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戴建武


戴建武,博士,研究员,博士生导师
 
教育及任职::
        武汉大学生物系细胞生物学专业 本科
        北京医科大学生物物理学专业 硕士
        美国杜克大学获细胞生物学专业 博士
        哈佛大学医学院 博士后研究
        2003-至今:中国科学院遗传与发育生物学研究所任研究员,再生医学研究中心主任。
        中科院“百人计划”杰出人才,国家杰出青年基金获得者。
        国家食品药品监督管理局医疗器械审评专家
        国家标准化管理委员会委员
        全国外科植入物和矫形器械标准化技术委员会委员
        组织工程医疗器械产品分技术委员会委员
        英国皇家化学学会生物材料咨询委员会委员
        Biomaterials 杂志编委
        联合国教科文组织科学伦理委员会中国代表
        中国干细胞分会秘书长。

主要研究方向:
        1)再生医学产品的研发
        2)组织器官再生机理的研究
 
入选的国家及部委项目:

2006-2010
科技部国家重大科学研究计划项目“干细胞自我更新调控网络的研究”项目首席科学家
2010-2012
国家自然基金委,重大科学研究计划培育项目“OCT4异构体的表达、功能和调节机制研究”,项目负责人
2010-2013
国家自然基金委重点项目“神经再生环境的构建”,项目负责人
2011-2013
国家自然基金委,中加(NSFC-CIHR)健康研究合作计划“胶原结合能力的血管内皮生长因子对猪心肌损伤的治疗作用及安全性评价”,项目负责人
2011-2015
科技部国家重大科学研究计划项目“三维培养干细胞自我更新调控网络的研究”,项目首席科学家
2011-2015
中国科学院“干细胞与再生医学”战略性科技先导专项“人工组织器官构建”项目负责人
2013-2015
中国科学院科研装备研制项目“面向干细胞微环境构建的低温细胞3D重建系统”项目负责人
2016-2018
中国科学院重点部署项目“组织器官再生与损伤修复”项目负责人
2016-2021
国家重点研发计划项目“出生缺陷组织器官再生修复产品的研发”项目首席科学家
2017-2022 中国科学院“器官重建与制造”战略性科技先导专项“临床研究转化”项目负责人及“脊髓组织制造”课题负责人

获奖情况:
        2010年:中国科学院遗传与发育生物学研究所益海嘉里“优秀导师奖”
        2012年:心肌梗死后心肌组织修复和功能重建的机制研究及临床应用,国家科技部,国家科学技术进步奖二等奖
        2014年:中央电视台年度科技创新人物。
        2016年:第六届中国侨界再生医学创新成果奖。
        2017年:中国细胞生物学学会干细胞生物学分会干细胞成果转化奖
 
代表性成果
        ?  突破了再生医学关键技术。研发了具有自主知识产权的系列再生医学产品,在子宫内膜、脊髓、心肌等组织损伤的大动物实验中都显示了良好的修复效果;提出组织内源干细胞的激活与分化是组织再生的重要机理;在率先组织领导了包括子宫内膜再生,脊髓损伤再生,心肌再生等多个产品的临床研究。
        ?  合作研发子宫内膜再生生物材料,目前已进入临床研究阶段,为子宫内膜损伤的不孕患者提供了一种有效的治疗手段,并由于该进展获评2014年中央电视台年度科技创新人物。
        ?  脊髓损伤再生研究取得重大突破。提出利用功能生物材料重建神经再生微环境的技术思路。研发的神经再生胶原支架材料可有效引导全横断脊髓损伤动物和患者神经再生和自主运动功能恢复。脊髓损伤再生修复的临床研究已走在世界前列。
 
团队成员:
 
工作人员:

陈  冰
博士
副研究员
肖志峰
博士
副研究员
赵燕南
博士
副研究员
韩  津
博士
副研究员
吴宪明
博士
副研究员
韩素芳
博士
助理研究员
李佳音
博士
工程师
施  雅
硕士
工程师
侯祥林
硕士
工程师
唐卫华
硕士
助理工程师
尹艳云
硕士
助理工程师
杨  斌
硕士
助理工程师
张娇娇
硕士
助理工程师
 
 
 

 
博士后:
        白苏冉  李星  徐白 张琪 沈贺
 
博士研究生:
        薛伟伟  薛晓钰  杨亚明  舒慕娅  杨颖  张海鹏  马德尊  范永恒 
硕士研究生:
栾梁琪  刘为远
 
客座研究人员:
        崔熠  房永祥 
 
 
 
毕业离所学生:
索广力 博士 (中科院苏州纳米所)
张经余 博士  (赛默飞世尔科技)
赵艳红 博士  (中检院)
林  航 博士  (匹兹堡大学)
赵文学 博士  (加州大学旧金山分校)
王  霞 博士  (清华大学)
王  斌 博士  (南京大学鼓楼医院)
孙文杰 博士  (山东大学)
张  晶 博士  (首都医科大学)
高  原 博士  (北京宝洁技术有限公司)
韩倩倩 博士  (中检院)
高  健 硕士  (雀巢(中国)有限公司)
曹佳妮 博士 (中科院动物所)
陈  磊 博士 (河南信阳师范学院)
苏冠男 博士 (重庆医科大学附属第一医院)
肖汉山 硕士 (天风证券)
魏建树 博士 (北京301医院)
杨  赟 博士 (加州大学圣地亚哥分校)
施春英 博士 (青岛大学)
刘素梅 博士 (宣武医院)
 
