周奕华，博士，研究员，博士生导师
1989年毕业于北京师范大学生物系，1992年获该校细胞遗传专业硕士学位。1994年-1996年在美国Clemson大学访问学习。1998年获中科院遗传所植物分子遗传学博士学位。2001年1月至2002年8月，在美国Michigan理工大学进行博士后研究工作。2002－2005年，中科院遗传发育所副研究员。2006年，中科院遗传发育所研究员，并担任课题组长。2011年获得国家杰出青年科学基金资助。主持或参与多项国家973，863及自然科学基金等项目。
Tel: 64807605 (O); 64807628 (L)
Email: yhzhou@genetics.ac.cn
我们实验室主要研究方向为植物分子遗传学与细胞壁生物学研究:
1、细胞壁形成与植物生长发育
植物如何形成细胞壁是一个重要的科学问题。作为植物细胞的基本结构，细胞壁的形成与植物生长发育密切相关。大量的研究表明，细胞壁形成的异常通常伴随着植物生长发育的异常。另外，作为基础代谢过程，细胞壁的合成与调控处于植物信号传导的最下游，植物对激素的反应、对环境的适应和对胁迫的应答最终会在细胞壁的形成和变化上体现出来。因此植物体内存在参与细胞壁形成及响应细胞壁改变的信号通路和应答机制。人们对这一过程的了解还极其不清楚。我们课题组通过研究矮秆、披叶等水稻突变体和拟南芥花粉管发育异常突变体及其野生型基因的功能，发现一些关键基因OsCSLD4 (Li et al., 2009) 、BC12（Zhang et al., 2010）、MGP4（Liu et al., 2011）、ILA1（Ning et al., 2011）等影响细胞有丝分裂或伸长过程，为揭示细胞壁形成及其在生长发育中的作用机制积累了数据。
2、细胞壁生物合成与水稻茎秆机械强度
茎秆强度是作物栽培育种中重要的农艺性状，与植株的抗倒伏性直接相关。主要由细胞壁、尤其是次生细胞壁提供，是其化学组成及物理结构的反映。目前对单子叶作物（如水稻）的茎秆强度分子机理研究还很不深入。本课题组独立或与李家洋院士实验室合作完成了BC14（Zhang et al., 2011）、BC3（Xiong et al., 2003）、BC12（Zhang et al., 2010）、BC11（Zhang et al., 2009）、BC10 （Zhou et al., 2009）等关键基因的图位克隆和功能研究工作。所开展的工作已涵盖从底物核苷酸糖运输到纤维素、非纤维素多糖合成与沉积，从膜泡转运到细胞骨架转换等细胞壁形成的重要过程。同时发现影响机械强度的重要 “出口”是纤维素的含量和纤维素微纤丝的排列。对于阐明作物茎秆强度这一重要农艺性状形成的分子机理及解决农业生产上存在的一些实际问题具有重要意义。
| 实验室成员： |
博士后： |
| 余柏胜 博士，助理研究员 |
宋学勤 博士 |
| 张保才 博士，助理研究员 |
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| 刘香玲，助理研究员 |
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| 博士研究生： |
硕博连读研究生： |
| 张泗举（2008级） |
刘立峰（2006级） |
| 黄德宝（2009级） |
石艳云（2008级） |
| 上官科科（2010级） |
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| 张冬梅 （2011级） |
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| 高亚平（2011级） |
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近期主要论文：
2011:
Ning J, Zhang B, Wang N, Zhou Y*, and Xiong L*. (2011) Increased leaf angle1, a Raf-Like MAPKKK that interacts with a nuclear protein family, regulates mechanical tissue formation in the lamina joint of rice. Plant Cell, (DOI:10.1105/tpc.111.093419) (*Corresponding author)
Zhang S, Song X, Yu B, Zhang B, Sun C, Knox J. P, and Zhou Y. (2011) Identification of quantitative trait loci affecting hemicellulose characteristics based on cell wall composition in a wild and cultivated rice species. Molecular Plant, (DOI 10.1093/mp/ssr076)
Zhang B, Liu X, Qian Q, Liu L, Dong G, Xiong G, Zeng D, and Zhou Y. (2011) A Golgi nucleotide sugar transporter modulates cell wall biosynthesis and plant growth in rice. Proc. Natl. Acad. Sci. USA. 108 (12): 5110-5115.
Song X., Zhang B., and Zhou Y. (2011) Golgi-localized UDP-glucose transporter is required for cell wall integrity in rice. Plant Signaling & Behavior, 6: 1097-1100.
Zhang B and Zhou Y. (2011) Study on rice brittleness mutants: A way to open the ‘black box’ of monocot cell wall biosynthesis. J. Integr. Plant Biol. 53: 136-142.
