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赵燕南


赵燕南,博士,青年研究员
        2016年入选中科院青年创新促进会会员,2020入选中科院青年创新促进会优秀会员。
 
教育经历
        2000/9-2004/7 内蒙古大学,获学士学位
        2004/9-2010/7 中科院遗传发育所,获博士学位
 
工作经历
        2010/07-2012/12 中科院遗传发育所,助理研究员
        2013/01-2020/12 中科院遗传发育所,副研究员
        2021/01-现在 中科院遗传发育所,青年研究员


研究内容
        研发脊髓损伤及心肌损伤修复生物材料产品。具体包括:医用胶原支架及水凝胶材料、靶向蛋白药物智能释放、干细胞三维培养及体内递送、组织类器官体外构建等。

发表论文
1.Wang Q#, He X#, Wang B, Pan J, Shi C, Li J, Wang L, Zhao Y*, Dai J*, Wang D*, Injectable collagen scaffold promotes swine myocardial infarction recovery by long-term local retention of transplanted human umbilical cord mesenchymal stem cells. Sci. China Life Sci. 2021; Feb;64(2):269-281
 
2.He X#, Wang Q#, Zhao Y#, Zhang H, Wang B, Pan J, Li J, Yu H, Wang L, Dai J*,Wang D*. Effect of intramyocardial grafting collagen scaffold with mesenchymal stromal cells in patients with chronic ischemic heart disease: A Randomized Clinical Trial. JAMA Network Open. 2020;3(9):e2016236. doi:10.1001/jamanetworkopen.2020.16236
 
3.Liu W, Xu B, Xue W, Yang B; Fan Y; Chen B, Xiao Z, Xue X, Sun Z, Shu M, Zhang Q, Shi Y, Zhao Y*, Dai J*. A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair, Biomaterials. 2020,243:119941. DOI:10.1016/j.biomaterials.
 
4.Shi J#,Fan C#,Zhuang Y, Sun J, Hou X, Chen B, Xiao Z, Chen Y, Zhan Z, Zhao Y*, Dai J*. Heparan sulfate proteoglycan promotes fibroblast growth factor-2 function for ischemic heart repair. Biomaterials Science. 7(12):5438-5450. 
 
5.Fan C#, Shi J#, Zhuang Y, Zhang L, Huang L, Yang W, Chen B, Chen Y, Xiao Z, Shen H, Zhao Y*, Dai J*. Myocardial-Infarction-Responsive Smart Hydrogels Targeting Matrix Metalloproteinase for On-Demand Growth Factor Delivery. Advanced Materials. 2019 Oct;31(40):e1902900.
 
6.Shi C#, Zhao Y#, Yang Y, Chen C, Hou X, Shao J, Yao H, Li Q, Xia Y, Dai J*. Collagen-binding VEGF targeting the cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction. Biomaterials Science. 2018. 30;6(2):356-363
 
7.Xiao Z#, Tang F#, Zhao Y#, Han G, Yin N, Li X, Chen B, Han S, Jiang X, Yun C, Zhao C, Cheng S, Zhang S*, Dai J*. Significant Improvement of Acute Complete Spinal Cord Injury Patients Diagnosed by a Combined Criteria Implanted with NeuroRegen Scaffolds and Mesenchymal Stem Cells. Cell Transplant. 2018. 27(6):907-915
 
8.Chen X#, Zhao Y#, Li X, Xiao Z, Yao Y, Chu Y, Farkas B, Romano I, Brandi F, Dai J*. Functional Multichannel Poly(Propylene Fumarate)-Collagen Scaffold with Collagen-Binding Neurotrophic Factor 3 Promotes Neural Regeneration After Transected Spinal Cord Injury. Adv Healthc Mater. 2018. 7(14):e1800315.
 
9.Shi L#, Zhao Y#, Xie Q, Fan C, Hilborn J, Dai J*, Ossipov DA*. Moldable Hyaluronan Hydrogel Enabled by Dynamic Metal-Bisphosphonate Coordination Chemistry for Wound Healing. Adv Healthc Mater. 2018 Mar;7(5). doi: 10.1002/adhm.201700973. 
 