 
媒体报道:(网页视频链接形式)

 

近期发表的文章(2013至今):
 
1. Chen X, Zhao Y, Li X, Xiao Z, Yao Y, Chu Y, Farkas B, Romano I, Brandi F, Dai, J.*. Functional Multichannel Poly(Propylene Fumarate)-Collagen Scaffold with Collagen-Binding Neurotrophic Factor 3 Promotes Neural Regeneration After Transected Spinal Cord Injury. Adv Healthc Mater. doi: 10.1002/adhm.201800315. [Epub ahead of print]
 
2. Fan C, Li X, Zhao Y, Xiao Z, Xue W, Sun J, Li X, Zhuang Y, Chen Y, Dai, J.* Cetuximab and Taxol co-modified collagen scaffolds show combination effects for the repair of acute spinal cord injury. Biomater Sci. 2018 Jun 25;6(7):1723-1734.
 
3. Li, X., Yang, B., Xiao, Z., Zhao, Y., Han, S., Yin, Y., Chen, B., Dai, J.* Comparison of subacute and chronic scar tissues after complete transected spinal cord injury. Experimental Neurology. doi: 10.1016/j.expneurol.2018.05.008. Epub 2018 May 16
 
4. Li L, Chen B, Yan H, Zhao Y, Lou Z, Li J, Fu B, Zhu X, McManus DP, Dai, J.*, Jia W. Three-dimensional hepatocyte culture system for the study of Echinococcus multilocularis larval development. PLoS Negl Trop Dis. 2018 Mar 14;12(3):e0006309.
 
5. Jia, W., Jiang, X.*, Liu, W., Wang, L., Zhu, B., Zhu, H., Liu, X., Zhong, M., Xie, D., Huang, W., Jia, W., Li, S., Liu, X., Zou, X., Cheng, D., Dai, J.*, Ren, C.* Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells. Int J Oncol. 52(6):1787-1800. 2018.
 
6. Xiao, Z., Tang, F., Zhao, Y., Han, G., Yin, N., Li, X., Chen, B., Han, S., Jiang, X., Yun, C., Zhao, C., Cheng, S., Zhang, S.*, Dai, J.* Significant improvement of acute complete spinal cord injury patients diagnosed by a combined criteria implanted with neuroRegen scaffolds and mesenchymal stem cells. Cell Transplantation. doi: 10.1177/0963689718766279. [Epub ahead of print]
 
7. Ding, L., Yan, G., Wang, B., Xu, L., Gu, Y., Ru, T., Cui, X., Lei, L., Liu, J., Sheng, X., Wang, B., Zhang, C., Yang, Y., Jiang, R., Zhou, J., Kong, N., Lu, F., Zhou, H., Zhao, Y., Chen, B., Hu, Y.*, Dai, J.*, Sun, H.* Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility. Sci China Life Sci. doi: 10.1007/s11427-017-9272-2. [Epub ahead of print]. 2018
 
8. Cui, Y., Yao, Y., Zhao, Y., Xiao, Z., Cao, Z., Han, S., Li, X., Huan, Y., Pan, J.*, Dai, J.* Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs. J Tissue Eng Regen Med. doi: 10.1002/term.2660. [Epub ahead of print]. 2018
 
9. Yin, W., Li, X., Zhao, Y., Tan, J., Wu, S., Cao, Y., Li, J., Zhu, H., Liu, W., Tang, G., Meng, L., Wang, L., Zhu, B., Wang, G., Zhong, M., Liu, X., Xie, D., Chen, B., Ren, C., Xiao, Z., Jiang, X.*, Dai, J.* Taxol-modified collagen scaffolds implantation promotes functional recovery after long-distance spinal cord complete transection in canines. Biomaterials Science. 6(5):1099-1108.  2018
 
10.Wang, Z., Shen, H., Song, S., Zhang, L., Chen, W., Dai, J., Zhang, Z.* Graphene oxide incorporated PLGA nanofibrous scaffold for solid phase gene delivery into mesenchymal stem cells. J Nanosci Nanotechnol. 18(4):2286-2293. 2018
 
11.Hao, W., Han, J., Chu, Y., Huang, L., Sun, J., Zhuang, Y., Li, X., Ma, H., Chen, Y.*, Dai, J.* Lower fluidity of supported lipid bilayers promotes neuronal differentiation of neural stem cells by enhancing focal adhesion formation. Biomaterials. 161:106-116. 2018
 
12.Cui, Y., Han, J.*, Xiao, Z., Qi, Y., Zhao, Y., Chen, B., Fang, Y., Liu, S., Wu, X., Dai, J.* Systematic Analysis of mRNA and miRNA expression of 3D-cultured neural stem cells (NSCs) in spaceflight. Front Cell Neurosci. 11:434. 2018
 
