艾有为,博士,研究员,博士生导师
1990年出生。2012与2016年获东北林大学士与博士学位,博导马建章院士。2010-2014年在哈兽研学习病毒学;2014-2021年在北生所进行博士/博后训练,师从王晓东院士研究细胞死亡机制。2018年获博新计划支持。
研究领域:
(一)细胞死亡与癌症、组织器官损伤、甚至人类的健康寿命息息相关。
本课题组综合生物、化学、医学等多学科知识,通过全基因组CRISPR-Cas9筛选、小分子化合物筛选等手段解析细胞死亡的机制,揭示全新的细胞生物学过程。具体研究内容包括:
1. 细胞死亡的机制;
2. 发明小分子药物治疗癌症、退行性、炎症性疾病;
3. 理解人类寿命的极限,开发延长健康寿命的药物。
(二)同时,本实验室关注更小的生命体病毒的基本生物学特征。旨在:
4. 开发广谱抗病毒药物。
本课题组常年招收硕博生、博士后、工作人员。诚挚欢迎有志将生命科学研究当作毕生事业、有志在生命科学研究领域做出“不枉此生”的科研工作的伙伴,加入我们的队伍!!!
Publications as PI
(# First author; * Corresponding author)
1) Bo Yan#, Zhangcheng Ding, Wenbin Zhang, Gaihong Cai, Hui Han, Yan Ma, Yang Cao, Jiawen Wang, She Chen, Youwei Ai*. Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death. (2022), Cell Chemical Biology 29 (6), 958-969.e5 ( IF 9.039/Q1)
Publications as PhD/post-doc
(# First author; * Corresponding author)
---Highlighted in Nature Chemical Biology.
---Commented in Protein & Cell.
---Invited commentary from Dr. Guido Kroemer.
4) Youwei Ai*#, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma*, Shuanhu Gao*, Xiangbing Qi*. An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. (2020). Nature communications 11 (1), 1-10 ( Lead Contact)
5) Dianrong Li#, Youwei Ai#, Jia Guo, Baijun Dong, Lin Li, Gaihong Cai, She Chen, Dan Xu, Fengchao Wang, Xiaodong Wang*. Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-Interacting kinase 3.(2020). eLife 9, e61564
6) Dianrong Li#, Jie Chen#, Youwei Ai, Xiaoqiong Gu, Li Li, Di Che, Zhaodi Jiang, Lin Li, She Chen, Huangwei Huang, Jiawen Wang, Tao Cai, Yang Cao, Xiangbin Qi, Xiaodong Wang*. Estrogen-related hormones induce apoptosis by stabilizing Schlafen-12 protein turnover.(2019). Molecular Cell 75 (6), 1103-1116. e9
9) Youwei Ai#, Dantong Zhu, Cuihui Wang, Chao Su, Jian Ma, Jianzhang Ma*, Xiaojun Wang*. Core-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation. (2014). Journal of Virology 88 (20), 12112-12122 |