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傅向东


傅向东,博士,研究员,博士生导师
 
学习经历
        1987-1991 武汉大学生物系遗传学专业,学士
        1991-1994 中国科学院武汉植物所植物学专业,硕士
        1998-2000 英国John Innes Centre和浙江大学联合培养农学专业,博士
 
工作经历
        1994-1996 浙江农业大学生物技术研究所,助理研究员
        1996-1997 英国John Innes Centre,访问学者
        1997-1998 浙江大学生物技术研究所,讲师
        2001-2005 英国John Innes Centre,博士后
        2005至今 中科院遗传与发育生物学研究所,研究员
        2015至今 中国科学院大学,教授
 
荣誉奖励
        2005年 国家自然科学基金委“杰出青年基金”
        2010年 “百人计划”终期评估中获得优秀
        2010年 “第十一届中国青年科技奖”
        2011年 中国科学院优秀导师奖
        2013年 “第八届大北农科技奖”一等奖
        2014年 全国优秀科技工作者
        2014年 科技部创新人才推进计划中青年科技创新领军人才
        2016年 中组部 “万人计划”领军人才科技创新领军人才
        2017年 第十届“谈家桢生命科学创新奖”
        2019年 中国科学院优秀导师奖
        2020年 第八届“中国侨届贡献奖”一等奖
        2020年 国家自然科学奖二等奖(第一完成人)


研究方向
 
        1. 解析植物激素与环境因子互作调控植物生长-代谢耦合的分子机制
        植物的生长发育受内源激素(如赤霉素、生长素等)和可变环境(如:光强度、土壤氮水平等)的共同影响。实验室的主要兴趣之一是解析激素与环境互作调控植物生长与碳-氮代谢平衡的耦合机制,为培育“资源节约型”农作物新品种提供理论支撑。
 
 
 
        2,研究农作物产量性状形成的遗传调控网络
        株(穗)型发育对产量和品质性状影响很大,涉及茎尖分生组织活性调控、侧生器官的形成及生长发育调控等过程的复杂生物学问题。通过GWAS分析、QTL定位和图位克隆等技术挖掘产量性状控制的新基因,解析高产、优质、高效等复杂性状间协同调控的分子机制,挖掘优异等位基因,并通过分子设计育种培育高产优质高效协同改良的农作物新品种。
 
 
水稻高产、优质、高效新基因(Nature Genetics, 2009; 2012; 2014; 2015)

代表性论文
1.Wu K#, Wang S#, Song W, Zhang J, Wang Y, Liu Q, Yu J, Ye Y, Li S, Chen J, Zhao Y, Wang J, Wu X, Wang M, Zhang Y, Liu B, Wu Y, Harberd NP*, Fu X* (2020) Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice. Science 367 (6478).
 
2.Zhu L, Cheng H, Peng G, Wang S, Zhang Z, Ni E, Fu X, Zhuang C, Liu Z, Zhou H (2020) Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles. Genomics, Proteomics & Bioinformatics, https://doi.org/10.1016/j.gpb. 2019.01.005.
 
3.Xu X#, Wu K#, Xu R, Wang S, Gao Z, Zhong Y, Li X, Liao H, Fu X* (2019) Pyramiding of the dep1-1 and NAL1NJ6 alleles achieves sustainable improvements in nitrogen-use efficiency and grain yield in japonica rice breeding. Journal of Genetics and Genomics 46(6), 325-328.
 
4.Li S, Tian Y, Wu K, Ye Y, Yu J, Zhang J, Liu Q, Hu M, Li H, Tong Y, Harberd NP, Fu X* (2018) Modulating plant growth-metabolism coordination for sustainable agriculture. Nature 520 (7720), 595-600.
 
5.Liu Q#, Han R#, Wu K, Zhang J, Ye Y, Wang S, Chen J, Pan Y, Li Q, Xu X, Zhou J, Tao D, Wu Y, Fu X* (2018) G-protein βγ subunits determine grain size through interaction with MADS-domain transcription factors in rice. Nature Communications 9, 852.
 
