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戴建武


戴建武,博士,研究员,博士生导师
 
教育经历及任职::
        武汉大学生物系细胞生物学专业 本科
        北京医科大学生物物理学专业 硕士
        美国杜克大学细胞生物学专业 博士
        哈佛大学医学院 博士后研究
        2003-至今:中国科学院遗传与发育生物学研究所研究员,再生医学研究中心主任。
        国家杰出青年基金获得者。
        国家食品药品监督管理局医疗器械审评专家     
        英国皇家化学学会生物材料咨询委员会委员
        中国细胞生物学学会干细胞分会副会长兼秘书长
        儿科重大疾病研究教育部重点实验室学术委员会委员
        Biomedical Materials 杂志主编
        Biomaterials 杂志编委
        SCIENCE CHINA LIFE SCIENCES 杂志编委
        中国损伤与修复杂志电子版 特约顾问
        中华神经医学杂志第三届编辑委员会 副总编辑


主要研究方向:
        1)组织器官再生微环境研究
        2)组织器官再生修复产品研发
        3)组织器官制造
 
承担的国家项目:
        2006-2010  科技部国家重大科学研究计划项目“干细胞自我更新调控网络的研究”项目首席科学家
        2010-2012  国家自然基金委,重大科学研究计划培育项目“OCT4异构体的表达、功能和调节机制研究”,项目负责人
        2010-2013  国家自然基金委重点项目“神经再生环境的构建”,项目负责人
        2011-2013  国家自然基金委,中加(NSFC-CIHR)健康研究合作计划“胶原结合能力的血管内皮生长因子对猪心肌损伤的治疗作用及安全性评价”,项目负责人
        2011-2015  科技部国家重大科学研究计划项目“三维培养干细胞自我更新调控网络的研究”,项目首席科学家
        2011-2015  中国科学院“干细胞与再生医学”战略性科技先导专项“人工组织器官构建”项目负责人
        2013-2015  中国科学院科研装备研制项目“面向干细胞微环境构建的低温细胞3D重建系统”项目负责人
        2016-2018  中国科学院重点部署项目“组织器官再生与损伤修复”项目负责人
        2016-2021  国家重点研发计划项目“出生缺陷组织器官再生修复产品的研发”项目首席科学家
        2017-2022  中国科学院“器官重建与制造”战略性科技先导专项“临床研究转化”项目负责人及“脊髓组织制造”课题负责人
        2019-2023  国家自然基金委重大项目“脊髓损伤再生修复机理及临床转化研究”项目负责人
 
获奖情况:
        2010年:中国科学院遗传与发育生物学研究所益海嘉里“优秀导师奖”
        2012年:心肌梗死后心肌组织修复和功能重建的机制研究及临床应用,国家科技部,国家科学技术进步奖二等奖
        2014年:中央电视台年度科技创新人物。
        2016年:第六届中国侨界再生医学创新成果奖。
        2017年:中国细胞生物学学会干细胞生物学分会干细胞成果转化奖
        2018年:子宫内膜再生研究获2018年度江苏省科学技术一等奖
 
代表性成果
          突破了再生医学关键技术。研发了具有自主知识产权的系列再生医学产品,在脊髓损伤再生修复、子宫内膜、脊髓、心肌等组织损伤的大动物实验中都显示了良好的修复效果;提出组织内源干细胞的激活与分化是组织再生的重要机理;在率先组织领导了包括子宫内膜再生、卵巢再生、脊髓损伤再生,心肌再生等多个产品的临床研究。
          合作研发子宫内膜再生修复产品并进入临床研究阶段,为子宫内膜损伤的不孕患者提供了一种有效的治疗手段,入选2014年中央电视台年度科技创新人物;卵巢再生修复取突破,第一个卵巢早衰患者2018年1月12日诞生世界上首位健康宝宝。子宫内膜再生卵巢再生及脊髓损伤再生成果入选国家改革开放40周年创新成果展。
          脊髓损伤再生研究取得重大突破。提出利用功能生物材料重建神经再生微环境的技术思路。研发的神经再生胶原支架材料可有效引导全横断脊髓损伤动物和患者神经再生和自主运动功能恢复。脊髓损伤再生修复的临床研究已走在世界前列。
 
