研发脊髓损伤及心肌损伤修复生物材料产品。具体包括：医用胶原支架及水凝胶材料、靶向蛋白药物智能释放、干细胞三维培养及体内递送、组织类器官体外构建等。
发表论文
2.Chen Z#，Zhang H#, Fan C，Zhuang Y，Yang W, Chen Y，Shen H，Xiao Z，Zhao Y*, Li X*, Dai J*. Adhesive, Stretchable, and Spatiotemporal Delivery Fibrous Hydrogels Harness Endogenous Neural Stem/Progenitor Cells for Spinal Cord Injury Repair. ACS Nano. 2021. doi: 10.1021/acsnano.1c06892.
3.Tang F#, Tang J#, Zhao Y#, Zhang J#, Xiao Z, Chen B, Han G, Yin N, Jiang X, Zhao C, Cheng S, Wang Z, Chen Y, Chen Q, Song K, Wang Z, Niu J, Wang L, Shi Q,Chen L, Yang H, Hou S*, Zhang S*,Dai J*. Sci. China Life Sci. 2021. doi: 10.1007/s11427-021-1985-5.
4.Wang Q#, He X#, Wang B, Pan J, Shi C, Li J, Wang L, Zhao Y*, Dai J*, Wang D*, Injectable collagen scaffold promotes swine myocardial infarction recovery by long-term local retention of transplanted human umbilical cord mesenchymal stem cells. Sci. China Life Sci. 2021; Feb;64(2):269-281
5.He X#, Wang Q#, Zhao Y#, Zhang H, Wang B, Pan J, Li J, Yu H, Wang L, Dai J*，Wang D*. Effect of intramyocardial grafting collagen scaffold with mesenchymal stromal cells in patients with chronic ischemic heart disease: A Randomized Clinical Trial. JAMA Network Open. 2020;3(9):e2016236. doi:10.1001/jamanetworkopen.2020.16236
6.Liu W, Xu B, Xue W, Yang B; Fan Y; Chen B, Xiao Z, Xue X, Sun Z, Shu M, Zhang Q, Shi Y, Zhao Y*, Dai J*. A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair, Biomaterials. 2020,243:119941. DOI:10.1016/j.biomaterials.
7.Shi J#，Fan C#，Zhuang Y, Sun J, Hou X, Chen B, Xiao Z, Chen Y, Zhan Z, Zhao Y*, Dai J*. Heparan sulfate proteoglycan promotes fibroblast growth factor-2 function for ischemic heart repair. Biomaterials Science. 7(12):5438-5450.
8.Fan C#, Shi J#, Zhuang Y, Zhang L, Huang L, Yang W, Chen B, Chen Y, Xiao Z, Shen H, Zhao Y*, Dai J*. Myocardial-Infarction-Responsive Smart Hydrogels Targeting Matrix Metalloproteinase for On-Demand Growth Factor Delivery. Advanced Materials. 2019 Oct;31(40):e1902900.
9.Shi C#, Zhao Y#, Yang Y, Chen C, Hou X, Shao J, Yao H, Li Q, Xia Y, Dai J*. Collagen-binding VEGF targeting the cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction. Biomaterials Science. 2018. 30;6(2):356-363
10.Xiao Z#, Tang F#, Zhao Y#, Han G, Yin N, Li X, Chen B, Han S, Jiang X, Yun C, Zhao C, Cheng S, Zhang S*, Dai J*. Significant Improvement of Acute Complete Spinal Cord Injury Patients Diagnosed by a Combined Criteria Implanted with NeuroRegen Scaffolds and Mesenchymal Stem Cells. Cell Transplant. 2018. 27(6):907-915
11.Chen X#, Zhao Y#, Li X, Xiao Z, Yao Y, Chu Y, Farkas B, Romano I, Brandi F, Dai J*. Functional Multichannel Poly(Propylene Fumarate)-Collagen Scaffold with Collagen-Binding Neurotrophic Factor 3 Promotes Neural Regeneration After Transected Spinal Cord Injury. Adv Healthc Mater. 2018. 7(14):e1800315.
