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戴建武


戴建武,博士,研究员,博士生导师
 
教育经历及任职::
        武汉大学生物系细胞生物学专业 本科
        北京医科大学生物物理学专业 硕士
        美国杜克大学细胞生物学专业 博士
        哈佛大学医学院 博士后研究
        2003-至今:中国科学院遗传与发育生物学研究所研究员,再生医学研究中心主任。
        国家杰出青年基金获得者。
        国家食品药品监督管理局医疗器械审评专家     
        英国皇家化学学会生物材料咨询委员会委员
        中国细胞生物学学会干细胞分会副会长兼秘书长
        儿科重大疾病研究教育部重点实验室学术委员会委员
        Biomedical Materials 杂志主编
        Biomaterials 杂志编委
        SCIENCE CHINA LIFE SCIENCES 杂志编委
        中国损伤与修复杂志电子版 特约顾问
        中华神经医学杂志第三届编辑委员会 副总编辑


主要研究方向:
        1)组织器官再生微环境研究
        2)组织器官再生修复产品研发
        3)组织器官制造
 
承担的国家项目:
        2006-2010  科技部国家重大科学研究计划项目“干细胞自我更新调控网络的研究”项目首席科学家
        2010-2012  国家自然基金委,重大科学研究计划培育项目“OCT4异构体的表达、功能和调节机制研究”,项目负责人
        2010-2013  国家自然基金委重点项目“神经再生环境的构建”,项目负责人
        2011-2013  国家自然基金委,中加(NSFC-CIHR)健康研究合作计划“胶原结合能力的血管内皮生长因子对猪心肌损伤的治疗作用及安全性评价”,项目负责人
        2011-2015  科技部国家重大科学研究计划项目“三维培养干细胞自我更新调控网络的研究”,项目首席科学家
        2011-2015  中国科学院“干细胞与再生医学”战略性科技先导专项“人工组织器官构建”项目负责人
        2013-2015  中国科学院科研装备研制项目“面向干细胞微环境构建的低温细胞3D重建系统”项目负责人
        2016-2018  中国科学院重点部署项目“组织器官再生与损伤修复”项目负责人
        2016-2021  国家重点研发计划项目“出生缺陷组织器官再生修复产品的研发”项目首席科学家
        2017-2022  中国科学院“器官重建与制造”战略性科技先导专项“临床研究转化”项目负责人及“脊髓组织制造”课题负责人
        2019-2023  国家自然基金委重大项目“脊髓损伤再生修复机理及临床转化研究”项目负责人
 
获奖情况:
        2010年:中国科学院遗传与发育生物学研究所益海嘉里“优秀导师奖”
        2012年:心肌梗死后心肌组织修复和功能重建的机制研究及临床应用,国家科技部,国家科学技术进步奖二等奖
        2014年:中央电视台年度科技创新人物。
        2016年:第六届中国侨界再生医学创新成果奖。
        2017年:中国细胞生物学学会干细胞生物学分会干细胞成果转化奖
        2018年:子宫内膜再生研究获2018年度江苏省科学技术一等奖
 
代表性成果
          突破了再生医学关键技术。研发了具有自主知识产权的系列再生医学产品,在脊髓损伤再生修复、子宫内膜、脊髓、心肌等组织损伤的大动物实验中都显示了良好的修复效果;提出组织内源干细胞的激活与分化是组织再生的重要机理;在率先组织领导了包括子宫内膜再生、卵巢再生、脊髓损伤再生,心肌再生等多个产品的临床研究。
          合作研发子宫内膜再生修复产品并进入临床研究阶段,为子宫内膜损伤的不孕患者提供了一种有效的治疗手段,入选2014年中央电视台年度科技创新人物;卵巢再生修复取突破,第一个卵巢早衰患者2018年1月12日诞生世界上首位健康宝宝。子宫内膜再生卵巢再生及脊髓损伤再生成果入选国家改革开放40周年创新成果展。
          脊髓损伤再生研究取得重大突破。提出利用功能生物材料重建神经再生微环境的技术思路。研发的神经再生胶原支架材料可有效引导全横断脊髓损伤动物和患者神经再生和自主运动功能恢复。脊髓损伤再生修复的临床研究已走在世界前列。
 
团队成员:
 
工作人员:
陈  冰  博士   副研究员
 
肖志峰  博士   副研究员
赵燕南  博士   副研究员
 
吴宪明  博士   副研究员
韩素芳  博士   助理研究员
 
施  雅  博士   工程师
侯祥林  硕士   工程师
 
李佳音  博士   工程师
尹艳云  硕士   助理工程师
 
张娇娇  硕士   助理工程师
刘文斌  硕士   助理工程师
 
张  权  学士   助理工程师
孙明瀚  硕士
 
褚淑秒  学士
 
博士后:
徐白 张琪 薛伟伟  薛晓钰
博士研究生:
舒慕娅  杨颖  张海鹏  马德尊  范永恒  金辰
硕士研究生:
刘为远  孙政
客座研究人员:
崔熠  邹云龙
 