13.Wang, N., Xiao, Z., Zhao, Y., Wang, B., Li, X., Li, J., Dai, J.* Collagen scaffold combined with human umbilical cord-derived mesenchymal stem cells promote functional recovery after scar resection in rats with chronic spinal cord injury. J Tissue Eng Regen Med. 12(2):e1154-e1163. 2018
 
14.Tang, H., Jia, W., Hou, X., Zhao, Y., Huan, Y., Chen, W., Yu, W., Mi Ma, O., Ye, G., Chen, B. *, Dai, J.* Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model. Biomed Mater. 13(3):03100. 2018
 
15.Han, S., Li, X., Xiao, Z., Dai, J.* Complete canine spinal cord transection model: a large animal model for the translational research of spinal cord regeneration. Sci China Life Sci. 61(1):115-117. 2018
 
16.Shi, C.,  Zhao, Y.,  Yang, Y.,  Chen, C.,  Hou, X., Shao, J., Yao, H., Li, Q., Xia, Y., Dai, J.*  Collagen-binding VEGF targeting cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction. Biomaterials Science. 6(2):356-363. 2018
 
17.Li, X., Dai, J.* Bridging the gap with functional collagen scaffolds: tuning endogenous neural stem cells for severe spinal cord injury repair. Biomater Sci. 6(2):265-271. 2018
 
18.Sun, J., Mou, C., Shi, Q., Chen, B., Hou, X., Zhang, W., Li, X., Zhuang, Y., Shi, J., Chen, Y., Dai, J.* Controlled release of collagen-binding SDF-1α from the collagen scaffold promoted tendon regeneration in a rat Achilles tendon defect model. Biomaterials. 162:22-33. 2018
 
19.Wang, X., Hu, H., Zhang, H., Li, C., An, B., Dai, J. * Single ultrasmall Mn2+-doped NaNdF4 nanocrystal as multimodal nanoprobe for magnetic resonance and second near-infrared fluorescence imaging. Nano Research. 11(2): 1069-1081. 2018
 
20.Han, S., Xiao, Z., Li, X., Zhao, H., Wang, B., Qiu, Z., Li, Z., Mei, X., Xu, B., Fan, C., Chen, B., Han, J., Gu, Y., Yang, H., Shi, Q., Dai, J.* Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine. Sci China Life Sci. 61: 2–13. 2018
 
21.Yao, Y., Cui, Y., Zhao, Y., Xiao, Z., Li, X., Han, S., Chen, B., Fang, Y., Wang, P., Pan, J.*, Dai, J.* Effect of longitudinally oriented collagen conduit combined with nerve growth factor on nerve regeneration after dog sciatic nerve injury. J Biomed Mater Res B Appl Biomater. doi: 10.1002/jbm.b.34020. 2017
 
22.Wang, L., Shi, Q., Dai, J., Gu, Y., Feng, Y., Chen, L.* Increased vascularization promotes functional recovery in the transected spinal cord rats by implanted vascular endothelial growth factor-targeting collagen scaffold. J Orthop Res. doi: 10.1002/jor.23678. 2017
 
23.Zhu, W., Qiu, Y., Sheng, F., Yuan, X., Xu, L., Bao, H., Dai, J., Zhu, Z.* An effective delivery vehicle of demineralized bone matrix incorporated with engineered collagen-binding human bone morphogenetic protein-2 to accelerate spinal fusion at low dose. J Mater Sci Mater Med. 29(1):2. 2017
 
24.Shi, L., Zhao, Y., Xie, Q., Fan, C., Hilborn, J., Dai, J.*,Ossipov, D.* Moldable hyaluronan hydrogel enabled by dynamic metal-bisphosphonate coordination chemistry for wound healing. Advanced Healthcare Materials. 5(12):2427-2436. 2017
 
25.Xu, B., Zhao, Y., Xiao, Z., Wang, B., Liang, H., Li, X., Fang, Y., Han, S., Li, X., Fan, C., Dai, J.* A Dual functional scaffold tethered with EGFR antibody promotes neural stem cell retention and neuronal differentiation for spinal cord injury repair. Adv Healthc Mater. 6(9):1601279. 2017
 
26.Xu, R., Zhao, M., Yang, Y., Huang, Z., Shi, C., Hou, X., Zhao, Y., Chen, B., Xiao, Z., Liu, J., Miao, Q.*, Dai. J.* MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway. Sci Rep. 7(1):8740. 2017
 
27.Xu, L., Ding, L., Wang, L., Cao, Y., Zhu, H., Lu, J., Li, X., Song, T., Hu, Y.*, Dai, J.* Umbilical cord-derived mesenchymal stem cells on scaffolds facilitate collagen degradation via upregulation of MMP-9 in rat uterine scars. Stem Cell Res Ther. 8(1):84. 2017
 
28.Li, X., Zhao, Y., Cheng, S., Han, S., Shu, M., Chen, B., Chen, X., Tang, F., Wang, N., Tu, Y., Wang, B., Xiao, Z.*, Zhang, S.*, Dai, J.* Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenousneural stem cells for acute spinal cord injury repair. Biomaterials. 137:73-86. 2017
 
