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周奕华


周奕华,博士,研究员,博士生导师

 

  1989年毕业于北京师范大学生物系,1992年获该校细胞遗传专业硕士学位。1994年-1996年在美国Clemson大学访问学习。1998年获中科院遗传所植物分子遗传学博士学位。2001年1月至2002年8月,在美国Michigan理工大学进行博士后研究工作。2002-2005年,中科院遗传发育所副研究员。2006年,中科院遗传发育所研究员,并担任课题组长。2011年获得国家杰出青年科学基金资助,并入选中国科学院“百人计划”。主持或参与多项国家973及自然科学基金等项目。

 

  Tel: 64807605 (O); 64807628 (L)

  Email: yhzhou@genetics.ac.cn



主要研究方向:植物分子遗传学与细胞壁生物学研究
 
科学意义与经济价值:细胞壁是植物细胞的特征性结构,也是形态建成等众多生命活动的物质基础。细胞壁是由纤维素、半纤维素、果胶、木质素等组成的复杂网络结构。在构成植物体的40多种细胞中,每种细胞都有与其功能相适配的细胞壁结构。因此,解析植物如何构造细胞壁是植物领域的重要科学问题之一,对理解植物环境适应性及众多生长发育机制具有重要的科学意义。细胞壁也构成了地球上最丰富的可再生资源,为人类提供了粮食、食品、纤维、医药及燃料等,具有重要的经济价值。
 
        1、细胞壁与作物抗倒伏性状改良
        抗倒伏是非常重要又极为复杂的农艺性状,受遗传、栽培条件及环境等众多因素影响。农作物倒伏归根溯源是由于支撑力不足,尤其风雨等外力作用会扰动支撑力矩,加剧作物倾覆或秸秆折断。而次生加厚的细胞壁是支撑植物直立生长的关键细胞结构,细胞壁的化学组成及网络结构决定了支撑力的强弱。为解决作物倒伏难题,我们课题组长期以水稻脆秆突变体等遗传材料为研究对象,利用正向遗传学、分子生物学等手段阐明了茎秆强度控制基因BC1 (Liu et al., 2013, PLoS Genet.)、BC15 (Wu et al., 2012, Plant Physiol.), BC13 (Song et al., 2012, Mol. Plant)、BC14 (Zhang et al., 2011, Proc. Natl. Acad. Sci. USA)、BC3 (Xiong et al., 2010, Plant J.)、BC12 (Zhang et al., 2010, Plant J.)及BC11 (Zhang et al., 2009, Plant Mol. Biol.)等基因的功能与作用机理,揭示了水稻茎秆强度调控的遗传网络。
 
        细胞壁是天然纳米级网络。细胞壁多糖如何形成承力的网络结构也是决定支撑力强弱的关键。近年来核磁共振、原子力显微镜等生物物理和超分辨技术的发展,使得细胞壁功能结构及其精准调控机制研究逐渐成为植物学重要的科学前沿。而我们发现木聚糖是一种重要的交联多糖,其上的乙酰化能控制木聚糖构象,进而影响它与纤维素和木质素的交联,为支撑力控制机制的解析打开了新的突破口。我们已在水稻中鉴定了催化木聚糖主链乙酰化修饰的乙酰基转移酶主链OsTBL1/2 (Gao et al., 2017, Plant Physiol.)和乙酰酯酶BS1 (Zhang et al., 2017, Nat. Plants)、侧链乙酰酯酶DARX1 (Zhang et al., 2019, Plant Cell),发现木聚糖乙酰化修饰存在乙酰化和去乙酰化过程,提出了细胞壁乙酰化修饰调控的新理论、即“双向调控”理论。获得了Nature PlantsPlant Cell专文评述。
 
 
        近期通过遗传学和分子生物学研究,揭示了水稻对不同氮环境的响应及其与生物质合成的交互节点(Gao, et al., 2020, Nat. Commun.),为协同水稻等农作物的氮利用效率与抗倒伏性提供了新途径。在该研究方向上,我们重点围绕水稻细胞壁功能结构如何建成这一核心科学问题,通过多项前沿新技术的应用,多尺度研究细胞壁的功能结构与力学特征及其控制机制,为培育高产抗倒伏水稻新材料/新种质提供理论依据和解决方案。
 