12.Shi L#, Zhao Y#, Xie Q, Fan C, Hilborn J, Dai J*, Ossipov DA*. Moldable Hyaluronan Hydrogel Enabled by Dynamic Metal-Bisphosphonate Coordination Chemistry for Wound Healing. Adv Healthc Mater. 2018 Mar;7(5). doi: 10.1002/adhm.201700973.
13.Chen B#, Xiao Z#，Zhao Y#，Dai J*. Functional biomaterial-based regenerative microenvironment for spinal cord injury repair. National Science Review. 2017. 4(4) 530-532
14.Li X#, Zhao Y#, Cheng S#, Han S, Shu M, Chen B, Chen X, Tang F, Wang N, Tu Y, Wang B, Xiao Z, Zhang S, Dai J. Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenous neural stem cells for acute spinal cord injury repair. Biomaterials. 2017. 137:73-86.
15.Zhao Y#, Tang F#, Xiao Z#, Han G, Wang N, Yin N, Chen B, Jiang X, Yun C, Han W, Zhao C, Cheng S, Zhang S*, Dai J*. Clinical Study of NeuroRegen Scaffold Combined with Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury. Cell Transplant. 2017. 26(5):891-900.
16.Li X#, Liu S#, Zhao Y#, Li J, Ding W, Han S, Chen B, Xiao Z, Dai J*. Training Neural Stem Cells on Functional Collagen Scaffolds for Severe Spinal Cord Injury Repair. Adv Funct Mater. 2016. 26(32):5835-5847
17.Zhang J#, Zhao Y#, Hou X, Chen B, Xiao Z, Han J, Shi C, Liu J, Miao Q, Dai J*. The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification. Biomaterials. 2014. 35(34):9322-31.
18.Su G#, Zhao Y#, Wei J#, Han J, Chen L, Xiao Z, Chen B, Dai J*. Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces. Biomaterials. 2013. 34(13):3215-22.
19.Su G#, Zhao Y#, Wei J#, Xiao Z, Chen B, Han J, Chen L, Guan J, Wang R, Dong Q, Dai J*. The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties. Biomaterials. 2013. 34(13):3215-3222.
20.Han S#, Zhao Y#, Xiao Z, Han J, Chen B, Chen L, Dai J*. The three-dimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells. J Genet Genomics. 2012. 39(12):633-41.
21.Shi C#, Li Q#, Zhao Y#, Chen W, Chen B, Xiao Z, Lin H, Nie L, Wang D* and Dai J*.(2011) Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration. Biomaterials. 2011. 32(10):2508-2515
22.He Q#, Zhao Y#, Chen B, Xiao Z, Zhang J, Chen L, Chen W, Deng F and Dai J*. Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. Acta Biomater. 2011. 7:1084-1093.
23.Zhao Y#, Zhang J#, Wang X ,Chen B, Xiao Z，Shi C, Wei Z，Hou X，Wang Q and Dai J*. The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies. J Control Release. 2010. 141(1):30-37
24.Zhang J#, Ding L#, Zhao Y#, Sun W, Chen B, Lin H, Wang X , Zhang L, Xu B* and Dai J*. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation. 2009. 119(13):1776-1784.
25.Zhao Y#, Lin H#, Zhang J, Chen B, Sun W, Wang X, Zhao W, Xiao Z and Dai J*. Crosslinked Three-Dimensional Demineralized Bone Matrix for the Adipose-Derived Stromal Cell Proliferation and Differentiation. Tissue Eng Part A. 2009. 15(1): 13-21
26.Yang Y#, Zhao Y#, Chen B, Han Q, Sun W, Xiao Z and Dai J*. Collagen-binding human epidermal growth factor promotes cellularization of collagen scaffolds. Tissue Eng Part A. 2009. 15(11):3589-3596.
27.Zhao Y#, Chen B#, Lin H, Sun W, Zhao W, Zhang J and Dai J*. The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2. J Biomed Mater Res A, 2009. 88(3): 725-734.
28.Lin H#, Zhao Y#, Sun W#, Chen B, Zhang J, Zhao W, Xiao Z and Dai J*. The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2. Biomaterials. 2008. 29(9):1189-1197.
