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税光厚


税光厚,博士, 研究员,博士生导师

  2004年获新加坡国立大学 (National University of Singapore)博士学位,同年进入新加坡国立大学生物化学系从事博士后研究。 2008-2012年任新加坡国立大学生命科学院高级研究员,新加坡国立大学脂组学中心副主任。 2013年加入中国科学院遗传与发育生物学研究所。2013年入选中国科学院百人计划。



研究方向

  开发高通量、高敏度、新颖的系统脂组学方法,并应用系统脂组学方法研究 (1) 脂组分变化与遗传、发育异常的内在联系; (2) 脂类与发育、代谢相关的疾病(糖尿病、心血管病),神经退行性疾病(老年痴呆症、帕金森病)等的内在联系。


发表的文章(*通讯作者; #共同第一作者)
1.Lam SM, Wang Y, Li B, Du J, Shui G*. Metabolomics through the lens of precision cardiovascular medicine. J Genet Genomics, in Press (2017).

2.Fan W, Lam SM, Xin J, Yang X, Liu Z, Liu Y, Wang Y, Shui G, Huang X. Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. PLoS Genet 13(2017):e1006664.

3.Lam SM, Tian H, Shui G*. Lipidomics, en route to accurate quantitation. Biochim Biophys Acta , in Press (2017).

4.Li QT, Lu X, Song Q, Chen HW, Wei W, Tao JJ, Bian XH, Shen M, Ma B, Zhang WK,  Bi YD, Li W, Lai YC, Lam SM, Shui G, Chen SY, Zhang JS. Selection for a zinc-finger protein contributes to seed oil increase during soybean domestication. Plant Physiol, in Press (2017).

5.Tian H, Lam SM, Shui G*. Metabolomics, a Powerful Tool for Agricultural Research. Int J Mol Sci 11(2016):1871.

6.Huang Y, Huang S, Lam SM, Liu Z, Shui G, Zhang YQ. Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids. J Cell Sci 129(2016):4034-4045.
 
7. Lam SM, Chua GH, Li XJ, Su B, Shui G*. Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging. Oncotarget 7 (2016): 55970-89.

8. Wang Y, Liu L, Zhang H, Fan J, Zhang F, Yu M, Shi L, Yang L, Lam SM, Wang H, Chen X, Wang Y, Gao F, Shui G, Xu Z. Mea6 controls VLDL transport through the coordinated regulation of COPII assembly. Cell Res. 26(2016):787-804.

9. Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, et al. Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study. J Alzheimers Dis. 50(2016):887-94.

10. Begum H, Li B, Shui G, Cazenave-Gassiot A, Soong R, Ong RT, Little P, Teo YY, Wenk MR. Discovering and validating between-subject variations in plasma lipids in healthy subjects. Sci Rep. 6(2016):19139

11. Jin J, Li Y, Ren J, Lam SM, Zhang Y, Hou Y, Zhang X, Xu R, Shui G, Ma RZ. Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 54(2016):410-23.

12. Xiang Y, Lam SM, Shui G*. What can lipidomics tell us about the pathogenesis of Alzheimer disease? Biol Chem. 396(2015):1281-91

13. Heinz LX, Baumann CL, Köberlin MS, Snijder B, Gawish R, Shui G, et al. The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep. 11(2015):1919-28.

14. Chua EC, Shui G, Cazenave-Gassiot A, Wenk MR, Gooley JJ. Changes in Plasma Lipids during Exposure to Total Sleep Deprivation. Sleep. 38(2015):1683-91.

15. Portevin D, Sukumar S, Coscolla M, Shui G, Li B, Guan XL, Bendt AK, Young D, Gagneux S, Wenk MR. Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis. Microbiologyopen. 3(2014):823-35.

17. Shui G*,Huang X*. Lipid is moving to the forefront of bio-medical research. J Genet Genomics. 41(2014): 229-30.

18. Cheong WF, Wenk MR, Shui G*. Comprehensive compositional study of lipid molecular species in crude palm oil using multiple lipidomic approaches. J Genet Genomics. 41(2014):293-304

19. Guyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang XD, Wenk MR, Goh ELK, Silver DL. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 509(2014):503-6.