        2、结构多糖与品质改良
        细胞壁结构多糖常常作为储备物质被植物储藏于果实/籽粒中,例如番茄、葡萄果实中富含果胶,咖啡豆、魔芋中在富含甘露聚糖,大麦、燕麦中富含葡聚糖,芦笋中则富含木聚糖。这些多糖的含量与结构对这些果蔬的品质有着重要的影响。然而对于这些多糖如何被合成及组装在果实/籽粒中,进而影响其品质的关键代谢及调控通路仍然知之甚少。

        我们以水稻等主要作物为材料,利用遗传学、植物化学、分子生物学等多学科手段,对籽粒中主要的结构多糖----葡甘露聚糖、阿拉伯木聚糖和混联葡聚糖的合成机理开展研究,分析这些结构多糖与蛋白质和淀粉的分子互作关系,揭示三者的分子结构特征。阐明稻米籽粒中甘露聚糖与葡聚糖生物合成的关键基因及调控通路,揭示籽实品质决定的关键分子网络。通过关键基因的挖掘、互作蛋白的筛选、复合体的分离以及酶活分析,解析木聚糖、甘露聚糖等糖链合成的复合体组分与特性,为水稻等作物品质改良提供新的视角和新的途径。
 
        3生物力调控植物生长发育
        植物的各种生命活动离不开生物力的驱动。细胞壁作为植物细胞外制衡胞内膨压与机械应力的承力结构,是多种生物力的产生与效应部位,决定细胞、器官及植株的形态与功能,因而备受关注。我们通过长期的研究,发现了赤霉素调控次生壁纤维素合成与茎秆机械强度的一条完整信号转导通路(Huang et al., 2015, Plant Cell);解析了叶枕部调控次生壁形成与叶夹角的作用通路ILA1-IIP4-NAC (Ning et al., 2011, Plant Cell; Zhang et al., 2018, Mol. Plant)。与其他团队合作,鉴定了参与果胶合成的多个关键酶(Liu et al., 2011, Plant J.; Peng et al., 2021, Mol. Plant),揭示了根与花粉管生长的控制机制。而对玉米果胶甲酯酶Ga1P的鉴定(Zhang et al., 2018, Nat. Commun.)明确了果胶甲酯化修饰程度对花粉管壁机械力的控制作用,首次发现玉米异交不亲和性由PME复合体介导的新机制,解答了玉米单向杂交不亲和性的‘世纪难题’。

        对细胞壁介导生物力调控植物生长发育的研究才刚刚起步,其中细胞壁---细胞膜---细胞骨架联动体系是研究机械应力调控植物生长发育的重要方面。实验室已积累了一系列生长发育改变的细胞壁变导材料,明确细胞壁的具体缺陷,并通过遗传筛选获得了生长发育恢复的抑制子,相关工作正在进行之中。
        此外,我们还从细胞壁多糖的角度开展稻瘟病抗性控制及植物与环境交互调控生长可塑性研究。
 
 
 
实验室成员:                       
张保才 博士,青年研究员
王义琴 博士,副研究员
张兰军 博士,助理研究员        
博士后:汪航、曹少雪、许作鹏(扬州大学)
 
博士研究生:                    
杨晗蕾(2016级)、高成旭(2017级)、高易宏(2018级)、文钊(2019级)、王炎(2020级)、徐瑞(2021级)
硕博连读研究生:马佳宁(2017级)、刘卓林(2019级)、李家曦(2020级)
硕士研究生:马佳欣(2018级)
客座学生:张玮(2020级,云南大学)
 
研究生国家奖学金获得情况:
上官科科(2010级)、王少干(2012级)、高成旭(2017级)、高易宏(2018级)

近期主要论文(*通讯作者)
2022:
Wang H, Yang H, Wen Z, Gao C, Gao Y, Tian Y, Xu Z, Liu X, Persson S, Zhang B*, Zhou Y*. (2022) Xylan-based nanocompartments orchestrate plant vessel wall patterning. Nat Plants (accept).
 