毕业离所学生:
索广力 博士 (中科院苏州纳米所)
张经余 博士  (赛默飞世尔科技)
赵艳红 博士  (中检院)
林  航 博士  (匹兹堡大学)
赵文学 博士  (加州大学旧金山分校)
王  霞 博士  (清华大学)
王  斌 博士  (南京大学鼓楼医院)
孙文杰 博士  (山东大学)
张  晶 博士  (首都医科大学)
高  原 博士  (北京宝洁技术有限公司)
韩倩倩 博士  (中检院)
高  健 硕士  (雀巢(中国)有限公司)
曹佳妮 博士 (中科院动物所)
陈  磊 博士 (河南信阳师范学院)
苏冠男 博士 (重庆医科大学附属第一医院)
肖汉山 硕士 (天风证券)
魏建树 博士 (北京301医院)
杨  赟 博士 (加州大学圣地亚哥分校)
施春英 博士 (青岛大学)
刘素梅 博士 (宣武医院)
栾梁琪 硕士
韩  津 博士 (专利局专利审查协作北京中心)
杨亚明 博士(中科院动物所)
 
 
 
媒体报道:(网页视频链接形式)

 

近期发表的文章(2015年至今):
 
1.He, X., Wang, Q., Zhao, Y., Zhang, H., Wang, B., Pan, J., Li, Jie., Yu. H., Wang, L., Dai, J. *, Wang, D. *,. Effect of Intramyocardial Grafting Collagen Scaffold With Mesenchymal Stromal Cells in Patients With Chronic Ischemic Heart Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(9):e2016236. doi:10.1001/jamanetworkopen.2020.16236
 
2.Zou, Y., Ma, D., Shen, H. Zhao, Y., Xu, B., Fan, Y., Sun, Z., Chen, B., Xue, W., Shi, Y., Xiao, Z., Gu, R. and Dai, J.*, Aligned collagen scaffold combination with human spinal cord-derived neural stem cells to improve spinal cord injury repair. Biomater. Sci., 2020. Advance Article , DOI: 10.1039/D0BM00431F
 
3. Wang, Q., He, X., Wang, B., Pan, J., Shi, C., Li, J., Wang, L., Zhao, Y., Dai, J. *, Wang, D. *, (2020). Injectable collagen scaffold promotes swine myocardial infarction recovery by long-term local retention of transplanted human umbilical cord mesenchymal stem cells. Science China Life Sciences. 10.1007/s11427-019-1575-x.
 
4.Cui,Y., Xu, B., Yin, Y., Chen, B., Zhao, Y., Xiao, Z., Yang, Bin, Shi, Y., Fang,Y., Ma,X., Dai, J.* Collagen particle with collagen-binding bone morphogenetic protein-2 promotes vertebral laminar regeneration in infant rabbits. Biomed Mater. 2020, doi: 10.1088/1748-605X/ab9fce. Online ahead of print
 
5.Shen, Y., Shen, H., Guo, D., Sun, X., Sun, Y., Hong, N., Wang, X., Xie, C., Zhao, Y., He, Q., Jin, L., Wen, Y., Jiang, B., Yu, C., Zhu, M., Cai, F., Dai, J.* Recent developments in regenerative ophthalmology. Sci China Life Sci. 2020, doi: 10.1007/s11427-019-1684-x.
 
6.Dai, J.The growth and development of Biomedical Materials. 2020, Biomedical Materials 15, 040201, doi:10.1088/1748-605x/ab816b.
 
7.Guangfeng Zhao, G., Li, R., Cao, Y., Song, M., Jiang, P., Wu, Q., Zhou, Z., Zhu, H., Wang, H., Dai, H., Liu, D., Yao, S., Lv, H., Wang, L., Dai, J.*, Zhou, Y.*, Hu, Y.* ΔNp63α-induced DUSP4/GSK3β/SNAI1 pathway in epithelial cells drives endometrial fibrosis. Cell Death Dis. 11(6):449. 2020
 
8.Liu, W., Xu, B., Xue, W., Yang, B., Fan, Y., Chen, B., Xiao, Z., Xue, X., Sun. Z., Shu, M., Zhang. Q., Shi, Y., Zhao, Y.*, Dai. J.* A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair. Biomaterials. 2020; 243:119941. doi:10.1016/j.biomaterials.2020.119941
 
9.Shen, H., Wu,S., Chen, X., Xu, B., Ma, D., Zhao, Y., Zhuang, Y., Chen, B., Hou, X., Li, J., Cao, Y., Fu, X., Tan, J., Yin, W., Li, J., Meng, L., Shi, Y., Xiao, Z.,* Jiang, X.,* Dai. J.* Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines. Sci China Life Sci, 2020, ISSN 1674-7305, https://doi.org/10.1007/s11427-019-1623-5..
 
10.Zou Y., Zhao Y., Xiao Z., Chen B., Ma D., Shen H. *, Gu R. *, Dai. J.*, Comparison of Regenerative Effects of Transplanting Three-dimensional Longitudinal Scaffold Loaded- hMSCs and hNSCs on Spinal Cord Completely Transected Rats. ACS Biomaterials Science & Engineering. 2020, 6, 4, 1909–1919
 
11.Wang L, Zhao Y, Yang F, Feng M, Zhao Y, Chen X, Mi J, Yao Y, Guan D, Xiao Z, Chen B, Dai. J.* Biomimetic collagen biomaterial induces in situ lung regeneration by forming functional alveolar. Biomaterials. 2020 Apr;236:119825.
 
12.Shen H, Lin H, Sun AX, Song S, Wang B, Yang Y, Dai. J.*, Tuan RS. Acceleration of chondrogenic differentiation of human mesenchymal stem cells by sustained growth factor release in 3D graphene oxide incorporated hydrogels. Acta Biomater. 2020: 44-55.
 
13.Ma D, Zhao Y, Huang L, Xiao Z, Chen B, Shi Y, Shen H, Dai. J.*. A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation. Biomaterials. 2020 Jan 31;237:119830.
 