20. Nakamura Y, Teo NZ, Shui G, Chua CH, Cheong WF, Parameswaran S, Koizumi R, Ohta H, Wenk MR, Ito T. Transcriptomic and lipidomic profiles of glycerolipids during Arabidopsis flower development. New Phytol. 203(2014):310-22。

21. Liu L, Jiang Q, Wang X, Zhang Y, Lin RC, Lam SM, Shui G, Zhou L, Li P, Wang Y, Cui X, Gao M, Zhang L, Lv Y, Xu G, Liu G, Zhao D, Yang H. Adipose-specific knockout of Seipin/Bscl2 results in progressive lipodystrophy. Diabetes, 63(2014):2320-31.

22. Zhang S, Shui G, Wang G, Wang C, Sun S, Zouboulis CC, Xiao R, Ye J, Li W, Li P. Cidea Control of Lipid Storage and Secretion in Mouse and Human Sebaceous Glands. Mol Cell Biol. 34(2014):1827-38.

23. Ng LF, Gruber J, Cheah I, Kiat Goo C, Fun Cheong W, Shui G, Ping Sit K, Wenk MR, Halliwell B. The mitochondria-targeted antioxidant, MitoQ extends lifespan and improves healthspan of a transgenic C. elegans models of Alzheimer disease. Free Radic Biol Med. 71(2014):390-4.

24. Liu YF, Li QT, Lu X, Song QX, Lam SM, Zhang WK, Ma B, Lin Q, Man WQ, Du WG, Shui GH, Chen SY, Zhang JS. Soybean GmMYB73 promotes lipid accumulation in transgenic plants. BMC Plant Biol. 14(2014):73.

25. Lam S.M., Wang Y., Duan XR, Wenk MR, Kalaria,RN, Chen CP, Lai MKP,Shui G*. The brain lipidomes of subcortical ischemic vascular dementia and mixed dementia. Neurobiology of Aging, 35(2014):2369-81.

26. Ang ML, Zainul Rahim SZ, Shui G, et al, Alonso S. An ethA/R-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo which correlate with altered mycolic acids composition. Infection and Immunity 82(2014):1850-9.

27. Liu Y, Wang W, Shui G*, Huang X*. CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway. Plos Genetics. 10(2014), e1004172.

28. Ee SM, Lo YL, Shui G, Wenk MR, Shin EJ, Kim HC, Ong WY. Distribution of Secretory Phospholipase A2 XIIA in the Brain and its Role in Lipid Metabolism and Cognition. Mol Neurobiol. 50(2014):60-75.

29. Lam SM, Tong L, Reux B, Duan X, Petznick A, Yong SS, Khee CB, Lear MJ, Wenk MR, Shui G*. Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eyesyndrome. J Lipid Res 55(2014):299-306.

31. Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk M, Shen HM. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled Akt-FoxO1 signalling pathway. Autophagy 10(2014):226-42.

32. Xue Y, Shui G, Wenk MR. TPS1 drug design for rice blast disease in magnaporthe oryzae. Springerplus 3(2014):18.

33. Yaligar J, Gopalan V, Kiat OW, Sugii S, Shui G, Lam BD, Henry CJ, Wenk MR, Tai ES, Velan SS. Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques. PLoS One 9(20143):e91436.

34. Lam SM, Shui G*. Lipidomics as a principal tool for advancing biomedical research. J Genet Genomics. 40(2013):375-90. 

35. Liu Z, Lim CY, Su MY, Soh SL, Shui G, Wenk MR, Grove KL, Radda GK, Han W, Xiao X. Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations. J Endocrinol. 219(2013):131-43.

36. Lam SM, Tong L, Reux B, Lear MJ, Wenk MR, Shui G*. Rapid and sensitive profiling of tear wax ester species using high performance liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. A. 1308(2013):166-71.

37. Chua ECP#, Shui G#, Lee I, Lau P; Tan LC, Yeo SY, Lam BD, Puvanendran K, Bulchand S, Summers SA, Rozen S, Wenk MR, Gooley JJ. Extensive diversity in the circadian lipidome: evidence for different circadian metabotypes. PNAS 110(2013):14468-73. (#co-first author).

38. Shui G*, Lam SM, Stebbins J, Kusunoki J, Duan X, Li B, Wei Cheong F, Soon D, Kelly R, & Wenk M Polar lipid derangements in type 2 diabetes mellitus: potential pathological relevance of fatty acyl heterogeneity in sphingolipid. Metabolomics 4(2013) 786-799.

39. Lim WL, Lam SM, Shui G, Mondal A, Ong D, Duan X, Creegan R, Martins IJ, Sharman MJ, Taddei K, Verdile G, Wenk MR, Martins RN. Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice.Neurobiol Aging 34(2013):2217-24.