29.Shi, C., Chen, W., Chen, B., Shan, T., Jia, W., Hou, X., Li, L., Ye, G.*, Dai, J.* Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF. Biomater Sci. 5(12):2427-2436. 2017
 
30.Huang, J., Fu, H., Li, C., Dai, J.*, Zhang, Z.* Recent advances in cell-laden 3D bioprinting: materials, technologies and applications. Journal of 3D printing in medicine. 1(4): 245–268. 2017
 
31.Chen, B., Xiao, Z., Zhao, Y., Dai, J.* Functional biomaterial-based regenerative microenvironment for spinal cord injury repair. National Science Review. 4(4):530-532. 2017
 
32.Zhao, Y., Xiao, Z., Chen, B., Dai, J.* The neuronal differentiation microenvironment is essential for spinal cord injury repair. Organogenesis. 9:1-8. 2017
 
33.Li, X., Tan, J., Xiao, Z., Zhao, Y., Han, S., Liu, D., Yin, W., Li, J., Li, J., Wanggou, S., Chen, B., Ren, C., Jiang, X., Dai, J.* Transplantation of hUC-MSCs seeded collagen scaffolds reduces scar formation and promotes functional recovery in canines with chronic spinal cord injury. Sci Rep. 7:43559. 2017
 
34.Fan,C., Li, X., Xiao, Z., Zhao, Y., Liang, H., Wang, B., Han, S., Li, X., Xu, B., Wang, N., Liu, S., Xue, W., Dai, J.* A modified collagen scaffold facilitates endogenous neurogenesis for acute spinal cord injuryrepair. Acta Biomater. 51:304-316. 2017
 
35.  Fang, Y., Wang, B., Zhao, Y., Xiao, Z., Li, J., Cui, Y., Han, S., Wei, J., Chen, B., Han, J., Meng, Q., Hou, X., Luo, J., Dai, J.*, Jing, Z.* Collagen scaffold microenvironments modulate cell lineage commitment for differentiation of bone marrow cells into regulatory dendritic cells. Sci Rep. 7:42049. 2017
 
36.Zhao, Y., Tang, F., Han, G., Wang, N., Yin, N., Chen, B., Jiang, X., Yun, C., Han, W., Zhao, C., Cheng, S., Xiao, Z.*, Zhang, S.*, Dai, J.* Clinical study of NeuroRegen scaffold combined with human mesenchymal stem cells for the repair of chronic complete spinal cord injury. Cell Transplantation. 26(5):891-900. 2017
 
37.Chen, Y., Wu, Y., Gao, J., Zhang, Z., Wang, L., Chen, X., Mi, J., Yao, Y., Guan, D., Chen, B.*, Dai, J.* Transdermal vascular endothelial growth factor delivery with surface engineered gold nanoparticles. ACS Appl Mater Interfaces. 9(6):5173-5180. 2017
 
38.Zhao, G., Cao, Y., Zhu, X., Tang, X., Ding, L., Sun, H., Li, J., Li, X., Dai, C., Ru, T., Zhu, H., Lu, J, Lin, C.,Wang. J., Yan, G., Wang, H., Wang, L., Dai,Y., Wang, B., Li, R., Dai, J.*, Zhou,Y.*, Hu,Y.* Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman’s syndrome. Sci China Life Sci. 60(4):404-416. 2017
 
39.Zhang, D., Huang, Z., Sun, P., Huang, H., Zhang, Y., Dai, J.*, Liu, J*., Shi, Q.* Acceleration of healing of traumatic tympanic membrane perforation in rats by implanted collagen membrane integrated with collagen-binding basic fibroblast growth factor. Tissue Eng Part A. 23(1-2):20-29. 2017
 
40.Li, X., Liu, S., Zhao, Y., Li, J., Ding, W., Han, S., Chen,B., Xiao, Z., Dai, J.* Training neural stem cells on functional collagen scaffolds for severe spinal cord injury repair. Advanced Functional Materials. 26(32):5835-5847. 2016
 
41.Huang, J., Fu, H., Wang,Z., Meng,Q., Liu, S.,Wang, H., Zheng, X., Dai, J.*, Zhang, Z.* BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting. RSC Adv. 6:108423-108430. 2016
 
42.Gu, Q., Zhu, H., Chen, L., Shuai, L., Fang, J., Wu, J., Liu, L., Li, W., Dai, J., Hao, J.*, Zhou, Q.* Three dimensional collagen scaffolds promote iPSC induction with higher pluripotency. Protein Cell. 7(11):844-848. 2016
 
43.Xiao, Z., Chen, B, Dai, J.* Building the regenerative microenvironment with functional biomaterials cord injury repair. Journal of Spine. S7-005. 2016
 
44.Wu, K., Huang, R., Wu, H., Liu, Y., Yang, C., Cao, S., Hou, X., Chen, B., Dai, J.*, Wu, C.* Collagen-binding vascular endothelial growth factor attenuates CCl4-induced liver fibrosis in mice. Mol Med Rep. 14(5):4680-4686. 2016
 