14.Qiao, Y., Xu, Z., Yu, Y., Hou, S., Geng, J., Xiao, T., Liang, Q., Dong, Q. Mei, Y., Wang, B., Qiao, H., Dai, J.*., Suo, G.*,Single cell derived spheres of umbilical cord mesenchymal stem cells enhance cell stemness properties, survival ability and therapeutic potential on liver failure. Biomaterials, 2020, 227: 119573.
 
15.Xue, W., Zhao, Y., Xiao, Z., Wu, X., Ma, D., Han, J., Li, X., Xue, X., Yang, Ying., Fang, Y., Fan, C., Liu, S., Xu, B., Han, S., Chen, B., Zhang, H., Fan, Y., Liu, W., Dong, Q., Dai, J.*. . Epidermal growth factor receptor‐extracellular‐regulated kinase blockade upregulates TRIM32 signaling cascade and promotes neurogenesis after spinal cord injury. Stem Cells.  2020 Jan;38(1).
 
16.Cui Y., Xu B., Yin Y., Chen B., Zhao Y., Xiao Z., Yang B., Meng Q., Fang Y., Liang Q., Zhou
L., Ma X., Dai, J.*. Repair of lumbar vertebral bone defects by bone particles combined with hUC-MSCs in weaned rabbit. Regenerative Medicine. 2019, 14(10):915-92.
 
17.Cui Y., Yin Y., Xiao Z., Zhao Y., Chen B., Yang B., Xu B., Song H., Zou Y., Ma X., Dai, J.*. (2019). LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells. Stem Cell Research & Therapy. 2019, 10(1):400.
 
18.Shi, J., Fan, C., Zhuang, Y., Sun, J., Hou, X., Chen, B., Xiao, Z., Chen, Y., Zhan, Z., Zhao, Y. *, Dai, J.*.. Heparan sulfate proteoglycan promotes fibroblast growth factor-2 function for ischemic heart repair. Biomaterials Science, 2019. 7(12), 5438-5450.
 
19.Shi, L., Zeng, Y., Zhao, Y., Yang, B., Ossipov, D., Tai, C. W., . Dai, J.*., Xu, C.*, Biocompatible Injectable Magnetic Hydrogel Formed by Dynamic Coordination Network[J]. ACS Appl. Mater. Interfaces 2019, 11, 49, 46233-46240
 
20.Yang Y., Chen R., Wu X., Zhao Y., Fan Y., Xiao Z., Han J., Sun L., Wang X., Dai, J.*. Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons. Stem Cell Reports. 2019, 13(5):862-876.
 
21.Jiang, P., Tang, X., Wang, H. Dai, C., Su, J., Zhu, H., Song, M., Liu, J., Nan, Z., Li, Y., Wang, J., Chen, B., Dai, J.*, Hu, Y.,. Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study. Sci. China Life Sci.2019, 62(12): 1617-1629.
 
22.Fan, C., Shi, J., Zhuang, Y., Zhang, L., Huang, L., Yang, W., Chen, B., Chen, Y., Xiao, Z., Shen, H., Zhao, Y., Dai, J.*., Myocardial Infarction Responsive Smart Hydrogels Targeting Matrix Metalloproteinase for On-Demand Growth Factor Delivery. Adv. Mater. 2019, 31(40). Liu, D., Li, X., Xiao, Z,. Yin, W., Zhao, Y., Tan, J., Chen, B., Jiang, X., Dai, J.* Different functional bio-scaffolds share similar neurological mechanism to promote locomotor recovery of canines with complete spinal cord injury. Biomaterials. 214:119230, 2019
 
23.Shen, H., Chen, X., Li, X., Jia, K., Xiao, Z., Dai, J.* Transplantation of adult spinal cord grafts into spinal cord transected rats improves their locomotor function. Sci China Life Sci. 62(6):725-733, 2019
 
24.Xue, B., Liu, D., Song, M., Zhao, G., Cao, Y., Yan, G., Dai, J.,* Hu, Y. * Leukemia inhibitory factor promotes the regeneration of rat uterine horns with full-thickness injury. Wound Repair Regen. doi: 10.1111/wrr.12729. [Epub ahead of print], 2019
 
25.Li, X., Chen, Z., Zhang, H., Zhuang, Y., Shen, H., Chen, Y., Zhao, Y., Chen, B., Xiao, Z., Dai,J.*Aligned scaffolds with biomolecular gradients for regenerative medicine. Polymers. 197: 20-31, 2019
 
26.Li, X., Liu, D., Xiao, Z., Zhao, Y., Han, S., Chen, B., Dai, J.* Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation. Biomaterials 197: 20-31, 2019
 
27.Han S, Yin W, Li X, Wu S, Cao Y, Tan J, Zhao Y, Hou X, Wang L, Ren C, Li J, Hu X, Mao Y, Li G, Li B, Zhang H, Han J, Chen B, Xiao Z, Jiang X, Dai, J.* Pre-Clinical Evaluation of CBD-NT3 Modified Collagen Scaffolds in Completely Spinal Cord Transected Non-Human Primates. J Neurotrauma. doi.org/10.1089/neu.2018.6078 [Epub ahead of print]. 2019
 
28.Liu, S., Xiao, Z., Li, X., Zhao, Y., Wu, X., Han, J., Chen, B., Li, J., Fan, C., Xu, B., Xue, X., Xue, W., Yang, Y., Dai, J.* Vascular endothelial growth factor activates neural stem cells through epidermal growth factor receptor signal after spinal cord injury. CNS Neurosci Ther.197:20-31, 2019
 