40. Baig S, Lim JY, Fernandis AZ, Wenk MR, Kale A, Su LL, Biswas A, Vasoo S, Shui G*, Choolani M*. Lipidomic analysis of human placental syncytiotrophoblast microvesicles in adverse pregnancy outcomes.
Placenta 34(2013):436-42.

41. Jovanović V, Abdul Aziz N, Lim YT, Ng Ai Poh A, Jin Hui Chan S, Ho Xin Pei E, Lew FC, Shui G, Jenner AM, Bowen L, McKinney EF, Lyons PA, Kemeny MD, Smith KG, Wenk MR, Macary PA.Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus. PLoS One 8(2013):e55639.

42. Blanc M, Hsieh wy, Robertson KA, Kai KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, Craigon M, Ruzsics Z, Haas J, Angulo A, Griffiths WJ, Glass CK, Wang Y, Ghazal P. Signal transducer and activator of transcription (Stat-1) couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity 38(2013):106-18.

43. Guan XL, Cestra G,Shui G, Kuhrs A, Schittenhelm R, Hafen E, van der Goot FG, Gonzalez-Gaitan M, Wenk MR. Biochemical membrane lipidomics during Drosophila development -an informational resource. Development Cell 24(2013):98-111.

44. Summermatter S, Shui G, Maag D, Santos G, Wenk MR, Handschin C. PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes 62(2013):85-95

45. Vigant F, Lee J, Hollman A, Tanner L, Akyol-Ataman Z, Yun T, Shui G, et al. A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion. Plos Pathogens 9(2013): e1003297.

46. Watterson S, Guerriero ML, Blanc M, Mazein A, Loewe L, Robertson KA, Gibb H, Shui G, Wenk MR, Hillston J and Ghazal P. A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction. Biochimie 95(2013):613-21.

47. Nakatsu F, Baskin JM, Chung J, Tanner LB, Shui G, Lee SY, Pirruccello M, Ingolia NT, Wenk MR, Camilli PD. A plasma membrane PI4P pool controlled by PI 4-kinase III impacts cholesterol homeostasis. J Cell Biol. 199(2012):1003-1016.

48. Thibault G, Shui G, Woong K, McAlister G, Gygi SP, Wenk MR, Ng DTW. The unfolded protein response buffers the lethal effects of lipid disequilibrium. Molecular Cell: 48(2012):16-27.

49. Patkar RN, Suresh A, Xue YK, Shui G, Wenk MR, Naqvi NI. Abc3-mediated efflux of an endogenous digoxin-like steroidal glycoside by Magnaporthe oryzae is necessary for host invasion during blast disease. Plos Pathogen 8(2012):e1002888.

50. Siddique MM, Bikman BT, Wang L, Ying L, Reinhardt E, Shui G, Wenk MR, Summers SA. Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro. PLoS One: 7(2012):e44042

51. Bikman BT, Guan Y, Shui G, Siddique MM, Holland WL, Kim JY, Fabriàs G, Wenk MR, Summers SA. Fenretinide prevents lipid-induced insulin resistance by inhibiting dihydroceramide desaturase and blocking ceramide synthesis. J. Bio. Chem. 287(2012):17426-37.

52. Tan SH, Shui G, Zhou J, Wenk MR, Shen HM. Induction of autophagy by palmitic acid via a PKC-mediated signaling pathway independent of Mtor. J. Bio. Chem. 287(2012):14364-76.

53. Mathuru AS, Kibat C, Cheong CF, Shui G, Korzh V, Wenk MR, Friedrich RW and Jesuthasan S. Chondroitin fragments are odorants that trigger fear behavior. Current Biology 22(2012):538-44.

54. Rodriguez-Navarro JA, Kaushik S, Koga H, Dall’Armi C, Shui G, Wenk MR, Di Paolo G, Cuervo AM. Inhibitory effect of dietary lipids on chaperone-mediated autophagy. PNAS 109(2012):E705-14 .

55. Wang WS, Lv Na, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P. Cidea is an essential transcriptional co-activator of C/EBP¦Â to control newborn survival and lipid secretion in mammary gland. Nature Medicine 18(2012):235-43.

56. Sundram JR, Chan HH, Poore CP, Pareek T, Cheong WF, Shui G, Tan N, Low CM, Wenk MR and Kesavapany S. Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration. J. Neurosci. 32(2012):1020-34.