主要研究方向:
        1)组织器官再生微环境研究
        2)组织器官再生修复产品研发
        3)组织器官制造
 
承担的国家项目:
        2006-2010  科技部国家重大科学研究计划项目“干细胞自我更新调控网络的研究”项目首席科学家
        2010-2012  国家自然基金委,重大科学研究计划培育项目“OCT4异构体的表达、功能和调节机制研究”,项目负责人
        2010-2013  国家自然基金委重点项目“神经再生环境的构建”,项目负责人
        2011-2013  国家自然基金委,中加(NSFC-CIHR)健康研究合作计划“胶原结合能力的血管内皮生长因子对猪心肌损伤的治疗作用及安全性评价”,项目负责人
        2011-2015  科技部国家重大科学研究计划项目“三维培养干细胞自我更新调控网络的研究”,项目首席科学家
        2011-2015  中国科学院“干细胞与再生医学”战略性科技先导专项“人工组织器官构建”项目负责人
        2013-2015  中国科学院科研装备研制项目“面向干细胞微环境构建的低温细胞3D重建系统”项目负责人
        2016-2018  中国科学院重点部署项目“组织器官再生与损伤修复”项目负责人
        2016-2021  国家重点研发计划项目“出生缺陷组织器官再生修复产品的研发”项目首席科学家
        2017-2022  中国科学院“器官重建与制造”战略性科技先导专项“临床研究转化”项目负责人及“脊髓组织制造”课题负责人
        2019-2023  国家自然基金委重大项目“脊髓损伤再生修复机理及临床转化研究”项目负责人
 
获奖情况:
        2010年:中国科学院遗传与发育生物学研究所益海嘉里“优秀导师奖”
        2012年:心肌梗死后心肌组织修复和功能重建的机制研究及临床应用,国家科技部,国家科学技术进步奖二等奖
        2014年:中央电视台年度科技创新人物。
        2016年:第六届中国侨界再生医学创新成果奖。
        2017年:中国细胞生物学学会干细胞生物学分会干细胞成果转化奖
        2018年:子宫内膜再生研究获2018年度江苏省科学技术一等奖
 
代表性成果
          突破了再生医学关键技术。研发了具有自主知识产权的系列再生医学产品,在脊髓损伤再生修复、子宫内膜、脊髓、心肌等组织损伤的大动物实验中都显示了良好的修复效果;提出组织内源干细胞的激活与分化是组织再生的重要机理;在率先组织领导了包括子宫内膜再生、卵巢再生、脊髓损伤再生,心肌再生等多个产品的临床研究。
          合作研发子宫内膜再生修复产品并进入临床研究阶段,为子宫内膜损伤的不孕患者提供了一种有效的治疗手段,入选2014年中央电视台年度科技创新人物;卵巢再生修复取突破,第一个卵巢早衰患者2018年1月12日诞生世界上首位健康宝宝。子宫内膜再生卵巢再生及脊髓损伤再生成果入选国家改革开放40周年创新成果展。
          脊髓损伤再生研究取得重大突破。提出利用功能生物材料重建神经再生微环境的技术思路。研发的神经再生胶原支架材料可有效引导全横断脊髓损伤动物和患者神经再生和自主运动功能恢复。脊髓损伤再生修复的临床研究已走在世界前列。
 
团队成员:
 
工作人员:
陈  冰  博士   副研究员
 
肖志峰  博士   副研究员
赵燕南  博士   副研究员
 
吴宪明  博士   副研究员
韩素芳  博士   助理研究员
 
施  雅  博士   工程师
侯祥林  硕士   工程师
 
李佳音  博士   工程师
尹艳云  硕士   助理工程师
 
张娇娇  硕士   助理工程师
刘文斌  硕士   助理工程师
 
张  权  学士   助理工程师
孙明瀚  硕士
 
褚淑秒  学士
 
博士后:
徐白 张琪 薛伟伟  薛晓钰
博士研究生:
舒慕娅  杨颖  张海鹏  马德尊  范永恒  金辰
硕士研究生:
刘为远  孙政
客座研究人员:
崔熠  邹云龙
 
