M, Shui G, Yang H and Huang X*. (2021) Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis. Science Bulletin In press
 
Yang L, Liang J, Lam S-M, Yavuz A, Shui G, Ding M and Huang X*. (2020) Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration. EMBO Reports 21:e50214 PMID: 33034119.
 
Guan L#, Zhan Z#, Yang Y, Miao Y, Huang X, and Ding M*. (2020) Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons. PLoS Genetics 16(9):e1008704.
 
Ji J, Yuan J, Guo X, Ji R, Quan Q, Ding M*, Li X*, and Liu Y*. (2019) Harmine suppresses hyper-activated Ras-MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans. Cancer Cell Int doi: 10.1186/s12935-019-0880-4.
 
Guo X, Yuan J, Song X, Wang X, Sun Q, Tian J, Li X*, Ding M*, and Liu Y*. (2019) Bacteria metabolites from Peganum harmala L. polysaccharides inhibits polyQ aggregation through proteasome-mediated protein degradation in C. elegans. Int J Biol Macromol doi: 10.1016/j.ijbiomac.2020.06.091.
 
Yang X, Liang J, Ding L, Li X, Lam S-M, Shui G, Ding M and Huang X*. (2019) Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. PLoS Genetics 15:e1008548 PMID: 31869331
 
Wang J# and Ding M*. (2018) Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in C. elegansPNAS doi:10.1073/pnas.1717468115.
 
Yao Y, Li X, Wang W, Liu Z, Chen J, Ding M and Huang X*. (2018) MRT, functioning with NURF complex, regulates lipid droplet size. Cell Reports 24:2972-2984 PMID: 30208321
 
Ding L, Yang X, Tian H, Liang J, Zhang F, Wang G, Wang Y, Ding M, Shui G and Huang X*. (2018) Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. EMBO J37:e97572 PMID: 30049710
 
Guan L#, Ma X#, Zhang J, Liu J, Wang Y, and Ding M*. (2016) The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions. PLoS Genetics Jul 14;12(7):e1006163. 
 
Cheng Y#, Wang J#, Wang Y, and Ding M*. (2015) Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. eLife 4:e05118.
 
Wu J, Cheng Y, Wang J, Chen L, Ding M, and Wu J*.(2015) Structural insight into the mechanism of synergic autoinhibition of SAD kinases. Nature Communications doi: 10.1038/ncomms9953.
 
Wang J, Chitturi J, Ge Q, Laskova V, Wang W, Li X, Ding M, Zhen M* and Huang X*. (2015) The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development 142:1447-1457.
 
Qin J, Liang J, and Ding M*. (2014) Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons. Journal of Neuroscience 34(31):10311-10324.
 
Zhang J, Li X, Jevince AR, Guan L, Wang J, Hall DH, Huang X*, and Ding M*. (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegansPLoS Genetics 9(6): e1001056.
 
Song S#, Zhang B#, Sun H, Li X, Xiang Y, Liu Z, Huang X*, and Ding M*. (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegansPLoS Genetics 6(8): e1003618.
 
Ding M* and Shen K. (2008) The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessay 30: 1075-1083.
 
Ding M, King RS, Berry EC, Wang Y, Hardin J, and Chisholm AD. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PLoS One 3: e3346.
 
Ding M, Chao D, Wang G, Shen K. (2007) Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science 317, 947-951.
 
Ding M, Woo WM, Chisholm AD. (2004) The cytoskeleton and epidermal morphogenesis in C. elegansExp Cell Res 301:84-90.
 
Ding M, Goncharov A, Jin Y, Chisholm AD. (2003) C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development 130:5791-5801.