Wang F, Cheng Z, Wang J, Zhang F, Zhang B, Luo S, Lei C, Pan T, Wang Y, Zhu Y, Wang M, Chen W, Lin Q, Zhu S, Zhou Y, et al. (2022) OsSCD2 regulates cell expansion by affecting the trafficking of cell wall components in rice. Plant Physiol. (accept).
 
2021:
Zhang B, Gao Y, Zhang L, Zhou Y* (2021). The plant cell wall: biosynthesis, construction, and functions. J. Integr. Plant Biol. 63: 251–272.
 
Peng J-S, Zhang B, Chen H, Wang M-Q, Wang Y-T, Li H-M, Cao S, Yi H-Y, Wang H, Zhou Y*, Gong J-M* (2021) Galactosylation of Rhamnogalacturonan-II for cell wall pectin biosynthesis is critical for root apoplastic iron reallocation in Arabidopsis.Mol. Plant DOI: 10.1016/j.molp.2021.06.016 (online).
 
Xiong E; Dong G; Chen F; Zhang C; Li S; Zhang Y; Shohag J I; Yang X; Zhou Y; Qian Q; Wu L; Yu Y. (2021) Formyl tetrahydrofolate deformylase affects hydrogen peroxide accumulation and leaf senescence by regulating the folate status and redox homeostasis in rice. Sci. China Life Sci. 64, 720-738.
 
Xu W, Cheng H, Zhu, S., Cheng J, Ji H, Zhang B, Cao S, Wang C, Tong G, Zhen C, Mu L, Zhou Y, Cheng Y. (2021). Functional understanding of secondary cell wall cellulose synthases in Populus trichocarpa via the Cas9/gRNA-induced gene knockouts. New Phytol. DOI: 10.1111/nph.17338, PMID: 33713445.
 
2020:
Gao Y, Xu Z, Zhang L, Li S, Wang S, Yang H, Liu X, Zeng D, Liu Q, Qian Q, Zhang B*, Zhou Y*(2020). GRF4-regulated MYB61 improves nitrogen utilization and biomass production in rice. Nat. Commun. 11, 5219.
 
 
Xue J#, Zhang B#, Zhan H#, Lv Y, Jia X, Wang T, Yang N, Lou Y, Zhang Z, Hu W, Gui J, Cao J, Xu P, Zhou Y, Hu J, Li L*, Yang Z*. (2020). Phenylpropanoid derivatives are essential components of sporopollenin in vascular plants. Mol. Plant 13, 1644–1653.
 
Zhao M, Tang S, Zhang H, He M, Liu J, Zhi H, Sui Y, Liu X, Jia G, Zhao Z, Yan J, Zhang B. Zhou Y, Chu J, Wang X, Zhao B, Tang W, Li J, Wu C, Liu X*, Dao X*. (2020). DROOPY LEAF1 controls leaf architecture by orchestrating early brassinosteroid signaling. Proc. Natl. Acad. Sci. USA 117, 21766–21774.
 
Zhao X, Ebert B, Zhang B, Liu H, Zhang Y, Zeng W, Rautengarten C, Li H, Chen X, Bacic A, Wang G, Men S, Zhou Y, Heazlewood J, Wu A*. (2020). UDP-Api/UDP-Xyl synthases affect plant development by controlling the content of UDP-Api to regulate the RGII borate complex. Plant J. 104, 252–267.
 
2019
Zhang L, Gao C, Mentink-Vigier F, Tang L, Zhang D, Wang S, Cao S, Xu Z, Liu X, Wang T, Zhou Y*, and Zhang B*. (2019) Arabinosyl deacetylase modulates the arabinoxylan acetylation profile and secondary wall formation. Plant Cell 31, 1113–1126.
 