29.Ding, L., Yan, G., Wang, B., Xu, L., Gu, Y., Ru, T., Cui, X., Lei, L., Liu, J., Sheng, X., Wang, B., Zhang, C., Yang, Y., Jiang, R., Zhou, J., Kong, N., Lu, F., Zhou, H., Zhao, Y., Chen, B., Hu, Y.*, Dai, J.*, Sun, H.* Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility. Sci China Life Sci. 61(12):1554-1565, 2018
 
30.Li, J., Chen, T., Huang, X., Zhao, Y., Wang, B., Yin, Y., Cui, Y., Zhao, Y., Zhang, R., Wang, X., Wang, Y., Dai, J.* Substrate-independent immunomodulatory characteristics of mesenchymal stem cells in three-dimensional culture. PloS One. 13(11):e0206811. 2018
 
31.Yin, W., Li, X., Zhao, Y., Tan, J., Wu, S., Cao, Y., Li, J., Zhu, H., Liu, W., Tang, G., Meng, L., Wang, L., Zhu, B., Wang, G., Zhong, M., Liu, X., Xie, D., Chen, B., Ren, C., Xiao, Z., Jiang, X.*, Dai, J.* Taxol-modified collagen scaffolds implantation promotes functional recovery after long-distance spinal cord complete transection in canines. Biomaterials Sci. 6(5):1099-1108. 2018
 
32.Cui, Y., Yao, Y., Zhao, Y., Xiao, Z., Cao, Z., Han, S., Li, X., Huan, Y., Pan, J.* Dai, J.* Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs. J Tissue Eng Regen Med. 12(5):1285-1296. 2018
 
33.Hao, Y.*, Ran, Y., Lu, B., Li, J., Zhang, J., Feng, C., Fang, J., Ma, R., Qiao, Z., Dai, X., Xiong, W., Liu, J., Zhou, Q., Hao, J., Li, R.*, Dai, J.* Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells on Canine Radiation-Induced Lung Injury. Int J Radiat Oncol Biol Phys. 102(2):407-416. 2018
 
34.Cui, Y., Lu, C., Chen, B., Han, J., Zhao, Y., Xiao, Z., Han, S., Pan, J.*, Dai, J.* Restoration of mandibular bone defects with demineralized bone matrix combined with three-dimensional cultured bone marrow-derived mesenchymal stem cells in minipig models. J Mater Sci Mater Med. 29(9):147. 2018
 
35.Hao, W., Han, J., Chu, Y., Huang, L., Zhuang, Y., Sun, J., Li, X., Zhao, Y., Chen, Y., Dai, J.* Collagen/Heparin Bi-Affinity Multilayer Modified Collagen Scaffolds for Controlled bFGF Release to Improve Angiogenesis In Vivo. Macromol Biosci. e1800086. 2018
 
36.Li, X., Fan, C., Xiao, Z., Zhao, Y., Zhang, H., Sun, J., Zhuang, Y., Wu, X., Shi, J., Chen, Y., Dai, J.* A collagen microchannel scaffold carrying paclitaxel-liposomes induces neuronal differentiation of neural stem cells through Wnt/β-catenin signaling for spinal cord injury repair. Biomaterials. 183:114-127. 2018
 
37.Cao, Y., Sun, H., Zhu, H., Zhu, X., Tang, X., Yan, G., Wang, J., Bai, D., Wang, J., Wang, L., Zhou, Q., Wang, H., Dai, C., Ding, L., Xu, B., Zhou, Y., Hao, J., Dai, J.*, Hu, Y.* Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther. 9(1):192. 2018
 
38.Liu, W., Xie, Y., Gao, T., Huang, F., Wang, L., Ding, L., Wang, W., Liu, S., Dai, J.*, Wang, B.* Reflection and observation: cell-based screening failing to detect HBV in HUMSCs derived from HBV-infected mothers underscores the importance of more stringent donor eligibility to reduce risk of transmission of infectious diseases for stem cell-based medical products. Stem Cell Res Ther. 9(1):177. 2018
 
39.Chen, X., Fan, Y., Xiao, Z., Li, X., Yang, B., Zhao, Y., Hou, X., Han, S., Dai, J.* Promotion of transplanted collagen scaffolds combined with brain-derived neurotrophic factor for axonal regeneration and motor function recovery in rats after transected spinal cord injury. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 32(6):650-659. 2018
 
40.Li, J., Li, X., Xiao, Z., Dai, J.* Review of the regeneration mechanism of complete spinal cord injury. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 32(6):641-649. 2018
 
41.Guan, D., Mi, J., Chen, X., Wu, Y., Yao, Y., Wang, L., Xiao, Z., Zhao, Y., Chen, B., Dai, J.* Lung endothelial cell-targeted peptide guided bFGF promotes the regeneration afterradiation induced lung injury. Biomaterials. 184:10-19. 2018
 
42.Chen, X., Zhao, Y., Li, X., Xiao, Z., Yao, Y., Chu, Y., Farkas, B., Romano, I., Brandi, F., Dai, J.* Functional multichannel Poly(Propylene Fumarate)-collagen scaffold with collagen-binding neurotrophic factor 3 promotes neural regeneration after transected spinal cord injury. Adv Healthc Mater. 7(14):e1800315. 2018
 