45.Shi, J., Sun, J., Zhang, W., Liang, H., Shi, Q., Li, X., Chen, Y., Zhuang, Y., Dai, J.* Demineralized bone matrix scaffolds modified by CBD-SDF-1α promote bone regeneration via recruiting endogenous stem cells. ACS Appl Mater Interfaces. 8 (41): 27511–27522. 2016
 
46.Gao, J. *, He, Y., Zhao, X., Ran X., Wu, Y., Su, Y. *, Dai, J.* Single step synthesis of amine-functionalized mesoporous magnetite nanoparticles and their application for copper ions removal from aqueous solution. J Colloid Interface Sci. 481:220-8. 2016
 
47.Li, X., Li, M., Sun, J., Zhuang, Y., Shi, J., Guan, D., Chen, Y., Dai, J.* Radially aligned electrospun fibers with continuous gradient of SDF1α for the guidance of neural stem cells. Small. 12(36):5009-5018. 2016
 
48.Wang, X.*, Zhang, Q., Zou, L., Hu, H., Zhang, M., Dai, J.* Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo–photothermal combination therapy of cancer. RSC Adv. 6: 20949-20960. 2016
 
49.Kou, D., Du, M., Hou, X., Chen, B., Li, X., Fang, Y., Zhao, Y., Wang, H.*, Wang, L.*, Dai, J.* Centimeter-sized biomimetic bone constructs fabricated via CBD-BMP2-collagen microcarriers and BMSC-gelatin microspheres. J. Mater. Chem. B. 4(3): 461–470. 2016
 
50.Lv, D., Yu, S., Ping, Y., Wu, H., Zhao, X., Zhang H., Cui, Y., Chen, B., Zhang, X., Dai, J., Bian, X.*, Yao X.* A three-dimensional collagen scaffold cell culture system for screening anti-glioma therapeutics. Oncotarget. 7(35):56904-56914. 2016
 
51.Xiao, Z., Tang, F., Tang, J., Yang, H., Zhao, Y., Chen, B., Han, S., Wang, N., Li, X., Cheng S., Han, G., Zhao, C., Yang, X., Chen, Y., Shi, Q., Hou, S.,Zhang, S., Dai, J.* One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients. Sci China Life Sci. 59(7):647-55. 2016
 
52.Han, J., Dai, J.* Microgravity may help future organ/tissue manufacture. Sci China Life Sci. 59(8):850-3. 2016
 
53.Sun, J., Zhao, Y., Li, Q., Chen, B., Hou, X., Xiao, Z., Dai, J.* Controlled release of collagen-binding SDF-1α improves cardiac function after myocardial infarction by recruiting endogenous stem cells. Sci Rep. 6:26683. 2016
 
54.Hou, X., Shi, C., Chen, W., Chen, B., Jia, W., Guo, Y., Ma, C., Ye, G., Kang, J., Dai J.* Transplantation of human adipose-derived mesenchymal stem cells on a bladder acellular matrix for bladder regeneration in a canine model. Biomed Mater.11(3):031001. 2016
 
55.Ma, Y., Wang, H., Yan, D., Wei, Y., Cao, Y., Yi, P., Zhang, H., Deng, Z., Dai, J., Liu, X., Luo, J., Zhang, Z., Sun, S., Guo, H. Magnetic resonance imaging revealed splenic targeting of canine parvovirus capsid protein VP2. Sci Rep. 6:23392. 2016
 
56.Su, J., Ding, L., Cheng, J., Yang, J., Li, X., Yan, G., Sun, H., Dai, J.*, Hu Y.* Transplantation of adipose-derived stem cells combined with collagen scaffolds restores ovarian function in a ratmodel of premature ovarian insufficiency. Hum Reprod. 31(5):1075-86. 2016
 
57.Han, S., Wang, B., Li, X., Xiao, Z., Han, J., Zhao, Y., Fang, Y., Yin, Y., Chen, B., Dai J.* Bone marrow-derived mesenchymal stem cells in three-dimensional culture promote neuronal regeneration by neurotrophic protection and immunomodulation. J Biomed Mater Res A. 104(7):1759-69. 2016
 
58.Cui, Y., Han, J., Xiao, Z., Chen, T., Wang, B., Chen, B., Liu, S., Han, S., Fang, Y., Wei, J., Wang, X., Ma, X.*, Dai, J.* The miR-20-Rest-Wnt signaling axis regulates neural progenitor cell differentiation.. Sci Rep. 6:23300. 2016
 
59.Liang, H., Li, X., Wang, B., Chen, B., Zhao, Y., Sun, J., Zhuang, Y., Shi, J., Shen, H., Zhang, Z., Dai, J.* A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix. Sci Rep. 6:18205. 2016
 
60.Li, X., Han, J., Zhao, Y., Ding, W., Wei, J., Li, J., Han, S., Shang, X., Wang, B., Chen, B., Xiao, Z., Dai, J.* Functionalized collagen scaffold implantation and cAMP administration collectively facilitate spinal cord regeneration. Acta Biomater. 30:233-245. 2016
 
61.Du, M., Chen, B., Meng, Q., Liu, S., Zheng, X., Zhang, C., Wang, H., Li, H., Wang, N., Dai, J.* 3D bioprinting of BMSC-laden methacrylamide gelatin scaffolds with CBD-BMP2-collagen microfibers. Biofabrication. 7(4):044104. 2015
 