6.Wang S#, Wu K#, Qian Q#, Qian L, Pan Y, Ye Y, Liu X, Wang J, Zhang J, Li S, Wu Y, Fu X* (2017) Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield. Cell Research 27(9), 1142-1156.
 
7.Chen X, Yao Q, Gao X, Jiang C, Harberd NP, Fu X* (2016) Shoot-to-Root mobile transcription factor HY5 coordinates plant carbon and nitrogen acquisition. Current Biology 26, 640-646.
 
8.Liu Q, Harberd NP, Fu X* (2016) SQUAMOSA Promoter Binding Protein-like Transcription Factors: Targets for Improving Cereal Grain Yield. Molecular Plant 9, 765-767.
 
9.Liu Q, Chen X, Wu K, Fu X* (2015) Nitrogen signaling and use efficiency in plants: what’s new? Current Opinion in Plant Biology 27, 192-198.
 
10.Wang S, Li S, Liu Q, Wu K, Zhang J, Wang S, Wang Y, Chen X, Zhang Y, Gao C, Wang F, Huang H, Fu X* (2015) The OsSPL16-GW7 regulatory module determines grain shape and simultaneously improves rice yield and grain quality. Nature Genetics 47(8), 949-954.
 
11.Ye Y, Liu B, Zhao M, Wu K, Cheng W, Chen X, Liu Q, Liu Z, Fu X*, Wu Y* (2015) CEF1/OsMYB103L is involved in GA-mediated regulation of secondary wall biosynthesis in rice. Plant Molecular Biology 89(4-5): 385-401.
 
12.Xu H, Liu Q, Yao T, Fu X* (2014) Shedding light on integrative GA signaling. Current Opinion in Plant Biology 21, 89-95.
 
13.Sun H#, Qian Q#, Wu K#, Luo J#, Wang S#, Zhang C, Ma Y, Liu Q, Huang X, Yuan Q, Han R, Zhao M, Dong G, Guo L, Zhu X, Gou Z, Wang W, Wu Y, Lin H, Fu X* (2014) Heterotrimeric G proteins regulate nitrogen-use efficiency in rice. Nature Genetics 46, 652-656.
 
14.Ma W, Li J, Qu B, He X, Zhao X, Li B, Fu X*, Tong Y * (2014) Auxin biosynthetic gene TAR2 is involved in low nitrogen mediated reprogramming of root architecture in Arabidopsis. Plant Journal 78, 70-79.
 
15.Wang S, Wu K, Yuan Q, Liu X, Liu Z, Lin X, Zeng R, Zhu H, Dong G, Qian Q, Zhang G *, Fu X* (2012) Control of grain size, shape and quality by OsSPL16 in rice. Nature Genetics 44, 950-954.
 
16.Gao X, Xiao S, Yao Q, Wang Y, Fu X* (2011) An Updated GA Signaling ’Relief of Repression’ Regulatory Model. Molecular Plant 4, 60-606.
 
17.  Wu J, Kong X, Wan J, Liu X, Zhang X, Guo X, Zhou R, Zhao G, Jing R, Fu X*, Jia J* (2011) Dominant and Pleiotropic Effects of a GAI Gene in Wheat Results from a Lack of Interaction between DELLA and GID1. Plant Physiology 157, 2120-2130.
 
18.  Huang X#, Qian Q#, Liu Z, Sun H, He S, Luo D, Xia G, Chu C, Li J, Fu X* (2009) Natural variation at the DEP1 locus enhances grain yield in rice. Nature Genetics 41, 494-497.
 
19.  Jiang C, Gao X, Liao L, Harberd NP, Fu X* (2007) Phosphate-starvation root architecture and anthocyanin accumulation responses are modulated by the GA-DELLA signaling pathway in Arabidopsis. Plant Physiology 145, 1460-1470.
 
20.  Jiang C, Fu X* (2007) GA action: turning on de-DELLA repressing signaling. Current Opinion in Plant Biology 10, 461-465.