Wang S, Yang H, Mei J, Liu X, Wen Z, Zhang L, Xu Z, Zhang B*, and Zhou Y*. (2019) Rice homeobox protein KNAT7 integrates the pathways regulating cell expansion and wall stiffness. Plant Physiol. 181, 669–682.
 
Zhang L, Zhang B*, and Zhou Y*. (2019). Cell wall compositional analysis of rice culms. Bio-protocol 9: e3398.
 
2018:
Zhang Z, Zhang B, Chen Z, Zhang D, Zhang H, Wang H, Zhang Y, Cai D, Liu J, Xiao S, Huo Y, Liu Jie, Zhang L, Wang M, Liu X, Xue Y*, Zhao L*, Zhou Y*, and Chen H*. (2018) A PECTIN METHYLESTERASE at the Maize Ga1 locus confers male function in unilateral cross-incompatibility. Nat. Commun. 9, 3678
 
Zhang D, Xu Z, Cao S, Chen K, Li S, Liu X, Gao C, Zhang B*, and Zhou Y*. (2018) An uncanonical CCCH-tandem zinc finger protein represses secondary wall synthesis and controls mechanical strength in rice. Mol. Plant 11, 163–174.
 
Sanchez-Rodriguez C.*, Shi Y., Kesten, C., Zhang, D., Sancho-Andres, G., Ivakov, A., Lampugnani, E., Sklodowski, K., Fujimoto, M., Nakano, A., Bacic, A., Wallace, I., Ueda, T., Damme, D., Zhou, Y., and Persson S. (2018) The cellulose synthases are cargo of the TPLATE adaptor complex. Mol. Plant 11, 346–349.
 
Zhang L-M, Leng C-Y, Luo H, Wu X-Y, Liu Z-Q, Zhang Y-M, Zhang H, Xia Y, Shang L, Liu C-M, Hao D-Y, Zhou Y, Chu C, Cai H-W, and Jing H-C*. (2018) Sweet sorghum originated through selection of dry, a plant-specifific NAC transcription factor gene. Plant Cell 30, 2286–2307.
 
Xu, J., Zhang, B., Lu, X., Zhou, Y., Fang, J., Li Y., and Zhang, S*. (2018) Nanoscale observation of microfibril swelling and dissolution in ionic liquids. ACS Sustainable Chem. Eng. 6, 909–917.
 
Zhang C, Shen Y, Tang D, Shi W, Zhang D, Du G, Zhou Y, Liang G, Li Y, and Cheng Z*. (2018) The zinc finger protein DCM1 is required for male meiotic cytokinesis by preserving callose in rice. PLoS Genet. 14, e1007769.
 
2017:
Zhang B, Zhang L, Li F, Zhang D, Liu X, Wang H, Xu Z, Chu C*, and Zhou Y*. (2017) Control of secondary cell wall patterning involves xylan deacetylation by a GDSL esterase. Nat. Plants 3,17017.
 
Gao Y, He C, Zhang D, Liu X, Xu Z, Tian Y, Liu X, Zang S, Pauly M, Zhou Y*, and Zhang B*. (2017) Two trichome birefringence-like proteins mediate xylan acetylation, which is essential for leaf blight resistance in rice. Plant Physiol. 173, 470–481.
 
Zhang B and Zhou Y*. (2017) Carbohydrate composition analysis in xylem. de Lucus M. and Etchells JP, eds. Humana Press. New York. Methods Mol. Biol. 1544: 213–222.
 
Xu Z#, Li S#, Zhang C, Zhang B, Zhu K, Zhou Y*, and Liu Q*. (2017) Genetic connection between cell-wall composition and grain yield via parallel QTL analysis in indica and japonica subspecies. Sci. Rep. 7: 12561.
 
Schneider R, Tang L, Lampugnani E R, Barkwill S, Lathe R, Zhang Y, McFarlane HE,  Pesquet E, Niittyla T, Mansfield SD, Zhou Y, and Persson S. (2017) Two complementary mechanisms underpin cell wall patterning during xylem vessel development. Plant Cell 29: 2433–2449.
 
