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傅向东


傅向东,博士,研究员,博士生导师
 
        1991年获武汉大学生物系学士学位。1994年获中国科学院武汉植物所硕士学位。1996-1997年在英国John Innes Centre应用遗传系做访问学者。1998-2000年在英国John Innes Centre作物遗传系,获浙江大学和John Innes Centre联合培养博士学位。2001-2005年在John Innes Centre细胞与发育生物学系做博士后。2005年入选中国科学院"百人计划",同年获得国家自然科学基金委“杰出青年基金”资助。现任中国科学院遗传发育所分子农业生物学中心主任,植物细胞与染色体工程国家重点实验室副主任,植物学通报、JGG以及Frontiers in Plant Genetics and Genomics杂志编委。先后获得“享受政府特殊津贴专家”、“第十一届中国青年科技奖”、“中青年科技创新领军人才”以及“第六届全国优秀科技工作者”等多项荣誉。。


        研究方向:解析赤霉素信号途径及其调控植物生长发育的分子机制;研究水稻穗发育和产量性状形成的遗传调控网络,利用分子设计培育“资源节约型”水稻新品种。主要研究内容包括:
 
1.赤霉素协同调控植物生长和代谢的分子机制
        赤霉素是调控植物生长发育的重要激素之一。DELLA蛋白是赤霉素信号途径的关键负调控因子,赤霉素通过26S Proteasome蛋白酶体降解途径降解DELLA蛋白,进而促进植物生长。水稻“绿色革命”基因sd1编码赤霉素生物合成途径的关键酶, 而小麦“绿色革命”基因Rht1编码赤霉素信号转导途径的DELLA蛋白。以拟南芥和水稻为材料,利用遗传筛选、蛋白互作等分析手段,分离赤霉素信号途径的新组分,解析赤霉素信号途径及其协同调控植物生长和代谢的分子机制,为水稻、小麦 “资源节约型”新品种培育奠定理论基础。
 
2.水稻穗发育和穗型形成的分子调控
        高产、优质历来是水稻育种追求的重要目标之一。水稻的产量性状由分蘖数、穗粒数、粒重等多个农艺性状决定,是受多基因与环境共同控制的复杂数量性状。水稻穗发育和穗型形成对产量形成的影响很大,是涉及SAM活性调控、侧生器官的形成及生长发育调控等过程的复杂生物学问题。通过QTL分析和突变体鉴定,克隆调控水稻穗发育和穗型的新基因。重点研究穗粒数和粒重决定的关键调控因子及其互作网络,揭示水稻穗发育和高产性状形成的分子基础。
 
3. 植物激素与环境互作调控植物的生长发育
        植物的生长发育受内源激素和可变生长环境的共同影响,目前我们对于激素与环境互作调控植物生长发育的分子机理的认识还非常有限。利用遗传筛选响应可变环境(如:光强度、氮水平等)的拟南芥和水稻突变体,研究植物生长发育适应可变环境的长距离信号传导,揭示植物内源激素与可变环境互作调控植物生长发育的分子机制。

近期发表的主要论文:
Chen, X., Yao, Q., Gao, X., Jiang, C., Harberd, N.P., and Fu, X.* (2016) Shoot-to-Root mobile transcription factor HY5 coordinates plant carbon and nitrogen acquisition. Curr. Biol. 26, 640-646.

Liu, Q., Chen, X., Wu, K., and Fu, X.* (2015) Nitrogen signaling and use efficiency in plants: what's new? Curr. Opin. Plant Biol. 27, 192-198.

Wang, S., Li, S., Liu, Q., Wu, K., Zhang, J., Wang, S., Wang, Y., Chen, X., Zhang, Y., Gao, C., Wang, F., Huang, H., and Fu, X.* (2015) The OsSPL16-GW7 regulatory module determines grain shape and simultaneously improves rice yield and grain quality. Nat. Genet. 47(8), 949-954.

Ye, Y., Liu, B., Zhao, M., Wu, K., Cheng, W., Chen, X., Liu, Q., Liu, Z., Fu, X.*, and Wu Y.* (2015) CEF1/OsMYB103L is involved in GA-mediated regulation of secondary wall biosynthesis in rice. Plant Mol. Biol. 89(4-5):385-401.

Huang, D., Wang, S., Zhang, B., Shang-Guan, K., Shi, Y., Zhang, D., Liu, X., Wu, K., Xu, Z., Fu, X., and Zhou, Y. (2015) A Gibberellin-mediated DELLA-NAC signaling cascade regulates cellulose synthesis in rice. Plant Cell 27(6):1681-1696.

Zhao, M., Liu, B., Wu, K., Ye, Y., Huang, S., Wang, S., Wang, Y., Han, R., Liu, Q., Fu, X.*, and Wu, Y.* (2015) Regulation of OsmiR156h through alternative polyadenylation improves grain yield in rice. PLOS ONE 10(5): e0126154.

Xu, H., Liu, Q., Yao, T., and Fu, X.* (2014) Shedding light on integrative GA signaling. Curr. Opin. Plant Biol. 21, 89-95.