43.Fan, C., Li, X., Zhao, Y., Xiao, Z., Xue, W., Sun, J., Li, X., Zhuang, Y., Chen, Y., Dai, J.* Cetuximab and Taxol co-modified collagen scaffolds show combination effects for the repair of acute spinal cord injury. Biomater Sci. 6(7):1723-1734. 2018
 
44.Li, X., Yang, B., Xiao, Z., Zhao, Y., Han, S., Yin, Y., Chen, B., Dai, J.* Comparison of subacute and chronic scar tissues after complete transected spinal cord injury. Experimental Neurology. 306:132-137. 2018
 
45.Li, L., Chen, B., Yan, H., Zhao, Y., Lou, Z., Li, J., Fu, B., Zhu, X., McManus, D.P., Dai, J.*, Jia, W. Three-dimensional hepatocyte culture system for the study of Echinococcus multilocularis larval development. PLoS Negl Trop Dis. 12(3):e0006309. 2018
 
46.Jia, W., Jiang, X.*, Liu, W., Wang, L., Zhu, B., Zhu, H., Liu, X., Zhong, M., Xie, D., Huang, W., Jia, W., Li, S., Liu, X., Zou, X., Cheng, D., Dai, J.*, Ren, C.* Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells. Int J Oncol. 52(6):1787-1800. 2018.
 
47.Xiao, Z., Tang, F., Zhao, Y., Han, G., Yin, N., Li, X., Chen, B., Han, S., Jiang, X., Yun, C., Zhao, C., Cheng, S., Zhang, S.*, Dai, J.* Significant improvement of acute complete spinal cord injury patients diagnosed by a combined criteria implanted with neuroRegen scaffolds and mesenchymal stem cells. Cell Transplantation. 27(6):907-915.2018
 
48.Wang, Z., Shen, H., Song, S., Zhang, L., Chen, W., Dai, J., Zhang, Z.* Graphene oxide incorporated PLGA nanofibrous scaffold for solid phase gene delivery into mesenchymal stem cells. J Nanosci Nanotechnol. 18(4):2286-2293. 2018
 
49.Hao, W., Han, J., Chu, Y., Huang, L., Sun, J., Zhuang, Y., Li, X., Ma, H., Chen, Y.*, Dai, J.* Lower fluidity of supported lipid bilayers promotes neuronal differentiation of neural stem cells by enhancing focal adhesion formation. Biomaterials. 161:106-116. 2018
 
50.Cui, Y., Han, J.*, Xiao, Z., Qi, Y., Zhao, Y., Chen, B., Fang, Y., Liu, S., Wu, X., Dai, J.* Systematic Analysis of mRNA and miRNA expression of 3D-cultured neural stem cells (NSCs) in spaceflight. Front Cell Neurosci. 11:434. 2018
 
51.Wang, N., Xiao, Z., Zhao, Y., Wang, B., Li, X., Li, J., Dai, J.* Collagen scaffold combined with human umbilical cord-derived mesenchymal stem cells promote functional recovery after scar resection in rats with chronic spinal cord injury. J Tissue Eng Regen Med. 12(2):e1154-e1163. 2018
 
52.Tang, H., Jia, W., Hou, X., Zhao, Y., Huan, Y., Chen, W., Yu, W., Mi Ma, O., Ye, G., Chen, B. *, Dai, J.* Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model. Biomed Mater. 13(3):03100. 2018
 
53.Han, S., Li, X., Xiao, Z., Dai, J.* Complete canine spinal cord transection model: a large animal model for the translational research of spinal cord regeneration. Sci China Life Sci. 61(1):115-117. 2018
 
54.Shi, C.,  Zhao, Y.,  Yang, Y.,  Chen, C.,  Hou, X., Shao, J., Yao, H., Li, Q., Xia, Y., Dai, J.*  Collagen-binding VEGF targeting cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction. Biomaterials Science. 6(2):356-363. 2018
 
55.Li, X., Dai, J.* Bridging the gap with functional collagen scaffolds: tuning endogenous neural stem cells for severe spinal cord injury repair. Biomater Sci. 6(2):265-271. 2018
 
56.Sun, J., Mou, C., Shi, Q., Chen, B., Hou, X., Zhang, W., Li, X., Zhuang, Y., Shi, J., Chen, Y., Dai, J.* Controlled release of collagen-binding SDF-1α from the collagen scaffold promoted tendon regeneration in a rat Achilles tendon defect model. Biomaterials. 162:22-33. 2018
 
57.Wang, X., Hu, H., Zhang, H., Li, C., An, B., Dai, J. * Single ultrasmall Mn2+-doped NaNdF4 nanocrystal as multimodal nanoprobe for magnetic resonance and second near-infrared fluorescence imaging. Nano Research. 11(2): 1069-1081. 2018
 
58.Han, S., Xiao, Z., Li, X., Zhao, H., Wang, B., Qiu, Z., Li, Z., Mei, X., Xu, B., Fan, C., Chen, B., Han, J., Gu, Y., Yang, H., Shi, Q., Dai, J.* Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine. Sci China Life Sci. 61: 2-13. 2018
 
59.Wang, L., Shi, Q., Dai, J.*, Gu, Y., Feng, Y., Chen, L.* Increased vascularization promotes functional recovery in the transected spinal cord rats by implanted vascular endothelial growth factor-targeting collagen scaffold. J Orthop Res. 36(3):1024-1034. 2018
 