57. Chan R, Oliveira TG, Small SA, Duff KE, Wenk MR, Shui G*, Di Paolo G*. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. J. Bio. Chem. 287(2012):2678-88.

58. Poh MK, Shui G, Shi PY, Wenk MR, Gu F. The importance of cholesterol during the entry and replication event of dengue virus. Antiviral Res: 93(2012):191-8.

59. Shui G*, et al. Mycolic acids as diagnostic markers for tuberculosis case detection and drug efficacy. EMBO Mol Med: 4(2012):27-37.

60. Gong J, Sun Z, Wu L, Xu W,Schieber N,Xu D, Shui G, Yang H, Parton RG, Li P. Fsp27 is localized to the contact site of lipid droplets and promotes their growth by fusion. J Cell Biol: 195(2011):953-63.

61. Lee HW, Tan CH, Long LY, Farooqui AQ, Shui G, Wenk MR, Ong WY. Lipidomic analyses of the rat brain after transcranial magnetic stimulation. Metabolomics: 8(2012): 19-33.

62. Lee HW, Tan CH, Shui G, Wenk MR, Ong WY. Role of prefrontal cortex calcium independent phospholipase A2 activity in the antidepressant like effect of maprotiline. Int J Neuropsychopharmacol. 15(2012):1087-98.

63. Ma MT; Yeo JF; Shui G, Wenk MR, Ong WY. Systems wide analyses of lipids in the brainstem during inflammatory orofacial pain -Evidence of increased phospholipase A(2) activity. Eur J Pain 16(2012):38-48.

64. Lim L, Jackson-Lewis V, Wong LC, Shui G, Goh XH, Kesavapany S, Jenner AM, Fivaz M, Przedborski S, Wenk MR. Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from oxidative stress. Cell Death and Diff. 19(2012): 416-27.

65. Fei W, Zhong L, Ta MT, Shui G, Wenk MR, Yang H. The size and phospholipid composition of lipid droplets can influence their proteome. Biochem Biophys Res Commun. 415(2011):455-62.

66. Fei W, Li H, Shui G, Bielby C, Du X, Brown AJ, Wenk MR, Li P, Yang H. Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis. J Lipid Res 52(2011):2136-47.

67. Lam SM, Tong L, Yong SS, Li BW, Chaurasia SS, Shui G*, Wenk MR*. Meibum lipid composition in Asians with Dry Eye Disease. Plos One 6(2011): e24339

68. Fei W#, Shui G#, Zhang P, Fergsuon C, Kapterian TS, Lin RC, Dawes IW, Zhang Y, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC and Yang H. A role for phosphatidic acid in the formation of “supersized” lipid droplets. Plos Genetics 7(2011): e1002201. (#co-first author).

69. Shui G*. Systems level analysis of lipidome. Front. Biol. 6(2011): 183-189

70. Gruber J, Ng LF, Fong S, Wong YT, Koh SA, Chen CB, Shui G, Cheong WF, Schaffer S, Wenk MR, Halliwell B. Mitochondrial ageing in Caenorhabditis elegans - shutting down rather than vicious cycling. Plos One 6 (2011): e19444

71. Shui G*, Cheong WF, Jappar IA, Hoi A, Xue YK, Fernandis AZ, Tan BKH, Wenk MR. Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: Applications to a rabbit model for atherosclerosis. J. Chromatogr. A. 1218 (2011): 4357-4365.

72. Shui G*, Stebbins JW, Lam BD, Cheong WF, Lam SM, Gregoire F, Kusonoki J, Wenk MR. Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys? Plos One 6 (2011): e19731

73. Tian Y, Bi J, Shui G, Xiang Y, Liu Y, Liu Z, Yang H, Wenk MR, and Huang X. Tissue-autonomous function of Drosophila Seipin in preventing ectopic lipid accumulation. Plos Genetics 7(2011):e1001364.

74. Holland WL, Bikman BT, Wang LP, Guan YG, Sargent KM, Knotts TA, Shui G, Wenk MR, Pagliassotti MJ and Summers SA. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin Invest. 121(2011):1858-70.