62.Shen, H., Ma, Y., Luo, Y., Liu, X., Zhang, Z.*, Dai, J.* Directed osteogenic differentiation of mesenchymal stem cell in three-dimensional biodegradable methylcellulose-based scaffolds. Colloids Surf B Biointerfaces. 135:332-38. 2015
 
63.Jia, W., Tang, H., Wu, J., Hou, X., Chen, B., Chen, W., Zhao, Y., Shi, C., Zhou, F., Yu, W., Huang, S., Ye, G., Dai, J.* Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model. Biomaterials. 69:45-55. 2015
 
64.Li, X., Li, H., Sun, J., Zhuang, Y., Xu, B., Dai, J.* Electrospun Collagen Fibers with Spatial Patterning of SDF1α for the Guidance of Neural Stem Cells. Adv Healthc Mater. 4(12):1869-76. 2015
 
65.Wu, J., Jia, W., Chen, W., Zhou, F., Fang, Z., Xianglin Hou, X., Chen, B., Ye, G.*, Dai, J.* Transplantation of hBMSCs loaded on collagen scaffolds for the regeneration of canine tissue-engineered urethras. J Genet Genome Res. 2:1. 2015
 
66.Yang, Y., Shi, C., Hou, X., Zhao, Y., Chen, B., Tan, B., Deng, Z., Li, Q., Liu, J., Xia, Z., Miao, Q., Dai, J.* Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction. J Control Release. 213:27-35. 2015
 
67.Li, X., Han, J., Zhao, Y., Ding, W., Wei, J., Han, S., Shang, X., Wang, B., Chen, B., Xiao, Z., Dai, J.* Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord Regeneration in Vivo. ACS Appl Mater Interfaces. 7(25):13960-71. 2015
 
68.Liang, H., Li, X., Chen, B., Wang, B., Zhao, Y., Zhuang, Y., Shen, H., Zhang, Z., Dai, J.* A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy. J Control Release. 209:101-109. 2015
 
69.Luo, Y., Shen, H., Fang, Y., Cao, Y., Huang, J., Zhang, M., Dai, J., Shi, X., Zhang, Z.* Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl Mater Interfaces. 7(11):6331-9. 2015
 
70.Lu, C., Meng, D., Cao, J., Xiao, Z., Cui, Y., Fan, J., Cui, X., Chen, B., Yao, Y., Zhang, Z., Ma, J., Pan, J.*, Dai, J.* Collagen scaffolds combined with collagen-binding ciliary neurotrophic factor facilitate facial nerve repair in mini-pigs. J Biomed Mater Res A. 103(5):1669-76. 2015
 
71.Tao, L., Li, Q., Ren, H., Chen, B., Hou, X., Mou, L., Zhou, S., Zhou, J., Sun, X., Dai, J.*, Ding, Y.* Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model. Artif Organs. 39(4):352-60. 2015
 
72.Shen, Q., Chen, B., Xiao, Z., Zhao, L., Xu, X., Wan, X., Jin, M., Dai, J.*, Dai, H.* Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis. Mol Med Rep. 11(4):2831-7. 2015
 
73.Song, T., Zhao, X., Sun, H., Li, X., Lin, N., Ding, L., Dai, J., Hu, Y.* Regeneration of uterine horns in rats using collagen scaffolds loaded with human embryonic stem cell-derived endometrium-like cells. Tissue Eng Part A. 21(1-2):353-61. 2015
 
74.Guan, J., Zhang, B., Zhang, J., Ding, W., Xiao, Z., Zhu, Z., Han, Q., Wu, C., Sun, Y., Tong, W., Dai, J.*, Wang, R.*. Nerve regeneration and functional recovery by collagen-binding BDNF in an intracerebral hemorrhage model. Tissue Eng Part A. 21(1-2):62-74. 2015
 
75.Han, S., Wang, B., Jin, W., Xiao, Z., Li, X., Ding, W., Kapur, M., Chen, B., Yuan, B., Zhu, T., Wang, H., Wang, J., Dong, Q., Liang, W., Dai, J.* The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine. Biomaterials. 41:89-96. 2015
 
76.Han, S., Wang, B., Jin, W., Xiao, Z., Chen, B., Xiao, H., Ding, W., Cao, J., Ma, F., Li, X., Yuan, B., Zhu, T., Hou, X., Wang, J., Kong, J., Liang, W.*, Dai, J.* The collagen scaffold with collagen binding BDNF enhances functional recovery by facilitating peripheral nerve infiltrating and ingrowth in canine complete spinal cord transaction. Spinal Cord. 52(12):867-73. 2014
 
77.Wang, H., Yan, X., Shen, L., Li, S., Lin, Y., Wang, S., Hou X., Shi, C., Yang Y., Dai, J.*, Tan, Q.* Acceleration of wound healing in acute full-thickness skin wounds using a collagen-binding peptide with an affinity for MSCs. Burns & Trauma. 2(4):181-6. 2014.
 