60.Yao, Y., Cui, Y., Zhao, Y., Xiao, Z., Li, X., Han, S., Chen, B., Fang, Y., Wang, P., Pan, J.*, Dai, J.* Effect of longitudinally oriented collagen conduit combined with nerve growth factor on nerve regeneration after dog sciatic nerve injury. J Biomed Mater Res B Appl Biomater. 106(6):2131-213. 2018
 
61.Zhu, W., Qiu, Y., Sheng, F., Yuan, X., Xu, L., Bao, H., Dai, J.*, Zhu, Z.* An effective delivery vehicle of demineralized bone matrix incorporated with engineered collagen-binding human bone morphogenetic protein-2 to accelerate spinal fusion at low dose. J Mater Sci Mater Med. 29(1):2. 2017
 
62.Shi, L., Zhao, Y., Xie, Q., Fan, C., Hilborn, J., Dai, J.* Ossipov, D.* Moldable hyaluronan hydrogel enabled by dynamic metal-bisphosphonate coordination chemistry for wound healing. Advanced Healthcare Materials. 5(12):2427-2436. 2017
 
63.Xu, B., Zhao, Y., Xiao, Z., Wang, B., Liang, H., Li, X., Fang, Y., Han, S., Li, X., Fan, C., Dai, J.* A Dual functional scaffold tethered with EGFR antibody promotes neural stem cell retention and neuronal differentiation for spinal cord injury repair. Adv Healthc Mater. 6(9):1601279. 2017
 
64.Xu, R., Zhao, M., Yang, Y., Huang, Z., Shi, C., Hou, X., Zhao, Y., Chen, B., Xiao, Z., Liu, J., Miao, Q.*, Dai. J.* MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway. Sci Rep. 7(1):8740. 2017
 
65.Xu, L., Ding, L., Wang, L., Cao, Y., Zhu, H., Lu, J., Li, X., Song, T., Hu, Y.*, Dai, J.* Umbilical cord-derived mesenchymal stem cells on scaffolds facilitate collagen degradation via upregulation of MMP-9 in rat uterine scars. Stem Cell Res Ther. 8(1):84. 2017
 
66.Li, X., Zhao, Y., Cheng, S., Han, S., Shu, M., Chen, B., Chen, X., Tang, F., Wang, N., Tu, Y., Wang, B., Xiao, Z.*, Zhang, S.*, Dai, J.* Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenousneural stem cells for acute spinal cord injury repair. Biomaterials. 137:73-86. 2017
 
67.Shi, C., Chen, W., Chen, B., Shan, T., Jia, W., Hou, X., Li, L., Ye, G.*, Dai, J.* Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF. Biomater Sci. 5(12):2427-2436. 2017
 
68.Huang, J., Fu, H., Li, C., Dai, J.*, Zhang, Z.* Recent advances in cell-laden 3D bioprinting: materials, technologies and applications. Journal of 3D printing in medicine. 1(4): 245–268. 2017
 
69.Chen, B., Xiao, Z., Zhao, Y., Dai, J.* Functional biomaterial-based regenerative microenvironment for spinal cord injury repair. National Science Review. 4(4):530-532. 2017
 
70.Zhao, Y., Xiao, Z., Chen, B., Dai, J.* The neuronal differentiation microenvironment is essential for spinal cord injury repair. Organogenesis. 9:1-8. 2017
 
71.Li, X., Tan, J., Xiao, Z., Zhao, Y., Han, S., Liu, D., Yin, W., Li, J., Li, J., Wanggou, S., Chen, B., Ren, C., Jiang, X., Dai, J.* Transplantation of hUC-MSCs seeded collagen scaffolds reduces scar formation and promotes functional recovery in canines with chronic spinal cord injury. Sci Rep. 7:43559. 2017
 
72.Fan,C., Li, X., Xiao, Z., Zhao, Y., Liang, H., Wang, B., Han, S., Li, X., Xu, B., Wang, N., Liu, S., Xue, W., Dai, J.* A modified collagen scaffold facilitates endogenous neurogenesis for acute spinal cord injuryrepair. Acta Biomater. 51:304-316. 2017
 
73.Fang, Y., Wang, B., Zhao, Y., Xiao, Z., Li, J., Cui, Y., Han, S., Wei, J., Chen, B., Han, J., Meng, Q., Hou, X., Luo, J., Dai, J.*, Jing, Z.* Collagen scaffold microenvironments modulate cell lineage commitment for differentiation of bone marrow cells into regulatory dendritic cells. Sci Rep. 7:42049. 2017
 
74.Zhao, Y., Tang, F., Han, G., Wang, N., Yin, N., Chen, B., Jiang, X., Yun, C., Han, W., Zhao, C., Cheng, S., Xiao, Z.*, Zhang, S.*, Dai, J.* Clinical study of NeuroRegen scaffold combined with human mesenchymal stem cells for the repair of chronic complete spinal cord injury. Cell Transplantation. 26(5):891-900. 2017
 
75.Chen, Y., Wu, Y., Gao, J., Zhang, Z., Wang, L., Chen, X., Mi, J., Yao, Y., Guan, D., Chen, B.*, Dai, J.* Transdermal vascular endothelial growth factor delivery with surface engineered gold nanoparticles. ACS Appl Mater Interfaces. 9(6):5173-5180. 2017
 
76.Zhao, G., Cao, Y., Zhu, X., Tang, X., Ding, L., Sun, H., Li, J., Li, X., Dai, C., Ru, T., Zhu, H., Lu, J, Lin, C.,Wang. J., Yan, G., Wang, H., Wang, L., Dai,Y., Wang, B., Li, R., Dai, J.*, Zhou,Y.*, Hu,Y.* Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman’s syndrome. Sci China Life Sci. 60(4):404-416. 2017
 
