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1.Yusheng Liu#, Han Zhao#, Fanghong Shao#, Yiwei Zhang#, Hu Nie, Jingye Zhang, Cheng Li, Zhenzhen Hou, Zi-Jiang Chen, Jiaqiang Wang*, Bing Zhou*, Keliang Wu*, and Falong Lu*. (2023). Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition. Nature Structural & Molecular Biology DOI: 10.1038/s41594-022-00908-2
专家点评NSMB | 陆发隆/刘玉胜/吴克良/周兵/王加强揭示通过poly(A)尾巴重塑母源mRNA调控人类卵子向胚胎转变
2.Bai Xu#, Man Yin#, Yaming Yang#, Yunlong Zou, Wenbin Liu, Lianyong Qiao, Jixiang Zhang, Zhan Wang, Yayu Wu, He Shen, Minghan Sun, Weiyuan Liu, Weiwei Xue, Yongheng Fan, Qi Zhang, Bing Chen, Xianming Wu, Ya Shi, Falong Lu*, Yannan Zhao*, Zhifeng Xiao*, and Jianwu Dai* (2023). Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat. Bioactive Materials 23: 300-313. DOI: 10.1016/j.bioactmat.2022.11.008
3.Yusheng Liu#*, Hu Nie#, Yiwei Zhang#, Falong Lu*, and Jiaqiang Wang*. (2023). Comprehensive analysis of mRNA poly(A) tails by PAIso-seq2. SCIENCE CHINA Life Sciences 66(1): 187-190. DOI: 10.1007/s11427-022-2186-8
4.Xiaoqian Liu#, Zunpeng Liu#, Zeming Wu#, Jie Ren#, Yanling Fan, Liang Sun, Gang Cao, Yuyu Niu, Baohu Zhang, Qianzhao Ji, Xiaoyu Jiang, Cui Wang, Qiaoran Wang, Zhejun Ji, Lanzhu Li, Concepcion Rodriguez Esteban, Kaowen Yan, Wei Li, Yusheng Cai, Si Wang, Aihua Zheng, Yong E. Zhang, Shengjun Tan, Yingao Cai, Moshi Song, Falong Lu, Fuchou Tang, Weizhi Ji, Qi Zhou, Juan Carlos Izpisua Belmonte, Weiqi Zhang*, Jing Qu*, and Guang-Hui Liu* (2023). Resurrection of endogenous retroviruses during aging reinforces senescence. Cell 186(2): 287-304.e26. DOI: 10.1016/j.cell.2022.12.017
5.Danni Hong#, Hongli Lin#, Lifang Liu, Muya Shu, Jianwu Dai, Falong Lu, Mengsha Tong, and Jialiang Huang. (2023). Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis. Briefings in Bioinformatics 24(1). DOI: 10.1093/bib/bbac508
6.Jingwen Liu# and Falong Lu* (2023). Visualization of in vivo cell-cell contact in the present and in the past. SCIENCE CHINA Life Sciences DOI: 10.1007/s11427-022-2262-y
7.Muya Shu#, Danni Hong#, Hongli Lin, Jixiang Zhang, Zhengnan Luo, Yi Du, Zheng Sun, Man Yin, Yanyun Yin, Lifang Liu, Shilai Bao, Zhiyong Liu, Falong Lu*, Jialiang Huang*, and Jianwu Dai*. (2022). Single-cell chromatin accessibility identifies enhancer networks driving gene expression during spinal cord development in mouse. Developmental Cell 57(24): 2761-2775.e6. DOI: 10.1016/j.devcel.2022.11.011
Dev Cell+Brief Bioinform | 戴建武/黄佳良/陆发隆团队联合解析小鼠脊髓发育过程中增强子调控网络
8.Shuang Wu#, Yiwei Zhang#, Lan Yao#, Jiaqiang Wang*, Falong Lu*, and Yusheng Liu*. (2022). m6A-modified RNA possess distinct poly(A) tails. Journal of Genetics and Genomics DOI: 10.1016/j.jgg.2022.10.001
9.Zhengnan Luo#, Yi Du#, Shuting Li, He Zhang, Muya Shu, Di Zhang, Shunji He, Guangqin Wang, Falong Lu*, and Zhiyong Liu*. (2022). Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development. Proc Natl Acad Sci USA 119(32). DOI: 10.1073/pnas.2119850119
PNAS | 刘志勇/陆发隆合作揭示小鼠耳蜗中三个Atoh1增强子协同调控听觉毛细胞发育
10.Yusheng Liu#*, Yiwei Zhang, Jiaqiang Wang*, and Falong Lu*. (2022). Transcriptome-wide measurement of poly(A) tail length and composition at sub-nanogram total RNA sensitivity by PAIso-seq. Nature Protocols 17(9): 1980-2007. DOI: 10.1038/s41596-022-00704-8
Nature Protocols | 最快3天就能出结果！陆发隆/刘玉胜/王加强发布poly(A)的全长RNA异构体测序方法