Sun, H., Qian, Q., Wu, K., Luo, J., Wang, S., Zhang, C., Ma, Y., Liu, Q., Huang, X., Yuan, Q., Han, R., Zhao, M., Dong, G., Guo, L., Zhu, X., Gou, Z., Wang, W., Wu, Y., Lin, H., and Fu, X.* (2014) Heterotrimeric G proteins regulate nitrogen-use efficiency in rice. Nat. Genet. 46, 652-656.

Ma, W., Li, J., Qu, B., He, X., Zhao, X., Li, B., Fu, X.*, and Tong, Y. * (2014) Auxin biosynthetic gene TAR2 is involved in low nitrogen mediated reprogramming of root architecture in Arabidopsis. Plant J. 78, 70-79.

Lu, Z., Yu, H., Xiong, G., Wang, J., Jiao, Y., Liu, G., Jing, Y., Meng, X., Hu, X., Qian, Q., Fu, X., Wang, Y., and Li, J. (2013). Genome-wide binding analysis of the transcription activator IPA1 reveals a complex network regulating rice plant architecture. Plant Cell 25, 3743-3759.

Wang, S., Wu, K., Yuan, Q., Liu, X., Liu, Z., Lin, X., Zeng, R., Zhu, H., Dong, G., Qian, Q., Zhang, G.*, and Fu, X.* (2012) Control of grain size, shape and quality by OsSPL16 in rice. Nat. Genet. 44, 950-954.

Li, S., Liu, Y., Zheng, L., Chen, L., Li, N., Corke, F., Lu, Y., Fu, X., Zhu, Z., Bevan, M.W., and Li, Y. (2012) The plant-specific G protein γ subunit AGG3 influences organ size and shape in Arabidopsis thaliana. New Phytol. 194, 690-703.

Gao, X., Xiao, S., Yao, Q., Wang, Y., and Fu, X.* (2011) An Updated GA Signaling 'Relief of Repression' Regulatory Model. Mol. Plant 4, 601-606.

Wu, J., Kong, X., Wan, J., Liu, X., Zhang, X., Guo, X., Zhou, R., Zhao, G., Jing, R., Fu, X.*, and Jia J.* (2011) Dominant and Pleiotropic Effects of a GAI Gene in Wheat Results from a Lack of Interaction between DELLA and GID1. Plant Physiol. 157, 2120-2130.

Huang, X., Qian, Q., Liu, Z., Sun, H., He, S., Luo, D., Xia, G., Chu, C., Li, J., and Fu, X.* (2009) Natural variation at the DEP1 locus enhances grain yield in rice. Nat. Genet. 41, 494-497.

Wang, F., Zhu, D., Huang, X., Li, S., Gong, Y., Yao, Q., Fu, X., Fan, L., and Deng, X. (2009) Biochemical Insights on Degradation of Arabidopsis DELLA Proteins Gained From a Cell-Free Assay System. Plant Cell 21, 2378-2390.

Gao, X., Huang, X., Xiao, S., and Fu, X.* (2008) Evolutionarily conserved DELLA mediated gibberellin signaling in plants. J. Integr. Plant Biol. 50, 825-834.

Feng, S., Martinez, C., Gusmaroli, G., Wang, Y., Zhou, J., Wang, F., Chen, L., Yu, L., Iglesias-Pedraz, J.M., Kircher, S., Schafer, E., Fu, X., Fan, L., and Deng, X. (2008) Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature 451,475- 479.

Jiang, C., Gao, X., Liao, L., Harberd, N.P., and Fu, X.* (2007) Phosphate-starvation root architecture and anthocyanin accumulation responses are modulated by the GA-DELLA signaling pathway in Arabidopsis. Plant Physiol. 145, 1460-1470.

Jiang, C., and Fu, X.* (2007). GA action: turning on de-DELLA repressing signaling. Curr. Opin. Plant Biol. 10, 461-465.

Achard, P., Liao, L., Jiang, C., Desnos, T., Bartlett, J., Fu, X.*, and Harberd, N.P.* (2007) DELLAs contribute to plant photomorphogenesis. Plant Physiol. 143, 1163-1172.
 
Fu, X., Richards, D.E., Fleck, B., Xie, D., Burton, N., and Harberd, N.P. (2004) The Arabidopsis mutant sleepy1gar2-1 protein promotes plant growth by increasing the affinity of the SCFSLY1 E3 ubiquitin ligase for DELLA protein substrates. Plant Cell 16, 1406-1418.
 
Fu, X., and Harberd, N.P. (2003) Auxin promotes Arabidopsis root growth by modulating gibberellin response. Nature 421, 740-743.
 
Fu, X., Richards, D.E., Ait-Ali, T., Hynes, L.W., Ougham, H., Peng, J., and Harberd, N.P. (2002) Gibberellin mediated proteasome dependent degradation of the barley DELLA protein SLN1 repressor. Plant Cell 14, 3191-3200.
 
Fu, X., Sudhakar, D., Peng, J., Richards, D.E., Christou, P., and Harberd, N.P. (2001) Expression of Arabidopsis GAI in transgenic rice represses multiple gibberellin responses. Plant Cell 13, 1791-1802.