Qi J, Wu B, Feng S, Lü S, Guan C, Zhang X, Qiu D, Hu Y, Zhou Y, Li C, Long M*, and Jiao Y* (2017) Mechanical regulation of organ asymmetry in leaves. Nat. Plants 3: 724–733.
 
Zhou T, Hua Y, Zhang B, Zhang X, Zhou Y, Shi L, and Xu F*. (2017) Low-boron tolerance strategies involving pectin-mediated cell wall mechanical properties in Brassica napus. Plant Cell Physiol. 58: 1991–2005.
 
2016:
Ma J, Cheng Z, Chen J, Shen J, Zhang B, Ren Y, Ding Y, Zhou Y, Zhang H, Zhou K, Wang J, Lei C, Zhang X, Guo X, Gao H, Bao Y, and Wan J*. (2016) Phosphatidylserine synthase controls cell elongation especially in the uppermost internode in rice by regulation of exocytosis. PLoS ONE 11, e0153119.
 
2015:
Huang D, Wang S, Zhang B, Shang-Guan K, Shi Y, Zhang D, Liu X, Wu K, Xu Z, Fu X, and Zhou Y*. (2015) A Gibberellin-midiated DELLA-NAC signaling cascade regulates cellulose synthesis in rice. Plant Cell 27, 1681–1696.
 
张保才, 周奕华*. (2015). 植物细胞壁形成机制的新进展.中国科学, 45: 544-556.
 
Liu S, Lan J, Zhou B, Qin Y, Zhou Y, Xiao X, Yang J, Gou J, Qi J, Huang Y, and Tang C*. (2015) HbNIN2, a cytosolic A/N-invertase, is responsible for sucrose catabolism in rubber-producing laticifers of Hevea brasiliensis (para rubber tree). New Phytol. 206, 709–725.
 
Wang X, Jing Y, Zhang B, Zhou Y, and Lin R*. (2015). Glycosyltransferase-like protein ABI8/ELD1/KOB1 promotes Arabidopsis hypocotyl elongation through regulating cellulose biosynthesis. Plant Cell Environ. 38, 411–422.
 
2014:
Shi Y, Liu X, Li R, Gao Y, Xu Z, Zhang B*, and Zhou Y. (2014) Retention of OsNMD3 in the cytoplasm disturbs protein synthesis efficiency and affects plant development in rice. J. Exp. Bot. 65, 3055–3069.
 
Wang C, Li S, Ng S, Zhang B, Zhou Y, Whelan J, Wu P, and Shou H*. (2014). Mutation in xyloglucan 6-xylosytransferase results in abnormal root hair development in Oryza sativa. J. Exp. Bot. 65, 4149–4157.
 
Zhu X, Sun Y, Zhang B, Mansoori N, Wan J, Liu Y, Wang Z, Shi YZ, Zhou Y, and Zheng S*. (2014). TRICHOME BIREFRINGENCE-LIKE27 affects aluminum sensitivity by modulating the O-acetylation of xyloglucan and aluminum-binding capacity in Arabidopsis. Plant Physiol. 166, 181–189.
 
2013:
Liu L, Shang-Guan K, Zhang B, Liu X, Yan M, Zhang L, Shi Y, Zhang M, Qian Q, Li J, and Zhou Y*. (2013) Brittle Culm1, a COBRA-like protein, functions in cellulose assembly through binding cellulose microfibrils. PLoS Genet. 9, e1003704.
 
Song X, Liu L, Jiang Y, Zhang B, Gao Y, Liu X, Lin Q, Ling H, and Zhou Y*. (2013) Disruption of secondary wall cellulose biosynthesis alters cadmium translocation and tolerance in rice plants. Mol. Plant 6, 768–780.
 
Kang J, Zhang H, Sun T, Shi Y, Wang J, Zhang B, Wang Z, Zhou Y, and Gu H*. (2013) Natural variation of C-repeat-binding factor (CBFs) genes is a major cause of divergence in freezing tolerance among a group of Arabidopsis thaliana populations along the Yangtze River in China. New Phytol. 199, 1069–1080.
 