毕业离所学生:
索广力 博士 (中科院苏州纳米所)
张经余 博士  (赛默飞世尔科技)
赵艳红 博士  (中检院)
林  航 博士  (匹兹堡大学)
赵文学 博士  (加州大学旧金山分校)
王  霞 博士  (清华大学)
王  斌 博士  (南京大学鼓楼医院)
孙文杰 博士  (山东大学)
张  晶 博士  (首都医科大学)
高  原 博士  (北京宝洁技术有限公司)
韩倩倩 博士  (中检院)
高  健 硕士  (雀巢(中国)有限公司)
曹佳妮 博士 (中科院动物所)
陈  磊 博士 (河南信阳师范学院)
苏冠男 博士 (重庆医科大学附属第一医院)
肖汉山 硕士 (天风证券)
魏建树 博士 (北京301医院)
杨  赟 博士 (加州大学圣地亚哥分校)
施春英 博士 (青岛大学)
李  星 博士(中南大学)
刘素梅 博士 (宣武医院)
栾梁琪 硕士(维通达生物技术有限公司)
韩  津 博士 (专利局专利审查协作北京中心)
杨亚明 博士(中科院动物所)
韩素芳 博士(华南农业大学)
薛伟伟 博士(复旦大学脑科学转化研究院)
 
 
 
媒体报道:(网页视频链接形式)

 
 
 
媒体报道:(网页视频链接形式)

 

近期发表的文章(2015年至今):
 
 
2. Chen Z, Zhang H, Fan C, Zhuang Y, Yang W, Chen Y, Shen H, Xiao Z, Zhao Y*, Li X*, Dai, J.* Adhesive, Stretchable, and Spatiotemporal Delivery Fibrous Hydrogels Harness Endogenous Neural Stem/Progenitor Cells for Spinal Cord Injury Repair. ACS Nano. 2021 Nov 29. doi: 10.1021/acsnano.1c06892.
 
3. Shen, H., Fan, C., You, Z., Xiao, Z., Zhao, Y*., Dai, J.* (2021). Advances in Biomaterial‐Based Spinal Cord Injury Repair. Advanced Functional Materials, 2110628.
 
4. Shen H, Xu B, Yang C, Xue W, You Z, Wu X, Ma D, Shao D, Leong K, Dai, J.* A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury. Biomaterials. 2021 Nov 25;280:121279. doi: 10.1016/j.biomaterials.2021.121279
 
5. Yu Y, Liu X, Zhao Z, Xu Z, Qiao Y, Zhou Y, Qiao H, Zhong J, Dai J, Suo G*. The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice. Front Pharmacol. 2021 Dec 6;12:747223. doi: 10.3389/fphar.2021.747223.
 
6. Wang H, Zhu C, Xu Z, Wei X, Shen H, Wang L, Wang B, Chen B, Zhao Y, Yu C, Dai, J.* Gao X. Clinical application of collagen membrane with umbilical cord-derived mesenchymal stem cells to repair nasal septal perforation. Biomed Mater. 2021 Nov 11;17(1)..
 
7. Zhang Q, Wu X, Fan Y, Jiang P, Zhao Y, Yang Y, Han S, Xu B, Chen B, Han J, Sun M, Zhao G, Xiao Z, Hu Y, Dai, J.* Single-cell analysis reveals dynamic changes of neural cells in developing human spinal cord. EMBO Rep. 2021 Nov 4;22(11):e52728 doi: 10.15252/embr.202152728
 
8. Chu Y, Huang L, Hao W, Zhao T, Zhao H, Yang W, Xie X, Qian L, Chen Y, Dai, J.* Long-term stability, high strength, and 3D printable alginate hydrogel for cartilage tissue engineering application. Biomed Mater. 2021 Sep 28;16(6). doi: 10.1088/1748-605X/ac2595
 
9.Tang F, Tang J, Zhao Y, Zhang J, Xiao Z, Chen B, Han G, Yin N, Jiang X, Zhao C, Cheng S, Wang Z, Chen Y, Chen Q, Song K, Zhang Z, Niu J, Wang L, Shi Q, Chen L, Yang H, Hou S, Zhang S, Dai, J.*. Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold. Sci China Life Sci. 2021 Aug 16. doi: 10.1007/s11427-021-1985-5.
 