77.Zhang, D., Huang, Z., Sun, P., Huang, H., Zhang, Y., Dai, J.*, Liu, J*., Shi, Q.* Acceleration of healing of traumatic tympanic membrane perforation in rats by implanted collagen membrane integrated with collagen-binding basic fibroblast growth factor. Tissue Eng Part A. 23(1-2):20-29. 2017
 
78.Li, X., Liu, S., Zhao, Y., Li, J., Ding, W., Han, S., Chen,B., Xiao, Z., Dai, J.* Training neural stem cells on functional collagen scaffolds for severe spinal cord injury repair. Adv Funct Mater. 26(32):5835-5847. 2016
 
79.Huang, J., Fu, H., Wang,Z., Meng,Q., Liu, S.,Wang, H., Zheng, X., Dai, J.*, Zhang, Z.* BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting. RSC Adv. 6:108423-108430. 2016
 
80.Gu, Q., Zhu, H., Chen, L., Shuai, L., Fang, J., Wu, J., Liu, L., Li, W., Dai, J., Hao, J.*, Zhou, Q.* Three dimensional collagen scaffolds promote iPSC induction with higher pluripotency. Protein Cell. 7(11):844-848. 2016
 
81.Xiao, Z., Chen, B, Dai, J.* Building the regenerative microenvironment with functional biomaterials cord injury repair. Journal of Spine. S7-005. 2016
 
82.Wu, K., Huang, R., Wu, H., Liu, Y., Yang, C., Cao, S., Hou, X., Chen, B., Dai, J.*, Wu, C.* Collagen-binding vascular endothelial growth factor attenuates CCl4-induced liver fibrosis in mice. Mol Med Rep. 14(5):4680-4686. 2016
 
83.Shi, J., Sun, J., Zhang, W., Liang, H., Shi, Q., Li, X., Chen, Y., Zhuang, Y., Dai, J.* Demineralized bone matrix scaffolds modified by CBD-SDF-1α promote bone regeneration via recruiting endogenous stem cells. ACS Appl Mater Interfaces. 8 (41): 27511–27522. 2016
 
84.Gao, J. *, He, Y., Zhao, X., Ran X., Wu, Y., Su, Y. *, Dai, J.* Single step synthesis of amine-functionalized mesoporous magnetite nanoparticles and their application for copper ions removal from aqueous solution. J Colloid Interface Sci. 481:220-8. 2016
 
85.Li, X., Li, M., Sun, J., Zhuang, Y., Shi, J., Guan, D., Chen, Y., Dai, J.* Radially aligned electrospun fibers with continuous gradient of SDF1α for the guidance of neural stem cells. Small. 12(36):5009-5018. 2016
 
86.Wang, X.*, Zhang, Q., Zou, L., Hu, H., Zhang, M., Dai, J.* Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo–photothermal combination therapy of cancer. RSC Adv. 6: 20949-20960. 2016
 
87.Kou, D., Du, M., Hou, X., Chen, B., Li, X., Fang, Y., Zhao, Y., Wang, H.*, Wang, L.*, Dai, J.* Centimeter-sized biomimetic bone constructs fabricated via CBD-BMP2-collagen microcarriers and BMSC-gelatin microspheres. J. Mater. Chem. B. 4(3): 461–470. 2016
 
88.Lv, D., Yu, S., Ping, Y., Wu, H., Zhao, X., Zhang H., Cui, Y., Chen, B., Zhang, X., Dai, J., Bian, X.*, Yao X.* A three-dimensional collagen scaffold cell culture system for screening anti-glioma therapeutics. Oncotarget. 7(35):56904-56914. 2016
 
89.Xiao, Z., Tang, F., Tang, J., Yang, H., Zhao, Y., Chen, B., Han, S., Wang, N., Li, X., Cheng S., Han, G., Zhao, C., Yang, X., Chen, Y., Shi, Q., Hou, S., Zhang, S., Dai, J.* One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients. Sci China Life Sci. 59(7):647-55. 2016
 
90.Han, J., Dai, J.* Microgravity may help future organ/tissue manufacture. Sci China Life Sci. 59(8):850-3. 2016
 
91.Sun, J., Zhao, Y., Li, Q., Chen, B., Hou, X., Xiao, Z., Dai, J.* Controlled release of collagen-binding SDF-1α improves cardiac function after myocardial infarction by recruiting endogenous stem cells. Sci Rep. 6:26683. 2016
 
92.Hou, X., Shi, C., Chen, W., Chen, B., Jia, W., Guo, Y., Ma, C., Ye, G., Kang, J., Dai J.* Transplantation of human adipose-derived mesenchymal stem cells on a bladder acellular matrix for bladder regeneration in a canine model. Biomed Mater.11(3):031001. 2016
 
93.Ma, Y., Wang, H., Yan, D., Wei, Y., Cao, Y., Yi, P., Zhang, H., Deng, Z., Dai, J., Liu, X., Luo, J., Zhang, Z., Sun, S., Guo, H. Magnetic resonance imaging revealed splenic targeting of canine parvovirus capsid protein VP2. Sci Rep. 6:23392. 2016
 
94.Su, J., Ding, L., Cheng, J., Yang, J., Li, X., Yan, G., Sun, H., Dai, J.*, Hu Y.* Transplantation of adipose-derived stem cells combined with collagen scaffolds restores ovarian function in a ratmodel of premature ovarian insufficiency. Hum Reprod. 31(5):1075-86. 2016
 