75. Peng ZF, Chen MJ, Manikandan J, Melendez AJ, Shui G, Russo-Marie F, Whiteman M, Beart PM, Moore PK, Cheung NS. Multifaceted involvement of NO in mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signaling cascades. J Cell Mol Med: 16(2012):41-58

76. Gamage AM, Shui G, Wenk MR, Chua KL. N-octanoyl homoserine lactone is the major quorum signaling molecule regulating biofilm formation and antibiotic production in B. pseudomallei. Microbiology 157(2011): 1176-1186.

77. Blanc M, Watterson S, O’Sullivan MC, Shui G, Gibbs H, Sing S, Khondoker M, Dickinson P, Lacaze P, Wall DM, Rodríguez-Martín S, Riemersma R, Wenk MR, Angulo A, Ghazal P. Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. Plos Biology 9(2011): e1000598.

78. Cheng D, Jenner AM, Shui G, Cheong WF, Mitchell TW, Nealon JR, Kim WS, McCann H, Wenk MR, Halliday GM, Garner B. Lipid pathway alterations in Parkinson’s disease primary visual cortex. Plos One 6(2011): e17299.

79. Oliveira T, Chan R, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff K, Wenk MR, Arancio O and Di Paolo G. Phospholipase D2 ablation ameliorates Alzheimer’s disease-linked synaptic dysfunction and cognitive deficits. J. Neurosci. 30(2010), 16419-16428.

80. Shui G*, Guan XL, Gopalakrishnan P, Xue Y, Goh JSY, Yang H, Wenk MR Characterization of Substrate Preference for Slc1p and Cst26p in Saccharomyces cerevisiae Using Lipidomic Approaches and Non-radioactive LPAAT Activity Assay. Plos One 5(2010): e11956.

81. Low KL, Shui G, Natter K, Yeo WK, Kohlwein S, Dick T, Rao S, Wenk MR.. Lipid droplet-associated proteins in Mycobacterium bovis BCG function in the biosynthesis and hydrolysis of triacylglycerol. J. Bio. Chem. 285(2010):21662-70

82. Jenner AM, Lim WLF, Ng MPE, Wenk MR, Shui G, Sharman MJ, Gandy SE, Martins RN. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE e2, e3 and e4 mice. Neurosciences 169(2010):109-15.

83. Shui G*, Guan XL, Low CP, Goh SYJ, Yang H, Wenk MR.. Toward One Step Analysis of Cellular Dynamic Lipidome Using Liquid Chromatography Coupled with Mass Spectrometry: Application to Saccharomyces Cerevisiae and Schizosaccharomyces Pombe Lipidomics. Mol BioSyst 6(2010):1008-17

84. Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM. Dual role of 3-methyladenine on modulation of autophagy via different temporal patterns on Class I and III phosphoinositide 3-kinase. J. Bio. Chem. 285(2010):10850-61

85. Sharman MJ#, Shui G#, Fernandis AZ, Lim WL, Berger T, Hone E, Taddei K, Martins IJ, Ghiso J, Buxbaum J, Gandy S, Wenk MR and Martins RN. Subtle changes in brain and plasma lipids in aged APOE knock-in mice. J Alzheimers Dis. 20(2010):105-11 (#Co-First Author)

86. Nakamura Y, Koizumi R, Shui G, Shimojima M, Wenk MR, Ito T, Ohta H. Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism to/and cope critically with phosphate starvation. PNAS 106(2009):20978-83.

87. McGehee AM, Dougan SK, Klemm E, Shui G, Park B, Kim YM, Wenk MR, Ploegh HL, Hu CC. XBP-1-deficient plasmablasts have normal protein folding but defects in glycosylation and lipid synthesis. Journal of Immunology 183(2009):3690-3699.

88. Novem V, Shui G, Wang D, Bendt AK, Sim SH, Liu Y, Thong TW, Sivalingam SP, Ooi EE, Wenk MR, Tan G.Structural characterization and comparison of lipid A from Burkholderia pseudomallei and Burkholderia thailandensis. Clinical and Vaccine Immunology 16(2009):1420-1428

89. Low KL, Rao S, Shui G, Bendt AK, Pethe K, Dick T, Wenk MR. Tetrahydrolipstatin, a lipase inhibitor is bactericidal to non-replicative Mycobacterium bovis BCG. Journal of Bacteriol.: 191(2009):5037-43.

90. Deng Y, Almsherqi ZA, Shui G, Wenk MR, Kohlwein SD. Docosapentaenoic acid (DPA) is a critical determinant of cubic membrane formation in amoeba Chaos mitochondria. FASEB J. 23(2009):2866-71.