78.Ma, F., Xiao, Z., Meng, D., Hou, X., Zhu, J., Dai, J.*, Xu, R.* Use of natural neural scaffolds consisting of engineered vascular endothelial growth factor immobilized on ordered collagen fibers filled in a collagen tube for peripheral nerve regeneration in rats.Int J Mol Sci. 15(10):18593-609. 2014
 
79.Hu, W., Zhao, J., Long, M., Zhang, X., Liu, Q., Hou, M., Kang, Q., Wang, Y., Xu, S., Kong, W., Zhang, H., Wang, S., Sun, Y.,  Hang, H., Huang, Y., Cai, W., Zhao, Y., Dai, J., Zheng, H., Duan, E., Wang J. Space Program SJ-10 of Microgravity Research. Microgravity Science and Technology. 26(3):159-69. 2014
 
80.Wang, B., Liu, T., Lai, CH., Rao, Y., Choi, MC., Chi, JT.., Dai, J., Rathmell, JC., Yao, TP.* Glycolysis-dependent Histone Deacetylase 4 degradation regulates inflammatory cytokine production. Mol Biol Cell. 25(21):3300-7. 2014
 
81.Zhang, J., Zhao, Y., Hou, X., Chen, B., Xiao, Z., Han, J., Shi, C., Liu, J., Miao, Q., Dai, J.* The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification. Biomaterials. 35(34):9322-31. 2014
 
82.Lv, Q., Lan, W., Sun, W., Ye, R., Fan, X., Ma, M., Yin, Q., Jiang, Y., Xu, G., Dai, J., Guo, R.*, Liu, X.* Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats. J Neurol Sci. 345(1-2):48-55. 2014
 
83.Wei, J., Han, J., Zhao, Y., Cui, Y., Wang, B., Xiao, Z., Chen, B., Dai, J.* The importance of three-dimensional scaffold structure on stemness maintenance of mouse embryonic stem cells. Biomaterials. 35(27):7724-33. 2014
 
84.Cui, Y., Lu, C., Meng, D., Xiao, Z., Hou, X., Ding, W., Kou, D., Yao, Y., Chen, B., Zhang, Z., Li, J., Pan, J.*, Dai, J.*.Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs. Biomaterials. 35(27):7819-27. 2014
 
85.Han, X., Zhang, W., Gu, J., Zhao, H., Ni, L., Han, J., Zhou, Y., Gu, Y., Zhu, X., Sun, J., Hou, X., Yang, H., Dai, J.*, Shi, Q.* Accelerated postero-lateral spinal fusion by collagen scaffolds modified with engineered collagen-binding human bone morphogenetic protein-2 in rats. PLoS One. 9(5):e98480. 2014
 
86.Ding, W., Dai, J. Methods for detecting transcribed pseudogenes: PCR on regions of high sequence similarity followed by cloning and sequencing. Methods Mol Biol. 1167:103-15. 2014
 
87.Liu, X., Li, X., Li, S., Zhou, X., Li, S., Wang, Q., Dai, J., Lai, R., Xie, L., Zhong, M., Zhang, Y., Zhou, L. An in vitro study of a titanium surface modified by simvastatin-loaded titania nanotubes-micelles. J Biomed Nanotechnol. 10(2):194-204. 2014
 
88.Chong, Y., Ma, Y., Shen, H., Tu, X., Zhou, X., Xu J., Dai, J., Fan, S.*, Zhang, Z.* The in vitro and in vivo toxicity of graphene quantum dots. Biomaterials. 35(19):5041-8. 2014
 
89.Ding, L., Li, X., Sun, H., Su, J., Lin, N., Péault, B., Song, T., Yang, J., Dai, J.*, Hu, Y.* Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus. Biomaterials. 35(18):4888-900. 2014
 
90.Ma, F., Xiao, Z., Chen, B., Hou X., Han, J., Zhao, Y., Dai, J.*, Xu, R.* Accelerating proliferation of neural stem/progenitor cells in collagen sponges immobilized with engineered basic fibroblast growth factor for nervous system tissue engineering. Biomacromolecules.15(3):1062-8. 2014
 
91.Cao, L., Li, B., Yi, P., Zhang, H., Dai, J., Tan, B.*, Deng, Z.* The interplay of T1- and T2-relaxation on T1-weighted MRI of hMSCs induced by Gd-DOTA-peptides. Biomaterials. 35(13):4168-74. 2014
 
92.Shi, Q., Gao, W., Han, X., Zhu, X., Sun, J., Xie, F., Hou, X., Yang, H., Dai, J.*, Chen, L.* Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model. Sci China Life Sci. 57(2):232-40. 2014
 
93.Wu, L., Xu, L., Xu, X., Fan, X., Xie, Y., Yang, L., Lan, W., Zhu, J., Xu, G., Dai, J., Jiang, Y., Liu, X.* Keep warm and get success: The role of postischemic temperature in the mouse middle cerebral artery occlusion model. Brain Res Bull. 101:12-17. 2014
 
94.Cui, Y., Xiao, Z., Chen, T., Wei, J., Chen, L., Liu, L., Chen, B., Wang, X., Li, X., Dai, J.* The miR-7 identified from collagen biomaterial based 3-D cultured cells regulates neural stem cell differentiation. Stem Cells Dev. 23(4):393-405. 2014
 