10.Cao Y, Shi Y, Xiao Z, Chen X, Chen B, Yang B, Shu M, Yin Y, Wu S, Yin W, Fu X, Tan J, Zhou Q, Wu Z, Jiang X, Dai, J.*. Contralateral Axon Sprouting but Not Ipsilateral Regeneration Is Responsible for Spontaneous Locomotor Recovery Post Spinal Cord Hemisection. Front Cell Neurosci. 2021 Aug 26;15:730348. doi: 10.3389/fncel.2021.730348.
 
11.Shu M, Xue X, Nie H, Wu X, Sun M, Qiao L, Li X, Xu B, Xiao Z, Zhao Y, Fan Y, Chen B, Zhang J, Shi Y, Yang Y, Lu F, Dai, J.* Single-cell RNA sequencing reveals Nestin+ active neural stem cells outside the central canal after spinal cord injury. Sci China Life Sci. 2021 May 28. doi: 10.1007/s11427-020-1930-0. Epub ahead of print.
 
12.Yin W, Xue W, Zhu H, Shen H, Xiao Z, Wu S, Zhao Y, Cao Y, Tan J, Li J, Liu W, Wang L, Meng L, Chen B, Zhao M, Jiang X, Li X, Ren C, Dai, J.* Scar tissue removal-activated endogenous neural stem cells aid Taxol-modified collagen scaffolds in repairing chronic long-distance transected spinal cord injury. Biomater Sci. 2021 May 27. doi: 10.1039/d1bm00449b.
 
13.Huang L, Chu Y, Zhang L, Liu X, Hao W, Chen Y, Dai, J.* High strength pure chitosan hydrogels via double crosslinking strategy. Biomed Mater. 2021 Jun 28;16(4). doi: 10.1088/1748-605X/ac058c
 
14.Xue W, Zhang H, Fan Y, Xiao Z, Zhao Y, Liu W, Xu B, Yin Y, Chen B, Li J, Cui Y, Shi Y, Dai, J.* Upregulation of Apol8 by Epothilone D facilitates the neuronal relay of transplanted NSCs in spinal cord injury. Stem Cell Res Ther. 2021 May 26;12(1):300.
 
15.Liu X, Hao M, Chen Z, Zhang T, Huang J, Dai, J.* Zhang Z. 3D bioprinted neural tissue constructs for spinal cord injury repair. Biomaterials. 2021 May;272:120771.
 
16.Cui Y, Yin Y, Zou Y, Zhao Y, Han J, Xu B, Chen B, Xiao Z, Song H, Shi Y, Xue W, Ma X, Dai, J.*. The Rotary Cell Culture System increases NTRK3 expression and promotes neuronal differentiation and migratory ability of neural stem cells cultured on collagen sponge. Stem Cell Res Ther. 2021 May 21;12(1):298.
 
17.Xue X, Shu M, Xiao Z, Zhao Y, Li X, Zhang H, Fan Y, Wu X, Chen B, Xu B, Yang Y, Liu W, Liu S, Dai, J.*. Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury. Sci China Life Sci. 2021 Mar 24. doi: 10.1007/s11427-020-1901-4.
 
18.Xue W, Fan C, Chen B, Zhao Y, Xiao Z, Dai, J.* Direct neuronal differentiation of neural stem cells for spinal cord injury repair. Stem Cells. 2021 Mar 3. doi: 10.1002/stem.3366
 
19.Liu D, Shu M, Liu W, Shen Y, Long G, Zhao Y, Hou X, Xiao Z, Dai, J.* Li X*. Binary scaffold facilitates in situ regeneration of axons and neurons for complete spinal cord injury repair. Biomater Sci. 2021 Feb 26. doi: 10.1039/d0bm02212h.
 
20.Liu D, Shen H, Shen Y, Long G, He X, Zhao Y, Yang Z, Dai, J.*, Li X. Dual-Cues Laden Scaffold Facilitates Neurovascular Regeneration and Motor Functional Recovery After Complete Spinal Cord Injury. Adv Healthc Mater. 2021 Mar 19:e2100089. doi: 10.1002/adhm.202100089.
 
