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何康敏


何康敏,博士,研究员,博士生导师
 
        2008年在北京大学医学部获得预防医学学士学位,期间在北京大学中国经济研究中心获得经济学学士双学位;2013年在北京大学获得生物力学与医学工程博士学位;2013年至2019年在哈佛医学院/波士顿儿童医院先后从事博士后、Instructor/Research Associate 研究;2019年加入中国科学院遗传与发育生物学研究所。以第一或共同通讯作者在Nature和Cell等杂志发表多篇科研论文。


主要研究方向:
        利用活细胞单分子荧光成像技术以及发展新的细胞生物学工具,通过多学科交叉的研究手段探索:
        1. 细胞内吞和胞内囊泡运输的动态过程和调控机制;
        2. 细胞囊泡运输过程中脂类分子的动态转运转化、功能和调控;
        3. 细胞受体信号转导动态网络的可视化和定量化。

博士后和实习生招聘信息
        本实验室常年招聘博士后和实习生,欢迎直接联系。

代表性论文:
 
Guozhi Bi#, Min Su#, Nan Li#, Yu Liang, Song Dang, Jiachao Xu, Meijuan Hu, Jizong Wang, Minxia Zou, Yanan Deng, Qiyu Li, Shijia Huang, Jiejie Li, Jijie Chai, Kangmin He*, Yu-Hang Chen*, Jian-Min Zhou*. The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling. Cell (2021) S0092-8674(21)00600-0. (*Co-corresponding author)
 
Kangmin He*, Robert Marsland III, Srigokul Upadhyayula, Eli Song, Song Dang, Ben Capraro, Weiming Wang, Wesley Skillern, Raphael Gaudin, Minghe Ma, Tom Kirchhausen*. Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic. Nature (2017) 552:410-414. (*Co-corresponding author)
 
Kangmin He#, Eli Song#, Srigokul Upadhyayula#, Song Dang, Raphael Gaudin, Wesley Skillern, Kevin Bu, Benjamin R. Capraro, Iris Rapoport, Ilja Kusters, Minghe Ma, Tom Kirchhausen. Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic. Journal of Cell Biology (2020) 219(3) pii: e201908142. (#Co-first author)
 
Nan Li, Rong Zhao, Yahong Sun, Zi Ye, Kangmin He*, Xiaohong Fang*. Single-molecule imaging and tracking of molecular dynamics in living cells. National Science Review (2017) 4:739–760. (*Co-corresponding author)
 
Kangmin He, Xiaohua Yan, Nan Li, Song Dang, Li Xu, Bing Zhao, Zijian Li, Zhizhen Lv, Xiaohong Fang, Youyi Zhang, Ye-Guang Chen. Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes. Cell Research (2015) 25:738-752.
 
Kangmin He, Rui Xing, Xiaohua Yan, Aiju Tian, Mingliang Zhang, Jinghe Yuan, Zhizhen Lv, Xiaohong Fang, Zijian Li, Youyi Zhang. mAbp1/HIP-55 is essential for the scission of clathrin-coated pits by regulating dynamin-actin interaction. FASEB Journal (2015) 29:2495-503.
 
Kangmin He, Xiaoli Shi, Xuejie Zhang, Song Dang, Xiaowei Ma, Fei Liu, Ming Xu, Zhizheng Lv, Dong Han, Xiaohong Fang, Youyi Zhang. Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes. Cardiovascular Research (2011) 92:39–47.
 
Kangmin He#, Wangxi Luo#, Yuliang Zhang, Fei Liu, Da Liu, Li Xu, Lei Qin, Chunyang Xiong, Zhizhen Lu, Xiaohong Fang, Youyi Zhang. Intercellular transportation of quantum dots mediated by membrane nanotubes. ACS nano (2010) 4:3015-3022. (#Co-first author)
 
Kangmin He, Shunqin Wang, Jinliang Zhang. Blood lead levels of children and its trend in China. Science of the Total Environment (2009) 407:3986-93.
 
Yi-Ying Chou Srigokul Upadhyayula, Justin Houser, Kangmin He, Wesley Skillern, Gustavo Scanavachi, Song Dang, Anwesha Sanyal, Kazuka G. Ohashi, Giuseppe Di Caprio, Alex J.B. Kreutberger, Tegy John Vadakkan, Tom Kirchhausen. Inherited nuclear pore substructures template post-mitotic pore assembly. Developmental Cell (2021) Accepted.
 
Frederick B Shipley, Neil Dani, Huixin Xu, Christopher Deister, Jin Cui, Joshua P Head, Cameron Sadegh, Ryann M Fame, Morgan L Shannon, Vanessa I Flores, Thomas Kishkovich, Emily Jang, Eric M Klein, Glenn J Goldey, Kangmin He, Yong Zhang, Michael J Holtzman, Tomas Kirchhausen, Claire Wyart, Christopher I Moore, Mark L Andermann, Maria K Lehtinen. Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Neuron (2020) S0896-6273(20)30655-3.
 
Mingliang Zhang, Zhen Zhang, Kangmin He, Jimin Wu, Nan Li, Rong Zhao, Jinghe Yuan, Han Xiao, Youyi Zhang, Xiaohong Fang. Quantitative Characterization of the Membrane Dynamics of Newly Delivered TGF-β Receptors by Single-Molecule Imaging. Analytical Chemistry (2018) 90:4282-4287.
 
Jing Shen, Jianghui Zhang, Han Xiao, Jimin Wu, Kangmin He, Zhizhen Lv, Zijian Li, Ming Xu, Youyi Zhang. Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis. Cell Death & Disease (2018) 9:81.
 
Yu Hu, Ji Hyung Kim, Kangmin He, Qi Wan, Jessica Kim, Melanie Flach, Tom Kirchhausen, Andrea Vortkamp, Florian Winau. Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. Journal of Experimental Medicine (2016) 213:2759-2772.
 
Francois Aguet, Srigokul Upadhyayula, Raphael Gaudin, Yi-ying Chou, Emanuele Cocucci, Kangmin He, Bi-Chang Chen, Kishore Mosaliganti, Mithun Pasham, Wesley Skillern, Wesley R. Legant, Tsung-Li Liu, Greg Findlay, Eric Marino, Gaudenz Danuser, Sean Megason, Eric Betzig, Tom Kirchhausen. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Molecular Biology of the Cell (2016) 27:3418-3435.
 
Yi-ying Chou, Christian Cuevas, Margot Carocci, Sarah H. Stubbs, Minghe Ma, David K. Cureton, Luke Chao, Frances Evesson, Kangmin He, Priscilla L. Yang, Sean P. Whelan, Susan R. Ross, Tom Kirchhausen, Raphael Gaudin. Identification and characterization of a novel broad-spectrum virus entry inhibitor. Journal of Virology (2016) 90:4494-4510.
 
Jinghe Yuan, Kangmin He, Ming Cheng, Jianqiang Yu, Xiaohong Fang. Analysis of the steps in single-molecule photobleaching traces by using the hidden markov model and maximum likelihood clustering. Chemistry – An Asian Journal (2014) 9:2303-2308.