95.Han, Q., Zhan, B., Chen, B., Dai, J., Xu, J., Wang, C., Wang, Z.* Evaluation of a bioactive bone-inducing material consisting of collagen scaffolds and collagen-binding BMP2. J Biomed Mater Res A. 102(9):3093-101. 2014
 
96.Yang, Y., Yu, K., Zhang, H., Dai, J., Deng, Z. In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent. Int J Mol Med. 33(1):215-20, 2014
 
97.Ma, F., Xiao, Z., Chen, B., Hou, X., Dai, J.*, Xu, R.* Linear ordered collagen scaffolds loaded with collagen-binding basic fibroblast growth factor facilitate recovery of sciatic nerve injury in rats. Tissue Eng Part A. 20(7-8):1253-62. 2014
 
98.Du, M., Liang, H., Mou, C., Li, X., Sun, J., Zhuang, Y., Xiao, Z., Chen, B., Dai, J.* Regulation of human mesenchymal stem cells differentiation into chondrocytes in extracellular matrix-based hydrogel scaffolds. Colloids and Surfaces B: Biointerfaces. 114(1):316–323. 2014
 
99.Huang, X., Li, X., Wang, Q., Dai, J., Hou, J.*, Chen, L.* Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates. Biomaterials. 34(26):6139-46. 2013
 
100. Han, J., Chen, L., Luo, G., Dai, B., Wang, X., Dai, J.*. Three-dimensional culture may promote cell reprogramming. Organogenesis. 9:118-120. 2013
 
101. Jiang, Y., Chen, B., Liu, Y., Zhufu, Z., Yan, X., Hou, X., Dai, J.*, Tan, Q*. Effect of collagen scaffold with adipose-derived stromal vascular fraction cells on diabetic wound healing: A study in a diabetic porcine model. Tissue Engineering and Regenerative Medicine. 10(4):192-199. 2013
 
102. Du, M., Zhu, Y., Yuan, L., Liang, H., Mou, C., Li, X., Sun, J., Zhuang, Y., Zhang, W., Shi, Q., Chen, B., Dai, J.* Assembled 3D cell niches in chitosan hydrogel network to mimic extracellular matrix. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 434: 78–87. 2013
 
103. Guan, J., Zhu, Z., Robert Zhao C., Xiao, Z., Wu, C., Han, Q., Chen, L., Tong, W., Zhang, J., Han, Q., Gao, J., Feng, M., Bao, X., Dai, J.*, Wang, R.* Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats. Biomaterials. 34(24):5937-5946. 2013
 
104. Su, G., Zhao, Y., Wei, J., Xiao, Z., Chen, B., Han, J., Chen, L., Guan, J., Wang, R., Dong, Q., Dai, J. * Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces. Biomaterials. 34(24): 5897-5906. 2013
 
105. Liu, X., Li, X., Zhou, L., Li, S., Sun, J., Wang, Z., Gao, Y., Jiang, Y., Lu, H., Wang, Q., Dai, J. * Effects of simvastatin-loaded polymeric micelles on human osteoblast-like MG-63 cells. Colloids Surf B Biointerfaces.102:420-7. 2013
 
106. Li, X., Xiao, Z., Han, J., Chen, L., Xiao, H., Ma, F., Hou, X., Li, X., Sun, J., Ding, W., Zhao, Y., Chen, B., Dai, J.* Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair. Biomaterials. 34(21):5107-16. 2013
 
107. Tan, Q., Chen, B., Yan, X., Lin, Y., Xiao, Z., Hou, X., Dai, J.* Promotion of diabetic wound healing by collagen scaffold with collagen-binding vascular endothelial growth factor in diabetic rat model. Journal of Tissue Engineering and Regenerative Medicine. 8(3):195-201. 2013
 
108. Li, N., Zhang, Q., Gao, S., Song, Q., Huang, R., Wang, L., Liu, L., Dai, J.* Tang, M.*, Cheng, G.* Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci. Rep. 3:1604. 2013
 
109. Su, G., Zhao, Y., Wei, J., Han, J., Chen, L., Xiao, Z., Chen, B., Dai, J. * The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties. Biomaterials. 34(13):3215-22. 2013
 
110. Yi, P., Chen, G., Zhang, H., Tian, F, Tan, B., Dai, J., Wang, Q.,* Deng, Z.* Magnetic resonance imaging of Fe3O4@SiO2-labeled human mesenchymal stem cells in mice at 11.7 T. Biomaterials. 4(12):3010-9. 2013
 
111. Han, J., Xiao, Z., Chen, L., Chen, B., Li, X., Han, S., Zhao, Y., Dai, J.* Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway. Biomaterials. 34(8):1921-8. 2013
 
112. Cao, J., Xiao, Z., Jin, W., Chen, B., Meng, D., Ding, W., Han, S., Hou, X., Zhu, T., Yuan, B., Wang, J., Liang, W., Dai, J.* Induction of rat facial nerve regeneration by functional collagen scaffolds. Biomatierials. 34(4):1302-10. 2013