10.Chen B#, Xiao Z#Zhao Y#,Dai J*. Functional biomaterial-based regenerative microenvironment for spinal cord injury repair. National Science Review. 2017. 4(4) 530-532
 
11.Li X#, Zhao Y#, Cheng S#, Han S, Shu M, Chen B, Chen X, Tang F, Wang N, Tu Y, Wang B, Xiao Z, Zhang S, Dai J. Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenous neural stem cells for acute spinal cord injury repair. Biomaterials. 2017. 137:73-86.
 
12.Zhao Y#, Tang F#, Xiao Z#, Han G, Wang N, Yin N, Chen B, Jiang X, Yun C, Han W, Zhao C, Cheng S, Zhang S*, Dai J*. Clinical Study of NeuroRegen Scaffold Combined with Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury. Cell Transplant. 2017. 26(5):891-900.
 
13.Li X#, Liu S#, Zhao Y#, Li J, Ding W, Han S, Chen B, Xiao Z, Dai J*. Training Neural Stem Cells on Functional Collagen Scaffolds for Severe Spinal Cord Injury Repair. Adv Funct Mater. 2016. 26(32):5835-5847
 
14.Zhang J#, Zhao Y#, Hou X, Chen B, Xiao Z, Han J, Shi C, Liu J, Miao Q, Dai J*. The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification. Biomaterials. 2014. 35(34):9322-31.
 
15.Su G#, Zhao Y#, Wei J#, Han J, Chen L, Xiao Z, Chen B, Dai J*. Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces. Biomaterials. 2013. 34(13):3215-22. 
 
16.Su G#, Zhao Y#, Wei J#, Xiao Z, Chen B, Han J, Chen L, Guan J, Wang R, Dong Q, Dai J*. The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties. Biomaterials. 2013. 34(13):3215-3222.
 
17.Han S#, Zhao Y#, Xiao Z, Han J, Chen B, Chen L, Dai J*. The three-dimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells. J Genet Genomics. 2012. 39(12):633-41.
 
18.Shi C#, Li Q#, Zhao Y#, Chen W, Chen B, Xiao Z, Lin H, Nie L, Wang D* and Dai J*.(2011) Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration. Biomaterials. 2011. 32(10):2508-2515
 
19.He Q#, Zhao Y#, Chen B, Xiao Z, Zhang J, Chen L, Chen W, Deng F and Dai J*. Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. Acta Biomater. 2011. 7:1084-1093.
 
20.Zhao Y#, Zhang J#, Wang X ,Chen B, Xiao Z,Shi C, Wei Z,Hou X,Wang Q and Dai J*. The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies. J Control Release. 2010. 141(1):30-37
 
21.Zhang J#, Ding L#, Zhao Y#, Sun W, Chen B, Lin H, Wang X , Zhang L, Xu B* and Dai J*.  Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation. 2009. 119(13):1776-1784.
 
22.Zhao Y#, Lin H#, Zhang J, Chen B, Sun W, Wang X, Zhao W, Xiao Z and Dai J*. Crosslinked Three-Dimensional Demineralized Bone Matrix for the Adipose-Derived Stromal Cell Proliferation and Differentiation. Tissue Eng Part A. 2009. 15(1): 13-21
 
23.Yang Y#, Zhao Y#, Chen B, Han Q, Sun W, Xiao Z and Dai J*. Collagen-binding human epidermal growth factor promotes cellularization of collagen scaffolds. Tissue Eng Part A. 2009. 15(11):3589-3596.
 
24.Zhao Y#, Chen B#, Lin H, Sun W, Zhao W, Zhang J and Dai J*. The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2. J Biomed Mater Res A, 2009. 88(3): 725-734.
 
25.Lin H#, Zhao Y#, Sun W#, Chen B, Zhang J, Zhao W, Xiao Z and Dai J*. The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2. Biomaterials. 2008. 29(9):1189-1197.