Zou H, Zhang Y, Wei W, Chen H, Song Q, Liu Y, Zhao M, Wang F, Zhang B, Lin Q, Zhang W, Ma B, Zhou Y, Zhang J, and Chen S*. (2013) The transcription factor AtDOF4.2 regulates shoot branching and seed coat formation in Arabidopsis. Biochem J. 449: 373–388.
 
2012:
Wu B, Zhang B, Dai Y, Zhang L, Shang-Guan K, Peng Y, Zhou Y*, and Zhu Z*. (2012) Brittle Culm15 encodes a membrane-associated chitinase-like protein required for cellulose biosynthesis in rice. Plant Physiol. 159, 1440–1452 (*Corresponding author)
 
Zhang S-J, Song X-Q, Yu B, Zhang B-C, Sun C-Q, Knox J. P, and Zhou Y-H*. (2012) Identification of quantitative trait loci affecting hemicellulose characteristics based on cell wall composition in a wild and cultivated rice species. Mol. Plant 5, 162–175.
 
Zhu X, Shi Y, Lei G, Fry S, Zhang B, Zhou Y, Braam J, Jiang T, Xu X, Mao C, Pan Y, Yang J, Wu P, and Zheng S*. (2012) XTH31, encoding an in vitro XEH/XET-active enzyme, regulates aluminum sensitivity by modulating in vivo XET action, cell wall xylolucan content, and aluminum binding capacity in Arabidopsis. Plant Cell 24, 4731–4747.
 
Bao C, Wang J, Zhang R, Zhang B, Zhang H, Zhou Y, and Huang S*. (2012) Arabidipsis VILLIN2 and VILLIN3 act redundantly in sclerenchyma development via bundling of actin filaments. Plant J. 71, 962–975
 
Chen M-Q, Zhang A-H, Zhang Q, Zhang B-C, Nan J, Li X, Liu N, Qu H, Lu C-M, Sudmorgen, Zhou Y-H, Xu Z-H, and Bai S-N*. (2012) Arabidopsis NMD3 is required for nuclear export of 60S ribosomal subunits and affects secondary cell wall thickening. PLoS ONE 7, e35904
 
2011:
Ning J, Zhang B, Wang N, Zhou Y*, and Xiong L*. (2011) Increased leaf angle1, a Raf-Like MAPKKK that interacts with a nuclear protein family, regulates mechanical tissue formation in the lamina joint of rice. Plant Cell 23, 4334–4347 (*Corresponding author)
 
Zhang B, Liu X, Qian Q, Liu L, Dong G, Xiong G, Zeng D, and Zhou Y*. (2011) A Golgi nucleotide sugar transporter modulates cell wall biosynthesis and plant growth in rice. Proc. Natl. Acad. Sci. USA. 108, 5110–5115.
 
Song X., Zhang B., and Zhou Y*. (2011) Golgi-localized UDP-glucose transporter is required for cell wall integrity in rice. Plant Signaling & Behavior 6, 1097–1100.
 
Zhang B and Zhou Y*. (2011) Study on rice brittleness mutants: A way to open the ‘black box’ of monocot cell wall biosynthesis. J. Integr. Plant Biol. 53, 136–142.
 
Liu X-L, Liu L, Niu Q-K, Xia C, Yang K-Z, Li R, Chen L-Q, Zhang X-Q, Zhou Y*, and Ye D*. (2011) MALE GAMETOPHYTE DEFECTIVE 4 encodes a rhamnogalacturonan II xylosyltransferase and is important for growth of pollen tubes and roots in Arabidopsis. Plant J. 65, 647–660 (*Corresponding author)
 
Lei M, Liu Y, Zhang B, Zhao Y, Wang X, Zhou Y, Raghothama K G, and Liu D*. (2011) Genetic and genomic evidence that sucrose is a global regulator of plant responses to phosphate starvation in Arabidopsis. Plant Physiol. 156, 1116–1130.
 
Wang W, Wang Li, Chen C, Xiong G, Tan X-Y, Yang K-Z, Wang Z-C, Zhou Y, Ye D, and Chen L-Q*. (2011) Arabidopsis CSLD1 and CSLD4 are required for cellulose deposition and normal growth of pollen tubes. J. Exp. Bot. 62, 5161–5177.
 