11.Honglian Zhang#, Ying Liu#, Yali Xie#, Yunji Zhu#, Jingwen Liu, and Falong Lu*. (2022). H3K27me3 shapes DNA methylome by inhibiting UHRF1-mediated H3 ubiquitination. SCIENCE CHINA Life Sciences 65(9): 1685-1700. DOI: 10.1007/s11427-022-2155-0
H3K27me3修饰区域低DNA甲基化的调控机制
12.Yujun Quan#, Meijiao Wang#, Chengpeng Xu, Xiaoxiao Wang, Yu Wu, Dandan Qin, Yuxuan Lin, Xukun Lu, Falong Lu*, and Lei Li*. (2022). Cnot8 eliminates naive regulation networks and is essential for naive-to-formative pluripotency transition. Nucleic Acids Research 50(8): 4414-4435. DOI: 10.1093/nar/gkac236
13.Yan Yao#, Mengyao Xu, Lianyong Qiao, Hu Nie, Falong Lu, and Xun Huang*. (2022). BAP60 plays an opposite role to the MRT-NURF complex in regulating lipid droplet size. Journal of Genetics and Genomics 49(4): 377-379. DOI: 10.1016/j.jgg.2022.02.003
14.Muya Shu#, Xiaoyu Xue#, Hu Nie, Xianming Wu, Minghan Sun, Lianyong Qiao, Xing Li, Bai Xu, Zhifeng Xiao, Yannan Zhao, Yongheng Fan, Bing Chen, Jixiang Zhang, Ya Shi, Yaming Yang, Falong Lu*, and Jianwu Dai*. (2022). Single-Cell RNA Sequencing Reveals Nestin+ Active Neural Stem Cells Outside the Central Canal after Spinal Cord Injury. SCIENCE CHINA Life Sciences 65, 295–308. DOI: 10.1007/s11427-020-1930-0
15.Zhengnan Luo#, Jixiang Zhang#, Lianyong Qiao, Falong Lu*, and Zhiyong Liu*. (2021). Mapping out genome-wide binding sites of Prox1 by CUT&RUN approach in mouse cochlea. Neuroscience Bulletin 37, 1703–1707. DOI: 10.1007/s12264-021-00757-x
16.Wenhui Mu#, Si Li#, Jingkai Xu#, Xize Guo, Haoda Wu, Zhenhua Chen, Lianyong Qiao, Gisela Helfer, Falong Lu, Chong Liu, and Qing-Feng Wu*. (2021). Hypothalamic Rax(+) tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice. Nature Communications 12(1): 2288. DOI: 10.1038/s41467-021-22640-z
17.Yusheng Liu#, Hu Nie, and Falong Lu*. (2020). Dynamic RNA 3’ Uridylation and Guanylation during Mitosis. iScience 23(8): 101402. DOI: 10.1016/j.isci.2020.101402
陆发隆团队报道细胞周期调控新机制：RNA 3’末端修饰
18.Le-Yun Wang#, Zhi-Kun Li#, Li-Bin Wang#, Chao Liu#, Xue-Han Sun#, Gui-Hai Feng#, Jia-Qiang Wang, Yu-Fei Li, Lian-Yong Qiao, Hu Nie, Li-Yuan Jiang, Hao Sun, Ya-Li Xie, Si-Nan Ma, Hai-Feng Wan, Fa-Long Lu*, Wei Li*, and Qi Zhou*. (2020). Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell 27(2): 315-325 e315. DOI: 10.1016/j.stem.2020.05.014
Cell Stem Cell丨周琪/李伟/陆发隆合作发现修复基因印记异常大幅提高动物克隆效率
19.Chunyan Fan#, Honglian Zhang#, Liangzheng Fu, Yuejiao Li, Yi Du, Zilong Qiu, and Falong Lu*. (2020). Rett mutations attenuate phase separation of MeCP2. Cell Discovery 6, 38. DOI: 10.1038/s41421-020-0172-0
20.Chenrui An#, Guihai Feng#, Jixiang Zhang, Shiwei Cao, Ying Wang, Nannan Wang, Falong Lu, Qi Zhou, and Haoyi Wang*. (2020). Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation. Cell Stem Cell 27(3): 482-497 e484. DOI: 10.1016/j.stem.2020.06.002
21.Yusheng Liu#, Hu Nie#, Hongxiang Liu, and Falong Lu*. (2019). Poly(A) inclusive RNA isoform sequencing (PAIso？seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails. Nature Communications 10(1): 5292. DOI: 10.1038/s41467-019-13228-9
Nat Comm | 陆发隆组发开PAIso-seq方法揭示RNA poly(A)尾巴内部广泛存在其他碱基修饰
22.Luis Tuesta#, Mohamed Djekidel, Renchao Chen, Falong Lu, Wengang Wang, Bernardo Sabatini, and Yi Zhang*. (2019). In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function. Nature Communications 10(1): 2508. DOI: 10.1038/s41467-019-10267-0
