Yuan Wang

Education:

2014: Ph.D. in Genetics, Fudan University, Shanghai, China

2007: B.S. in Biotechnology, Hainan University, Haikou, China

 

Professional Experience:

2022-       , Principle Investigator, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

2022-       , Principle Investigator, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS)

2015-2022, Postdoctoral fellow, University of California, Riverside.

Research Interests:

 

The Wang lab is interested in how epigenetic regulation shapes cell fate specification during plant organ and tissue development, as well as how non-coding RNAs involve in soybean shoot and root development and resilience.

 

1.How epigenetic regulation specifies organogenesis and cell fate determination.

Epigenetic regulation on gene expression is versatile and elaborate. Compared to the previous studies of global epigenetic influences on whole organism, we found some epigenetic regulators showing cell-type/tissues specific spatial and temporal expression patterns. We are trying to uncover how epigenetic regulation contributes to cell-type specification and the plant architecture.

 

2.The regulatory function of non-coding RNAs on soybean development.

Non-coding RNAs regulate gene expression in various ways. They largely influence plant development and resilience. For example, microRNA could serve as mobile molecules in legume to regulate nodulation. We saw impairment of small interfering RNAs leading to the pleotropic defects in soybean shoot and root development. We hope to understand the mechanisms how non-coding RNAs contribute to soybean development and maintain the balance between growth, productivity and symbiosis.

Selected publication：

1.Yuan Wang^#, Brandon H. Le^#, Jianqiang Wang, Chenjiang You, Yonghui Zhao, Mary Galli, Ye Xu, Andrea Gallavotti, Thomas Eulgem, Beixin Mo, Xuemei Chen*. ZMP recruits and excludes Pol IV–mediated DNA methylation in a site-specific manner.2022, Science Advances. DOI: 10.1126/sciadv.adc9454.

 

2.Shaofang Li^#, Yuan Wang^#, Yonghui Zhao, Xinjie Zhao, Xuemei Chen, Zhizhong Gong.

(2020) Global co-transcriptional splicing in Arabidopsis and the correlation with splicing regulation in mature RNAs. Molecular Plant.13(2):266-277.

 

3.Yuan Wang^#, Shaofang Li^#, Yonghui Zhao, Chenjiang You, Brandon Le, Zhizhong Gong, Beixin Mo, Yiji Xia, and Xuemei Chen*. (2019) NAD+-capped RNAs are widespread in the Arabidopsis transcriptome and can probably be translated. Proceedings of the National Academy of Sciences of the United States of America.116 (24): 12094-12102.

 

4.Yuan Wang, Shiyong Sun, Wenjiao Zhu, Zhenying Cai, Hong Li, Kunpeng Jia, Hongquan Yang, and Xuelu Wang. (2013) Strigolactone / MAX2-induced degradation of the brassinosteroid transcriptional effector BES1 regulates shoot branching in Arabidopsis. Developmental Cell. 27, 681–688