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  Location: Home >> Faculty >> Center for Genome Biology
  Center for Genome Biology

Lei Li

Dr Lei Li got his BS in biotechnology at Northwest A&F University. As a graduate student, he obtained his PhD working on plant immune pattern recognition receptor complex and virulence function of pathogen effectors at the Institute of Genetics and Developmental Biology in the laboratory of Prof. Jian-Min Zhou. Then, he moved to the Max-Planck-Institute for Developmental Biology as a postdoc working with Prof. Detlef Weigel on the mechanism of plant hybrid necrosis.

We are interested in the molecular mechanism of plant-microbe interaction. Focusing on plant and fungi interaction, we are interested in understanding the molecular dialogue between plants and fungal pathogens, mechanisms of plant immune genes conferring resistance to pathogens, as well as molecular details underlying plant-endophytic fungi interaction. We will employ a variety of approaches including molecular genetics, biochemistry, functional genomics, and cell biology to investigate co-evolution between plants and microbes. The lab is new, and we are always eager to hear from enthusiastic researchers from any related backgrounds interested in joining the lab. For more information, please refer to
1. Li, L., Weigel, D. (2021) One hundred years of hybrid necrosis: hybrid autoimmunity as a window into mechanisms and evolution of plant–pathogen interactions. Annual Review of Phytopathology. https://doi/10.1146/annurev-phyto-020620-114826.
2. Schulze, S.*, Yu, L.*, Ehinger, A., Kolb, D., Saile, S., Stahl, M., Franz-Wachtel, M., Li, L., Kasmi, F., Cevik, V., Kemmerling, B. (2021). The TIR-NBS-LRR protein CSA1 is required for autoimmune cell death in Arabidopsis pattern recognition co-receptor bak1 and bir3 mutants. bioRxiv,
3. Zhu, W., Li, L., Neuh?user, B., Thelen, M., Wang, M., Chen, J., Wei, L., Venkataramani, K., Exposito-Alonso, M., Liu, C., Keck, J., Barragan, C., Schwab, B., Lutz, U., Ludewig, U., Weigel, D. (2021). Small peptides modulate the immune function of the ion channel-like protein ACD6 in Arabidopsis thaliana. bioRxiv,
4. Cambiagno, D., Giudicatti, A., Arce, A., Gagliardi, D., Li, L., Yuan, W., Lundberg, D., Weigel, D., Manavella, P. (2020). HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing. Molecular Plant,
5. Li, L., Habring, A., Wang, K., Weigel, D. (2020). Oligomerization of NLR immune receptor RPP7 triggered by atypical resistance protein RPW8/HR. Cell Host Microbe 27, 405-417.
6. Pramoj, P., Lundberg, D., Weigel, D., Li, L.#, (2020). Blue native polyacrylamide gel electrophoresis (BN‐PAGE) for the analysis of protein oligomers in plants.  Current Protocol in Plant Biology 5, e20107. doi: 10.1002/cppb.20107.
7. Wang, W., Yang, J., Zhang, J., Liu, Y.-X., Tian, C., Qu, B., Gao, C., Xin, P., Cheng, S., Zhang, W., Miao, P., Li, L., Zhang, X., Chu, J., Zuo, J., Li, J., Bai, Y., Lei, X., Zhou, J.M. (2020). An Arabidopsis secondary metabolite directly targets expression of the bacterial Type III secretion system to inhibit bacterial virulence. Cell Host Microbe 27, 601–613.e7.
8. Wang, J., Grubb, L.E., Wang, J., Liang, X., Li, L., Gao, C., Ma, M., Feng, F., Li, M., Li, L., Zhang, X., Yu, F., Xie, Q., Chen, S., Zipfel, C., Monaghan, J., Zhou, J.M. (2018). A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase. Molecular Cell 69, 493–504.e6.
9. Zhu, W., Zaidem, M., Van de Weyer, A.L., Gutaker, R.M., Chae, E., Kim, S.T., Bemm, F., Li, L., Todesco, M., Schwab, R., Unger, F., Beham, M.J., Demar, M., Weigel, D. (2018). Modulation of ACD6 dependent hyperimmunity by natural alleles of an Arabidopsis thaliana NLR resistance gene. PLoS Genetics 14, e1007628.
10. Li, L.*,#, Kim, P.*, Yu, L.*, Cai, G., Chen, S., Alfano, J.R. and Zhou, J.M.# (2016) Activation-dependent destruction of a co-receptor by a pseudomonas syringae effector dampens plant immunity. Cell Host Microbe 20, 504-514. (# co-corresponding authors, * co-first authors).
11. Li, L., Yu, Y., Zhou, Z., and Zhou, J.M. (2016). Plant pattern-recognition receptors controlling innate immunity. Science China Life Sciences 59,878-888.
12. Liang, X.*, Ding, P. *, Lian, K., Wang, J., Ma, M., Li, L., Li, L., Li, M., Zhang, X., Chen, S., Zhang, Y.#, and Zhou, J.M.# (2016). Arabidopsis heterotrimeric G proteins directly regulate FLS2-mediated immunity. eLife 10.7554/eLife.13568.
13. Yang, H., Mu, J., Chen, L., Feng, J., Hu, J., Li, L., Zhou, J.M., and Zuo, J. (2015). S-nitrosylation positively regulates ascorbate peroxidase activity during plant stress responses. Plant Physiology 167, 1604-1615.
14. Li, L.*, Li, M.*, Yu, L., Zhou, Z., Liang, X., Liu, Z., Cai, G., Gao, L., Zhang, X., Wang, Y., Chen, S., and Zhou, J.M. (2014). The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity. Cell Host Microbe 15, 329-338.
15. Sun, Y.*, Li, L.*, Macho, A.P., Han, Z., Hu, Z., Zipfel, C., Zhou, J.M.#, and Chai, J.# (2013). Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science 342, 624-628.