Liu X-L, Liu L, Niu Q-K, Xia C, Yang K-Z, Li R, Chen L-Q, Zhang X-Q, Zhou Y*, and Ye D*. (2011) MALE GAMETOPHYTE DEFECTIVE 4 encodes a rhamnogalacturonan II xylosyltransferase and is important for growth of pollen tubes and roots in Arabidopsis. Plant J. 65: 647-660 (*Corresponding author)
Lei M, Liu Y, Zhang B, Zhao Y, Wang X, Zhou Y, Raghothama K G, and Liu D. (2011) Genetic and genomic evidence that sucrose is a global regulator of plant responses to phosphate starvation in Arabidopsis. Plant Physiol. 156: 1116-1130.
Wang W, Wang Li, Chen C, Xiong G, Tan X-Y, Yang K-Z, Wang Z-C, Zhou Y, Ye D, and Chen L-Q. (2011) Arabidopsis CSLD1 and CSLD4 are required for cellulose deposition and normal growth of pollen tubes. J. Exp. Bot. 62: 5161-5177.
Wang Z-P, Xie Z-Q, Zhang B, Hou L-Y, Zhou Y, Li L-H, and Han X-G. (2011) Aerobic and anaerobic nonmicrobial methane emissions from plant material. Environ. Sci. Technol. 45: 9531-9537.
2010:
Xiong G, Li R, Qian Q, Song X, Liu X, Yu Y, Zeng D, Wan J, Li J and Zhou Y. (2010) The rice dynamin-related protein DRP2B mediates membrane trafficking and thereby plays a critical role in secondary cell wall cellulose biosynthesis. Plant J. 64: 56-70.
Zhang M, Zhang B, Qian Q, Yu Y, Li R, Zhang J, Liu X, Zeng D, Li J and Zhou Y. (2010) Brittle Culm12, a dual-targeting Kinesin-4 protein, controls cell cycle progression and wall properties in rice. Plant J. 63: 312-328.
Li R, Xiong G, and Zhou Y. (2010) Membrane trafficking mediated by OsDRP2B is specific for cellulose biosynthesis. Plant Signaling & Behavior 5 (11): 1-4.
Li R, Xiong G, Zhang B, and Zhou Y. (2010) Rice plants response to the disruption of OsCSLD4 gene. Plant Signaling & Behavior 5 (2): 1-4.
2009:
Li M, Xiong G, Li R, Cui J, Tang D, Zhang B, Pauly M, Cheng Z, and Zhou Y. (2009) Rice cellulose synthase-like D4 is essential for normal cell wall biosynthesis and plant growth. Plant J. 60: 1055-1069.
Zhang B, Deng L, Qian Q, Xiong G, Zeng D, Li R, Guo L, Li J, and Zhou Y. (2009) A missense mutation in the transmembrane domain of CESA4 affects protein abundance in the plasma membrane and results in abnormal cell wall biosynthesis in rice. Plant Mol. Biol. 71: 509-524. (Cover story)
Zhou Y, Li S, Qian Q, Zeng D, Zhang M, Guo L, Liu X, Deng L, Liu X, and Li J. (2009) BC10, a DUF266-containing and golgi-located type II membrane protein, is required for cell wall biosynthesis in rice (Oryza sativa L.). Plant J. 57, 446-462.
2008以前:
Qi J, Qian Q, Bu Q, Li S, Chen Q, Sun J, Liang W, Zhou Y, Chu C, Li X, Ren F, Palme K, Zhao B, Chen J, Chen M, and Li C (2008). Mutation of the rice NARROW LEAF1 gene, which encodes a novel protein, affects vein patterning and polar auxin transport. Plant Physiology, 147, 1947-1959.
Lu, S., Zhou, Y., Li, L., and Chiang V. (2006) Distinct Roles of Cinnamate 4-hydroxylase Genes in Populus. Plant Cell Physiology, 47, 905-914.
Dai Y, Wang H Z, Li B H, Huang J, Liu X F, Zhou Y, Mou Z H, and Li J Y. (2005) Increased expression of MAP KINASE KINASE7 causes deficiency in polar auxin transport and leads to plant architectural abnormality in Arabidopsis. The Plant Cell, 18, 308-320.
Zhao H Y, Liu J, Shiyou L, Zhou Y, Wei J H, Song Y R, and T Wang. (2005) Isolation and functional characterization of a cinnamate 4-hydroxylase promoter from populus tomentosa. Plant Science, 168, 1157-1162.
Li Y 1, Qian Q1, Zhou Y1, Yan M, Sun L, Zhang M, Fu Z, Wang Y, Han B, Pang X, Chen M, Li J. (2003) BRITTLE CULM1, which encodes a COBRA-like protein, affects the mechanical properties of rice plants. The Plant Cell, 15, 2020-2031. (1Contribute equally)
Li L G, Zhou Y, Cheng X F, Sun J Y, Marita J M, Ralph J, Chiang V. (2003) Combinatorial modification of multiple lignin traits in trees through multigene cotransformation. Proc. Natl. Acad. Sci. USA. 100, 4939-4944.
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