95.Han, S., Wang, B., Li, X., Xiao, Z., Han, J., Zhao, Y., Fang, Y., Yin, Y., Chen, B., Dai J.* Bone marrow-derived mesenchymal stem cells in three-dimensional culture promote neuronal regeneration by neurotrophic protection and immunomodulation. J Biomed Mater Res A. 104(7):1759-69. 2016
 
96.Cui, Y., Han, J., Xiao, Z., Chen, T., Wang, B., Chen, B., Liu, S., Han, S., Fang, Y., Wei, J., Wang, X., Ma, X.*, Dai, J.* The miR-20-Rest-Wnt signaling axis regulates neural progenitor cell differentiation.. Sci Rep. 6:23300. 2016
 
97.Liang, H., Li, X., Wang, B., Chen, B., Zhao, Y., Sun, J., Zhuang, Y., Shi, J., Shen, H., Zhang, Z., Dai, J.* A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix. Sci Rep. 6:18205. 2016
 
98.Li, X., Han, J., Zhao, Y., Ding, W., Wei, J., Li, J., Han, S., Shang, X., Wang, B., Chen, B., Xiao, Z., Dai, J.* Functionalized collagen scaffold implantation and cAMP administration collectively facilitate spinal cord regeneration. Acta Biomater. 30:233-245. 2016
 
99.Du, M., Chen, B., Meng, Q., Liu, S., Zheng, X., Zhang, C., Wang, H., Li, H., Wang, N., Dai, J.* 3D bioprinting of BMSC-laden methacrylamide gelatin scaffolds with CBD-BMP2-collagen microfibers. Biofabrication. 7(4):044104. 2015
 
100.Shen, H., Ma, Y., Luo, Y., Liu, X., Zhang, Z.*, Dai, J.* Directed osteogenic differentiation of mesenchymal stem cell in three-dimensional biodegradable methylcellulose-based scaffolds. Colloids Surf B Biointerfaces. 135:332-38. 2015
 
101.Jia, W., Tang, H., Wu, J., Hou, X., Chen, B., Chen, W., Zhao, Y., Shi, C., Zhou, F., Yu, W., Huang, S., Ye, G., Dai, J.* Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model. Biomaterials. 69:45-55. 2015
 
 
103.Wu, J., Jia, W., Chen, W., Zhou, F., Fang, Z., Xianglin Hou, X., Chen, B., Ye, G.*, Dai, J.* Transplantation of hBMSCs loaded on collagen scaffolds for the regeneration of canine tissue-engineered urethras. J Genet Genome Res. 2:1. 2015
 
104.Yang, Y., Shi, C., Hou, X., Zhao, Y., Chen, B., Tan, B., Deng, Z., Li, Q., Liu, J., Xia, Z., Miao, Q., Dai, J.* Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction. J Control Release. 213:27-35. 2015
 
105.Li, X., Han, J., Zhao, Y., Ding, W., Wei, J., Han, S., Shang, X., Wang, B., Chen, B., Xiao, Z., Dai, J.* Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord Regeneration in Vivo. ACS Appl Mater Interfaces. 7(25):13960-71. 2015
 
106.Liang, H., Li, X., Chen, B., Wang, B., Zhao, Y., Zhuang, Y., Shen, H., Zhang, Z., Dai, J.* A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy. J Control Release. 209:101-109. 2015
 
107.Luo, Y., Shen, H., Fang, Y., Cao, Y., Huang, J., Zhang, M., Dai, J.Shi, X., Zhang, Z.* Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl Mater Interfaces. 7(11):6331-9. 2015
 
108.Lu, C., Meng, D., Cao, J., Xiao, Z., Cui, Y., Fan, J., Cui, X., Chen, B., Yao, Y., Zhang, Z., Ma, J., Pan, J.*, Dai, J.* Collagen scaffolds combined with collagen-binding ciliary neurotrophic factor facilitate facial nerve repair in mini-pigs. J Biomed Mater Res A. 103(5):1669-76. 2015
 
109.Tao, L., Li, Q., Ren, H., Chen, B., Hou, X., Mou, L., Zhou, S., Zhou, J., Sun, X., Dai, J.*, Ding, Y.* Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model. Artif Organs. 39(4):352-60. 2015
 
110.Shen, Q., Chen, B., Xiao, Z., Zhao, L., Xu, X., Wan, X., Jin, M., Dai, J.*, Dai, H.* Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis. Mol Med Rep. 11(4):2831-7. 2015
 
111.Song, T., Zhao, X., Sun, H., Li, X., Lin, N., Ding, L., Dai, J.Hu, Y.* Regeneration of uterine horns in rats using collagen scaffolds loaded with human embryonic stem cell-derived endometrium-like cells. Tissue Eng Part A. 21(1-2):353-61. 2015
 
112.Guan, J., Zhang, B., Zhang, J., Ding, W., Xiao, Z., Zhu, Z., Han, Q., Wu, C., Sun, Y., Tong, W., Dai, J.*, Wang, R.*. Nerve regeneration and functional recovery by collagen-binding BDNF in an intracerebral hemorrhage model. Tissue Eng Part A. 21(1-2):62-74. 2015
 
113.Han, S., Wang, B., Jin, W., Xiao, Z., Li, X., Ding, W., Kapur, M., Chen, B., Yuan, B., Zhu, T., Wang, H., Wang, J., Dong, Q., Liang, W., Dai, J.* The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine. Biomaterials. 41:89-96. 2015