21.Zhang L, Fan C, Hao W, Zhuang Y, Liu X, Zhao Y, Chen B, Xiao Z, Chen Y, Dai, J.* NSCs Migration Promoted and Drug Delivered Exosomes-Collagen Scaffold via a Bio-Specific Peptide for One-Step Spinal Cord Injury Repair. Adv Healthc Mater. 2021 Feb 1:e2001896. doi: 10.1002/adhm.202001896.
 
22.  Wang, Q., He, X., Wang, B., Pan, J., Shi, C., Li, J., Wang, L., Zhao, Y., Dai, J. *, Wang, D. *,. Injectable collagen scaffold promotes swine myocardial infarction recovery by long-term local retention of transplanted human umbilical cord mesenchymal stem cells. Science China Life Sciences. 2021 Feb;64(2):269-281.
 
23.Yang, Y., Fan, Y., Zhang, Q., Xiao, Z., Liu, W., Chen, B., Sun, Z., Xue, X., Shu, M., Dai, J.* . Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury. Biomaterials. 2021 Feb;269:120479
 
24.Zhang H, Xue W, Xue X, Fan Y, Yang Y, Zhao Y, Chen B, Yin Y, Yang B, Xiao Z, Dai, J.*   Spatiotemporal dynamic changes, proliferation, and differentiation characteristics of Sox9-positive cells after severe complete transection spinal cord injury. Exp Neurol. 2021 Mar;337:113556
 
25.Long G , Liu D , He X , Shen Y , Zhao Y , Hou X , Chen B , OuYang W , Dai, J.*, Li X *. A dual functional collagen scaffold coordinates angiogenesis and inflammation for diabetic wound healing. Biomater Sci. 2020 Nov 21;8(22):6337-6349.[LJY1] 
 
26.Zhang X, Liu Y, Clark KL, Padget AM, Alexander PG, Dai, J., Zhu W*, Lin H*. Mesenchymal stem cell-derived extracellular matrix (mECM): a bioactive and versatile scaffold for musculoskeletal tissue engineering. Biomed Mater. 2020 Dec 23;16(1):012002.
 
27.He, X., Wang, Q., Zhao, Y., Zhang, H., Wang, B., Pan, J., Li, Jie., Yu. H., Wang, L., Dai, J. *, Wang, D. *,. Effect of Intramyocardial Grafting Collagen Scaffold With Mesenchymal Stromal Cells in Patients With Chronic Ischemic Heart Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(9):e2016236. doi:10.1001/jamanetworkopen.2020.16236
 
28.Zou, Y., Ma, D., Shen, H. Zhao, Y., Xu, B., Fan, Y., Sun, Z., Chen, B., Xue, W., Shi, Y., Xiao, Z., Gu, R. and Dai, J.*, Aligned collagen scaffold combination with human spinal cord-derived neural stem cells to improve spinal cord injury repair. Biomater. Sci., 2020. Advance Article , DOI: 10.1039/D0BM00431F
 
29.  Wang, Q., He, X., Wang, B., Pan, J., Shi, C., Li, J., Wang, L., Zhao, Y., Dai, J. *, Wang, D. *, (2020). Injectable collagen scaffold promotes swine myocardial infarction recovery by long-term local retention of transplanted human umbilical cord mesenchymal stem cells. Science China Life Sciences. 10.1007/s11427-019-1575-x.
 
30.Cui,Y., Xu, B., Yin, Y., Chen, B., Zhao, Y., Xiao, Z., Yang, Bin, Shi, Y., Fang,Y., Ma,X., Dai, J.* Collagen particle with collagen-binding bone morphogenetic protein-2 promotes vertebral laminar regeneration in infant rabbits. Biomed Mater. 2020, doi: 10.1088/1748-605X/ab9fce. Online ahead of print
 
31.Shen, Y., Shen, H., Guo, D., Sun, X., Sun, Y., Hong, N., Wang, X., Xie, C., Zhao, Y., He, Q., Jin, L., Wen, Y., Jiang, B., Yu, C., Zhu, M., Cai, F., Dai, J.* Recent developments in regenerative ophthalmology. Sci China Life Sci. 2020, doi: 10.1007/s11427-019-1684-x.
 
32.Dai, J.  The growth and development of Biomedical Materials. 2020, Biomedical Materials 15, 040201, doi:10.1088/1748-605x/ab816b.
 
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