Wang Z-P, Xie Z-Q, Zhang B, Hou L-Y, Zhou Y, Li L-H, and Han X-G*. (2011) Aerobic and anaerobic nonmicrobial methane emissions from plant material. Environ. Sci. Technol. 45, 9531–9537.
 
2010:
Xiong G, Li R, Qian Q, Song X, Liu X, Yu Y, Zeng D, Wan J, Li J and Zhou Y*. (2010) The rice dynamin-related protein DRP2B mediates membrane trafficking and thereby plays a critical role in secondary cell wall cellulose biosynthesis. Plant J. 64, 56–70.
 
Zhang M, Zhang B, Qian Q, Yu Y, Li R, Zhang J, Liu X, Zeng D, Li J and Zhou Y*. (2010) Brittle Culm12, a dual-targeting Kinesin-4 protein, controls cell cycle progression and wall properties in rice. Plant J. 63, 312–328.
 
Li R, Xiong G, and Zhou Y*. (2010) Membrane trafficking mediated by OsDRP2B is specific for cellulose biosynthesis. Plant Signaling & Behavior 5 (11), 1–4.
 
Tang C, Huang D, Yang J, Liu S, Sakr S, Li H, Zhou Y, and Qin Y*. (2010) The sucrose transporter HbSUT3 plays an active role in sucrose loading to laticifer and rubber productivity in exploited trees of Hevea brasiliensis (rara rubber tree). Plant, Cell Environ. 33,1708–1720.
 
2009:
Li M, Xiong G, Li R, Cui J, Tang D, Zhang B, Pauly M, Cheng Z, and Zhou Y*. (2009) Rice cellulose synthase-like D4 is essential for normal cell wall biosynthesis and plant growth. Plant J. 60, 1055–1069.
 
Zhang B, Deng L, Qian Q, Xiong G, Zeng D, Li R, Guo L, Li J, and Zhou Y*. (2009) A missense mutation in the transmembrane domain of CESA4 affects protein abundance in the plasma membrane and results in abnormal cell wall biosynthesis in rice. Plant Mol. Biol. 71, 509–524. (Cover story)
 
Zhou Y, Li S, Qian Q, Zeng D, Zhang M, Guo L, Liu X, Deng L, Liu X, and Li J*. (2009) BC10, a DUF266-containing and Golgi-located type II membrane protein, is required for cell wall biosynthesis in rice (Oryza sativa L.). Plant J. 57, 446–462.
 
2008以前:
 
Lu, S., Zhou, Y., Li, L., and Chiang V*. (2006) Distinct roles of cinnamate 4-hydroxylase genes in populus. Plant Cell Physiol. 47, 905–914.
 
Dai Y, Wang H Z, Li B H, Huang J, Liu X F, Zhou Y, Mou Z H, and Li J*. (2005) Increased expression of MAP KINASE KINASE7 causes deficiency in polar auxin transport and leads to plant architectural abnormality in Arabidopsis. Plant Cell 18, 308–320.
 
Zhao H Y, Liu J, Shiyou L, Zhou Y, Wei J H, Song Y, and Wang T*. (2005) Isolation and functional characterization of a cinnamate 4-hydroxylase promoter from populus tomentosa. Plant Sci. 168, 1157–1162.
 
Li Y 1, Qian Q1, Zhou Y1, Yan M, Sun L, Zhang M, Fu Z, Wang Y, Han B, Pang X, Chen M, and Li J*. (2003) BRITTLE CULM1, which encodes a COBRA-like protein, affects the mechanical properties of rice plants. Plant Cell 15, 2020–2031. (1Contribute equally)
 
Li L G, Zhou Y, Cheng X F, Sun J Y, Marita J M, Ralph J, and Chiang V*. (2003) Combinatorial modification of multiple lignin traits in trees through multigene cotransformation. Proc. Natl. Acad. Sci. USA. 100, 4939–4944.