91. Lee HW, Shui G, Farooqui AQ, Wenk MR, Tan CH, Ong WY. Lipidomic analyses of the mouse brain after antidepressant treatment – evidence for endogenous release of omega-3 fatty acids? Int J Neuropsychopharmacol 12(2009) : 953-964

92. Kutik S, Rissler m, Guan X, Guiard B, Shui G, Meisinger G, Rehling P, Wenk MR, Pfanner N, Wiedemann N. The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J Cell Biol. 183(2008):1213-1221.

93. Chan R, Uchil OD, Jin J, Shui G, Ott DE, Mothes W, and Wenk MR. Retroviruses Human Immunodeficiency Virus and Murine Leukemia Virus Are Enriched in Phosphoinositides. J Virol. 82(2008): 11228-38.

94. Low CP, Shui G, Li PL, Buttner S, Madeo F, Dawes IW, Wenk MR, and Yang H. Distinct lipotoxic cell death pathways in the fission yeast. J Cell Sci. 121(2008):2671-84.

95. Fei W, Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG, Yang H. Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol. 180(2008):473-82.

96. Lu LE, Yung LYL, Ong CN, Tan YL, Balasubramaniam S, Hartono D, Shui G, Wenk MR, and Ong WY. Translocation and effects of gold nanoparticles after inhalation exposure in rats. Nanotoxicology 1 (2007), 235-242.

97. Shui G, Bendt AK, Pethe K, Dick T and Wenk MR. Sensitive profiling of chemically diverse bioactive lipids. J. Lipid Res. 48(2007):1976-84.

98. Wang H, Jenner A, Lee CY, Shui G, Tang SY, Whiteman M, Wenk MR, Halliwell B. The identification of antioxidants in dark soya sauce. Free Radical Res. 41(2007):479-88

99. Guan XL, He X, Ong WY, Yeo WK, Shui G. and Wenk MR. Unbiased global profiling of lipids during kainite induced neuronal injury. FASEB J. 20 (2006), 1152-61.

100. Huang Q, Shen HM, Shui G, Wenk MR, Wong CN. Emodin inhibits tumor cell adhesion through disruption of the membrane lipid rafts-associated integrin signaling pathway. Cancer Res. 66 (2006), 5807-15.

101. Shui G, Leong LP。 “Residue from star fruitJuice processing waste as a value-added food ingredient and its potential as antioxidant nutraceuticals”. Food Chem. 97 (2006), 277-284.

102. Shui G, Leong LP, “Rapid Screening and Identification of Antioxidants in Biological Samples Using High Performance Liquid Chromatography/Mass Spectrometry and Its Application on Salacca Edulis Reinw”. J. Agric. Food Chem. (2005), 53(4), 880-886.

103. Shui G, Leong LP and Wong SP. “Rapid Screening and Characterisation of Antioxidants of Cosmos Caudatus Using Liquid Chromatography Coupled with Mass Spectrometry. J. Chromatogr. B. 827(2005), 127-138.

104. Shui G, Wong SP, Leong LP. “Characterization of Antioxidants and Change of Antioxidant Levels during Storage of Manilkara zapota L.” J. Agric. Food Chem. 52(2004), 7834-7841.

105. Shui G, Leong LP. “An Improved Method for the Analysis of Major Antioxidants of Hibiscus Esculentus Linn”. J. Chromatogr. A. 1048 (2004) 17-24.

106.Shui G, Leong LP. “Analysis of Polyphenolic Antioxidants in Star FruitUsing High Performance Liquid Chromatography and Mass Spectrometry ”. J. Chromatogr. A. 1022 (2004) 67-75.

107.Shui G, Leong LP and Effendy J. “Two Commonly-Used Reactive Nitrogen Species Scavenging Methods for Total Antioxidant Capacity Assay: A comparison”. XII Biennial Meeting of the Society for Free Radical Research International – SFRR. Buenos Aires, Argentina, May 5-9, Bologna, Italy; Monduzzi Editore; 2004:12-15. (ISI Proceedings)

108.Shui G, Leong LP. “Separation and Determination of Organic Acids and Phenolic Compounds of Fruit Juices and Drinks by High Performance Liquid Chromatography”, J. Chromatogr. A 977 (2002) 89-97

109.Leong LP, Shui G. An Investigation of Antioxidant Capacity of fruits in the Singapore markets. Food Chem. 76(2002) 69-75.