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姜丹华


姜丹,博士,研究,博士生导师
 
        2003年获山东大学学士学位,2006年获上海大学硕士学位,2012年获新加坡国立大学 (National University of Singapore) 博士学位,2013年至2018年分别在新加坡Temasek Life Sciences Laboratory 及奥地利Gregor Mendel Institute 从事博士后研究。2018年加入中国科学院遗传与发育生物学研究所。


研究内容
 
        实验室将以模式植物拟南芥及作物为材料,研究
 
        1. 组蛋白变体的功能
        2. 染色质复制和表观遗传记忆的机理
        3. 表观遗传在植物发育和环境响应中的功能

发表文章(*Co-first author)
 
1. Wang H, Jiang D, Axelsson E, Lorkovic ZJ, Montgomery S, Holec S, Pieters BJGE, Al Temimi AHK, Mecinovic J, Berger F. LHP1 interacts with ATRX through plant-specific domains at specific loci targeted by PRC2. Molecular Plant, 2018, 11:1038-1052.
 
2. Jiang D, Berger F. DNA replication-coupled histone modification maintains Polycomb gene silencing in plants. Science, 2017, 357: 1146-1149.
 
3. Wollmann H, Stroud H, Yelagandula R, Tarutani Y, Jiang D, Jing L, Jamge B, Takeuchi H, Holec S, Nie X, Kakutani T, Jacobsen SE, Berger F. The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana. Genome Biology, 2017, 18: 94.
 
4. Lorkovic ZJ, Park C, Goiser M, Jiang D, Kurzbauer MT, Schlogelhofer P, Berger F. Compartmentalization of DNA damage response between heterochromatin and euchromatin is mediated by distinct H2A histone variants. Current Biology, 2017, 27: 1192-1199.
 
5. Jiang D, Berger F. Histone variants in plant transcriptional regulation. Biochimica et Biophysoca Acta (BBA)-Gene Regulatory Mechanisms, 2017, 1: 123-130.
 
6. Li Z*, Jiang D*, Fu X, Luo X, Liu R, He Y. Intergration of histone methylations with RNA processing by the nuclear mRNA cap binding complex. Nature Plants, 2016, 2: 16015.
 
7. Gu X, Le C, Wang Y, Li Z, Jiang D, Wang Y, He Y. Arabidopsis FLC clade members form flowering-repressor complexes coordinating responses to endogenous and environmental cues. Nature Communications, 2013, 4: 1947.
 
8. Gu X*, Jiang D*, Yang W*, Jacob Y, Michaels S, He Y. Arabidopsis homologs of retinoblastoma-associated protein 46/48 associate with a histone deacetylase to act redundantly in chromatin silencing. Plos Genetics, 2011, e1002366.
 
9. Jiang D, Kong N, Gu X, Li Z, He Y. Arabidopsis COMPASS-like complexes mediate histone H3 lysine 4 trimethylation to control the floral transition and plant development. Plos Genetics, 2011, e1001330.
 
10. Yang W, Jiang D, Jiang J, He Y. A plant-specific histone H3 lysine 4 demethylase represses floral transition in Arabidopsis. Plant Journal, 2010, 62: 663-673.
 
11. Jiang D, Gu X, He Y. Establishment of the winter-annual growth habit via FRIGIDA-mediated histone methylation at FLOWERING LOCUS C in Arabidopsis. Plant Cell, 2009, 21: 1733-1746.
 
12. Gu X, Jiang D, Wang Y, Bachmair A, He Y. Repression of the floral transition via histone H2B monoubiquitination. Plant Journal, 2009, 57: 522-533.
 
13. Jiang D, Wang Y, Wang Y, He Y. Rerpression of the FLOWERING LOCUS C and FLOWERING LOCUS T by the Arabidopsis polycomb repressive complex 2 components. Plos ONE, 2008, 3: e3404.
 
14. Jiang D*, Yang W*, He Y, Amasino RM. Arabidopsis relatives of human histone-lysine specific demethylase 1 repress expression FWA and FLOWERING LOCUS C and thus promote floral transition. Plant Cell, 2007, 19: 2975-2987.
 
15. Li X, Jiang D, Yong K, Zhang D. Varied transcriptional efficiencies of multiple Arabidopsis U6 small nuclear RNA genes. Journal of Integrative Plant Biology, 2007, 49: 222-229.
 
16. Jiang D, Yin C, Yu A, Zhou X, Liang W, Yuan Z, Xu Y, Yu Q, Wen T, Zhang D. Duplication and expression analysis of multicopy miRNA family members in Arabidopsis and rice. Cell Research, 2006, 16: 507-518.