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艾有为


艾有为,博士,研究员,博士生导师
        1990年出生。2012年与2016年分别获东北林业大学学士与博士学位。2012-2014年在农科院联培完成博士论文;2014-2021年在北京生命科学研究所进行博士/博士后训练。2018年获博新计划支持,2021年获中科院BR计划支持。2021年加入中国科学院遗传与发育生物学研究所,任发育生物学研究中心研究员、博士生导师。

研究领域:
        细胞死亡与癌症发生、细胞因子风暴造成的肺炎、感染、神经退行性疾病、心脏病在内的多组织器官损伤,甚至个体死亡息息相关。
 
        本课题组综合生物化学、分子与细胞生物学、遗传学、化学生物学、生物信息学、医学免疫学等多学科知识,通过全基因组CRISPR-Cas9(敲除/激活)筛选、小分子化合物激动剂或者拮抗剂筛选、亲和沉淀互作蛋白筛选、结合经典生化技术及多组学分析等手段来解析细胞死亡的机制,揭示全新的细胞生物学过程。具体研究内容包括:
 
        1.细胞死亡的机制;
        2.发明小分子药物操控细胞死亡治疗癌症;
        3.发明小分子药物操控细胞死亡治疗神经退行性、炎症性疾病;
        4.个体死亡的机制与干预。
 
        本课题组常年招收硕博生、博士后、工作人员。诚挚欢迎有志将生命科学研究当作毕生事业、有志在生命科学研究领域做出不枉此生的科研工作的伙伴,加入我们的队伍!!!

Publications as PI
(# First author; * Corresponding author)
 
1) Bo Yan#, Zhangcheng Ding, Wenbin Zhang, Gaihong Cai, Hui Han, Yan Ma, Yang Cao, Jiawen Wang, She Chen, Youwei Ai*. Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death. (2022), Cell Chemical Biology 29 (6), 958-969.e5 (IF 9.039/Q1)
 
---Commented by Heidi Greulich (Broad Institute) in Cell Chemical Biology: A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation.
 
Publications as PhD/post-doc
(# First author; * Corresponding author)
 
1) Bo Yan#*, Youwei Ai#*, Qi Sun, Yan Ma, Yang Cao, Jiawen Wang, Zhiyuan Zhang, Xiaodong Wang. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. (2021). Molecular Cell 81 (2), 355-369. e10 (Lead Contact)
 
---Recommended in Faculty Opinions (F1000Prime) (10.3410/f.739220181.793581481)
---Highlighted in Nature Chemical Biology.
---Commented in Protein & Cell.
 
2) Bo Yan, Youwei Ai*, Zhiyuan Zhang, Xiaodong Wang*. Assessing POR and CYB5R1 oxidoreductase-mediated oxidative rupture of PUFA in liposomes. (2021). STAR protocols 2 (1), 100360
 
3 Youwei Ai#, Bo Yan#, Xiaodong Wang*. The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis. (2021). Molecular & Cellular Oncology 8 (2), 1881393
 
---Invited commentary from Dr. Guido Kroemer.
 
4) Youwei Ai*#, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma*, Shuanhu Gao*, Xiangbing Qi*. An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. (2020). Nature communications 11 (1), 1-10 (Lead Contact)
 
5) Dianrong Li#, Youwei Ai#, Jia Guo, Baijun Dong, Lin Li, Gaihong Cai, She Chen, Dan Xu, Fengchao Wang, Xiaodong Wang*. Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-Interacting kinase 3.(2020). eLife 9, e61564
 
6) Dianrong Li#, Jie Chen#, Youwei Ai, Xiaoqiong Gu, Li Li, Di Che, Zhaodi Jiang, Lin Li, She Chen, Huangwei Huang, Jiawen Wang, Tao Cai, Yang Cao, Xiangbin Qi, Xiaodong Wang*. Estrogen-related hormones induce apoptosis by stabilizing Schlafen-12 protein turnover.(2019). Molecular Cell 75 (6), 1103-1116. e9
 
7) Youwei Ai*#, Jianzhang Ma*, Xiaojun Wang*. Clues for two-step virion infectivity factor regulation by core binding factor beta.(2017). The Journal of General Virology 98 (5), 1113
 
8) Youwei Ai*#, Jianzhang Ma*. Multiple lysines combined in HIV-1 Vif determines the responsiveness to CBF-β. (2015). Biochemical and Biophysical Research Communications 457 (3), 385-390
 
9) Youwei Ai#, Dantong Zhu, Cuihui Wang, Chao Su, Jian Ma, Jianzhang Ma*, Xiaojun Wang*. Core-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation. (2014). Journal of Virology 88 (20), 12112-12122