23.Qi Qiu#, Hailiang Mei#, Xian Deng#, Kaixuan He#, Baixing Wu#, Qingqing Yao, Jixiang Zhang, Falong Lu, Jinbiao Ma*, and Xiaofeng Cao*. (2019). DNA methylation repels targeting of Arabidopsis REF6. Nature Communications 10(1): 2063. DOI: 10.1038/s41467-019-10026-1
24.Shogo Matoba#, Huihan Wang, Lan Jiang, Falong Lu, Kumiko Iwabuchi, Xiaoji Wu, Kimiko Inoue, Lin Yang, William Press, Jeannie Lee, Atsuo Ogura, Li Shen*, and Yi Zhang*. (2018). Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development. Cell Stem Cell 23(3): 343-354 e345. DOI: 10.1016/j.stem.2018.06.008
25.Mohamed Nadhir Djekidel#, Azusa Inoue#, Shogo Matoba, Tsukasa Suzuki, Chunxia Zhang, Falong Lu, Lan Jiang, and Yi Zhang*. (2018). Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent. Cell Reports 23(7): 1939-1947. DOI: 10.1016/j.celrep.2018.04.036
26.Falong Lu#*. (2018). The start of a human life program. Journal of Genetics and Genomics 45(4): 183-184. DOI: 10.1016/j.jgg.2018.04.001
27.Azusa Inoue#, Lan Jiang, Falong Lu, and Yi Zhang*. (2017). Genomic imprinting of Xist by maternal H3K27me3. Genes & Development 31(19): 1927-1932. DOI: 10.1101/gad.304113.117
28.Azusa Inoue#, Lan Jiang#, Falong Lu#, Tsukasa Suzuki, and Yi Zhang*. (2017). Maternal H3K27me3 controls DNA methylation-independent imprinting. Nature 547(7664): 419-424. DOI: 10.1038/nature23262
重大发现：张毅组Nature揭示基因印迹的新机制【附朱冰点评】丨BioArt特别推荐
29. Falong Lu#, Yuting Liu#, Azusa Inoue#, Tsukasa Suzuki, Keji Zhao, and Yi Zhang*. (2016). Establishing chromatin regulatory landscape during mouse preimplantation development. Cell 165(6): 1375-1388. DOI: 10.1016/j.cell.2016.05.050
表观遗传学大牛张毅在Cell发表早期胚胎发育研究新成果
30. Xia Cui#, Falong Lu#, Qi Qiu#, Bing Zhou#, Lianfeng Gu, Shuaibin Zhang, Yanyuan Kang, Xiekui Cui, Xuan Ma, Qingqing Yao, Jinbiao Ma, Xiaoyu Zhang, and Xiaofeng Cao*. (2016). REF6 recognizes specific DNA sequence to regulate H3K27me3 demethylation and organ boundary formation. Nature Genetics 48(6): 694-699. DOI: 10.1038/ng.3556
31. Minchul Kim#, Falong Lu, and Yi Zhang*. (2016). Loss of HDAC-Mediated Repression and Gain of NF-kappaB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer. Cell Reports 17(1): 275-288. DOI: 10.1016/j.celrep.2016.09.003
32. Fangfang Jiang#, Falong Lu, Peixue Li, Wei Liu*, Lu Zhao, Qifu Wang, Xiaofeng Cao, Lei Zhang, and Yong Q. Zhang*. (2016). Drosophila Homolog of FMRP Maintains Genome Integrity by Interacting with Piwi. Journal of Genetics and Genomics 43(1): 11-24. DOI: 10.1016/j.jgg.2015.11.001
33. Falong Lu# and Yi Zhang*. (2015). Cell totipotency: molecular features, induction, and maintenance. National Science Review 2(2): 217-225. DOI: 10.1093/nsr/nwv009
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35. Shuaibin Zhang#, Bing Zhou#, Yanyuan Kang, Xia Cui, Ao Liu, Angelique Deleris, Maxim V. C. Greenberg, Xiekui Cui, Qi Qiu, Falong Lu, James A. Wohlschlegel, Steven E. Jacobsen, and Xiaofeng Cao*. (2015). C-terminal domains of histone demethylase JMJ14 interact with a pair of NAC transcription factors to mediate specific chromatin association. Cell Discovery 1: 15003. DOI: 10.1038/celldisc.2015.3
36. Falong Lu#, Yuting Liu#, Lan Jiang#, Shinpei Yamaguchi, and Yi Zhang*. (2014). Role of Tet proteins in enhancer activity and telomere elongation. Genes & Development 28(19): 2103-2119. DOI: 10.1101/gad.248005.114
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专利：
陆发隆，刘玉胜；“一种待测样品中具有poly（A）尾巴的RNA的测序文库的构建方法”，专利号：ZL201910837492.2
刘玉胜，陆发隆； “poly(A)尾巴非A修饰在促进mRNA翻译中的应用”，专利申请号：202210410067.7
